The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians最新文献

{"title":"Associations between electronic nicotine delivery systems and birth outcomes.","authors":"Summer Sherburne Hawkins,&nbsp;Blair Johnson Wylie,&nbsp;Michele R Hacker","doi":"10.1080/14767058.2021.1929156","DOIUrl":"https://doi.org/10.1080/14767058.2021.1929156","url":null,"abstract":"<p><strong>Objectives: </strong>Nicotine crosses the placenta and is a known teratogen. The use of electronic nicotine delivery systems (ENDS) has increased among pregnant women in the US, but there is limited knowledge about their effects on birth outcomes. We examined the associations between ENDS and cigarette use during pregnancy with birth outcomes.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of 57,046 respondents from 32 US states in the 2016-2017 Pregnancy Risk Assessment Monitoring System. Respondents self-reported use of ENDS and cigarettes during the last 3 months of pregnancy; this was linked with birth outcomes documented on the birth certificate, including birth weight, gestational age, small-for-gestational age, and preterm birth.</p><p><strong>Results: </strong>During the last 3 months of pregnancy, 0.5% of women used ENDS only, 0.8% were dual users of ENDS and cigarettes, and 8.0% used cigarettes only. In adjusted models, infants of women who used ENDS only weighed 57.8 grams less (95% CI -134.2, 18.6; <i>p</i> = .14) and were born 0.21 weeks earlier (95% CI -0.45, 0.03; <i>p</i> = .09) than infants of non-users. Infants born to dual users were 193.9 grams less (95% CI -274.9, -112.8; <i>p</i> < .01) and had a 1.93 higher odds of being born small-for-gestational age (95% CI 1.31, 2.83; <i>p</i> < .01) than infants of non-users.</p><p><strong>Conclusions: </strong>Our results provide some indication that prenatal ENDS use may adversely affect birth outcomes by reducing birth weight and gestational age. Estimates were imprecise, suggesting that larger samples of ENDS users with more detailed information about patterns of use are needed.</p>","PeriodicalId":520807,"journal":{"name":"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","volume":" ","pages":"6868-6875"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14767058.2021.1929156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39013094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress levels among an international sample of pregnant and postpartum women during the COVID-19 pandemic.","authors":"Diego F Wyszynski,&nbsp;Sonia Hernandez-Diaz,&nbsp;Vanessa Gordon-Dseagu,&nbsp;Noemi Ramiro,&nbsp;Karestan C Koenen","doi":"10.1080/14767058.2021.1936489","DOIUrl":"https://doi.org/10.1080/14767058.2021.1936489","url":null,"abstract":"<p><strong>Background: </strong>Stress is a complex condition that can have a profound effect on an individual's sense of wellbeing and their ability to live a happy and healthy life. COVID-19 and its associated stressors have the potential to disrupt numerous facets of our everyday lives. Pregnant and postpartum women are especially vulnerable to changes in the availability of routine health and social care services and of their support networks. The current study sought to explore stress levels and their influencers among an international cohort of pregnant and postpartum women during the COVID-19 pandemic.</p><p><strong>Methods: </strong>We conducted an anonymous, online, cross-sectional survey in 64 countries between May and June 2020. The survey was hosted on the Pregistry platform and made available in 12 languages, with respondents sought through a variety of social media platforms and parenting forums. In addition to levels of stress, we collected data related to demographics, COVID-19 exposure and worries, lifestyle changes, traditional and social media use, precautionary measures related to COVID-19, and mental health.</p><p><strong>Results: </strong>In total, 7185 women were included in our sample. We found statistically significant (<i>p</i>-value <0.05) reductions in stress score among older women (≥35 years of age), those either living with a partner or married, those who had graduated from college, and those with medical coverage. Higher stress scores were found among women who resided in Africa, Asia and the Pacific, the Middle East, and North America compared with those in Europe. When race and ethnicity were included in the model, black women were found to have higher stress compared to white women. Level of family and community support was inversely associated with level of stress.