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Molecular Pharmaceutics最新文献

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IF 4.5 2区 医学
Molecular Pharmaceutics Pub Date : 2025-08-04
Pradeep Valekar,  and , Ira S. Buckner*, 
{"title":"","authors":"Pradeep Valekar,  and , Ira S. Buckner*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"22 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5c00709","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanomedicine for Treating Major Brain Diseases: Advances and Future Directions. 治疗重大脑部疾病的纳米药物：进展和未来方向。
IF 4.5 2区 医学
Molecular Pharmaceutics Pub Date : 2025-08-04 Epub Date: 2025-06-30 DOI: 10.1021/acs.molpharmaceut.5c00277
Girisha Sagar, Barnabas Wilson, Geetha Kannoth Mukundan, Kalpana Divekar, Josephine Leno Jenita
{"title":"Nanomedicine for Treating Major Brain Diseases: Advances and Future Directions.","authors":"Girisha Sagar, Barnabas Wilson, Geetha Kannoth Mukundan, Kalpana Divekar, Josephine Leno Jenita","doi":"10.1021/acs.molpharmaceut.5c00277","DOIUrl":"10.1021/acs.molpharmaceut.5c00277","url":null,"abstract":"<p><p>Traditional drug delivery systems lack target specificity. Various macromolecules, which are useful to treat central nervous system (CNS) diseases, have failed in clinical trials. This is because the molecules fail to cross the blood-brain barrier (BBB) effectively. The diseases of the brain are a major cause of disability and death. Various brain diseases affect 3.4 billion people worldwide. Nanomedicine, the medical application of nanotechnology for the diagnosis and treatment of diseases, improves drugs' solubility, stability, bioavailability, safety, and therapeutic efficacy. Site-specific ligand conjugated nanomedicine increases the target-specificity of nanomedicine toward specific receptors or determinants and delivers the drugs to the target organ. Nanomedicine provides better patient care while minimizing side effects and treatment cost. Further, it has the ability to change the traditional way of diagnosing and treating diseases. This review discusses recent advances in the usefulness of nanomedicine to treat major brain diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and stroke. The article also addresses the challenges in the development of nanoformulation and associated nanotoxicity.</p>","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":" ","pages":"4413-4434"},"PeriodicalIF":4.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Water Mobility and Clustering in Lyophilized Human Serum Albumin. 冻干人血清白蛋白的水流动性和聚集性。
IF 4.5 2区 医学
Molecular Pharmaceutics Pub Date : 2025-08-04 Epub Date: 2025-07-24 DOI: 10.1021/acs.molpharmaceut.5c00317
Yunhua Chen, Xiaoda Yuan, Shaoxin Feng, Zhiyi Lin, Ehab Moussa, Evgenyi Y Shalaev
{"title":"Water Mobility and Clustering in Lyophilized Human Serum Albumin.","authors":"Yunhua Chen, Xiaoda Yuan, Shaoxin Feng, Zhiyi Lin, Ehab Moussa, Evgenyi Y Shalaev","doi":"10.1021/acs.molpharmaceut.5c00317","DOIUrl":"10.1021/acs.molpharmaceut.5c00317","url":null,"abstract":"<p><p>Water plays a critical role in the stability of lyophilized protein therapeutics by stabilizing protein structures while also contributing to degradation processes like deamidation. Previous studies suggest a critical water threshold where degradation rates change, possibly due to shifts in water distribution between bound and free forms. However, the use of human serum albumin (HSA) as a model to understand the role of water clustering in protein stability has not been systematically explored. Our study examines water distribution, mobility, and clustering in lyophilized HSA using dynamic vapor sorption (DVS), solid-state NMR (ssNMR) spectroscopy, and molecular dynamics (MD) simulations. The water sorption isotherm follows Type II behavior, with Brunauer-Emmett-Teller (BET) analysis indicating a monolayer water content of 6 wt %. MD simulations also show water clusters forming at a similar threshold (∼5.5%). ssNMR analysis reveals increased water mobility between 7.4 and 11.5% water content, marking the transition from bound to free water. Our findings suggest that there is a critical water threshold for lyophilized HSA at 5-6%, where initial clustering occurs, leading to free water with increased mobility (7.4-11.5%). This indicates progressive water interactions and dynamics. This alignment of experimental and modeling data provides a useful insight into the role of water distribution in protein stability in lyophiles. In addition, these results offer a basis for further studies to explore the relationship between water thresholds and protein degradation, with potential applications for optimizing the stability of lyophilized pharmaceutical products.