Clinical neuroimaging (Hoboken, N.J.)最新文献

Differentiating Benign and Malignant Thyroglossal Duct Cysts With Ultrasonography, CT, and PET/CT. 超声、CT及PET/CT鉴别甲状舌管囊肿良恶性。

Clinical neuroimaging (Hoboken, N.J.) Pub Date : 2026-01-01 Epub Date: 2026-02-04 DOI: 10.1002/neo2.70054

Joanna W Elhaj, Trevor Abts, Yunyi Wang, Jing Ning, Salmaan Ahmed, J Matthew Debnam

{"title":"Differentiating Benign and Malignant Thyroglossal Duct Cysts With Ultrasonography, CT, and PET/CT.","authors":"Joanna W Elhaj, Trevor Abts, Yunyi Wang, Jing Ning, Salmaan Ahmed, J Matthew Debnam","doi":"10.1002/neo2.70054","DOIUrl":"10.1002/neo2.70054","url":null,"abstract":"Background purpose: To determine if US, CT, and/or 18F-FDG PET/CT can differentiate benign and malignant thyroglossal duct cysts (TGDCs).Methods: In this retrospective review, we identified 72 patients with cytologically proven benign TGDCs and 11 patients with cytologically proven malignant TGDCs. Patient demographics, US and CT features, and maximum standardized uptake value (SUVmax) on PET/CT were compared. On US, TGDCs were assigned a summary score with one point each for irregular margins, solid-component appearance, vascular flow on Doppler US, and calcifications. Score performance in differentiating benign and malignant TGDCs was analyzed.Results: Malignant TGDCs were detected at a younger age (optimal cut-off, 43.5 years) (p = 0.001) and were larger (optimal cut-off, > 1.9 cm) (p = 0.041). Malignant TGDCs more frequently had irregular margins on US (p <0.001), calcifications on US (p <0.001) and CT (p = 0.009), and higher SUVmax on PET/CT (p = 0.001). Summary scores could be calculated for 79 TGDCs. All 54 TGDCs with a score of 0 or 1 were benign, whereas both TGDCs with a score of 4 were malignant. The 23 TGDCs with a score of 2 or 3 could not be differentiated by score.Conclusion: Malignant TGDCs are diagnosed at an earlier age, are larger, and have higher uptake on PET/CT than benign TGDCs. On US, cystic TGDCs or those containing only solid tissue with smooth margins may not need an FNA (fine needle aspiration) and may be followed with serial US. TGDCs with solid tissue with irregular margins, increased vascular flow, and calcifications are likely malignant; FNA before excision may be beneficial for documenting malignancy and genetic testing. All other TGDCs require FNA for differentiation. On PET/CT, TGDCs with increased uptake require FNA.","PeriodicalId":520854,"journal":{"name":"Clinical neuroimaging (Hoboken, N.J.)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13166108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147937312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proton Magnetic Resonance Spectroscopy of the Developing Human Brain. 发育中的人脑的质子磁共振波谱。

Clinical neuroimaging (Hoboken, N.J.) Pub Date : 2025-01-01 Epub Date: 2025-10-12 DOI: 10.1002/neo2.70039

Firoozeh Shomal Zadeh, Qinqin Yang, Ali Gholipour, Camilo Jaimes

{"title":"Proton Magnetic Resonance Spectroscopy of the Developing Human Brain.","authors":"Firoozeh Shomal Zadeh, Qinqin Yang, Ali Gholipour, Camilo Jaimes","doi":"10.1002/neo2.70039","DOIUrl":"https://doi.org/10.1002/neo2.70039","url":null,"abstract":"Neurodevelopmental disorders are pervasive and pose a significant public health problem. Many of these disorders can have a lifelong impact on the quality of life and may affect an individual's ability to function independently. In numerous pediatric and fetal neurological disorders, biochemical alterations precede or mediate structural and functional abnormalities that result in the patient's symptoms. Therefore, the ability of Proton Magnetic Resonance Spectroscopy (1H-MRS) to characterize these changes offers a valuable complement to neuro-anatomical imaging by allowing for a more timely and specific diagnosis, which may, in turn, enable earlier initiation of therapies and support services. This manuscript discusses the technical foundations of 1H-MRS and demonstrates its clinical relevance through representative applications in the developing human brain, including the evaluation of neurodevelopmental trajectories, diagnosis of inherited metabolic disorders, assessment of hypoxic-ischemic encephalopathy (HIE), monitoring of brain development in congenital heart disease (CHD), and its role in neuro-oncology. Despite its promise as a valuable tool in neuroradiology, the widespread adoption of 1H-MRS remains limited by technical constraints and challenges in spectral interpretation. Therefore, this manuscript also outlines the key barriers that hinder its full clinical potential and discusses how targeted technological innovations, along with the development of large-scale reference datasets, can enhance the reliability and diagnostic utility of 1H-MRS in improving outcomes for neurodevelopmental disorders.","PeriodicalId":520854,"journal":{"name":"Clinical neuroimaging (Hoboken, N.J.)","volume":"2 1","pages":"e70039"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13651947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Mammillary Body Manual Segmentation: Application for Quantitative MRI Analysis of Critically Ill Infants. 新型乳状体人工分割：在危重婴儿MRI定量分析中的应用。