</p><p><strong>Conclusion: </strong>Our study is one of the first to explore stress levels among pregnant and postpartum women during the COVID-19 pandemic. We found statistically significant differences in stress levels by age, education, marital status, region of residence, race/ethnicity and level of support. Understanding stress during the COVID-19 pandemic, and exploring ways to address it, will be key to contributing to the mental and physical health of expectant and new mothers, as well as their children, in both the short and long term.</p>","PeriodicalId":520807,"journal":{"name":"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","volume":" ","pages":"7043-7051"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14767058.2021.1936489","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39029021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal respiratory inhibition.","authors":"Hideki Minowa","doi":"10.1080/14767058.2021.1944094","DOIUrl":"https://doi.org/10.1080/14767058.2021.1944094","url":null,"abstract":"<p><strong>Objective: </strong>To present information on neonatal respiratory inhibition (NRI) to the medical staff caring for infants.</p><p><strong>Methods: </strong>The author reviewed investigations of the above conditions. NRI is defined as severe hypoxemia accompanied by clinical manifestations of central cyanosis and a decrease in SpO₂ to less than 70%. Neonatal respiratory inhibition consists of respiratory inhibition after crying (RIAC), feeding hypoxemia, and respiratory inhibition after gastroesophageal reflux (RIGER). The infants were monitored continuously via pulse oximetry from birth until discharge. To identify the details of NRI, we analyzed detailed notes taken by both parents and medical staff during monitoring using specific software designed to interpret pulse oximetry measurements.</p><p><strong>Results: </strong>Among infants who weighed at least 2000 g and who were born at a gestational age of at least 36 weeks, NRI was observed in ∼50% of infants, including RIAC in ∼25%, feeding hypoxemia in 40%, and RIGER in 2 ∼ 4%, respectively. Among the infants with NRI, ∼40% experienced one or more episodes of prolonged cyanosis for at least 60 s. RIAC, feeding hypoxemia, and RIGER is significantly associated with each other. Among perinatal factors, NRI was related to maternal diabetes mellitus, twin pregnancy, asymmetric intrauterine growth restriction, threatened premature labor, cesarean section, shorter gestational periods, and abnormal ultrasound findings, including increased echogenicity in the ganglionic eminence (GE), a cyst in the GE, a subependymal cyst, and slight lateral ventricular enlargement. Almost all infants with RIAC and RIGER, even those with severe cases, recovered until discharge around day 5. Despite the provision of nursing guidance in feeding control, ∼60% of infants experienced feeding hypoxemia continuously. The more frequently the infants experienced feeding hypoxemia, the more severe the degree of feeding hypoxemia became. Breastfeeding reduced the frequency and degree of feeding hypoxemia compared to bottle feeding. Approximately 40% of infants with feeding hypoxemia required additional feeding control after being discharged.</p><p><strong>Conclusions: </strong>NRI is very common and occurs in many infants worldwide. The infants with NRI experienced repeated severe hypoxemia due to RIAC, feeding hypoxemia, and RIGER after birth. Breastfeeding and careful feeding control should be recommended to mothers of infants with repeated feeding hypoxemia. Spreading knowledge about NRI worldwide is very important.