Journal of clinical practice and research最新文献

{"title":"Clinical Relevance of Multiplex PCR for Respiratory Pathogens in Hospitalized Adults with Influenza-Like Illness.","authors":"Yasemin Derya Gülseren, Derya Aydın, Alev Çetin Duran","doi":"10.14744/cpr.2026.17751","DOIUrl":"https://doi.org/10.14744/cpr.2026.17751","url":null,"abstract":"<p><strong>Objective: </strong>Influenza-like illness (ILI) is a major cause of hospitalization during respiratory virus seasons. This study aimed to investigate the pathogens detected in patients presenting with ILI symptoms and to analyze the results in conjunction with clinical, laboratory, and radiological findings.</p><p><strong>Materials and methods: </strong>This retrospective, single-center study included 446 hospitalized adults with ILI between epidemiological week 40 of 2024 and week 20 of 2025. Respiratory pathogens were identified using a multiplex real-time polymerase chain reaction (PCR) assay detecting 18 viral and 5 bacterial pathogens. Demographic, clinical, laboratory, and radiological data were retrieved from electronic medical records. Disease severity was assessed using the CURB-65 score. Patients with <i>Streptococcus pneumoniae</i> detected by PCR were further evaluated according to radiological evidence of pneumonia.</p><p><strong>Results: </strong>At least one respiratory pathogen was detected in 184/446 patients (41.2%), whereas no pathogen was identified in 262 patients (58.8%). The most frequently detected pathogens were <i>S. pneumoniae</i>, influenza viruses, and seasonal coronaviruses. The most common coinfection was influenza A plus <i>S. pneumoniae</i>. Among patients with pneumococcal PCR positivity, those with radiologically confirmed pneumonia were significantly older, had higher CURB-65 scores, and more frequently had concomitant influenza infection than patients without radiological evidence of pneumonia.</p><p><strong>Conclusion: </strong>Multiplex molecular assays provide valuable information for respiratory pathogen detection, but molecular results, especially for bacterial pathogens such as <i>S. pneumoniae</i>, should be interpreted together with clinical and radiological findings.</p>","PeriodicalId":521104,"journal":{"name":"Journal of clinical practice and research","volume":"48 5","pages":"540-548"},"PeriodicalIF":0.4,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning-Based Fatigue Detection from EEG Signals: A Methodological Pilot Framework with Potential for Nursing Applications.","authors":"Serife Cetin, Eda Dagdevir","doi":"10.14744/cpr.2026.17486","DOIUrl":"https://doi.org/10.14744/cpr.2026.17486","url":null,"abstract":"<p><strong>Objective: </strong>Fatigue is a significant occupational health issue that adversely affects attention and decision-making. This study aimed to objectively predict fatigue levels using EEG signals and machine learning models and to develop a physiologically based assessment framework with potential future applications in nursing.</p><p><strong>Materials and methods: </strong>Time-domain, frequency-domain, entropy, Hjorth, and wavelet features were extracted from EEG data collected from 12 participants aged 21-40 years, with fatigue levels labeled using various scales.</p><p><strong>Results: </strong>Classification performance varied across validation strategies. Under 5-fold cross-validation, Random Forest achieved the highest performance (accuracy=1.00, macro-F1=1.00), while KNN and NB also demonstrated strong performance. However, under LOOCV, sensitivity, precision, and macro-F1 values decreased despite relatively high accuracy. LOSO validation yielded more balanced results, with Random Forest maintaining the best performance (accuracy=0.97, macro-F1=0.91).</p><p><strong>Conclusion: </strong>EEG-derived features provide valuable information for fatigue assessment. Although high performance was achieved under certain validation strategies, subject-independent evaluation revealed more realistic performance levels. The proposed framework offers a practical approach to fatigue monitoring. Future studies should focus on larger, domain-specific datasets and multimodal integration to enhance generalizability.