Molecular Pharmaceutics最新文献

{"title":"Automated Radiosynthesis of High-Molar-Activity 4-Borono-2-[18F]Fluorophenylalanine: Validation in Rodent Tumor Models and Nonhuman Primates","authors":"Weijian Ye,&nbsp;Junqi Hu,&nbsp;Zhiqiang Tan,&nbsp;Junjie Wei,&nbsp;Boyu Liu,&nbsp;Huiyi Wei,&nbsp;Wenqing Ran,&nbsp;Siqi Zhang,&nbsp;Kuan Hu,&nbsp;Steven H. Liang,&nbsp;Ming-Rong Zhang,&nbsp;Hao Xu,&nbsp;Lu Wang","doi":"10.1021/acs.molpharmaceut.6c00177","DOIUrl":"10.1021/acs.molpharmaceut.6c00177","url":null,"abstract":"<p>The clinical efficacy of [¹⁰B]borono-<span>l</span>-phenylalanine([¹⁰B]BPA)-mediated Boron Neutron Capture Therapy (BNCT)relies heavily on accurate patient stratification using the companiondiagnostic tracer 4-borono-2-[¹⁸F]fluorophenylalanine ([¹⁸F]FBPA). However, widespread clinical deployment is currentlyhindered by the limited production capacity and low molar activityof traditional electrophilic synthesis. To address this unmet need,we established a fully automated, GMP-compliant radiosynthesis of[¹⁸F]FBPA using a spirocyclic iodonium ylide (SCIDY) precursoron a commercial module. This optimized protocol delivered clinical-grade[¹⁸F]FBPA with a decay-corrected radiochemical yield of15.5% ± 6.3% and a high molar activity of 75.9 ± 20.0 GBq/μmol. <em>In vivo</em> evaluation in subcutaneous xenografts showed highspecificity for LAT1-positive tumors. Furthermore, in orthotopic C6glioma and CAL27 tongue squamous cell carcinoma models, the tracerdemonstrated effective blood-brain barrier penetration and good contrast,achieving Tumor-to-Normal (T/N) ratios of ∼ 3.3. Translationalpharmacokinetic studies in nonhuman primates revealed rapid renalclearance and low background accumulation in critical head-and-neckorgans, with a favorable effective dose of 0.012 mSv/MBq. This studypresents a robust, clinical-ready strategy for producing high-molar-activity[¹⁸F]FBPA, bridging the gap between advanced radiochemistryand precise BNCT treatment planning.</p>","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"23 8","pages":"4133–4143"},"PeriodicalIF":4.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Preclinical Evaluation of Dual-Target 68Ga/177Lu-Labeled FAP-Bisphosphonate Radioligands with Enhanced Osteoma Retention","authors":"Ruiyue Zhao,&nbsp;Yuling Deng,&nbsp;Wenbin Jin,&nbsp;Mingheng Xu,&nbsp;Wanmei Liang,&nbsp;Shaoyu Liu,&nbsp;Jiawei Zhong,&nbsp;Jie Lv,&nbsp;Jianxing He,&nbsp;Lin Zhu,&nbsp;Xinlu Wang","doi":"10.1021/acs.molpharmaceut.5c01617","DOIUrl":"10.1021/acs.molpharmaceut.5c01617","url":null,"abstract":"<p>Bone metastases and associated skeletal-related events(SREs) severelycompromise the survival and quality of life of patients with advancedcancer. Although bisphosphonates enable efficient bone targeting,their radiolabeled analogues exhibit limited uptake in osteolyticlesions due to the low hydroxyapatite content. Fibroblast activationprotein, highly expressed in cancer-associated fibroblasts withinthe tumor microenvironment, provides tumor specificity and may enhancetracer accumulation in osteolytic bone metastases. To overcome thislimitation, we developed two heterodimeric [⁶⁸Ga]Ga/[¹⁷⁷Lu]Lu-DOTA-FAPI-bisphosphonate radioligands ([⁶⁸Ga]Ga/[¹⁷⁷Lu]Lu-DFP-1/2) by integrating a FAP-targetingmoiety with a bisphosphonate backbone. Both compounds were synthesizedwith high radiochemical purity (&gt;95%) and excellent in vitro stability.In A549-FAP xenograft models, dynamic PET/CT imaging revealed comparabletumor uptake of [⁶⁸Ga]Ga-DFP-1/2 and [⁶⁸Ga]Ga-FAPI-04up to 2 h postinjection, with [⁶⁸Ga]Ga-DFP-2 demonstratingfaster clearance from nontarget organs. In tibial A549-FAP osteogenicmodels, [⁶⁸Ga]Ga-DFP-2 showed significantly higher uptake(4.88 ± 1.01% ID/mL) than mono-FAP or monobisphosphonate tracers(<em>p</em> &lt; 0.05). In osteolytic A549 models, [⁶⁸Ga]Ga-DFP-2 uptake (3.16 ± 0.82% ID/mL) also exceeded that ofmonobisphosphonate tracers (<em>p</em> &lt; 0.01). Biodistributionstudies confirmed prolonged [¹⁷⁷Lu]Lu-DFP-2 retention (26.94± 4.40% ID/g at 168 h). Collectively, these findings demonstratethat [⁶⁸Ga]Ga/[¹⁷⁷Lu]Lu-DFP-2 possesses favorabledual bone- and tumor-targeting characteristics and holds strong translationalpromise as a novel theranostic agent for the imaging and treatmentof lung cancer bone metastases.