Research in heart yield and translational medicine最新文献

{"title":"ESC 2025 Madrid: Practice-Changing Trials and What They Mean for Cardiology and Electrophysiology.","authors":"Ali Bozorgi","doi":"10.18502/jthc.v20i2.19840","DOIUrl":"https://doi.org/10.18502/jthc.v20i2.19840","url":null,"abstract":"","PeriodicalId":524236,"journal":{"name":"Research in heart yield and translational medicine","volume":"20 2","pages":"167-169"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Correlation between Pulmonary Hypertension and Pectoralis Muscle Area and Density.","authors":"Marzieh Mirtajaddini, Nasim Naderi, Somayeh Sadat Jalali, Alireza Hosseinpour, Hamidreza Pouraliakbar, Sepideh Taghavi, Razieh Omidvar, Hooman Bakhshandeh, Armin Attar, Tahereh Sadeghi, Fatemeh Ghorbani","doi":"10.18502/jthc.v20i2.19708","DOIUrl":"https://doi.org/10.18502/jthc.v20i2.19708","url":null,"abstract":"<p><strong>Highlights: </strong>Markers of sarcopenia showed a weak correlation with the prognosis of PH.Some indices including right atrial pressure and systemic arterial oxygen saturation were considered as predictors of PH prognosis.</p><p><strong>Background: </strong>Sarcopenia is a predictor of mortality in multiple conditions, but the potential prognostic value of sarcopenia indices in pulmonary hypertension (PH) has not been clarified. This study aimed to determine whether there is an association between computed tomography (CT) scan-measured pectoralis muscle area (PMA) and density (PMD) and adverse clinical outcomes in PH patients.</p><p><strong>Methods: </strong>In this cross-sectional study, the medical records of PH patients (clinical classes I and IV) referred to Rajaie Cardiovascular Institute from March 2016 through March 2021 were retrospectively reviewed. CT scan-measured PMA and PMD were compared between survivors and non-survivors, along with blood biomarkers and right heart catheterization variables. Binary logistic regression analysis was performed to identify potential predictors of mortality.</p><p><strong>Results: </strong>A total of 45 patients with PH (34 survivors and 11 non-survivors) were included in the analysis. PMA was not significantly different between the two groups (P=0.12), whereas PMD differed weakly between survivors and non-survivors (survivors: 45 HU [25.8-51.3] vs. non-survivors: 31 HU [23-36]; P=0.062). In logistic regression analysis, none of the sarcopenia indices predicted mortality (P >0.05). Nonetheless, phosphodiesterase-5 (PDE-5) inhibitor use, right atrial pressure, and systemic arterial oxygen saturation were identified as potential predictors (P<0.05).</p><p><strong>Conclusions: </strong>Although CT scan-measured PMA and PMD showed only a weak correlation with the prognosis of PH, these factors may serve as potential markers of mortality in patients with idiopathic and chronic thromboembolic PH. Further confirmation is needed through future studies with larger sample sizes.</p>","PeriodicalId":524236,"journal":{"name":"Research in heart yield and translational medicine","volume":"20 2","pages":"126-136"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of Eptifibatide in Addition to Ticagrelor in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.","authors":"Fatemeh Baharvand, Zeinab Hasani, Seifollah Jafari, Mohammad Ali Esfandiar, Arsalan Salari, Motahare Hatami, Hamed Vahidi, Niloofar Akbari Parsa, Mahboobeh Gholipour","doi":"10.18502/jthc.v20i1.19217","DOIUrl":"https://doi.org/10.18502/jthc.v20i1.19217","url":null,"abstract":"<p><strong>Highlights: </strong>In STEMI patients undergoing PCI, ticagrelor-based TAPT (with aspirin and eptifibatide) demonstrates significantly increased bleeding risk compared with clopidogrel-based TAPT.The ticagrelor group showed significantly higher rates of minor bleeding events, including gastrointestinal bleeding, hematuria, and epistaxis.No significant differences were observed between the groups in either major bleeding or procedure-related bleeding complications.</p><p><strong>Background: </strong>Primary percutaneous coronary intervention (PCI) is the gold-standard treatment for patients with ST-segment elevation myocardial infarction (STEMI). In some cases, glycoprotein IIb/IIIa inhibitors, considered part of triple antiplatelet therapy (TAPT), are administered. Most trials investigating the role of glycoprotein IIb/IIIa inhibitors in STEMI were conducted before the era of potent P2Y12 receptor inhibitors. It is, thus, reasonable to reevaluate the safety of eptifibatide, a widely used glycoprotein IIb/IIIa inhibitor, in patients treated with the latest generation of P2Y12 receptor inhibitors such as ticagrelor.