The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry最新文献

{"title":"Altered Resting State Hippocampal Connectivity Associated With Amyloid and Tau in Older Adults Without Dementia From a Population-Based Cohort Study.","authors":"Anna Roberts, Carmen Andreescu, Ann Cohen, Neelesh K Nadkarni, Davneet Minhas, Charles Laymon, Brian Lopresti, Beth Snitz, Helmet T Karim","doi":"10.1016/j.jagp.2026.09.003","DOIUrl":"https://doi.org/10.1016/j.jagp.2026.09.003","url":null,"abstract":"<p><strong>Objective: </strong>Default mode network (DMN) structures, including hippocampus, accumulate amyloid-beta and tau pathology in Alzheimer's disease (AD) and display connectivity changes prior to the onset of cognitive dysfunction.</p><p><strong>Methods: </strong>We recruited cognitively healthy older adults who underwent PiB and AV1451 imaging and resting state functional imaging. We evaluated nonlinear associations between hippocampal DMN connectivity and amyloid-beta and tau in cross-sectional analyses.</p><p><strong>Results: </strong>Left and right anterior hippocampal to DMN intranetwork connectivity was greater with greater amyloid and was lower with even greater levels of amyloid (inverted U-shape association). We found that inter-network hippocampal connectivity was greater with greater amyloid and tau. Greater intra and inter-DMN connectivity was associated with greater cognitive function especially memory and attention, consistent with protective association processes.</p><p><strong>Conclusion: </strong>Intranetwork DMN connectivity was greater with low to moderate amyloid and was lower with greater amyloid and tau in preclinical AD-connectivity may help maintain cognitive function, especially memory. Functional connectivity may potentially offset the impact of early amyloid and tau accumulation and transitionally spare cognitive function.</p>","PeriodicalId":520785,"journal":{"name":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Strategies to Promote Community Reintegration for Patients With New Disabilities After Critical Illness: A Qualitative Study Integrating Patient and Family Perspectives.","authors":"Leslie P Scheunemann, Erica Motter, Pan Su Peter Kim, Peter Eisenhauer, Nimit Gandhi, Janelle Christensen, Timothy D Girard, Charles F Reynolds, Natalie E Leland","doi":"10.1016/j.jagp.2026.08.022","DOIUrl":"https://doi.org/10.1016/j.jagp.2026.08.022","url":null,"abstract":"","PeriodicalId":520785,"journal":{"name":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Editorial Title: Beyond Survival: Meaning, Loneliness, and Depression at 100.","authors":"Perminder S Sachdev","doi":"10.1016/j.jagp.2026.08.018","DOIUrl":"https://doi.org/10.1016/j.jagp.2026.08.018","url":null,"abstract":"","PeriodicalId":520785,"journal":{"name":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of Psychiatric Hospitalization Precipitants and Outcomes in a Comprehensive Dementia Care Program.","authors":"Syeda Momina Umer, Ghufran Saeed Rizvi, Duaa Fatima","doi":"10.1016/j.jagp.2026.09.004","DOIUrl":"https://doi.org/10.1016/j.jagp.2026.09.004","url":null,"abstract":"","PeriodicalId":520785,"journal":{"name":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability, Feasibility, and Preliminary Efficacy of a Digital Cognitive Intervention for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) in Older Adults.","authors":"Cutter A Lindbergh, Roger Altizer, James J Grady, Holly E Eddy, David C Steffens, Sarah Shizuko Morimoto","doi":"10.1016/j.jagp.2026.09.002","DOIUrl":"10.1016/j.jagp.2026.09.002","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to examine the acceptability, feasibility, and preliminary efficacy of a digital cognitive intervention (DCI) for older adults with post-acute sequelae of SARS-CoV-2 infection (PASC).</p><p><strong>Methods: </strong>39 older adults (60-82 years old) with PASC neurocognitive symptoms (PASC-Neuro) were enrolled in a 6-week trial of neuroscience-based DCI. Treatment acceptability and feasibility were quantified via validated self-report questionnaires, recruitment and retention rates, and incidence of adverse events (AEs). Changes in clinical outcomes, collected before and after treatment, were examined using repeated measures statistical tests.</p><p><strong>Results: </strong>The DCI program was acceptable, credible, and usable to participants. Recruitment and retention rates were high (>85%). AEs were generally mild, transient, and tolerable. Significant improvements were observed in depression, anxiety, everyday functioning, and cognitive performance (set-shifting and verbal fluency).</p><p><strong>Conclusions: </strong>These findings support the potential of a DCI program for older adults with PASC-Neuro.</p>","PeriodicalId":520785,"journal":{"name":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Strategies to Promote Resilience and Community Reintegration for Patients With New Disabilities After Critical Illness: A Qualitative Study Integrating Patient and Family Perspectives\".","authors":"Wen Zhang, Chang Hu","doi":"10.1016/j.jagp.2026.09.001","DOIUrl":"https://doi.org/10.1016/j.jagp.2026.09.001","url":null,"abstract":"","PeriodicalId":520785,"journal":{"name":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Domain-Specific Subjective Cognitive complaints and Cognitive Test Performance After Surgery in Older Adults: A Patient-Centered Prospective Cohort Study.","authors":"Brian J Lilienstein, Laura P Sands, Serena Padda, Jacqueline M Leung","doi":"10.1016/j.jagp.2026.08.020","DOIUrl":"https://doi.org/10.1016/j.jagp.2026.08.020","url":null,"abstract":"<p><strong>Background: </strong>Subjective cognitive complaints are clinically important in the assessment of perioperative neurocognitive changes because current nomenclature incorporates cognitive concerns reported by patients or others. However, the relationship between patients' subjective cognitive complaints and contemporaneous changes in cognitive test performance during the immediate postoperative period remains poorly understood.