</p>","PeriodicalId":520807,"journal":{"name":"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","volume":" ","pages":"7132-7138"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14767058.2021.1944094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39036221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective evaluation of clinical characteristics and maternal outcomes of women with pathologically confirmed postpartum retained placental fragments.","authors":"Misgav Rottenstreich,&nbsp;Ohad Atia,&nbsp;Netanel Greifner,&nbsp;Reut Rotem,&nbsp;Sorina Grisaru-Granovsky,&nbsp;Fiona Vernea,&nbsp;Orna Reichman,&nbsp;Hen Y Sela","doi":"10.1080/14767058.2021.1947228","DOIUrl":"https://doi.org/10.1080/14767058.2021.1947228","url":null,"abstract":"<p><strong>Objective: </strong>To determine the incidence, risk factors, and short-term maternal outcomes of women with pathologically confirmed retained products of conception (RPOC) following vaginal delivery.</p><p><strong>Methods: </strong>Prospective cohort study of women with suspicion of RPOC following vaginal delivery, from March 2018 to April 2019. Women were followed for eight weeks postpartum. Women with complete retained placenta were excluded. Women with pathologically confirmed RPOC were compared to those without. Univariate analysis was conducted (ORs; [95% CI]) and was followed by multivariate analysis (aOR; [95% CI]).</p><p><strong>Results: </strong>During the study period, there were 16,583 vaginal deliveries. A total of 96 women (0.58%) with a suspicion of RPOC were enrolled, of these, 53 women (55%) had pathologically confirmed RPOC. The most significant risk factors for pathologically confirmed RPOC were placental abruption (aOR 5.0 [2.29-11.13]) and Oxytocin augmentation of labor (aOR 1.7 [1.07-2.63]). Pathologically confirmed RPOC were associated with higher rates of prolonged hospitalization (OR 9.2 [2.83-30.05]), postpartum hemorrhage (PPH) (OR 6.6 [3.60-11.98]), hemoglobin drop > 3 g/dl (OR 11.4 [5.49-23.49]), and blood transfusion (OR 8.6 [2.07-38.18]). Women who had exploration of uterine cavity without pathological confirmation of RPOC, still had higher rates of perineal laceration (OR 17.6 [4.93-63.08]), PPH (OR 6.1 [3.05-12.21]), and a hemoglobin drop <b>></b> 3 g/dl (OR 6.0 [2.13-16.95]).</p><p><strong>Conclusions: </strong>Pathologically confirmed RPOC following vaginal delivery has unique characteristics and is associated with significantly higher rates of PPH and blood transfusions. These findings may assist in the development of better criteria for selecting women for manual exploration and for preventive measures to reduce PPH and complications.</p>","PeriodicalId":520807,"journal":{"name":"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","volume":" ","pages":"7322-7329"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14767058.2021.1947228","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39080037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between postnatal weight gain and need for treatment in retinopathy of prematurity.","authors":"Ma José Cabañas Poy,&nbsp;José Bruno Montoro Ronsano,&nbsp;Félix Castillo Salinas,&nbsp;Nieves Martín Begué,&nbsp;Susana Clemente Bautista,&nbsp;Ma Queralt Gorgas Torner","doi":"10.1080/14767058.2021.1940937","DOIUrl":"https://doi.org/10.1080/14767058.2021.1940937","url":null,"abstract":"<p><strong>Objective: </strong>To study the association between gestational age (GA) and weight at birth and the development of retinopathy of prematurity (ROP), and in particular the link between postnatal weight gain during the first 6 weeks and need for ROP treatment.</p><p><strong>Material and methods: </strong>Retrospective observational study of premature infants who underwent ophthalmoscopy at Hospital Universitari Vall d'Hebron in Barcelona, Spain, between June 2017 and December 2018. We collected data on obstetric and birth characteristics, comorbidities, GA and weight at birth, and weekly weight for the first 6 weeks.</p><p><strong>Results: </strong>Ninety patients with a mean ± SD GA of 26.87 ± 1.90 weeks and a mean birth weight of 884.29 ± 227.40 g were studied. The mean weight at 6 weeks was 1656.89 ± 478.51 g, which corresponds to a gain of 776.17 ± 298.12 g. Thirty-seven patients (41.1%) were diagnosed with ROP and nine (10%) needed treatment. Significant predictors of the need for treatment in patients with ROP were GA (<i>p</i> = .018) and weight at 6 weeks (<i>p</i> = .021). Birth weight was not significant (<i>p</i> = .361).