</p><p><strong>Methods: </strong>This cross-sectional study involved STEMI patients who underwent primary PCI and required adjunctive eptifibatide therapy during the procedure at Dr. Heshmat Educational and Remedial Center in Rasht, Iran, between December 22, 2021, and June 22, 2022. Patients were stratified into two groups according to their administered P2Y12 receptor inhibitor. All patients received eptifibatide, and its safety when used concomitantly with ticagrelor was assessed.</p><p><strong>Results: </strong>The study included 241 patients with a mean age of 57.72 (SD:11.55) years. Procedure-related bleeding showed no significant difference between the groups (P=0.641), and no major bleeding events occurred in either group. Gastrointestinal bleeding and epistaxis rates were significantly higher in the ticagrelor-based TAPT group than in the clopidogrel-based group (P=0.033 and P=0.013, respectively). Among male patients, genitourinary bleeding was significantly more frequent in the ticagrelor-based TAPT subgroup than in the clopidogrel-based subgroup (P=0.035).</p><p><strong>Conclusions: </strong>In STEMI patients undergoing primary PCI, ticagrelor-based TAPT is associated with a higher risk of minor bleeding than clopidogrel. Nevertheless, given its established clinical advantages over clopidogrel, ticagrelor should not be withheld from eligible STEMI patients. The decision to prescribe ticagrelor should remain at the interventionist's discretion, with careful consideration of individual benefit-risk profiles.</p>","PeriodicalId":524236,"journal":{"name":"Research in heart yield and translational medicine","volume":"20 1","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Slow-Flow Syndrome: A Review on Natural History of Disease and Best Practices.","authors":"Muhammad Iqhrammullah, Derren Rampengan","doi":"10.18502/jthc.v20i1.19222","DOIUrl":"https://doi.org/10.18502/jthc.v20i1.19222","url":null,"abstract":"<p><strong>Highlights: </strong>Prevalence and Diagnosis: Coronary Slow Flow (CSF) occurs in 1-7% of patients undergoing angiography, diagnosed via corrected TIMI frame count (cTFC) exceeding 21 ± 3 frames, alongside scintigraphy and ECG analysis.Key Risk Factors: CSF is linked to cardiovascular risks like hypertension, diabetes, and inflammation, with genetic and psychological factors also playing a role in its development.Clinical Management: Treatment focuses on symptom relief using nitrates calcium channel blockers, statins, and anti-inflammatory agents, alongside lifestyle modifications and stress management.Long-Term Outcomes: CSF can lead to complications like myocardial infarction and left ventricular dysfunction, with a 10-year mortality rate of 15.3%, emphasizing the need for early detection and tailored care.</p><p><p>Coronary slow flow (CSF) poses significant clinical challenges, marked by delayed coronary blood flow despite angiographically normal epicardial arteries. With a prevalence of 1% to 7%, the underlying pathogenesis and clinical manifestations of this condition remain incompletely understood. This review examines the natural history of CSF, including its pathophysiological mechanisms, ranging from inflammatory cascades to microvascular dysfunction. Diagnostic approaches, such as corrected TIMI frame count, scintigraphy, and ECG analysis, provide valuable insights into its complex presentation. Further, the review outlines management strategies, focusing on pharmacological interventions like calcium channel blockers and anti-inflammatory agents. Understanding CSF's natural history is crucial for implementing effective preventive measures, spanning primary to tertiary prevention. Still, further research is essential to fully elucidate its pathophysiology and optimize therapeutic strategies for improving patient outcomes in this complex disorder.