Topology- and graph-informed imaging informatics : first International Workshop, TGI3 2024, Held in Conjunction with MICCAI 2024, Marrakesh, Morocco, October 10, 2024, Proceedings. International Workshop on Topology- and Graph-Informed ...最新文献

筛选
英文 中文
P-Count: Persistence-based Counting of White Matter Hyperintensities in Brain MRI. P-Count:基于持续的脑MRI白质高信号计数。
Xiaoling Hu, Annabel Sorby-Adams, Frederik Barkhof, W Taylor Kimberly, Oula Puonti, Juan Eugenio Iglesias
{"title":"<i>P-Count</i>: Persistence-based Counting of White Matter Hyperintensities in Brain MRI.","authors":"Xiaoling Hu, Annabel Sorby-Adams, Frederik Barkhof, W Taylor Kimberly, Oula Puonti, Juan Eugenio Iglesias","doi":"10.1007/978-3-031-73967-5_10","DOIUrl":"https://doi.org/10.1007/978-3-031-73967-5_10","url":null,"abstract":"<p><p>White matter hyperintensities (WMH) are a hallmark of cerebrovascular disease and multiple sclerosis. Automated WMH segmentation methods enable quantitative analysis via estimation of total lesion load, spatial distribution of lesions, and number of lesions (i.e., number of connected components after thresholding), all of which are correlated with patient outcomes. While the two former measures can generally be estimated robustly, the number of lesions is highly sensitive to noise and segmentation mistakes - even when small connected components are eroded or disregarded. In this article, we present <i>P-Count</i>, an algebraic WMH counting tool based on persistent homology that accounts for the topological features of WM lesions in a robust manner. Using computational geometry, <i>P-Count</i> takes the persistence of connected components into consideration, effectively filtering out the noisy WMH positives, resulting in a more accurate count of true lesions. We validated <i>P-Count</i> on the ISBI2015 longitudinal lesion segmentation dataset, where it produces significantly more accurate results than direct thresholding.</p>","PeriodicalId":520840,"journal":{"name":"Topology- and graph-informed imaging informatics : first International Workshop, TGI3 2024, Held in Conjunction with MICCAI 2024, Marrakesh, Morocco, October 10, 2024, Proceedings. International Workshop on Topology- and Graph-Informed ...","volume":"15239 ","pages":"100-110"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144987003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Topological Comparison of the Fluorescence Imitating Brightfield Imaging and H&E Imaging. 荧光模拟明场成像与H&E成像的拓扑比较。
Meiliong Xu, Nate Anderson, Richard M Levenson, Prateek Prasanna, Chao Chen
{"title":"A Topological Comparison of the Fluorescence Imitating Brightfield Imaging and H&E Imaging.","authors":"Meiliong Xu, Nate Anderson, Richard M Levenson, Prateek Prasanna, Chao Chen","doi":"10.1007/978-3-031-73967-5_12","DOIUrl":"10.1007/978-3-031-73967-5_12","url":null,"abstract":"<p><p>Fluorescence Imitating Brightfield Imaging (FIBI) represents an innovative approach in microscopy, providing real-time, non-destructive imaging of tissue without the need for the preparation of thin sections mounted on glass slides. The non-destructive nature of the technology permits tissue preservation for downstream analysis, which makes FIBI a promising alternative to traditional hematoxylin and eosin (H&E) staining in histopathology. Previous research has shown that FIBI can identify morphological features with similar or, in some cases, higher quality compared with H&E images. To comprehensively quantify the advantages and limitations of FIBI in tissue visualization, we propose a novel framework for characterizing the topological difference of FIBI and H&E slide pairs. Experiments are performed on slide pairs of FIBI and H&E imaging of the same tissue area. The proposed approach shows that FIBI can make morphological structures, like vessels, more salient and holds great promise as a complementary technique to H&E, offering novel insights into tissue architecture and potentially improving histopathological diagnostic accuracy.</p>","PeriodicalId":520840,"journal":{"name":"Topology- and graph-informed imaging informatics : first International Workshop, TGI3 2024, Held in Conjunction with MICCAI 2024, Marrakesh, Morocco, October 10, 2024, Proceedings. International Workshop on Topology- and Graph-Informed ...","volume":"15239 ","pages":"122-133"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信