</p><p><strong>Conclusions: </strong>GA and weight gain during the first 6 weeks of life are significantly associated with the need for treatment in infants with ROP. Sex and birth weight were not significant predictors. Postnatal weight gain at 6 weeks is predictive of the need for ROP treatment.</p>","PeriodicalId":520807,"journal":{"name":"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","volume":" ","pages":"8027-8031"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14767058.2021.1940937","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39095112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum bonding: the impact of stressful life events during pregnancy.","authors":"Vincenzo Zanardo,&nbsp;Federica Tedde,&nbsp;Claudio Zandonella Callegher,&nbsp;Andrea Sandri,&nbsp;Lara Giliberti,&nbsp;Valeria Manghina,&nbsp;Gianluca Strafaceee","doi":"10.1080/14767058.2021.1937986","DOIUrl":"https://doi.org/10.1080/14767058.2021.1937986","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to determine if and to what extent a woman's exposure to stressful life events were associated with impaired maternal bonding by using a sample of high-income Italian women.</p><p><strong>Methods: </strong>In the second day postpartum, 425 healthy puerperae responded to Life Experiences Survey (LES), Mother-to-Infant Bonding Scale (MBS), and to the Edinburgh Postnatal Depression Scale (EPDS).</p><p><strong>Results: </strong>Analysis revealed that the stressful life events scored by LES were a significantly predictor of impaired bonding as measured by MIBS (<i>β</i> = 0.04; <i>t</i> = 3.45; <i>p</i> < .001) and of postpartum depression symptoms as measured by EPDS total score (<i>β</i> = 0.32; <i>t</i> = 4.86; <i>p</i> < .001) as well as its subscales <i>Anhedonia</i> (<i>β</i> = 0.059; <i>t</i> = 4.99; <i>p</i> < .001), <i>Anxiety</i> (<i>β</i> = 0.03; <i>t</i> = 5.72; <i>p</i> < .001), and <i>Depression</i> (<i>β</i> = 0.05; <i>t</i> = 6.53; <i>p</i> < .001). Moreover, the partial correlation between EPDS total score and MIBS accounting for LES positive and negative scores was statistically significant (<i>r</i> = 0.208; <i>n</i> = 332; <i>p</i> < .001).</p><p><strong>Conclusion: </strong>The findings emphasize the importance of identifying mothers with negative experiences toward pregnancy and delivery to address possible interventions beyond hospital-based antenatal care to improve bonding and maternal mental outcomes.</p>","PeriodicalId":520807,"journal":{"name":"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","volume":" ","pages":"7849-7856"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14767058.2021.1937986","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39120648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil gelatinase-associated lipocalin distribution in preterm newborns without acute kidney injury as defined by a reference method.","authors":"Aurélie De Mul,&nbsp;Paloma Parvex,&nbsp;Alexandra Wilhelm-Bals","doi":"10.1080/14767058.2021.1873939","DOIUrl":"https://doi.org/10.1080/14767058.2021.1873939","url":null,"abstract":"<p><strong>Introduction: </strong>Neutrophil gelatinase-associated lipocalin (NGAL) has been proposed as an early acute kidney injury (AKI) biomarker in the neonatal population. Our goal is to describe this biomarker behavior in this high-risk population, in absence of AKI as confirmed by inulin clearance.</p><p><strong>Materials and methods: </strong>Prospective study including 42 preterm newborns (mean gestational age: 30.7 ± 2.3 weeks) with a urinary NGAL collection between day 1 and 6 of life.</p><p><strong>Results: </strong>Median urinary neutrophil gelatinase-associated lipocalin (uNGAL) value is 122.8 ng/ml (7-1981.5 ng/ml). Statistically significant higher uNGAL values are found in female. uNGAL median values are decreasing when comparing extremely, very, and late preterm groups (812.2 ng/ml [75.8-1453.9] vs. 124.4 ng/ml [31.4-1981.5] vs. 65.3 ng/ml [7.1-1091]). There is a statistically significant inverse correlation between gestational age and uNGAL values (Pearson's coefficient <i>r</i>= -0.37). uNGAL median values are higher in groups exposed to gentamicin, neonatal asphyxia, early onset sepsis, or patent ductus arteriosus. Median inulin clearance is 18.8 ml/min/1.73 m² [14.8-25.5 ml/min/1.73 m²]. There is no correlation between uNGAL values and inulin clearance results (Pearson's coefficient <i>r</i>=-0. 