Brain medicine : from neurons to behavior and better health最新文献

Effects of Tai Chi Qigong on sleep quality in older male cancer survivors: A randomized controlled clinical trial. 太极拳对老年男性癌症幸存者睡眠质量的影响：一项随机对照临床试验。

Brain medicine : from neurons to behavior and better health Pub Date : 2026-09-08 DOI: 10.61373/bm026a.0063

Evelyn Arana-Chicas, Michael R Irwin, Cindy K Blair, Jinghua An, Samuel Tundealao, Yong Lin, Shou-En Lu, Chunxia Chen, Biren Saraiya, Dolores Guest, Wadih Arap, Emily Heidt, Anita Y Kinney

{"title":"Effects of Tai Chi Qigong on sleep quality in older male cancer survivors: A randomized controlled clinical trial.","authors":"Evelyn Arana-Chicas, Michael R Irwin, Cindy K Blair, Jinghua An, Samuel Tundealao, Yong Lin, Shou-En Lu, Chunxia Chen, Biren Saraiya, Dolores Guest, Wadih Arap, Emily Heidt, Anita Y Kinney","doi":"10.61373/bm026a.0063","DOIUrl":"10.61373/bm026a.0063","url":null,"abstract":"To compare the efficacy of Tai Chi and Qigong (TCQ) versus exercise intensity-matched (EIM) and usual care (UC) on sleep quality in older male cancer survivors. We conducted a three-arm randomized controlled trial among male cancer survivors aged 55 years and older. Participants were randomized to UC or one of two group-based interventions (TCQ or EIM), delivered twice weekly for 12 weeks with follow-up through 12 months. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Linear contrasts estimated within-arm changes and between-arm differences with 95% confidence intervals (CIs). A total of 113 participants (mean age 69.1 (SD = 7 years); 77.0% White; 88.5% non-Hispanic) were enrolled. At 3-months post-intervention, between-arm differences in sleep quality were not significant (p > 0.05). The EIM arm showed significant within-arm improvements in sleep quality at the 6-week midpoint (p = 0.004), 1-week post-intervention (p = 0.048), and 3 months post-intervention (p = 0.011) from baseline. The TCQ arm showed nonsignificant trends toward within-arm improvement in sleep quality at the same time points. No significant effects were observed at 12 months. The EIM arm significantly improved sleep efficiency at 3 months compared with TCQ (p = 0.04). By 12 months, 62% of TCQ participants achieved clinical remission of sleep disturbance (PSQI ≤5), compared with 47% in the EIM arm and 43% in the UC arm (p > 0.05). Attendance was similar across TCQ (78.4%) and EIM (76.8%). TCQ and EIM produced modest short-term improvements in sleep quality among older male survivors.","PeriodicalId":520835,"journal":{"name":"Brain medicine : from neurons to behavior and better health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atlas of GLP-1 expression in the mouse brain: Neuroanatomical basis for metabolic and psychiatric effects. 小鼠脑内GLP-1表达图谱：代谢和精神影响的神经解剖学基础。

Brain medicine : from neurons to behavior and better health Pub Date : 2026-03-30 Epub Date: 2025-03-10 DOI: 10.61373/bm026a.0006

Vitaly Ryu, Anisa Gumerova, Georgii Pevnev, Tony Yuen, Mone Zaidi

{"title":"Atlas of GLP-1 expression in the mouse brain: Neuroanatomical basis for metabolic and psychiatric effects.","authors":"Vitaly Ryu, Anisa Gumerova, Georgii Pevnev, Tony Yuen, Mone Zaidi","doi":"10.61373/bm026a.0006","DOIUrl":"10.61373/bm026a.0006","url":null,"abstract":"Recently, glucagon-like peptide 1 (GLP-1) and its new blockbuster class of analogs have emerged as powerful therapeutics to combat obesity and diabetes, with growing evidence for potential efficacy in addiction, depression, and other psychiatric conditions. Although metabolic diseases are common in both women and men, certain pathological and clinical features exhibit sex-specific differences, as do psychiatric disorders. Importantly, as part of a broader network of peptides and hormones regulating ingestive and reward-related behaviors, GLP-1 appears to have stronger effects on appetite suppression, glycemic regulation, and body weight loss in females compared with males-though sex differences in its psychiatric effects remain underexplored. We utilized RNAscope to create a comprehensive atlas of sex-specific (n = 3 per sex) GLP-1 expressing sites in the murine brain. Notably, in the hindbrain, Glp1 densities and total numbers of Glp1-expressing neurons in the raphe obscurus nucleus, ventral and ventrolateral parts of the solitary nucleus were higher in females compared with males. In the olfactory bulb, Glp1 densities were greater in the granular cell layer of males in comparison with females. Collectively, this atlas should serve as a resource to advance our understanding of GLP-1's central functions in both metabolic and psychiatric contexts.","PeriodicalId":520835,"journal":{"name":"Brain medicine : from neurons to behavior and better health","volume":"2 1","pages":"21-31"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147641164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The brain geography of GLP-1: An atlas for a new era. GLP-1的大脑地理：新时代的地图集。

Brain medicine : from neurons to behavior and better health Pub Date : 2026-03-30 Epub Date: 2026-03-24 DOI: 10.61373/bm026d.0030

Julio Licinio, Ma-Li Wong

引用次数: 0

Adenosine as the metabolic common path of rapid antidepressant action: The coffee paradox. 腺苷作为快速抗抑郁作用的代谢共同途径：咖啡悖论。

Brain medicine : from neurons to behavior and better health Pub Date : 2025-12-31 Epub Date: 2025-11-11 DOI: 10.61373/bm025c.0134

Julio Licinio, Ma-Li Wong

引用次数: 0

Exercise as metabolic medicine: Movement counters diet-induced behavioral despair via gut-brain signaling. 运动作为代谢药物：运动通过肠道-大脑信号对抗饮食引起的行为绝望。

Brain medicine : from neurons to behavior and better health Pub Date : 2025-11-05 Epub Date: 2025-10-21 DOI: 10.61373/bm025d.0122

Julio Licinio, Ma-Li Wong, Nicholas Fabiano

引用次数: 0

Cardiac rhythms as windows into brain stimulation response: Promise and pitfalls in precision psychiatry. 心律作为脑刺激反应的窗口：精准精神病学的希望与陷阱。

Brain medicine : from neurons to behavior and better health Pub Date : 2025-10-22 Epub Date: 2025-10-14 DOI: 10.61373/bm025d.0119

Julio Licinio, Helen S Mayberg

引用次数: 0

Therapeutic apheresis: A promising method to remove microplastics? 治疗性分离：去除微塑料的一种有前途的方法？

Brain medicine : from neurons to behavior and better health Pub Date : 2025-05-01 Epub Date: 2025-05-20 DOI: 10.61373/bm025l.0056

Stefan R Bornstein, Timo Gruber, Danai Katsere, Ayoub El Attaoui, Leopold Wohlsperger, Mohamad Yaman, Waldemar Kanczkowski, Gunther Piwernetz, Richard Straube, Karin Voit-Bak, Julio Licinio, Charlotte Steenblock

引用次数: 0

A novel animal paradigm of long-term, stress-induced hippocampal atrophy. 长期应激性海马萎缩的一种新的动物模式。

Brain medicine : from neurons to behavior and better health Pub Date : 2025-01-01 Epub Date: 2024-05-02 DOI: 10.61373/bm024l.0040

Ma-Li Wong, Claudio Mastronardi, Julio Licinio

引用次数: 0