</p>","PeriodicalId":521104,"journal":{"name":"Journal of clinical practice and research","volume":"48 5","pages":"530-539"},"PeriodicalIF":0.4,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited Public Health Utility of LCT Genotyping for Lactose Intolerance Screening in Adolescents: A Cross-Sectional Study from Türkiye.","authors":"Hatice Mutlu, Ece Eker, Fulya Çetinkaya, Yonca Eğin, Şengül Aydın, Göksel Vatansever, Ayşe Gül Güven, Zehra Aycan","doi":"10.14744/cpr.2026.33422","DOIUrl":"https://doi.org/10.14744/cpr.2026.33422","url":null,"abstract":"<p><strong>Objective: </strong>Lactose intolerance (LI) is a common cause of gastrointestinal complaints in adolescents and young adults, often leading to unnecessary dietary restrictions and reduced calcium intake. Although lactase non-persistence (LNP) is genetically determined, its clinical expression varies considerably. Genetic variants associated with lactase persistence/non-persistence (LCT/MCM6 locus), particularly rs4988235 and rs3754686, are frequently used in genetic testing; however, their clinical utility remains uncertain, especially in populations with a high prevalence of LNP, such as Türkiye.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, 209 individuals aged 12-25 years were evaluated. Lactose-related symptoms were assessed using a validated questionnaire (a score ≥7 defined symptomatic individuals). Consumption of raw milk and fermented dairy products was recorded using a standardized frequency scale. Genotyping of rs4988235 and rs3754686 was performed using TaqMan real-time PCR. Associations between genotype, symptom status, age at symptom onset, and dietary patterns were statistically analyzed.</p><p><strong>Results: </strong>Among the participants, 116 (55.5%) were symptomatic and 93 (44.5%) were asymptomatic. Symptomatic individuals were significantly older (p<0.001). The genotype distributions of rs4988235 and rs3754686 did not differ between symptomatic and asymptomatic individuals and were not associated with age at symptom onset. Dairy consumption patterns were not associated with symptom severity, although fermented dairy consumption was slightly higher among symptomatic individuals (p=0.046).</p><p><strong>Conclusion: </strong>Common LCT/MCM6 variants did not predict clinical LI in this adolescent and young adult population. Therefore, routine genetic testing appears unlikely to provide limited additional value in supporting the diagnosis of lactose intolerance, particularly in populations with a high prevalence of LNP. Symptom-based assessment and functional testing should remain central to diagnosis and management, and, supporting appropriate nutritional guidance and avoiding unnecessary dietary restriction.</p>","PeriodicalId":521104,"journal":{"name":"Journal of clinical practice and research","volume":"48 5","pages":"505-511"},"PeriodicalIF":0.4,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FOXM1 Drives Subtype-Specific Dysregulation of Prognostic miRNAs in Breast Cancer Cells.","authors":"Zuhal Hamurcu, Venhar Cınar, Ayse Doga Karipcin, Ahsen Güler, Zeynep Yılmaz Sükranlı, Mehmet Memis, Elif Funda Sener, Serpil Taheri, Bulent Ozpolat","doi":"10.14744/cpr.2026.18248","DOIUrl":"https://doi.org/10.14744/cpr.2026.18248","url":null,"abstract":"<p><strong>Objective: </strong>Breast cancer is a heterogeneous disease comprising distinct molecular subtypes, including estrogen receptor-positive (ER+) breast cancer and triple-negative breast cancer (TNBC). MicroRNAs (miRNAs) regulate post-transcriptional gene expression and play important roles in cancer progression by functioning as oncogenic or tumor-suppressive molecules. Forkhead box M1 (FOXM1) is an oncogenic transcription factor that is frequently upregulated in aggressive breast cancers, particularly TNBC, and is associated with proliferation, invasion, metastasis, therapy resistance, and poor prognosis.</p><p><strong>Materials and methods: </strong>Clinically relevant miRNAs associated with survival in patients with ER+ and ER- breast cancer were identified using publicly available datasets. The expression levels of miR-34a-5p, miR-873-5p, miR-193b-5p, miR-330-5p, miR-10b-5p, miR-155-5p, and miR-484 were evaluated in MDA-MB-231 TNBC cells and MCF-7 ER+ breast cancer cells following FOXM1 knockdown.</p><p><strong>Results: </strong>FOXM1 knockdown was associated with increased expression of several tumor-suppressive miRNAs, including miR-34a-5p, miR-873-5p, miR-193b-5p, miR-330-5p, miR-10b-5p, and miR-484, in MDA-MB-231 cells. In contrast, most of these miRNAs were not markedly altered in MCF-7 cells, except for miR-10b-5p, whose expression decreased following FOXM1 knockdown. miR-155-5p expression remained largely unchanged in both cell lines.