</p><p><strong>Objectives: </strong>To identify if subjective cognitive complaints reported before hospital discharge were associated with cognitive changes measured with cognitive tests.</p><p><strong>Design: </strong>Prospective cohort study.</p><p><strong>Participants: </strong>Patients aged ≥65 years undergoing elective noncardiac surgery.</p><p><strong>Measurements: </strong>Pre- and postoperatively for the first three days daily, patients' cognitive function was measured by the timed Verbal Fluency test, the Word List learning task, and Digit Span Backward to assess the cognitive domains of memory and learning (Word List), executive function (Verbal Fluency), attention and working memory (Digit Span Backward and Word List), and language (verbal fluency). Patient's subjective opinion of cognition was measured by the Subjective Cognitive Questionnaire (SCQ). The SCQ statements were matched to Word List; Verbal Fluency; and Digit Span Backwards respectively. Logistic regression analyses were performed for each pairing. Sensitivity, specificity, and receiver operating characteristic (ROC) curves were derived. Postoperative delirium was measured daily using the Confusion Assessment Method for the first 3 postoperative days.</p><p><strong>Results: </strong>About 197 patents were recruited and 10 excluded because of incomplete SCQ responses or missing delirium assessments. Subjective cognitive complaints were associated with objective decline on the following cognitive tests: Word List (OR 1.31, 95% CI 1.07-1.60; p = 0.008), Verbal Fluency (OR 1.79, 95% CI 1.37-2.34; p <0.0001), and Digit Span Backwards (OR 5.15, 95% CI 1.86-13.54, p = 0.001). Discrimination was poor to moderate (AUC 0.52-0.66), with generally higher specificity but low sensitivity.</p><p><strong>Conclusions: </strong>Subjective cognitive complaints were associated with objective perioperative cognitive decline. Patient-reported symptoms may reflect early cognitive vulnerability, however, subjective cognitive complaints showed low sensitivity, limiting their utility as standalone screening tools.</p>","PeriodicalId":520785,"journal":{"name":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focused Ultrasound for Prolonged Grief Disorder: A Novel Approach to Targeting Reward Circuitry Underlying Persistent Yearning and Related Clinical Features.","authors":"Alexander Manevich, Holly G Prigerson","doi":"10.1016/j.jagp.2026.08.021","DOIUrl":"https://doi.org/10.1016/j.jagp.2026.08.021","url":null,"abstract":"<p><p>Prolonged Grief Disorder (PGD) is a recently recognized psychiatric disorder in ICD-11 and DSM-5-TR, characterized by persistent yearning and/or preoccupation with the deceased, alongside other grief-related symptoms. PGD affects 5%-16% of bereaved individuals and is associated with mental and physical morbidity, functional impairment, elevated suicidality, and premature death, underscoring its importance as a public health priority, with particular relevance to older adults given their increasing and often cumulative exposure to bereavement. Current treatment for PGD relies primarily on grief-focused psychotherapy, which is associated with substantial dropout, and does not lead to full remission for many patients. Despite growing interest in pharmacological, psychedelic, and neuromodulatory approaches, no biologically-based intervention has yet demonstrated efficacy for the core symptoms of PGD. At the same time, emerging neurobiological evidence implicates alterations across multiple interacting neural systems in PGD, with reward-related circuitry showing particular relevance to persistent yearning. Low-intensity Focused Ultrasound (LIFUS) enables noninvasive, reversible, high-precision modulation of deep brain structures. This addresses several key limitations of conventional neuromodulation approaches (e.g., rTMS and DBS) while maintaining a promising safety and tolerability profile. Recent studies have investigated LIFUS across a range of neurological and psychiatric disorders, including opioid use disorder, with early findings suggesting therapeutic potential. Taken together, these observations suggest that LIFUS may offer a promising and theoretically grounded direction for future research in PGD. In this paper, we outline the scientific rationale for investigating LIFUS neuromodulation as a novel intervention for PGD, discuss its potential implications for research and clinical translation, and conclude that an initial clinical trial is warranted to evaluate the feasibility, safety, tolerability, and preliminary efficacy of LIFUS for PGD.</p>","PeriodicalId":520785,"journal":{"name":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Making of Wisdom: Embodiment, Life History, and Agentic AI in Later Life.","authors":"Yuto Satake, Dilip V Jeste","doi":"10.1016/j.jagp.2026.08.019","DOIUrl":"https://doi.org/10.1016/j.jagp.2026.08.019","url":null,"abstract":"","PeriodicalId":520785,"journal":{"name":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making Exercise Work After Stroke and Sustaining Action.","authors":"Jie Chen, Pallavi Tyagi","doi":"10.1016/j.jagp.2026.08.017","DOIUrl":"https://doi.org/10.1016/j.jagp.2026.08.017","url":null,"abstract":"","PeriodicalId":520785,"journal":{"name":"The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148932472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}