Transcranial magnetic stimulation (2024)最新文献

{"title":"Developing a reverse translational model of low-intensity rTMS in alcohol use disorder: The influence of theta burst stimulation protocols on binge alcohol drinking in mice.","authors":"Akriti Dhungana, Daniel M McCalley, Alesha M Heath, Eric P Kraybill, Fatemeh S Mojabi, Jairelisse Morales Morales, Allison R Morningstar, Allyson K Davis, Claudia B Padula, William J Giardino, M Windy McNerney","doi":"10.1016/j.transm.2025.100098","DOIUrl":"10.1016/j.transm.2025.100098","url":null,"abstract":"<p><strong>Background: </strong>Repetitive Transcranial Magnetic Stimulation (rTMS) is a promising treatment tool for Alcohol Use Disorder (AUD). A challenge facing the field is that the optimal TMS parameters to reduce drinking are unknown. There are now rodent TMS coils which can be adapted to evaluate rTMS-induced changes in alcohol consumption in a rapid, cost-effective manner.</p><p><strong>Objective: </strong>Develop a preclinical model of rTMS in alcohol consuming rodents and collect pilot data to evaluate the influence rTMS parameters (here, theta burst pattern) on change in alcohol consumption and biochemistry.</p><p><strong>Methods: </strong>66 C57BL/6 J mice (32 F) received sham, intermittent Theta Burst Stimulation (iTBS), or continuous Theta Burst Stimulation (cTBS) (14 sessions, 2 sessions/day, low intensity 16mT stimulation). Alcohol consumption and preference were evaluated before and after rTMS using a two-bottle choice, Drinking in the Dark (DID) paradigm. Cortical brain tissue was assayed for BDNF gene expression via qPCR. During DID sessions, control mice (n = 31) were given access to water only.</p><p><strong>Results: </strong>Relative to sham, iTBS increased alcohol consumption (d=0.72) and preference (d=0.44), however these results were not statistically significant. Female mice receiving iTBS, experienced a significant, large increase in alcohol consumption (p = 0.02, d=1.5). Among water only mice, iTBS (d=-1.01) and cTBS (d=-1.03) significantly reduced BDNF expression.</p><p><strong>Conclusions: </strong>This preclinical model is a feasible method to evaluate rTMS-induced changes in alcohol consumption. This pilot analysis warrants future work evaluating the influence of rTMS parameters and sex on changes in drinking or drug-seeking behaviors.</p>","PeriodicalId":520872,"journal":{"name":"Transcranial magnetic stimulation (2024)","volume":"4 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12201979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing TMS for PTSD - From networks to individuals.","authors":"Patlapa Sompolpong, Sanne J H van Rooij","doi":"10.1016/j.transm.2025.100178","DOIUrl":"10.1016/j.transm.2025.100178","url":null,"abstract":"","PeriodicalId":520872,"journal":{"name":"Transcranial magnetic stimulation (2024)","volume":"4 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and tolerability of dual-site accelerated transcranial magnetic stimulation treatment for obsessive-compulsive disorder and major depressive disorder.","authors":"Carolina Jimenez, Jungho Cha, Zarghona Imtiaz, Sonia Olson, Shannon O'Neill, Ki Sueng Choi, Martijn Figee, Andrew H Smith","doi":"10.1016/j.transm.2025.100182","DOIUrl":"10.1016/j.transm.2025.100182","url":null,"abstract":"","PeriodicalId":520872,"journal":{"name":"Transcranial magnetic stimulation (2024)","volume":"4 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A feasibility study of sequenced TMS and TBS dosing in adolescents with major depressive disorder.","authors":"Cicek N Bakir, Paul A Nakonezny, Dicle Buyuktaskin, Lucero Sangster-Carrasco, Irem Azamet, Jennifer Vande Voort, Paul E Croarkin","doi":"10.1016/j.transm.2025.100093","DOIUrl":"10.1016/j.transm.2025.100093","url":null,"abstract":"<p><p>This feasibility study focused on a staged approach to transcranial magnetic stimulation (TMS) interventions for adolescents with depression. Adolescents (N = 6) who did not respond to standard TMS were offered a two-week course of either continuous or intermittent theta burst stimulation (TBS) based on an intracortical facilitation - (ICF) biomarker. A within-subjects linear mixed model analysis of repeated measures was conducted to assess changes in depressive symptoms using the Children's Depression Rating Scale-Revised (CDRS-R). The analysis revealed a significant overall improvement in depressive symptoms from baseline to 6-month follow-up (p = 0.02; d=0.82). Significant pairwise comparisons were observed between baseline and week 2 [LSM decrease = -5.83 (SE = 2.`21), adjusted p = 0.04], and between baseline and 6-month follow-up [LSM decrease = -18.39 (SE = 7.05), adjusted p = 0.04]. There is a theoretical rationale for the use of ICF to guide dosing of TBS and this study suggests feasibility. While this study does not provide evidence to support the utility of the ICF biomarker, it may provide a template for future studies.</p>","PeriodicalId":520872,"journal":{"name":"Transcranial magnetic stimulation (2024)","volume":"3 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}