Clinical neuroimaging (Hoboken, N.J.) Pub Date : 2025-01-01 Epub Date: 2025-02-26 DOI: 10.1002/neo2.70011

Mackenzie S Kagan, David Zurakowski, Emi Takahashi, Russell W Jennings, Dusica Bajic

{"title":"Novel Mammillary Body Manual Segmentation: Application for Quantitative MRI Analysis of Critically Ill Infants.","authors":"Mackenzie S Kagan, David Zurakowski, Emi Takahashi, Russell W Jennings, Dusica Bajic","doi":"10.1002/neo2.70011","DOIUrl":"10.1002/neo2.70011","url":null,"abstract":"Background and purpose: Previous qualitative studies have shown that mammillary body (MB) assessment can serve as an early marker of poor long-term neurodevelopmental outcomes. This study aims to establish a reliable quantitative method for analyzing the surface area, volume, and signal intensity of MB in infancy.Methods: A novel methodology was retrospectively tested in a cohort of critically ill preterm and term-born patients following long-gap esophageal atresia (EA) repair, and healthy term-born controls (n = 13/group) using non-sedated brain MRI on a 3T Siemens scanner. Manual bilateral MB segmentation of T2-weighted data and quantification of MB surface area, volume, and tissue mean signal intensity were performed using ITK-SNAP. Endpoint measures were assessed for normality, and their relationship with group status was evaluated using a general linear model with age at scan as a covariate.Results: High intra- and inter-tracer reliability was observed between a novice and neuroanatomical expert for MB segmentation. Despite straightforward manual masking and novel quantification of infant MB, no significant differences were found among the three groups (preterm and term-born patients, and term-born controls) for any of the MB endpoints analyzed: surface area, volume, and signal intensity. The data analysis revealed a trend of lower values in patient groups for signal intensity only.Conclusions: This novel study describes efficient and accurate MB masking and quantification, supporting MB as a potential early marker. However, the negative results presented in infants born with long-gap EA should not be generalized until future prospective studies with larger sample sizes are conducted and linked to neurodevelopmental outcomes.","PeriodicalId":520854,"journal":{"name":"Clinical neuroimaging (Hoboken, N.J.)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 7-tesla study of cerebellar alterations relating to bladder control in women with multiple sclerosis voiding dysfunction using functional connectivity. 利用功能连通性对多发性硬化症女性排尿功能障碍患者膀胱控制相关的小脑改变进行7特斯拉研究。

Clinical neuroimaging (Hoboken, N.J.) Pub Date : 2025-01-01 Epub Date: 2025-06-26 DOI: 10.1002/neo2.70022

Kevin Colbert, Betsy Salazar, Charles Mazeaud, Kristopher Hoffman, Ahmed Bayoumi, Jessica A Bernard, John Lincoln, Rose Khavari

{"title":"A 7-tesla study of cerebellar alterations relating to bladder control in women with multiple sclerosis voiding dysfunction using functional connectivity.","authors":"Kevin Colbert, Betsy Salazar, Charles Mazeaud, Kristopher Hoffman, Ahmed Bayoumi, Jessica A Bernard, John Lincoln, Rose Khavari","doi":"10.1002/neo2.70022","DOIUrl":"10.1002/neo2.70022","url":null,"abstract":"Background and purpose: Neurogenic lower urinary tract dysfunction (NLUTD) affects over 80% of individuals with multiple sclerosis (MS), leading to significant morbidity and mortality due to storage and voiding dysfunction. This study aims to investigate the altered functional connectivity (FC) in cerebellar regions involved in bladder control in women with MS and NLUTD, compared to healthy controls, in both empty and full bladder states using concurrent urodynamics and functional magnetic resonance imaging (fMRI).Methods: We recruited 11 women with clinically stable MS and NLUTD and 10 healthy controls. Brain imaging data was collected using 7T MRI scanners, and functional connectivity was analyzed with three cerebellar regions of interest (ROIs) associated with bladder control. Functional connectivity data was processed using the CONN toolbox, and FC patterns were compared between groups during both resting empty and full bladder states.Results: In the empty bladder state, MS patients exhibited stronger intracerebellar FC, particularly in the right Crus 1, suggesting decreased motor control of the pelvic floor. Additionally, decreased FC was observed in the precuneus and prefrontal cortex, regions associated with bladder control. During the full bladder state, MS patients showed decreased FC in temporal, occipital, and prefrontal cortex, indicating impaired executive control over voiding.Conclusion: This study highlights altered cerebellar connectivity in MS patients with NLUTD, providing novel insights into the neural mechanisms underlying bladder dysfunction and identifying potential therapeutic targets for restoring continence.","PeriodicalId":520854,"journal":{"name":"Clinical neuroimaging (Hoboken, N.J.)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144987071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0