</p><p><strong>Conclusion: </strong>Our findings demonstrate that FOXM1 knockdown was associated with differential expression of clinically relevant miRNAs in the two breast cancer cell models examined. These findings suggest that FOXM1-associated alterations in miRNA expression may contribute to the aggressive phenotype of TNBC and warrant further mechanistic investigation.</p>","PeriodicalId":521104,"journal":{"name":"Journal of clinical practice and research","volume":"48 5","pages":"521-529"},"PeriodicalIF":0.4,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Number of Falls and Fall Risk Factors in Geriatric Individuals Living in a Nursing Home.","authors":"Yasemin Ateş Sarı, Sevilay Seda Baş, Büşra Kalkan Balak, Bahar Anaforoğlu, Nezehat Özgül Ünlüer","doi":"10.14744/cpr.2026.68303","DOIUrl":"https://doi.org/10.14744/cpr.2026.68303","url":null,"abstract":"<p><strong>Objective: </strong>Falls are a major cause of morbidity and mortality among older adults worldwide, highlighting the need to identify fall risk factors, particularly among nursing home residents. This study aimed to evaluate fall risk factors according to fall history in nursing home-dwelling geriatric individuals and to examine the association between these factors and the number of falls.</p><p><strong>Materials and methods: </strong>This cross-sectional study included geriatric individuals living in nursing homes who were classified as fallers (n=54) or non-fallers (n=66). Participants' demographic characteristics and fall-related risk factors were recorded. Comorbidity was assessed using the Charlson Comorbidity Index. Physical performance was evaluated using gait speed, the 5-Repetition Sit-to-Stand Test, and handgrip strength. Physical activity level was assessed using the Physical Activity Scale for the Elderly. Sarcopenia risk was evaluated using the SARC-F questionnaire. Nutritional status was assessed using the Mini Nutritional Assessment. Incontinence severity was evaluated using the Incontinence Severity Index, and activities of daily living (ADL) were assessed using the Katz Index of ADL.</p><p><strong>Results: </strong>Fallers were older, used more medications, had a greater comorbidity burden, and demonstrated poorer physical performance and lower activity levels, a higher risk of sarcopenia, poorer nutritional status, greater incontinence severity, and reduced independence in ADL. Furthermore, fall frequency was significantly associated with assistive device use, gait speed, and nutritional status (p<0.05).</p><p><strong>Conclusion: </strong>These findings demonstrate that multifactorial, targeted interventions addressing physical performance, mobility, and nutrition are essential for reducing fall risk and recurrent falls in geriatric individuals.</p>","PeriodicalId":521104,"journal":{"name":"Journal of clinical practice and research","volume":"48 5","pages":"512-520"},"PeriodicalIF":0.4,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bicycle Handlebar-Related Blunt Abdominal and Pelvic Injuries in Children and Adults: A Radiological Perspective.","authors":"Murat Tepe, Emre Emekli, Yunus Topal, Alperen Şensoy, Cansel Bayrak, Gülben Eruysal","doi":"10.14744/cpr.2026.73861","DOIUrl":"https://doi.org/10.14744/cpr.2026.73861","url":null,"abstract":"<p><strong>Objective: </strong>Bicycle handlebar-related abdominopelvic trauma can cause clinically significant injuries despite minimal external signs, potentially resulting in delayed diagnosis. Radiological evidence regarding CT injury patterns associated with this mechanism remains limited. This study aimed to evaluate and characterize the CT findings of bicycle handlebar-related blunt abdominal and pelvic injuries in pediatric and adult patients and to describe injury patterns, organ involvement, and clinical management.</p><p><strong>Materials and methods: </strong>This retrospective study included patients who presented with bicycle handlebar-related abdominopelvic injuries between July 2010 and November 2025. Patients who underwent contrast-enhanced abdominopelvic CT because of suspected abdominopelvic trauma were analyzed. CT findings were categorized and graded using the AAST injury scale.