</p>","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"23 8","pages":"4037–4047"},"PeriodicalIF":4.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147757498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[68Ga]Ga-DOTA-DP-UBI 29-41: A Novel 68Ga-Labeled Ubiquicidin 29-41 Derivative Containing d-Proline for Bacterial Infection PET Imaging","authors":"Yuhao Jiang,&nbsp;Peiwen Han,&nbsp;Yu Qian,&nbsp;Liyin Zhang,&nbsp;Yifu Sun,&nbsp;Guangxing Yin,&nbsp;Dajie Ding,&nbsp;Lina Diao,&nbsp;Ziqing Zhao,&nbsp;Jianyong Jiang,&nbsp;Junbo Zhang","doi":"10.1021/acs.molpharmaceut.6c00462","DOIUrl":"10.1021/acs.molpharmaceut.6c00462","url":null,"abstract":"<p>Bacterial infection poses a persistentand severe threat to humanhealth. Accurate differentiation between bacterial infection and sterileinflammation is critical for timely clinical treatment. In this study,a novel ⁶⁸Ga-labeled radiotracer ([⁶⁸Ga]Ga-DOTA-DP-UBI29-41) was radiosynthesized by labeling the UBI 29-41 derivative (DOTA-DP-UBI29-41) with ⁶⁸Ga. This radiotracer was designed by introducing <span>d</span>-proline (DP) as a linker between the ubiquicidin 29-41 (UBI29-41) targeting segment and the 1,4,7,10-tetraazacyclododecane-<em>N</em>,<em>N</em>′,<em>N</em>,<em>N</em>′-tetraacetic acid (DOTA) chelating group. The radiotracerexhibited high radiochemical purity (RCP &gt; 98%) and favorable <em>in vitro</em> stability in normal saline at room temperatureand mouse serum at 37 °C, with hydrophilic properties (Log<em>D</em> = −3.58 ± 0.04). <em>In vitro</em> bacterial experiments confirmed the specific and rapid binding ofthis radiotracer to <em>Staphylococcus aureus</em>, with binding reaching equilibrium within 30 min of incubation andexhibiting concentration-dependent competitive inhibition with UBI29-41. Biodistribution studies in mouse models revealed effectiveaccumulation of the tracer at bacterial infection sites (1.98 ±0.66% ID/g at 30 min p.i.), significantly lower renal uptake (stabilizedat ∼25% ID/g) than previous ⁶⁸Ga-labeled UBI 29-41derivatives, and a distinct difference in uptake between bacterium-infectedand sterile inflamed muscles (an infection-to-inflammation ratio of2.11 at 120 min p.i.). PET/CT imaging further confirmed that the tracercould clearly visualize bacterial infection foci and distinguish infectionfrom sterile inflammation in dual-pathology mice, with rapid bloodclearance kinetics, renal metabolism, and excretion. Collectively,these results indicate that [⁶⁸Ga]Ga-DOTA-DP-UBI 29-41will be a promising PET tracer for the specific diagnosis of bacterialinfection and differentiation from sterile inflammation.</p>","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"23 8","pages":"4263–4272"},"PeriodicalIF":4.