Korean Journal of Clinical Laboratory Science最新文献_第10页

Polysomnography Analysis of Electroencephalography in Patients Expending Benzodiazepine Drugs 服用苯二氮卓类药物患者脑电图的多导睡眠图分析

Korean Journal of Clinical Laboratory Science Pub Date : 2021-12-31 DOI: 10.15324/kjcls.2021.53.4.333

D. Jang, Dong-Kyu Lim, Jae Kyung Kim

引用次数: 1

Obesity, Obstructive Sleep Apnea, and Metabolic Dysfunction 肥胖、阻塞性睡眠呼吸暂停和代谢功能障碍

Korean Journal of Clinical Laboratory Science Pub Date : 2021-12-31 DOI: 10.15324/kjcls.2021.53.4.285

Jinkwan Kim, Sang-Shin Pyo, D. Yoon

{"title":"Obesity, Obstructive Sleep Apnea, and Metabolic Dysfunction","authors":"Jinkwan Kim, Sang-Shin Pyo, D. Yoon","doi":"10.15324/kjcls.2021.53.4.285","DOIUrl":"https://doi.org/10.15324/kjcls.2021.53.4.285","url":null,"abstract":"Sleep plays an important role in maintaining overall human health. There is increasing interest regarding the impact of sleep related disorders on metabolic diseases. Obstructive sleep apnea (OSA) is a common health problem, and in the last decade, the emergence of increasing obesity rates has further led to a remarkable increase in the prevalence of OSA, along with more prominent metabolic diseases. Obesity is the strongest risk factor for OSA. However, OSA is also known to cause obesity, suggesting an interaction between OSA and obesity. Although the underlying mechanisms leading to OSA-induced metabolic diseases are probably multi-factorial and are yet to be fully elucidated, the activation of inflammation and oxidative stress and the dysregulation of appetite-regulating hormones have emerged as important pathophysiological components of metabolic dysfunction and obesity observed in patients with OSA. Here, we will review the current state of research regarding the association of OSA with metabolic diseases and the possible pathophysiological mechanisms by which OSA could lead to such diseases. This will enhance our understanding of the potential interactions between OSA and obesity and between OSA and metabolic dysfunction.","PeriodicalId":52807,"journal":{"name":"Korean Journal of Clinical Laboratory Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47116238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Interaction of High Sensitivity C-Reactive Protein and Uric Acid on Obesity in Koreans: Based on the Seventh Korea National Health and Nutrition Examination Survey (KNHANES VII, 2016∼2018) 高敏C反应蛋白和尿酸与韩国人肥胖的相互作用：基于第七次韩国国民健康和营养调查（KNHANES VII2016～2018）

Korean Journal of Clinical Laboratory Science Pub Date : 2021-12-31 DOI: 10.15324/kjcls.2021.53.4.342

Sang-Shin Pyo

{"title":"The Interaction of High Sensitivity C-Reactive Protein and Uric Acid on Obesity in Koreans: Based on the Seventh Korea National Health and Nutrition Examination Survey (KNHANES VII, 2016∼2018)","authors":"Sang-Shin Pyo","doi":"10.15324/kjcls.2021.53.4.342","DOIUrl":"https://doi.org/10.15324/kjcls.2021.53.4.342","url":null,"abstract":"We used data from the 7th Korea National Health and Nutrition Examination Survey (KNHANES) (2016∼2018) to investigate an association between high sensitivity C-reactive protein (hsCRP) and uric acid in the obese. Obesity was defined as a body mass index (BMI) of 25 kg/m 2 or more, severe obesity as a BMI of 30 kg/m 2 or more, and morbid obesity as a BMI of 35 kg/m 2 or more. In the complex samples multiple logistic regression, despite adjustment by adding major risk factors, the odds ratio (OR) for obesity was higher in the group with high levels of both, hsCRP and uric acid than the reference group at all stages (obesity, OR 1.89, P＜0.001 vs. severe obesity, OR 5.04, P＜0.001 vs. morbid obesity, OR 8.20, P＜0.001). The association between hsCRP and uric acid in obese patients increased from 1.89 to 8.20 as the obesity level increased, suggesting that participants with increased BMI were significantly affected by hsCRP and uric acid. Moreover, the interaction between hsCRP and uric acid was statistically significant even in the model corrected for major confounding factors (P for interaction=0.009).","PeriodicalId":52807,"journal":{"name":"Korean Journal of Clinical Laboratory Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45364776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparison of Optimal Storage Temperature and Collection Reagents for Living Bacterial Cells in Swab Samples 棉签样品中活菌细胞最佳保存温度和收集试剂的比较

Korean Journal of Clinical Laboratory Science Pub Date : 2021-12-31 DOI: 10.15324/kjcls.2021.53.4.326

Yeong Ju Lee, H. You, Song Hee Lee, S. Lee, Han Lee, H. Sung, Hee-Gyoo Kang, S. Hyun

