Dr Sulaiman Al Habib Medical Journal最新文献_第7页

Virtual Screening and Inhibition of Middle East Respiratory Syndrome Coronavirus Replication by Targeting Papain-like Protease 以木瓜样蛋白酶为靶点虚拟筛选及抑制中东呼吸综合征冠状病毒复制

Dr Sulaiman Al Habib Medical Journal Pub Date : 2021-01-01 DOI: 10.2991/dsahmj.k.210921.001

M. Kandeel, B. Park, M. Morsy, K. Venugopala, K. Oh‐hashi, M. Al-Nazawi, H. Kwon

{"title":"Virtual Screening and Inhibition of Middle East Respiratory Syndrome Coronavirus Replication by Targeting Papain-like Protease","authors":"M. Kandeel, B. Park, M. Morsy, K. Venugopala, K. Oh‐hashi, M. Al-Nazawi, H. Kwon","doi":"10.2991/dsahmj.k.210921.001","DOIUrl":"https://doi.org/10.2991/dsahmj.k.210921.001","url":null,"abstract":"Infection by the emerging, potentially zoonotic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) presents a severe health hazard to humans and is often fatal. Given the lack of particular medicines against MERS-CoV, drug discovery studies are needed to bridge this knowledge gap. In this study, we introduce virtual screening-guided identification of MERS-CoV Papain-like Protease (PL pro )-binding drugs. After a two-step virtual screening method, enzyme assays and antiviral testing with a MERS-CoV plaque reduction assay were used to further investigate the five compounds with the highest computational score. The top five screened compounds showed a 10.2–40% decrease in MERS-CoV PL pro activity. The top two compounds showed promising inhibition of MERS-CoV replication, reducing virus plaque formation by 30.6% and 24%. Compounds 1 and 4 in this study can be further modified to target binding with MERS-CoV PL pro active triad residues. Furthermore, the compounds produced stable interaction with the protein and protein conformation. With their reported inhibition of MERS-CoV enzyme and virus replication, supported by favorable absorption, distribution, metabolism, and excretion and toxicity profiles, the two reported benzimidazole and piperazine derivatives could be considered lead compounds against MERS-CoV.","PeriodicalId":52781,"journal":{"name":"Dr Sulaiman Al Habib Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73164048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Multisystem Inflammatory Syndrome Associated with COVID-19 in Pediatrics: A Case Report in Saudi Arabia 儿科与COVID-19相关的多系统炎症综合征:沙特阿拉伯一例报告

Dr Sulaiman Al Habib Medical Journal Pub Date : 2020-12-01 DOI: 10.2991/dsahmj.k.201204.001

R. Sleiman, Waleed A. Okash, Abdulaziz Sayah Alruwaili, Dareen A. Elkhateeb, A. Youcef, R. Harb

引用次数: 3

Neupogen (Filgrastim) Induced Acute Hematuria/Proteinuria with 3 Days of Use in a 7-Year-old Boy Diagnosed as Aplastic Anemia Neupogen(非格昔汀)在诊断为再生障碍性贫血的7岁男孩中引起急性血尿/蛋白尿3天

Dr Sulaiman Al Habib Medical Journal Pub Date : 2020-07-01 DOI: 10.2991/dsahmj.k.200704.001

S. Azam, Hassan Eliwan, Fatima Eltayeb Hago, A. Hammoudi

引用次数: 2

Awareness of Lebanese Pharmacists towards the Use and Misuse of Gabapentinoids and Tramadol: A Cross-sectional Survey 黎巴嫩药剂师对加巴喷丁类药物和曲马多使用和误用的认识:一项横断面调查

Dr Sulaiman Al Habib Medical Journal Pub Date : 2020-02-01 DOI: 10.2991/dsahmj.k.200206.002

Farah Tarhini, Reem Taky, Lynne H. Jaffal, Jinan Kresht, Gaelle El-Chaer, S. Awada, N. Lahoud, D. Khachman

引用次数: 4

Strengthening Mortality Statistics for Health Programs in Malaysia: Lessons from the Field 加强马来西亚卫生方案死亡率统计:来自实地的经验教训