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast-Selective Lipid Nanoparticles for Tumor Stromal Transfection","authors":"Na Yeon Kim,&nbsp;Yeon Hui Yang,&nbsp;Takatsugu Ishimoto,&nbsp;Ji-Ho Park","doi":"10.1021/acs.molpharmaceut.6c00877","DOIUrl":"10.1021/acs.molpharmaceut.6c00877","url":null,"abstract":"<p>Fibroblasts are abundant and functionally diverse componentsofthe tumor microenvironment and have emerged as attractive targetsfor stromal modulation in solid tumors. However, selective gene deliveryto fibroblasts remains challenging due to their heterogeneity andclose spatial association with tumor and immune cells, particularlywhen using ligand-free lipid nanoparticle (LNP)-based delivery systems.In this study, we applied a selectivity-driven screening approachto identify LNP formulations that preferentially transfect fibroblastsbased on lipid composition. Systematic variation of clinically relevantionizable and helper lipids identified specific LNP compositions thatconsistently favored fibroblast-selective mRNA expression. <em>In vitro</em> analysis showed that specific lipid compositionsconferred preferential transgene expression in fibroblasts, whichwas maintained under competitive tumor cell-fibroblast coculture conditions.Consistent with these findings, peritumoral administration of optimizedLNPs in tumor-bearing mice demonstrated preferential mRNA expressionin stromal fibroblasts within the tumor microenvironment. These resultsestablish the lipid composition of LNPs as a key determinant of fibroblast-selectivemRNA expression across <em>in vitro</em>, coculture, and peritumoral <em>in vivo</em> models.</p>","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"23 8","pages":"4377–4386"},"PeriodicalIF":4.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug Delivery-Enabled Antibiofilm Therapeutics from Traditional Chinese Medicine-Derived Bioactives: Recent Advances and Future Perspectives","authors":"Ying Chen,&nbsp;Duoyang Fan,&nbsp;Haohan Li,&nbsp;Jinfang Xiao,&nbsp;Wei Yang,&nbsp;Wenbin Zeng,&nbsp;Fei Chen","doi":"10.1021/acs.molpharmaceut.6c00514","DOIUrl":"10.1021/acs.molpharmaceut.6c00514","url":null,"abstract":"<p>Biofilm-associatedinfections remain difficult to treat becausethe extracellular polymeric substance matrix, charge-selective transport,microenvironmental gradients, and persister formation together limiteffective drug exposure and reduce the antimicrobial efficacy. TraditionalChinese Medicine-derived bioactives provide structurally diverse small-moleculepayloads with promising antibiofilm potential, but their therapeuticutility is often constrained by poor aqueous solubility, chemicalinstability, rapid clearance, and insufficient local retention atthe infected sites. This Review surveys recent advances in drug delivery-enabledantibiofilm therapeutics based on TCM-derived bioactives, with emphasison how delivery design addresses distinct biofilm-associated barriers.Representative payload liabilities are first discussed to clarifywhy formulation design is central to improving performance. Majordelivery platforms, including nanoparticles, hydrogels, and microneedle-assistedsystems, are then compared by using shared pharmaceutics criteriasuch as loading strategy, release behavior, penetration, retention,and model relevance. In addition, photodynamic, photothermal, andsonodynamic approaches are examined as combination strategies thatcan augment delivery-enabled biofilm control. Rather than catalogingnatural products or delivery systems, this Review focuses on the relationshipamong biofilm barriers, payload properties, delivery design, and preclinicalevaluation. Current challenges related to model relevance, qualityconsistency, safety, manufacturability, and further development arealso discussed. Overall, this Review aims to provide a practical frameworkfor the rational design of antibiofilm therapeutics based on TCM-derivedbioactives.</p>","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"23 8","pages":"3973–4002"},"PeriodicalIF":4.