</p>","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":" ","pages":"4731-4737"},"PeriodicalIF":4.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.5 2区 医学
Molecular Pharmaceutics Pub Date : 2025-08-04
Munishwar Nath Gupta, Prathamesh Kudtarkar, Aarti Pawar and Premlata Ambre*, 
{"title":"","authors":"Munishwar Nath Gupta,&nbsp;Prathamesh Kudtarkar,&nbsp;Aarti Pawar and Premlata Ambre*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"22 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5c00282","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.5 2区 医学
Molecular Pharmaceutics Pub Date : 2025-08-04
Hassan Shahfar*,  and , Christopher J. Roberts, 
{"title":"","authors":"Hassan Shahfar*,&nbsp; and ,&nbsp;Christopher J. Roberts,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"22 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5c00673","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.5 2区 医学
Molecular Pharmaceutics Pub Date : 2025-08-04
Alfonso Arguello, Gaurav Sadhnani, Jerry Leung, Fatma Moawad, Pieter R. Cullis, Sarah Hedtrich and Davide Brambilla*, 
{"title":"","authors":"Alfonso Arguello,&nbsp;Gaurav Sadhnani,&nbsp;Jerry Leung,&nbsp;Fatma Moawad,&nbsp;Pieter R. Cullis,&nbsp;Sarah Hedtrich and Davide Brambilla*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"22 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5c00403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.5 2区 医学
Molecular Pharmaceutics Pub Date : 2025-08-04
Christopher I. Williams, Farbod Mahmoudinobar, David C. Thompson, J. Wade Davis and Sandeep Kumar*, 
{"title":"","authors":"Christopher I. Williams,&nbsp;Farbod Mahmoudinobar,&nbsp;David C. Thompson,&nbsp;J. Wade Davis and Sandeep Kumar*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"22 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5c00250","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.5 2区 医学
Molecular Pharmaceutics Pub Date : 2025-08-04
Drishty Satpati*, 
{"title":"","authors":"Drishty Satpati*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"22 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.4c01180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.5 2区 医学
Molecular Pharmaceutics Pub Date : 2025-08-04
Luiza Orszulak*, Aldona Minecka, Roksana Bernat, Taoufik Lamrani, Karolina Jurkiewicz, Barbara Hachuła, Magdalena Tarnacka, Monika Geppert-Rybczyńska, Maciej Zubko, Marcela Staniszewska, Michał Smoleński, Justyna Dobosz, Grzegorz Garbacz, Kamil Kamiński and Ewa Kamińska, 
{"title":"","authors":"Luiza Orszulak*,&nbsp;Aldona Minecka,&nbsp;Roksana Bernat,&nbsp;Taoufik Lamrani,&nbsp;Karolina Jurkiewicz,&nbsp;Barbara Hachuła,&nbsp;Magdalena Tarnacka,&nbsp;Monika Geppert-Rybczyńska,&nbsp;Maciej Zubko,&nbsp;Marcela Staniszewska,&nbsp;Michał Smoleński,&nbsp;Justyna Dobosz,&nbsp;Grzegorz Garbacz,&nbsp;Kamil Kamiński and Ewa Kamińska,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"22 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5c00276","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.5 2区 医学
Molecular Pharmaceutics Pub Date : 2025-08-04
Karolina Krautforst, Julita Kulbacka, Marco Fornasier, Rita Mocci, Andrea Porcheddu, Antonio Pusceddu, Davide Moccia, Sergio Murgia* and Urszula Bazylińska*, 
{"title":"","authors":"Karolina Krautforst,&nbsp;Julita Kulbacka,&nbsp;Marco Fornasier,&nbsp;Rita Mocci,&nbsp;Andrea Porcheddu,&nbsp;Antonio Pusceddu,&nbsp;Davide Moccia,&nbsp;Sergio Murgia* and Urszula Bazylińska*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":52,"journal":{"name":"Molecular Pharmaceutics","volume":"22 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5c00340","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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