</p>","PeriodicalId":524236,"journal":{"name":"Research in heart yield and translational medicine","volume":"20 1","pages":"55-68"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Health Literacy and Adherence to Medical Treatment on Hypertension Control in the Elderly.","authors":"Feride Taskin Yilmaz, Selma Sabanciogullari, Ahmet Kerim Turesin, Secil Copur","doi":"10.18502/jthc.v20i2.19703","DOIUrl":"https://doi.org/10.18502/jthc.v20i2.19703","url":null,"abstract":"<p><strong>Highlights: </strong>Uncontrolled hypertension is common in elderly hypertensive individuals.Health literacy is higher in elderly patients with controlled hypertension.Increasing of health literacy affects the adherence to medical treatment positively.</p><p><strong>Background: </strong>Health literacy is an important factor in facilitating disease management among individuals with hypertension. This study aimed to determine the effect of health literacy on adherence to antihypertensive treatment in elderly patients with controlled and uncontrolled hypertension.</p><p><strong>Methods: </strong>This descriptive and comparative study included 203 elderly patients diagnosed with hypertension for at least 6 months who were on antihypertensive treatment. Data were collected using a patient information form, the Health Literacy Scale (HLS), and the Medication Adherence Self-Efficacy Scale Short Form (MASES-SF).</p><p><strong>Results: </strong>The mean age of the participants was 69.70±12.49 years. Age, duration of disease, and duration of medication use were higher in patients with uncontrolled hypertension. Moreover, patients with controlled hypertension were more likely to have regular health checkups, watch health-related programs in the media, and research the accuracy of disease-related information (P<0.05). In addition, patients with controlled hypertension were more likely to use medication once daily, have another chronic disease, and have a family history of hypertension (P<0.05). The mean MASES-SF and HLS scores of patients with controlled hypertension were statistically higher than those of patients with uncontrolled hypertension (P<0.01).</p><p><strong>Conclusions: </strong>Controlled hypertension showed a positive correlation with health literacy and treatment adherence. Furthermore, the health literacy level was identified as a determinant of medication adherence in elderly patients.</p>","PeriodicalId":524236,"journal":{"name":"Research in heart yield and translational medicine","volume":"20 2","pages":"79-88"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Function in Pediatric Nephrotic Syndrome: Tissue Doppler Echocardiography.","authors":"Noor Mohammad Noori, Elham Zarifi, Alireza Teimouri","doi":"10.18502/jthc.v20i2.19707","DOIUrl":"https://doi.org/10.18502/jthc.v20i2.19707","url":null,"abstract":"<p><strong>Highlights: </strong>Children with idiopathic nephrotic syndrome show early heart dysfunction before symptoms appear.Tissue Doppler Echocardiography revealed reduced myocardial velocities, elevated MPI, and altered relaxation times.These cardiac changes strongly correlate with kidney function.</p><p><strong>Background: </strong>Nephrotic syndrome (NS) is a common pediatric glomerular disorder traditionally considered renal-limited. Nonetheless, growing evidence suggests systemic implications, including subclinical cardiovascular involvement. This study aimed to evaluate early myocardial dysfunction in children with idiopathic NS using Doppler tissue echocardiography (DTE).</p><p><strong>Methods: </strong>In a case-control study, 87 children with idiopathic NS and 87 age- and sex-matched healthy controls were enrolled between 2021 and 2023 at Ali Asghar Pediatric Hospital in Zahedan, Iran. All participants underwent comprehensive DTE from apical four-chamber views to assess systolic and diastolic function. Key parameters included S', E', and A' velocities; isovolumetric contraction time (ICT); isovolumetric relaxation time (IRT); ejection time (ET); myocardial performance index (MPI); and E/E' and A/A' ratios. Laboratory data and treatment response were also analyzed. Data were analyzed using SPSS version 26, with a significance level set at 0.05.</p><p><strong>Results: </strong>Children with NS demonstrated significantly reduced S', E', and A' velocities; prolonged left ventricular IRT; shortened ICT and ET; and elevated MPI values, indicating early biventricular dysfunction. The right ventricular E/E' ratio was significantly lower in treatment responders, suggesting improved diastolic function. MPI and timing parameters showed strong correlations with renal and metabolic markers, including blood urea nitrogen, serum albumin, and lipid levels.