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Depth Comparison of Fasted State Simulated Intestinal Fluid (FaSSIF) Versions via NMR Spectroscopy and Complementary Methods","authors":"Malte Mildner,&nbsp;Svetla Daskalova,&nbsp;Shakhawath Hossain,&nbsp;Lena Scheller,&nbsp;Per Larsson,&nbsp;Lorenz Meinel,&nbsp;Ann-Christin Pöppler","doi":"10.1021/acs.molpharmaceut.6c00481","DOIUrl":"10.1021/acs.molpharmaceut.6c00481","url":null,"abstract":"<p>Efficientscreening methods in the early drug developmentstageare key to quickly finding promising drug candidates. Solutions simulatingconditions in the small intestine, the main absorption region fororally administered drugs, such as FaSSIF-V2 and V3, are essential.Updated versions aim to better mimic the natural environment withmodified concentrations of the main components, taurocholate and lecithin,or inclusion of oxidation products. Here, we use NMR spectroscopyto investigate the aggregation behavior and interactions between drugsand/or polymers with the components in FaSSIF-V2 and -V3 on a molecularlevel. BCS-class II compounds carbamazepine, ketoconazole, and efavirenzserved as model drugs. We found that while the individual FaSSIF versionsalone showed a different apparent diffusion, addition of either drugsor polymers evened out these differences. The more complex compositionof FaSSIF-V3 results in a higher signal overlap in the NMR spectra.Furthermore, the simultaneous presence of similar chemical entitieswith different solubilities is challenging for the DOSY analysis,as one NMR signal contains differently diffusing species. NMR spectroscopycomplemented by solubility and DLS measurements as well as MD simulationsshowed that the different diffusion behavior of FaSSIF-V2 and -V3is indeed a result of the solubility variations of the lecithin-likemolecules. Furthermore, it was observed that all model drugs behaveddifferently in the FaSSIF media, spanning behavior from barely interacting(carbamazepine) to drug molecules in fast exchange between bile colloidsand free solution (ketoconazole) to molecules fully incorporated intothe bile aggregates (efavirenz). Although FaSSIF-V3 mimics the naturalenvironment better, FaSSIF-V2 behaved overall more robustly acrossthe different analytical tools and the molecular-level picture obtainedfor the individual media was overall similar.</p>","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"23 8","pages":"4273–4287"},"PeriodicalIF":4.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voices in Molecular Pharmaceutics: Meet Professor Prateek Jha, Who Employs Multiscale Modeling to Better Understand Drug Release","authors":"Prateek K. Jha","doi":"10.1021/acs.molpharmaceut.6c00290","DOIUrl":"10.1021/acs.molpharmaceut.6c00290","url":null,"abstract":"","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"23 8","pages":"3971–3972"},"PeriodicalIF":4.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic Insight into Self-Gelation Involved in Prescription Design for Optimization of Tablet Performance","authors":"Xiaoqian Liu,&nbsp;Weitao Fang,&nbsp;Ruijie Zhang,&nbsp;Wuheng Yue,&nbsp;Zhiwei Xiong,&nbsp;Baimin Niu,&nbsp;Huizhen Sun,&nbsp;Jiaxin Chen,&nbsp;Jue Wang,&nbsp;Jiawei Han","doi":"10.1021/acs.molpharmaceut.6c00282","DOIUrl":"10.1021/acs.molpharmaceut.6c00282","url":null,"abstract":"<p>Somedrugs undergo gelation during the formulation developmentprocess, which not only poses significant challenges to the manufacturingprocess of solid dosage forms but also significantly restricts thedrug dissolution and absorption. Could such gelation be utilized bydesigning the prescription to overcome the adverse effects and watersolubility defect of drugs? Herein, this study attempted to designthe self-gelation tablets of indomethacin (IND) by introducing small-moleculeligands and to explore the self-gelation mechanism. As a result, thedesigned tablets occurred to have spontaneous gelation with a typical3D structure and viscoelasticity upon contact with a small amountof water, accompanied by amorphization