Nephrology and Dialysis最新文献

{"title":"Nephropathy associated with the E3/E4 allelic variant of the APOE gene. Case 2","authors":"O. Vorobyeva, T. E. Nichik, S. I. Popova","doi":"10.28996/2618-9801-2022-4-895-897","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-4-895-897","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69402423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The modern concept of etiology, pathogenesis, the role of anticytokine therapy and methods of extracorporeal treatment for new coronavirus infection (SARS-CoV-2). Review","authors":"S. Masolitin, T.G. Kim, A.V. Yaralian, E. Y. Kalinin, D. V. Losev","doi":"10.28996/2618-9801-2022-2-292-300","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-2-292-300","url":null,"abstract":"\"The review highlights the relevance and significance of the new coronavirus infection, characterizes the virus, the route of invasion, and organ damage. The attention is focused on the risk factors of viral invasion, and the premorbid background of patients. Special attention is paid to the virus interaction with the ACE-2 receptors and the role of the latter in multiorgan dysfunction. The role of the immune system in the antiviral response is covered. We also considered independent predictors of death in new coronavirus infection. The mechanisms of lung damage in COVID-19 are reviewed with particular attention to the pathophysiological mechanism of the synthesis of pro-inflammatory cytokines and the role of the latter in organ dysfunction. A definition of the \"\"cytokine storm\"\" that is usually understood as an overactive immune response with the release of a large number of interferons, interleukins, chemokines, and other mediators is given. The review highlights the most significant and currently known pathogenetic chains of cytokine production. Among them are proinflammatory cytokines, the most significant are Il-1, Il-6, TNF. High cytokine levels are associated with poor outcomes. Special attention is paid to the feasibility and role of anti-cytokine therapy with drugs tocilizumab and sarilumab. It has been noted that treatment aimed at the pathogenetic mechanisms of the development of the \"\"cytokine storm\"\" by antagonists of the Il-6 receptor can interrupt this life-threatening inflammatory response and, consequently, multiorgan dysfunction. The main pathogenetic pathways and risk factors for the development of acute kidney injury (Acute Kidney Injury – AKI) in SARS-CoV-2 have been analyzed. The use of extracorporeal treatment methods, possibly the main methods of combating the massive release of the pool of medium-molecular compounds during the development of a \"\"cytokine storm\"\" are reviewed. It is noted that along with anti-cytokine therapy, extracorporeal methods can effectively reduce the level of proinflammatory cytokines and prevent multiple organ damage. The main issues of expediency, role and place of application of various extracorporeal methods in complex intensive care for new coronavirus infection (SARS-CoV-2) are highlighted. © 2022 JSC Vidal Rus. All rights reserved.\"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69399418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 and virus-associated skin diseases in patients after kidney transplantation","authors":"I. Dymkov, A. Perlina, I.V. Terentiev, E. Prokopenko, P. Kulikov, D. Perlin","doi":"10.28996/2618-9801-2022-2-322-328","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-2-322-328","url":null,"abstract":"Background: COVID-19 in solid organ transplant recipients is usually characterized by a more severe disease course and is often associated with life-threatening complications. Identification of additional factors that may affect the risk and severity of the new coronavirus infection could have a significant impact on choosing a management strategy for renal graft recipients. Aim: to evaluate the possibility of cross-immunity between skin manifestations of viral etiology and COVID-19. Materials and methods: from May 2020 to February 2021 we examined 180 renal graft recipients with a history of transplantation from 2 months to 26.5 years. All patients were categorized into two groups: group I, those who had confirmed moderate or severe COVID-19 disease, and group II, and those without any history of clinical manifestations of the new coronavirus infection (including those with potentially asymptomatic disease). During the study period which lasted for 71 months on average (range, 2 to 318 months), laboratory workup was performed on all patients (on average, twice): dermatological examination and detection of serum antibodies to herpes simplex virus 1, 2, cytomegalovirus, Epstein-Barr virus, COVID-19. Results: in recipients with HPV-associated skin manifestations, the incidence of COVID-19 was significantly lower than in recipients who did not have them: – 30.4% and 50%, respectively, p=0.011. The incidence of new coronavirus infection did not differ in the groups of patients with cutaneous manifestations caused by herpes simplex viruses type 1 and 2 and without them. Among recipients with Epstein-Barr virus seropositivity, there were significantly fewer cases of COVID-19 compared to