29, <i>p</i>: .06).</p><p><strong>Conclusions: </strong>In this preterm newborn's series without AKI, the median uNGAL and its high variability are in accordance with published reference ranges. Correlation between uNGAL and gestational age exists, as well as gender impact. Newborns exposed to different renal insults present higher uNGAL values, suggesting potential undetected tubular toxicity or reflecting NGAL production in case of inflammatory or ischemic processes.</p>","PeriodicalId":520807,"journal":{"name":"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","volume":" ","pages":"4956-4960"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14767058.2021.1873939","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38826711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastroschisis: a systematic review of diagnosis, prognosis and treatment.","authors":"Rui Gilberto Ferreira,&nbsp;Carolina Rodrigues Mendonça,&nbsp;Lelia Luanne Gonçalves Ramos,&nbsp;Fernanda Sardinha de Abreu Tacon,&nbsp;Waldemar Naves do Amaral,&nbsp;Rodrigo Ruano","doi":"10.1080/14767058.2021.1909563","DOIUrl":"https://doi.org/10.1080/14767058.2021.1909563","url":null,"abstract":"<p><strong>Objectives: </strong>The present systematic review aims to investigate the diagnosis, prognosis, delivery assistance, pregnancy results and postnatal management in gastroschisis.</p><p><strong>Study design: </strong>The following data sources were evaluated: The CINAHL, Embase and MEDLINE/PubMed databases were searched, observational and intervention studies published over the past 20 years. The quality of the studies was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE).</p><p><strong>Results: </strong>A total of 3770 infants diagnosed with gastroschisis were included (44 studies); 1534 fetuses were classified as simple gastroschisis and 288 as complex gastroschisis. Intrauterine fetal demise occurred in 0.47% and elective termination occurred in 0.13%. Preterm delivery occurred in 23.23% and intrauterine growth restriction in 4.43%. Cesarean section delivery was performed in 54.6%. Neonatal survival was 91.29%. The main neonatal complications were: sepsis (11.78%), necrotizing enterocolitis (2.33%), short bowel syndrome (1.37%), bowel obstruction (0.79%), and volvulus (0.23%). Immediate surgical repair was performed in 80.1% with primary closure in 69%. The average to oral feeding was 33 (range: 11-124.5) days. Average hospital duration was 38 days and 89 days in neonates with simple and complex grastroschisis, respectively.</p><p><strong>Conclusions: </strong>The present systematic review provides scientific data for counseling families with fetal gastroschisis.</p>","PeriodicalId":520807,"journal":{"name":"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","volume":" ","pages":"6199-6212"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14767058.2021.1909563","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38841899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reciprocal assessment of urinary beta-2-microglobulin and BUN levels in renal dysfunction of neonates with birth asphyxia.","authors":"S Z Jalali,&nbsp;M Enteshari,&nbsp;F Saadat","doi":"10.1080/14767058.2021.1918667","DOIUrl":"https://doi.org/10.1080/14767058.2021.1918667","url":null,"abstract":"<p><strong>Objective: </strong>Asphyxia at birth is one of the major causes of morbidity and mortality in all neonates due to various organ dysfunctions, for example, kidneys. Recent advances in this area have suggested new urinary proteins for the assessment of renal damage, including beta-2 microglobulin (β2-MG). The aim of this study was to investigate the changes of urinary β2-MG in asphyxiated neonates and to evaluate the value of combined detection of multiple biomarkers in the early diagnosis of acute kidney injury (AKI) in asphyxiated neonates.