Dr Sulaiman Al Habib Medical Journal Pub Date : 2019-12-01 DOI: 10.2991/dsahmj.k.191214.003

C. Rao, M. A. Omar, S. Ganapathy, N. I. Tamin

{"title":"Strengthening Mortality Statistics for Health Programs in Malaysia: Lessons from the Field","authors":"C. Rao, M. A. Omar, S. Ganapathy, N. I. Tamin","doi":"10.2991/dsahmj.k.191214.003","DOIUrl":"https://doi.org/10.2991/dsahmj.k.191214.003","url":null,"abstract":"Malaysia is one of a few Asian countries with a longstanding history of vital registration systems. Yet, issues with data quality have limited the utility of available vital statistics for public health policy, program evaluation, and research [1,2]. Although death registration is complete for states located on Peninsular Malaysia, the problem of marginal underreporting of deaths still persists in the eastern states of Sabah and Sarawak [3]. However, initiatives have been recently launched by the Malaysian National Registration Department [Jabatan Pendaftaran Negara (JPN)] to resolve issues with registration rules and infrastructure in these states. The more significant concern lies with the poor quality of registered causes of death. About 50% of all deaths in Malaysia occur in hospitals and are registered with medically certified causes, which are of good quality. However, the remaining deaths that occur at home are registered with causes reported by family members. For statistical purposes, these are termed as “nonmedically certified deaths.” Each year, only about a third of these deaths are reported to be from specific causes, and the remaining 65–70% of these deaths are registered annually with vague and ill-defined causes including “old age,” “heart failure,” and “sudden death” [3]. These limitations in vital registration data necessitated the use of generic model-based adjustments to fill these data gaps, while estimating national mortality and burden of disease estimation for the years 2000 and 2008 [4,5]. These persistently high proportions of illdefined causes can still be observed even for the most recent period from 2009 to 2017 (Figure 1).","PeriodicalId":52781,"journal":{"name":"Dr Sulaiman Al Habib Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86755267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Recurrent Urinary Tract Infections: A Red Herring for Primary Appendiceal Carcinoma 复发性尿路感染:原发性阑尾癌的转移焦点

Dr Sulaiman Al Habib Medical Journal Pub Date : 2019-12-01 DOI: 10.2991/dsahmj.k.191214.002

S. Saad, M. Younis

引用次数: 0

Sexual Ambiguity—A Social Predicament 性别模糊——一种社会困境

Dr Sulaiman Al Habib Medical Journal Pub Date : 2019-11-01 DOI: 10.2991/dsahmj.k.191118.001

Zair Hassan, O. Ullah, W. A. Khan, Faheemullah Khan, Iftikhar Ali

引用次数: 0

Outcomes of Guillain–Barré Syndrome Patients Admitted to Intensive Care Unit in Tertiary Care Hospital 三级医院重症监护病房收治格林-巴- <s:1>综合征患者的预后

Dr Sulaiman Al Habib Medical Journal Pub Date : 2019-10-01 DOI: 10.2991/dsahmj.k.191004.001

M. Ijaz, Faheemullah Khan, Muhammad Jaffar Khan, Asadullah Khan, W. Ahmad, Iftikhar Ali

引用次数: 0

Uncommon Cause of Endotracheal Tube Obstruction during Anesthesia Recovery 麻醉恢复过程中气管插管梗阻的不常见原因

Dr Sulaiman Al Habib Medical Journal Pub Date : 2019-10-01 DOI: 10.2991/dsahmj.k.191022.001

Sami Menasri, M. Hussein

引用次数: 0

Perforated Bowel after Obstruction in a Neonate with Milk Curd Syndrome following Ready to Feed Infant Formula 在准备好喂养婴儿配方奶粉后，患有乳凝综合征的新生儿梗阻后肠穿孔

Dr Sulaiman Al Habib Medical Journal Pub Date : 2019-09-01 DOI: 10.2991/dsahmj.k.190917.001

S. Rahman, A. Ghribi, Mohammad Hassan Alabdulghani, Moamen Taha Gad

引用次数: 1