{"title":"Comparison of Optimal Storage Temperature and Collection Reagents for Living Bacterial Cells in Swab Samples","authors":"Yeong Ju Lee, H. You, Song Hee Lee, S. Lee, Han Lee, H. Sung, Hee-Gyoo Kang, S. Hyun","doi":"10.15324/kjcls.2021.53.4.326","DOIUrl":"https://doi.org/10.15324/kjcls.2021.53.4.326","url":null,"abstract":"are useful and common sampling tools in various research fields, such as medicine, ecology, biotechnology, forensic medicine, and pollutant monitoring systems. Collection reagents are one of the essential components in sampling. It is important to develop a sample collection kit and designate an appropriate storage temperature because samples need to be stored for a long time. The purpose of this study was to identify the effects of three collection reagents and three storage temperatures on the recovery of living bacteria without media. We selected Escherichia coli and Staphylococcus aureus as representative environmental bacteria. Distilled water (DW), phosphate buffered saline (PBS), and Tris-EDTA (TE) buffer were used as collection reagents and stored at 22°C, 4°C, and − 70°C after sampling. The results of using each collection reagent and storage temperature on the bacteria were compared using relative light units (RLU) and the number of colony forming units (CFU). When using − 70°C storage temperature and the TE buffer, the number of living bacteria and the RLU values remained constant. It is therefore recommended that the sample be stored at − 70°C immediately after collection and a TE buffer solution be used as the collection reagent.","PeriodicalId":52807,"journal":{"name":"Korean Journal of Clinical Laboratory Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45388336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MNNG-Regulated Differentially Expressed Genes that Contribute to Cancer Development in Stomach Cells 胃癌细胞中mnng调控的差异表达基因

Korean Journal of Clinical Laboratory Science Pub Date : 2021-12-31 DOI: 10.15324/kjcls.2021.53.4.353

Tae-Jin Kim, Myeong-Kwan Kim, Dongju Jung

{"title":"MNNG-Regulated Differentially Expressed Genes that Contribute to Cancer Development in Stomach Cells","authors":"Tae-Jin Kim, Myeong-Kwan Kim, Dongju Jung","doi":"10.15324/kjcls.2021.53.4.353","DOIUrl":"https://doi.org/10.15324/kjcls.2021.53.4.353","url":null,"abstract":"Cancer is a global health problem. There are diverse types of cancers, but there are several common pathways which lead to the development of cancer. Changes in gene expression might be the most common similarity found in almost all cancers. An understanding of the underlying changes in gene expression during cancer progression could lay a valuable foundation for the development of cancer therapeutics and even cancer vaccines. In this study, a well-known carcinogen, N-methyl-N’-nitro-N-nitrosoguanidine (MNNG), was employed to induce changes in gene expression in normal stomach cells. MNNG is known to cause cancer by inducing damage to DNA in MNNG-treated mammalian cells and animals fed with this carcinogen. An analysis was performed by comparing the differentially expressed genes (DEGs) caused by MNNG treatment with DEGs in stomach cancer cell lines. To this end, methods of analysis for functional categorization and protein-protein interaction networks, such as gene ontology (GO), the database for annotation, visualization, and integrated discovery (DAVID), Kyoto encyclopedia of genes and genomics (KEGG) and search tool for the retrieval of interacting genes/proteins (STRING), were used. As a result of these analyses, MNNG-regulated specific genes and interaction networks of their protein products that contributed to stomach cancer were identified. Copyright Ⓒ","PeriodicalId":52807,"journal":{"name":"Korean Journal of Clinical Laboratory Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49051656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Protective Effects of Lespedeza bicolor Extract on B16/F10 Melanoma Cell Lines Damaged by Lead Acetate, Heavy Metal Compounds 胡枝子提取物对醋酸铅、重金属化合物损伤的B16/F10黑色素瘤细胞株的保护作用

Korean Journal of Clinical Laboratory Science Pub Date : 2021-12-31 DOI: 10.15324/kjcls.2021.53.4.363

Y. Seo

引用次数: 0

Diagnosis and Prognosis of Sepsis 脓毒症的诊断与预后

Korean Journal of Clinical Laboratory Science Pub Date : 2021-12-31 DOI: 10.15324/kjcls.2021.53.4.309

Chang-Eun Park

{"title":"Diagnosis and Prognosis of Sepsis","authors":"Chang-Eun Park","doi":"10.15324/kjcls.2021.53.4.309","DOIUrl":"https://doi.org/10.15324/kjcls.2021.53.4.309","url":null,"abstract":"Sepsis is a physiological response to a source of infection that triggers mechanisms that compromise organ function, leading to death if not treated early. Biomarkers with high sensitivity, specificity, speed, and accuracy that could differentiate sepsis from non-infectious systemic inflammatory response syndrome (SIRS) could bring about a revolution in sepsis treatment. Given the limitations and time required for microbial verification of pathogens, the accurate diagnosis of infection before employing antibiotic therapy is important and clinically necessary. Procalcitonin (PCT), lactate, C-reactive protein (CRP), cytokines, and proadrenomedullin (ProADM) are the common biomarkers used for diagnosis. The procalcitonin (PCT)-guided antibiotic treatment in patients with acute respiratory infections effectively reduces antibiotic exposure and side effects while improving survival rates. The evidence regarding sepsis screening in hospitalized patients is limited. Clinicians, researchers, and healthcare decision-makers should consider these findings and limitations when implementing screening tools, future research, or policy on sepsis recognition in hospitalized patients. The use of biomarkers in pediatric sepsis is promising, although such use should always be correlated with clinical evaluation. Biomarkers may also improve the prediction of mortality, especially in the early phase of sepsis, when the levels of certain pro-inflammatory cytokines and proteins are elevated.","PeriodicalId":52807,"journal":{"name":"Korean Journal of Clinical Laboratory Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49128152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Distribution Variations of Chigger Mites Collected in Jinan, Jeollabuk-do 全罗北道济南市恙螨分布变化

Korean Journal of Clinical Laboratory Science Pub Date : 2021-12-31 DOI: 10.15324/kjcls.2021.53.4.317

Chul Park, H. Lee

引用次数: 3