</p><p><strong>Conclusions: </strong>DTE-derived MPI serves as a valuable noninvasive marker for the early detection of subclinical cardiac dysfunction in pediatric NS. Incorporating MPI into routine cardiac assessments may improve risk stratification and guide therapeutic monitoring in this population.</p>","PeriodicalId":524236,"journal":{"name":"Research in heart yield and translational medicine","volume":"20 2","pages":"116-125"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Invasive Left Atrial Pressure and Mitral Valve Area in Rheumatic Mitral Stenosis: A Cross-Sectional Study.","authors":"Rojin Yaqubi, Naser Khezerlou, Soheil Nemati, Hanieh Faraji, Elnaz Javanshir, Zahra Shamsian","doi":"10.18502/jthc.v20i2.19705","DOIUrl":"https://doi.org/10.18502/jthc.v20i2.19705","url":null,"abstract":"<p><strong>Highlights: </strong>Mean left atrial pressure (LAP) measured invasively correlates with mitral valve area (MVA) assessed by 3D-TEE in patients with severe rheumatic mitral stenosis.Patients with MVA<1 cm² had significantly higher LAP and echocardiography-derived pulmonary artery pressures than those with MVA≥1 cm².</p><p><strong>Background: </strong>Mitral stenosis (MS) is typically assessed using both echocardiographic and invasive methods, which are critical for treatment planning. The present study analyzed the correlation between invasively measured left atrial pressure (LAP) and mitral valve area (MVA) assessed by three-dimensional transesophageal echocardiography (3D-TEE) in patients with rheumatic MS undergoing percutaneous transluminal mitral commissurotomy (PTMC).</p><p><strong>Methods: </strong>We conducted a cross-sectional study of 135 patients with severe rheumatic MS who were candidates for PTMC at Shahid Madani Heart Hospital, Tabriz, Iran, between April 2023 and April 2024. All patients underwent two-dimensional transthoracic echocardiography (2DTTE) and 3D-TEE for MVA measurement. Invasive LAP and pulmonary pressures were recorded pre-procedure. Comparisons were made between patients with MVA<1 cm² and those with MVA≥1 cm².</p><p><strong>Results: </strong>The mean MVA measured by 3D-TEE was 1.03±0.07 cm². LAP was significantly higher in patients with MVA<1 cm² than in those with MVA≥1 cm² (P=0.040). Pulmonary artery pressures also differed significantly between the groups (P=0.016 and P=0.012). Among the 135 participants, 109 patients (63.3% with MVA<1 cm² and 93.6% with LAP>15 mm Hg) reported dyspnea, while 20 patients (65% with MVA<1 cm² and 100% with LAP>15 mm Hg) reported fatigue.</p><p><strong>Conclusions: </strong>In this study, we observed a significant correlation between invasive LAP and MVA measured by 3D-TEE. These findings suggest that invasive LAP measurement offers additional value in assessing the hemodynamic burden of severe MS.</p>","PeriodicalId":524236,"journal":{"name":"Research in heart yield and translational medicine","volume":"20 2","pages":"97-104"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mystery of Situational Syncope: A Case Series of Three Patients with Uncommon Histories.","authors":"Amir Hossein Behnoush, Amir Mohammad Khalaji, Arya Aminorroaya, Hamed Tavolinejad, Somayeh Yadangi, Masih Tajdini","doi":"10.18502/jthc.v20i1.19224","DOIUrl":"https://doi.org/10.18502/jthc.v20i1.19224","url":null,"abstract":"<p><strong>Highlights: </strong>As syncope can be triggered by several less-studied situations, rare underlying causes of syncope, such as cough, marijuana smoking, and flight, should not be missed in clinical settings.