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Cell tracing techniques in stem cell transplantation. 干细胞移植中的细胞追踪技术。
IF 4.8
Stem cell reviews Pub Date : 2007-12-01 DOI: 10.1007/s12015-007-9004-y
Li Yan, Ying Han, Yuanlong He, Huahong Xie, Jingmei Liu, Lina Zhao, Jingbo Wang, Liuchun Gao, Daiming Fan
{"title":"Cell tracing techniques in stem cell transplantation.","authors":"Li Yan,&nbsp;Ying Han,&nbsp;Yuanlong He,&nbsp;Huahong Xie,&nbsp;Jingmei Liu,&nbsp;Lina Zhao,&nbsp;Jingbo Wang,&nbsp;Liuchun Gao,&nbsp;Daiming Fan","doi":"10.1007/s12015-007-9004-y","DOIUrl":"https://doi.org/10.1007/s12015-007-9004-y","url":null,"abstract":"<p><p>Pluripotent stem cells have shown great therapeutic promise because of their natural capacity to regenerate damaged tissue. Likewise, autologous stem cells or genetically modified stem cells have already been successfully applied in animal or clinical experimental studies including cardiopathy, diabetic disease, system lupus erythema, pancreatic disease, and liver disease. In these studies regarding stem cell transplants in different diseases, identifying the location of implanted cells and distinguishing them from endogenous cells is the first and most important step. Moreover, different tracing techniques were applied in different studies for their different sensitivity, dynamic range, convenience and reliability of their assays. Therefore, we will here review different tracing techniques and their applications in stem cell transplants, including both experiment studies and preclinical trials.</p>","PeriodicalId":520781,"journal":{"name":"Stem cell reviews","volume":" ","pages":"265-9"},"PeriodicalIF":4.8,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12015-007-9004-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41020854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 40
From stem cells to oligodendrocytes: prospects for brain therapy. 从干细胞到少突胶质细胞:脑治疗的前景。
IF 4.8
Stem cell reviews Pub Date : 2007-12-01 DOI: 10.1007/s12015-007-9006-9
Cui P Chen, Mary E Kiel, Dorota Sadowski, Randall D McKinnon
{"title":"From stem cells to oligodendrocytes: prospects for brain therapy.","authors":"Cui P Chen,&nbsp;Mary E Kiel,&nbsp;Dorota Sadowski,&nbsp;Randall D McKinnon","doi":"10.1007/s12015-007-9006-9","DOIUrl":"https://doi.org/10.1007/s12015-007-9006-9","url":null,"abstract":"<p><p>Multiple sclerosis is an autoimmune disease that destroys myelin-forming oligodendrocytes of the CNS. While the damage can be partially controlled using anti-inflammatory cytokines and steroids, endogenous repair is insufficient to replace lost cells. Until now cell replenishment (transplant therapy) has been viewed as unlikely to succeed due to allograft rejection in this sensitized immune environment. However, advances in stem cell biology give new hope for deriving patient-specific, autologous oligodendrocytes which may tip the balance to favor repair. The challenge will be to engineer these cells to respond to cues that can target their migration into lesions for brain and spinal cord repair.</p>","PeriodicalId":520781,"journal":{"name":"Stem cell reviews","volume":" ","pages":"280-8"},"PeriodicalIF":4.8,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12015-007-9006-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41055277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Ethical issues in using and not using embryonic stem cells. 使用和不使用胚胎干细胞的伦理问题。
IF 4.8
Stem cell reviews Pub Date : 2005-12-01 DOI: 10.1385/SCR:1:4:325
Frances M Kamm
{"title":"Ethical issues in using and not using embryonic stem cells.","authors":"Frances M Kamm","doi":"10.1385/SCR:1:4:325","DOIUrl":"https://doi.org/10.1385/SCR:1:4:325","url":null,"abstract":"","PeriodicalId":520781,"journal":{"name":"Stem cell reviews","volume":" ","pages":"325-30"},"PeriodicalIF":4.8,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/SCR:1:4:325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26476338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Ethics and embryonic stem cell research. 伦理与胚胎干细胞研究。
IF 4.8
Stem cell reviews Pub Date : 2005-12-01 DOI: 10.1385/SCR:1:4:317
Allen Wood
{"title":"Ethics and embryonic stem cell research.","authors":"Allen Wood","doi":"10.1385/SCR:1:4:317","DOIUrl":"https://doi.org/10.1385/SCR:1:4:317","url":null,"abstract":"","PeriodicalId":520781,"journal":{"name":"Stem cell reviews","volume":" ","pages":"317-24"},"PeriodicalIF":4.8,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/SCR:1:4:317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26476337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Wishful thinking will not obviate embryo use. 一厢情愿的想法不会阻止胚胎的使用。
IF 4.8
Stem cell reviews Pub Date : 2005-12-01 DOI: 10.1385/SCR:1:4:309
Louis M Guenin
{"title":"Wishful thinking will not obviate embryo use.","authors":"Louis M Guenin","doi":"10.1385/SCR:1:4:309","DOIUrl":"https://doi.org/10.1385/SCR:1:4:309","url":null,"abstract":"<p><p>Upon hearing of purported nonembryo sources of human pluripotent stem cells, we need to ask not only whether the proposed sources yield such cells, but whether it is true as claimed that it would be morally better to shift to the purported alternatives. I argue that it would not be morally better. When we consider the morality of each proposal in turn, we find as to several that what defends them also defends the use of surplus embryos and clones in general. That leaves no reason to abandon the general case for the special case of compromised life forms. Another of the proposals is morally indefensible. Still other proposed techniques would themselves use or risk using embryos, not to mention that they may fail to produce pluripotent cells of sufficient quality. We shall not achieve a moral gain by adopting any of these proposals in lieu of using donated embryos barred from the womb by donor instructions.</p>","PeriodicalId":520781,"journal":{"name":"Stem cell reviews","volume":" ","pages":"309-15"},"PeriodicalIF":4.8,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/SCR:1:4:309","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26476336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Altered nuclear transfer: a way forward for embryonic stem cell research. 改变核移植:胚胎干细胞研究的前进方向。