</p><p><strong>Results: </strong>Twenty-three patients had CT findings indicative of abdominopelvic injury, with a total of 25 distinct injuries identified. Nineteen patients (82.6%) were pediatric patients aged 6-16 years, and 4 (17.4%) were adults aged 21-30 years; 86.9% were male. The most common organ injuries involved the spleen (24%) and liver (20%). CT was performed within 24 hours in 87.0% of patients, whereas delayed imaging occurred in 13.0%. Of the 19 intra-abdominal organ injuries, 89.5% were AAST grades 1-3, and 10.5% were grades 4-5. Most patients (82.6%) were managed conservatively, whereas 17.4% required surgical or interventional treatment.</p><p><strong>Conclusion: </strong>Bicycle handlebar-related trauma is a distinctive mechanism of blunt abdominopelvic injury associated with a broad spectrum of CT findings, predominantly affecting school-aged boys but also occurring in adults. Awareness of characteristic CT patterns and standardized injury grading can facilitate timely diagnosis and appropriate management in both pediatric and adult populations.</p>","PeriodicalId":521104,"journal":{"name":"Journal of clinical practice and research","volume":"48 5","pages":"488-494"},"PeriodicalIF":0.4,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Pompe Disease from a Broad and Systemic Perspective.","authors":"Aliye Gülbahçe, Hatice Güneş, Ahmet Müderrisoğlu, Funda İpekten, Ali Baykan, Fatih Kardaş","doi":"10.14744/cpr.2026.24232","DOIUrl":"https://doi.org/10.14744/cpr.2026.24232","url":null,"abstract":"<p><p>Pompe disease is a lysosomal storage disorder caused by α-1,4-glucosidase deficiency. The broad spectrum of clinical manifestations results from glycogen accumulation in the muscles and central nervous system (CNS). In this study, we aimed to evaluate the clinical course of Pompe disease. This brief report included six patients. The collected data included demographic characteristics, clinical findings, echocardiography, electroencephalography, electromyography, and brain magnetic resonance imaging. High-dose enzyme replacement therapy reduced the severity of hypertrophic cardiomyopathy in patients with infantile-onset Pompe disease. Three patients exhibited speech difficulties, one patient was diagnosed with epilepsy, and MRI revealed white matter abnormalities in three patients. The neurological findings observed in patients with CNS involvement suggest that those with infantile-onset Pompe disease should be closely monitored for neurocognitive development. Novel treatments capable of crossing the blood-brain barrier may benefit these patients.</p>","PeriodicalId":521104,"journal":{"name":"Journal of clinical practice and research","volume":"48 5","pages":"567-571"},"PeriodicalIF":0.4,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Expression Profiling of <i>URGCP</i> and <i>NTRK1-3</i>/MAPK Pathway Genes in Soft Tissue Sarcomas.","authors":"Zeliha Akdağ, Ferda Bir, Emel Kılıçarslan, Lale Şatıroğlu Tufan, Yavuz Dodurga","doi":"10.14744/cpr.2026.86857","DOIUrl":"https://doi.org/10.14744/cpr.2026.86857","url":null,"abstract":"<p><strong>Objective: </strong>Sarcoma is a heterogeneous malignant cancer of mesenchymal origin, and approximately 80% of cases are soft tissue sarcomas (STSs). <i>NTRK</i> genes play roles in nerve cell development, while the MAPK signaling pathway contributes to tumor cell migration, invasion, and metastasis. <i>URGCP</i> is an oncogene involved in tumor development in many cancers; however, its role and molecular mechanism in STS remain unknown. This study aimed to investigate the expression and correlations of the <i>NTRK1, NTRK2</i>, and <i>NTRK3</i> genes, MAPK signaling pathway genes, and the <i>URGCP</i> oncogene in STS subtypes.</p><p><strong>Materials and methods: </strong>RNA was isolated from formalin-fixed, paraffin-embedded (FFPE) tissue samples obtained from 80 patients with STS. The expression levels of <i>NTRK1, NTRK2, NTRK3, MEK1, MEK2, ERK1</i>, and the <i>URGCP</i> oncogene were analyzed using quantitative real-time PCR (qPCR). Correlations among these genes and their associations with STS were evaluated.</p><p><strong>Results: </strong>The analyses did not reveal statistically significant correlations between <i>NTRK</i> genes and genes involved in the MAPK signaling pathway. In addition, no statistically significant association was observed between <i>URGCP</i> expression and STS.</p><p><strong>Conclusion: </strong>Although this study did not demonstrate a significant association between URGCP and soft tissue sarcoma, it reveals a link between NTRK genes and the MAPK signaling pathway in STS.