seronegative patients – 26.2% and 54.8%, respectively, p=0.0002. Conclusion: HPV-associated dermal manifestations of serum EBV-seropositivity in recipients after kidney transplantation is associated with a lower incidence of moderate and severe COVID-19. Further studies are needed to confirm the possibility of cross-immunity against COVID-19 with other infections. © 2022 JSC Vidal Rus. All rights reserved.","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69400371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts of the Young nephrologist's competition, XVII Conference of Russian Dialysis Society","authors":"","doi":"10.28996/2618-9801-2022-2-388-402","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-2-388-402","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69400783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive biomarkers in elderly patients with chronic cardiorenal syndrome","authors":"E. Efremova, A. Shutov","doi":"10.28996/2618-9801-2022-2-357-365","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-2-357-365","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69400919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stone formation on the ureteral stent during pregnancy","authors":"N. Bychkova, E. Prokopenko, I. Nikolskaya","doi":"10.28996/2618-9801-2022-2-374-376","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-2-374-376","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69401094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of the course and diagnosis of lupus podocytopathy","authors":"D.V. Starikov, N. Kozlovskaya, E. Stolyarevich, T. Bondarenko, O. Volkova","doi":"10.28996/2618-9801-2022-4-898-906","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-4-898-906","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69402708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The management of medical care with dialysis methods in outpatients during the COVID-19 pandemic","authors":"A. Ilyin, K. Gurevich, A.Yu. Denisov, E. Shilov, M. Shilova, N.A. Brygina, O.A. Kodyusheva","doi":"10.28996/2618-9801-2022-2-301-321","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-2-301-321","url":null,"abstract":"Introduction: The COVID-19 pandemic has changed the health care system for patients with CKD5. Dialysis patients are at particularly high risk of COVID-19, severe infection, and poor outcomes. Materials and methods: In 2020, in 86 FME RF clinics, 11 331 patients (54.1% – men) received dialysis treatment, 21.8% had DM, 10 717 patients were treated with HD and HDF methods, 614 patients were on PD, and 2854 employees provided medical care. The data were collected using the EuCliD database and statistically processed online at sites https://molbiol.kirov.ru and https://medstatistic.ru. Results: COVID-19 is more often detected in men, patients 40 to 79 y.o., in patients with DM. The rate of sick patients <50 y.o. (31.2% of all treated) was 22.8% of all infected and in the group>50 y.o. (68.8% of all treated), the rate of patients was 77.2%. There were no significant differences between the incidence of COVID-19 infection in groups ≥50 and <60 y.o., ≥60 and <70 y.o., ≥70 and <80 y.o., ≥80 y.o. COVID-19 positive patients (on HD and PD) who died in 2020 – 324 people, were 2.9% of all treated in 2020 and 31.6% of all infected dialysis patients. In FME RF clinics 18.6% and 18.4% of all patients in the RF were treated by HD and PD respectively, but the proportion of mortality from COVID-19 in FME RF clinics was 10.5% at HD and 11.0% at PD respectively. In dialysis centers, FME RF patients with COVID-19 on HD were 2.2 times less than in the dialysis population of RF as a whole (p<0.001), and on PD – 1.98 times less than in RF (p<0.001). In RF patients with COVID-19 on PD and HD, it was found that the mortality rate was significantly lower in patients on PD vs HD (p<0.001). There was no significant effect on the outcomes in COVID-19 patients depending on the method of treatment in FME RF clinics (p=0.349). Conclusion: Patients on dialysis are at greater risk of COVID-19 and fatal outcomes. The administrative, organizational, and medical work of FME RF led to positive results both in the prevention of infection and in treatment outcomes. © 2022 JSC Vidal Rus. All rights reserved.","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69399481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using the modified Charlson comorbidity index to predict the risk of death in elderly and senile patients with chronic kidney disease","authors":"E. Efremova, A. Shutov, I. M. Efremov, V. Midlenko","doi":"10.28996/2618-9801-2022-2-349-356","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-2-349-356","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69400810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mineral-bone disorders and extra-bone calcification in a patient on maintenance hemodialysis","authors":"O. Manchenko, N. Belavina, A. Zhdanova, G. Volgina, E. Zeltyn-Abramov","doi":"10.28996/2618-9801-2022-3-506-509","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-3-506-509","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69401832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}