{"title":"HOXB13-Mediated Lipid Metabolism Regulates Prostate Cancer Metastasis.","authors":"Jianhua Xiong","doi":"10.17161/sjm.v1i1.23157","DOIUrl":"10.17161/sjm.v1i1.23157","url":null,"abstract":"<p><p>The molecular mechanisms driving increased lipogenesis and lipid accumulation, key features of prostate cancer (PCa), remain largely unexplored. Recently, Lu and colleagues identified a novel role for the homeodomain transcription factor HOXB13 in regulating lipid metabolism and PCa progression, independent of its traditional involvement in androgen receptor (AR) signaling. Their study demonstrates how HOXB13 modulates PCa metastasis through epigenetic reprogramming, specifically by interacting with histone deacetylase 3 (HDAC3). These findings not only deepen our understanding of the molecular processes underlying PCa metastasis but also suggest lipid metabolism as a promising therapeutic target for castration-resistant and HOXB13-low PCa.</p>","PeriodicalId":521234,"journal":{"name":"Serican journal of medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13178936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147966792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jia Peng, Mansoureh Nouri, Hamed Maasoumyhaghighi, Jinghui Liu, Xiaoqi Liu
{"title":"PLK1: A Promising Therapeutic Target for Prostate Cancer Treatment.","authors":"Jia Peng, Mansoureh Nouri, Hamed Maasoumyhaghighi, Jinghui Liu, Xiaoqi Liu","doi":"10.17161/sjm.v1i1.23189","DOIUrl":"10.17161/sjm.v1i1.23189","url":null,"abstract":"<p><p>Prostate cancer is the most diagnosed cancer and a leading cause of cancer-related mortality among men in the United States. Androgen deprivation therapy (ADT) has long been the cornerstone of treatment for advanced prostate cancer. However, most patients eventually develop resistance, leading to progression into the lethal castration-resistant prostate cancer (CRPC) stage, which is associated with poor survival rates. While next-generation androgen receptor signaling inhibitors (ARSIs), such as enzalutamide and abiraterone, have revolutionized CRPC treatment, resistance to these therapies remains a significant challenge, rendering the disease incurable. Recent studies have identified Polo-like kinase 1 (PLK1), a master regulator of mitosis, as a key driver of prostate cancer progression, particularly in CRPC. PLK1 activation has been linked to critical pathways, including oxidative stress responses, lipid metabolism, and androgen receptor (AR) signaling, which collectively promote tumor growth and ARSI resistance. Moreover, PLK1 can regulate chromosomal stability and DNA damage repair pathways, contributing to sensitivity to irradiation therapy. Additionally, PLK1 plays a role in driving resistance to targeted therapies, such as PARP inhibitors, in BRCA-mutant CRPC. Compelling evidence further suggests that combining PLK1 inhibition with paclitaxel could serve as an effective therapeutic strategy to overcome resistance in CRPC by targeting microtubule dynamics. This review examines the mechanistic role and broader implications of PLK1 in CRPC treatment, offering valuable insights into potential combination therapies to improve efficacy and patient outcomes.</p>","PeriodicalId":521234,"journal":{"name":"Serican journal of medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13313582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}