</p><p><strong>Study design: </strong>This case-control study was performed on 84 term neonates in two control and case groups who were hospitalized at the neonatal intensive care unit. Using the Sarnat scoring system, the asphyxiated neonates were neurologically divided. Renal function tests and urinary β2-MG (uβ2-MG) levels of participants who registered based on inclusion criteria were measured. The data analyzed using descriptive and inferential statistical tests. The diagnostic value of the biomarker was determined using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>This study showed that uβ2-MG was not a statistically significant difference in both asphyxiated neonates with AKI and non-AKI (<i>p</i> = .085). Whereas, uβ2-MG levels were statistically significant in neurological grading of asphyxiated infants to two groups (<i>p</i> = .013). A new predictor, uβ2-MG and blood urea nitrogen (BUN); named BB1, was substituted as the diagnostic value in neonates with asphyxia with an area under the receiver operating characteristic curve (AUC) (95% CI) of 0.88 (0.76-1.0). This AUC was significantly greater than the value for uβ2-MG associated with AKI (<i>p</i> = .003).</p><p><strong>Conclusion: </strong>Our findings showed that mutual detection of uβ2-MG levels with BUN should be an early indicator for the diagnosis of renal injury with greater specificity and improved prognostic accuracy after neonatal asphyxia.</p>","PeriodicalId":520807,"journal":{"name":"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","volume":" ","pages":"6624-6630"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14767058.2021.1918667","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38868597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodevelopmental outcomes in mild and moderate isolated ventriculomegaly originating <i>in utero</i>.","authors":"Guoyu Sun,&nbsp;Baihua Jing,&nbsp;Faliang Zhou,&nbsp;Hongyan Liu,&nbsp;Lili Liu,&nbsp;Junya Chen,&nbsp;Xinlin Hou","doi":"10.1080/14767058.2021.1919869","DOIUrl":"https://doi.org/10.1080/14767058.2021.1919869","url":null,"abstract":"<p><strong>Objective: </strong>To determine the differences in outcomes between mild and moderate isolated ventriculomegaly (IVM).</p><p><strong>Methods: </strong>We conducted a prospective cohort study on 94 fetuses with IVM and evaluated the neurodevelopmental outcomes at 12 months of age using the ASQ-3 and BSID-I neurodevelopmental assessment tools. Progression of VM was defined as an increase in the width of the ventricular by at least 3 mm during sequential ultrasound monitoring. The population was divided into two groups according to ventricular width: mild (10-12 mm) and moderate (12.1-15 mm), which were further evaluated for VM progression in utero separately.</p><p><strong>Results: </strong>Neurodevelopmental assessments at 12 months were the main form of evaluations. Neurodevelopmental impairment (NDI) was defined as a mental development index (MDI) or psychomotor development index (PDI) < 85. There were no significant differences in NDI values between the mild and moderate groups (<i>p</i> = .155). Compared with the non-<i>in utero</i> progression group (7.6%), the rate of NDI was significantly higher (<i>p</i> = .004) in the group with progression (33.3%). Using linear regression and correlation, no negative correlation was found between the maximum value of atrial diameter (AD) in utero and the PDI (<i>r</i> = -0.021, <i>p</i> = .914) or MDI (<i>r</i> = -0.073, <i>p</i> = .703) score. However, the maximum change in the AD in utero was negatively correlated with both PDI (<i>r</i> = -0.460, <i>p</i> = .011) and MDI (<i>r</i>=-0.422, <i>p</i> = .020) scores.</p><p><strong>Conclusion: </strong>There were likely no differences in neurodevelopmental outcomes between mild and moderate IVM. In fetuses with mild to moderate VM, intrauterine progression may be a poor prognostic factor for neurodevelopmental outcomes.</p>","PeriodicalId":520807,"journal":{"name":"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","volume":" ","pages":"6691-6698"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14767058.2021.1919869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38879530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}