transformation. Such a self-gelationbehavior was significantly influenced by the composition ratios, storagetemperatures, and medium pH values. In comparison to pure IND tablet,the designed IND-ligand tablets performed significantly increasedapparent solubility (&gt;200-fold) and intrinsic dissolution rate(&gt;6000-fold)and maintained the long-term supersaturated dissolution with acid–baseinteractions, which was revealed by nucleation inhibition, fluorescencequenching, and phase solubility tests. Moreover, the self-gelled tabletssignificantly enhanced the membrane permeability of IND, demonstratingthe potential for promoting oral absorption. Thus, this study revealedthe self-gelation mechanism of the tablet combination and confirmedsuch prescription design involving self-gelation as an efficient solubilizationstrategy.</p>","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"23 8","pages":"4203–4216"},"PeriodicalIF":4.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Multifunctional Nanotheranostics for Dual-Modal Imaging-Guided Precision Therapy of Nasopharyngeal Carcinoma”","authors":"Qianyu Yang,&nbsp;Yingkun Guo,&nbsp;Yang Zhou,&nbsp;Jiali Song,&nbsp;Yujun Song,&nbsp;Hanmei Li,&nbsp;Huile Gao,&nbsp;Weiyuan Huang","doi":"10.1021/acs.molpharmaceut.6c00905","DOIUrl":"10.1021/acs.molpharmaceut.6c00905","url":null,"abstract":"","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"23 8","pages":"4387–4388"},"PeriodicalIF":4.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Plasticizer Polarity on the Permeability of Hydroxypropyl Methylcellulose Phthalate Films","authors":"Naitik Jariwala,&nbsp;Samuel De Kerpel,&nbsp;Becky Provinciael,&nbsp;Kurt Vermeire,&nbsp;Guy Van den Mooter","doi":"10.1021/acs.molpharmaceut.5c01573","DOIUrl":"10.1021/acs.molpharmaceut.5c01573","url":null,"abstract":"<p>The aim of this studywas to gain detailed insights into how differentplasticizers influence the permeability of isolated hydroxypropylmethyl cellulose phthalate (HPMC-P) films. Since the migration ofplasticizers from film coatings may critically affect their functionality,it is essential to monitor the impact of their leaching on the associatedfilm properties. In this work, the leaching behavior of plasticizersfrom isolated HPMC-P films was estimated using their thermal propertiesby modulated temperature differential scanning calorimetry (MT-DSC)at varying plasticizer concentrations. The films plasticized withacetyl triethyl citrate (ATEC) and dibutyl sebacate (DBS) exhibitedlower permeability compared to those plasticized with polyethyleneglycol 400 (PEG 400). This reduced permeability can be attributedto the slower leaching rates of ATEC and DBS and to the persistenthydrophobic character that they impart to the films, even after prolongedaqueous exposure. In contrast, films plasticized with PEG 400 demonstratedthe highest permeability because of the hydrophilicity induced inthe polymeric films. However, a subsequent decline in their diffusionrate was observed once PEG 400 had leached out of the films. Furthermore,the correlation between leaching behavior and flux profiles providedan understanding of the influence of plasticizer on film permeabilitybased on their polarity. Moreover, saturation in plasticization efficiencywas noted with DBS-based films at higher plasticizer concentrations(greater than 10% w/w). Overall, our study highlights the importanceof selecting appropriate plasticizers for the development of polymerfilms and provides insights into tailoring film permeability and drugrelease kinetics.</p>","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"23 8","pages":"4025–4036"},"PeriodicalIF":4.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148349992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}