</p>","PeriodicalId":521104,"journal":{"name":"Journal of clinical practice and research","volume":"48 5","pages":"495-504"},"PeriodicalIF":0.4,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Past, Present, and Future of Cutaneous Larva Migrans in Türkiye: From Selim Kurtoğlu's 1981 Case to Current Clinical and Epidemiological Reality.","authors":"Muhammed Burak Yücel, Levent Kartal, Selim Kurtoğlu","doi":"10.14744/cpr.2026.95639","DOIUrl":"https://doi.org/10.14744/cpr.2026.95639","url":null,"abstract":"<p><strong>Objective: </strong>To place Selim Kurtoğlu's 1981 Turkish report of cutaneous larva migrans (CLM) within the context of pre-digital medical history and the updated Türkiye-related literature.</p><p><strong>Materials and methods: </strong>We conducted a historical documentary review of the 1981 article and a scoping search of PubMed/MEDLINE, Google Scholar, TR Dizin, DergiPark, journal websites, bibliographic catalogs, and accessible archives. The search was updated on July 27, 2026.</p><p><strong>Results: </strong>Robert James Lee's 1874 report served as the international historical anchor. Kurtoğlu's 1981 article described a 2.5-month-old boy from Nevşehir with widespread pruritic, tunnel-like lesions and cited a 1947 Turkish parasitology item by Şekban under the term \"köstebek hastalığı\"; however, neither the cited item nor Şekban's biographical details could be independently verified. The updated search identified 11 subsequent digitally accessible Türkiye-related CLM publications and one 2026 Turkish report of a CLM mimic. The CLM literature included travel-associated disease, probable local acquisition, pediatric and atypical presentations, a 22-patient regional series, and discussions related to climate.</p><p><strong>Conclusion: </strong>Kurtoğlu's 1981 report demonstrates that the history of CLM in Türkiye is older and more complex than digital databases alone suggest. The 1947 Şekban citation remains a historical trace awaiting archival confirmation, and older Turkish medical periodicals and local archives are essential for reconstructing the national chronology.</p>","PeriodicalId":521104,"journal":{"name":"Journal of clinical practice and research","volume":"48 5","pages":"580-588"},"PeriodicalIF":0.4,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the Initial Source of Recognition-Clinician versus Caregiver-Affect the Age at Orchidopexy for Undescended Testis? A Retrospective Comparative Analysis of 283 Cases.","authors":"Mevlüt Keleş, Erdal Benli, Abdullah Çırakoğlu, Onur Yalçın, Ahmet Anıl Acet","doi":"10.14744/cpr.2026.92673","DOIUrl":"10.14744/cpr.2026.92673","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate institutional adherence to international guidelines regarding the timing of treatment for undescended testis (UDT) and investigate the impact of the initial source of recognition on age at orchidopexy.</p><p><strong>Materials and methods: </strong>We conducted a retrospective analysis of 283 patients who underwent orchidopexy for UDT between 2012 and 2022. Chronological age, laterality, and the initial source of recognition (clinician vs. primary caregiver) were evaluated using IBM SPSS Statistics, version 28. Variables were compared using the chi-square test, independent-samples t-test, or Mann-Whitney U test, with statistical significance defined as p<0.05.</p><p><strong>Results: </strong>The mean age at orchidopexy was 4.8±5.6 years, reflecting an overall trend toward delayed consultation. A subgroup analysis of 185 patients with documented recognition data showed that caregiver-detected cases underwent surgery at a significantly older age than clinician-detected cases (5.08±4.98 vs. 3.57±3.68 years; p=0.020). A sensitivity analysis excluding adult patients confirmed that this difference remained significant within the pediatric cohort (p=0.016). However, most procedures in both groups were performed well beyond the recommended 18-month guideline threshold.</p><p><strong>Conclusion: </strong>Delayed orchidopexy remains a prevalent clinical challenge with potential long-term implications for testicular health. Although clinician-led detection significantly improves surgical timing compared with caregiver recognition, systemic improvements in early primary care screening and caregiver awareness are essential to ensure strict adherence to optimal surgical timelines.</p>","PeriodicalId":521104,"journal":{"name":"Journal of clinical practice and research","volume":"48 4","pages":"437-442"},"PeriodicalIF":0.4,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}