IF 4.8
Stem cell reviews Pub Date : 2005-12-01 DOI: 10.1385/SCR:1:4:293
William B Hurlbut
{"title":"Altered nuclear transfer: a way forward for embryonic stem cell research.","authors":"William B Hurlbut","doi":"10.1385/SCR:1:4:293","DOIUrl":"https://doi.org/10.1385/SCR:1:4:293","url":null,"abstract":"<p><p>The present conflict over the moral status of the human embryo reflects deep differences in our basic convictions and is unlikely to be resolved through deliberation or debate. While there are currently no federally legislated constraints on the use of private funds for this research, there is a consensus opinion in the scientific community that without NIH support for newly created embryonic stem cell lines, progress in this important realm of research will be severely constrained. A May, 2005, report by the President's Council on Bioethics, \"Alternative Sources of Pluripotent Stem Cells,\" outlines several proposals for obtaining pluripotent stem cells without the destruction of human embryos. One of these methods, Altered Nuclear Transfer, proposes to use the technology of somatic cell nuclear transfer (SCNT), but with a preemptive genetic or epigenetic alteration that precludes the integrated and coordinated organization essential for natural embryogenesis. Drawing on insights from systems biology, the distinction between totipotency (capacity to form a whole organism) and pluripotency (capacity to form all the cell types) is explored. The implications of this distinction are used to discuss the moral arguments for the inviolability of nascent human life and the moral standing of entities with only partial and unorganized developmental potential. Away forward is proposed that may open positive avenues of advance in both stem cell research and a broader arena of research in developmental biology.</p>","PeriodicalId":520781,"journal":{"name":"Stem cell reviews","volume":" ","pages":"293-300"},"PeriodicalIF":4.8,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/SCR:1:4:293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26476333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Consensus and the search for pluripotent stem cells. 共识和对多能干细胞的研究。
IF 4.8
Stem cell reviews Pub Date : 2005-12-01 DOI: 10.1385/SCR:1:4:287
Michael W Kalichman, Lawrence M Hinman
{"title":"Consensus and the search for pluripotent stem cells.","authors":"Michael W Kalichman,&nbsp;Lawrence M Hinman","doi":"10.1385/SCR:1:4:287","DOIUrl":"https://doi.org/10.1385/SCR:1:4:287","url":null,"abstract":"","PeriodicalId":520781,"journal":{"name":"Stem cell reviews","volume":" ","pages":"287-9"},"PeriodicalIF":4.8,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/SCR:1:4:287","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26476330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The search for alternative sources of human pluripotent stem cells. 寻找人类多能干细胞的替代来源。
IF 4.8
Stem cell reviews Pub Date : 2005-12-01 DOI: 10.1385/SCR:1:4:291
Adam Schulman
{"title":"The search for alternative sources of human pluripotent stem cells.","authors":"Adam Schulman","doi":"10.1385/SCR:1:4:291","DOIUrl":"https://doi.org/10.1385/SCR:1:4:291","url":null,"abstract":"","PeriodicalId":520781,"journal":{"name":"Stem cell reviews","volume":" ","pages":"291-2"},"PeriodicalIF":4.8,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/SCR:1:4:291","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26476331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Debating embryonic dignity in a liberal society. 在一个自由社会中争论胚胎尊严。
IF 4.8
Stem cell reviews Pub Date : 2005-12-01 DOI: 10.1385/SCR:1:4:305
Nicanor Pier Giorgio Austriaco
{"title":"Debating embryonic dignity in a liberal society.","authors":"Nicanor Pier Giorgio Austriaco","doi":"10.1385/SCR:1:4:305","DOIUrl":"https://doi.org/10.1385/SCR:1:4:305","url":null,"abstract":"","PeriodicalId":520781,"journal":{"name":"Stem cell reviews","volume":" ","pages":"305-7"},"PeriodicalIF":4.8,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/SCR:1:4:305","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26476335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Deriving morally uncontroversial human pluripotent stem cell lines: obligation or election? 获得道德上无争议的人类多能干细胞系:义务还是选择?
IF 4.8
Stem cell reviews Pub Date : 2005-12-01 DOI: 10.1385/SCR:1:4:301
Renée Mirkes
{"title":"Deriving morally uncontroversial human pluripotent stem cell lines: obligation or election?","authors":"Renée Mirkes","doi":"10.1385/SCR:1:4:301","DOIUrl":"https://doi.org/10.1385/SCR:1:4:301","url":null,"abstract":"","PeriodicalId":520781,"journal":{"name":"Stem cell reviews","volume":" ","pages":"301-3"},"PeriodicalIF":4.8,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/SCR:1:4:301","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26476334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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