</p><p><p>Syncope, characterized by a transient loss of consciousness, is among the most common reasons for emergency department visits worldwide and can be categorized into reflex syncope, orthostatic hypotension, and cardiac syncope. Situational syncope, a subtype of reflex syncope, is less frequently investigated than other forms. Herein, we describe three patients who presented to the Syncope Unit of Tehran Heart Center with unusual situational syncope triggers, along with the diagnostic methods and treatments used.The first case was a 62-year-old woman who experienced five syncopal episodes over the past 2 years, all of which occurred at an airport during airplane takeoff. Following a prescription for midodrine to be taken before flights, no further syncopal episodes occurred. The second patient was an 18-year-old man with two syncopal episodes, both occurring after smoking marijuana. He was advised to discontinue marijuana use, and no further episodes were reported during a 1-year follow-up period. The final case was a 42-year-old man who was a heavy smoker, presenting with several syncopal episodes following bouts of violent coughing. After cough suppressant medications proved ineffective, he was successfully treated with gabapentin.In conclusion, given the complex nature of diagnosing syncope in some cases, physicians should consider rare triggers when taking the medical history of patients with unexplained syncope.</p>","PeriodicalId":524236,"journal":{"name":"Research in heart yield and translational medicine","volume":"20 1","pages":"74-78"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Hypertension with and without Left Ventricular Hypertrophy and the Expression of a Panel of microRNAs in an Iranian Population.","authors":"Shokoufeh Hajsadeghi, Reza Nekouian, Maryam Mollababaei, Hamed Motevalli, Ehsan Kalantar, Aida Iranpour, Seyyed Amir Yasin Ahmadi, Mohammad Sedigh Dakkali","doi":"10.18502/jthc.v20i1.19218","DOIUrl":"https://doi.org/10.18502/jthc.v20i1.19218","url":null,"abstract":"<p><strong>Highlights: </strong>Left ventricular hypertrophy (LVH) is a critical independent predictor of cardiovascular mortality and is strongly associated with hypertension.Given the diagnostic potential of microRNAs (miRNAs) as biomarkers in hypertension, this study aimed to investigate their expression profiles.The findings underscore the significant involvement of miR-222 and miR-155 in hypertension and LVH pathogenesis.</p><p><strong>Introduction: </strong>Given the established role of microRNAs (miRNAs) in hypertension (HTN), this study aimed to analyze the expression of a defined miRNA panel in hypertensive individuals, both with and without left ventricular hypertrophy (LVH), compared with normotensive controls within an Iranian population.</p><p><strong>Methods: </strong>We conducted a cross-sectional study with case-control sampling, comprising three study groups: controls, HTN, and HTN+LVH. Through an extensive literature review, we selected a panel of eight miRNAs (miR-1, miR-21, miR-29a, miR-29b, miR-133, miR-155, miR-221, and miR-222) for analysis using real-time PCR. Gene expression data were analyzed through a general linear model implemented in R programming.</p><p><strong>Results: </strong>The study analyzed 100 total samples. We used miR-29a and miR-133 as endogenous controls for calculations. Analysis revealed no significant association between miR-29b or miR-221 expression and the study groups (P>0.2 for both). Additionally, miR-1 demonstrated downregulation in both hypertensive groups (P<0.05), although this effect lost significance after adjusting for potential confounders (P=0.05-0.2). The HTN+LVH group showed significant downregulation of miR-21 (P<0.05). The duration of HTN diagnosis correlated with the upregulated expression of both miR-155 and miR-222. The strongest association emerged for miR-222, with the study groups explaining 25.7% of its variation (the highest R² value among all models).</p><p><strong>Conclusions: </strong>HTN without LVH might be associated with the downregulation of miR-1 and miR-155 and the upregulation of miR-222. HTN, along with LVH, might be associated with the downregulation of miR-1 and miR-21 and the upregulation of miR-222. Increasing years of experiencing HTN were correlated with the upregulation of miR-155 and miR-222. The largest effect size was for miR-222.</p>","PeriodicalId":524236,"journal":{"name":"Research in heart yield and translational medicine","volume":"20 1","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Chapter for Our Journal: Introducing Research in Heart Yield and Translational Medicine (RHYTHM).","authors":"Abbasali Karimi, Ali Bozorgi, Payam Kabiri","doi":"10.18502/jthc.v20i1.19215","DOIUrl":"https://doi.org/10.18502/jthc.v20i1.19215","url":null,"abstract":"","PeriodicalId":524236,"journal":{"name":"Research in heart yield and translational medicine","volume":"20 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}