Philosophical transactions of the Royal Society of London. Series B, Biological sciences最新文献_第4页

The microbiota-proteostasis axis: implications in neurodegenerative diseases. 微生物-蛋白质平衡轴：在神经退行性疾病中的意义。

IF 4.7

Philosophical transactions of the Royal Society of London. Series B, Biological sciences Pub Date : 2026-10-01 DOI: 10.1098/rstb.2025.0265

Daniel M Czyż, Brittani M Brown

{"title":"The microbiota-proteostasis axis: implications in neurodegenerative diseases.","authors":"Daniel M Czyż, Brittani M Brown","doi":"10.1098/rstb.2025.0265","DOIUrl":"https://doi.org/10.1098/rstb.2025.0265","url":null,"abstract":"Disruption of protein homoeostasis, or proteostasis, is a hallmark of protein conformational diseases (PCDs), including Alzheimer's and Parkinson's disease. These disorders are characterized by progressive protein aggregation and cellular dysfunction, yet no effective therapies exist. Emerging evidence indicates that microbial communities influence host proteostasis, giving rise to the concept of the microbiota-proteostasis axis. Microbes and their products can modulate host proteins by engaging with host proteostasis. As such, microbial dysbiosis has been linked to proteostasis disruption through the production of metabolites, extracellular vesicles, functional amyloids, and toxins or effector proteins capable of seeding or destabilizing host proteins associated with PCDs. These microbial factors have been shown in experimental models to converge on key proteostasis pathways, including protein synthesis, folding and clearance, thereby potentially reducing cellular buffering capacity and lowering the threshold for proteotoxic collapse. In parallel, microbiota-driven influence on inflammatory responses and immune signalling further amplifies systemic proteostasis disruption. In this review, we synthesize emerging evidence defining the microbiota-proteostasis axis and highlight how microbial factors influence host proteostasis. Importantly, these host-microbe interactions often precede neurodegeneration, suggesting potential for early detection and intervention. Together, these insights support targeting the microbiota as a potential strategy to enhance proteostasis and delay or prevent neurodegenerative disease. This article is part of the Theo Murphy meeting issue 'ProteostaSys: a systems view of proteostasis'.","PeriodicalId":520748,"journal":{"name":"Philosophical transactions of the Royal Society of London. Series B, Biological sciences","volume":"381 1960","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13628083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein rheostasis: quality control in metastable proteomes. 蛋白质流变：亚稳态蛋白质组的质量控制。

IF 4.7

Philosophical transactions of the Royal Society of London. Series B, Biological sciences Pub Date : 2026-10-01 DOI: 10.1098/rstb.2025.0279

Michele Vendruscolo

引用次数: 0

Developing kind emotions in caring environments. 在关爱的环境中培养善良的情感。

IF 4.7

Philosophical transactions of the Royal Society of London. Series B, Biological sciences Pub Date : 2026-09-24 DOI: 10.1098/rstb.2025.0141

Ruth Speidel, Tal Orlitsky, Marian S Schulz, Tina Malti

{"title":"Developing kind emotions in caring environments.","authors":"Ruth Speidel, Tal Orlitsky, Marian S Schulz, Tina Malti","doi":"10.1098/rstb.2025.0141","DOIUrl":"10.1098/rstb.2025.0141","url":null,"abstract":"Kind emotions (e.g. empathy for others, self-compassion and gratitude) motivate kind actions and involve understanding, appreciating or 'feeling with' both one's own and others' emotions. They are an essential capacity for humans' potential to care for fellow humans and non-human entities. How do such emotions evolve, and what type of caring environments and mechanisms are needed for their development? In this review, we provide insights into how children's kind emotions emerge, develop and are nurtured by caring environments. We begin by reviewing the development of kind emotions across the early years and identify consequences of kind emotions on prosociality and well-being. Next, we summarize research on the mechanisms and functions of caring environments in shaping the development of kind emotions, including caring relationships and practices of care across diverse relationships (e.g. with parents and peers) and layers of the ecosystem (e.g. familial, educational, societal and natural). Finally, we provide recommendations for future developmental research in this area. This article is part of the theme issue 'Mechanisms, development, phylogeny and functions of emotional expressions'.","PeriodicalId":520748,"journal":{"name":"Philosophical transactions of the Royal Society of London. Series B, Biological sciences","volume":"381 1959","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smiling in time: the interactive development of infant smiling with mothers, fathers and strangers. 及时微笑：婴儿与母亲、父亲和陌生人微笑的互动发展。

IF 4.7

Philosophical transactions of the Royal Society of London. Series B, Biological sciences Pub Date : 2026-09-24 DOI: 10.1098/rstb.2025.0142

Eliala Alice Salvadori, Daniel S Messinger, Alan B Cobo-Lewis, Itir Onal Ertugrul, Cristina Colonnesi

{"title":"Smiling in time: the interactive development of infant smiling with mothers, fathers and strangers.","authors":"Eliala Alice Salvadori, Daniel S Messinger, Alan B Cobo-Lewis, Itir Onal Ertugrul, Cristina Colonnesi","doi":"10.1098/rstb.2025.0142","DOIUrl":"10.1098/rstb.2025.0142","url":null,"abstract":"A developmental examination of the temporal dynamics of infant smiling during early social interaction is lacking. We ask how infants and adults influence each other's expressions of positive affect by examining the timing of transitions among dyadic states defined by the presence and absence of each partner's smiles. Fifty-eight infants interacted with their mothers, fathers and a stranger at 4 and 8 months. A survival analysis of the time course of infant (and adult partner) smiles and non-smiles indicated that infants initiated smiles and reciprocated smiles at lower rates than their adult partners, yet ended smiles at higher rates. Nevertheless, adult smiles were associated with higher infant smile rates, while infant smiles prolonged adult smiles, suggesting a dyadic path to mutual positivity. Eight-month-olds initiated smiles at higher rates than 4-month-olds when neither partner was smiling, suggesting increasing infant smiling initiative. Partner-specific patterns revealed selective infant responsiveness. Although strangers initiated and sustained smiles at higher rates than mothers, infants were more probably to reciprocate mother than stranger smiles. In the first year of life, infants showed a tendency to down-regulate positive affect expressions across age and context, as well as partner-specific smile reciprocation proclivities and a developmental increase in smile initiation. This article is part of the theme issue 'Mechanisms, development, phylogeny and functions of emotional expressions'.","PeriodicalId":520748,"journal":{"name":"Philosophical transactions of the Royal Society of London. Series B, Biological sciences","volume":"381 1959","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149033030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The development of play face mimicry: comparative insights from human infants, adults and orangutans. 游戏面部模仿的发展：来自人类婴儿、成人和猩猩的比较见解。

IF 4.7

Philosophical transactions of the Royal Society of London. Series B, Biological sciences Pub Date : 2026-09-24 DOI: 10.1098/rstb.2025.0132

Tonko Willem Zijlstra, Christopher Riddell, Milica Nikolic, Mariska E Kret

{"title":"The development of play face mimicry: comparative insights from human infants, adults and orangutans.","authors":"Tonko Willem Zijlstra, Christopher Riddell, Milica Nikolic, Mariska E Kret","doi":"10.1098/rstb.2025.0132","DOIUrl":"10.1098/rstb.2025.0132","url":null,"abstract":"Laughter and its associated facial expression, the play face, are critically important in the social lives of animals. Perhaps owing to this, play faces are mimicked in social interactions across many species. Despite growing interest, few works have directly compared play face mimicry across species and age groups within the same experimental framework, limiting our understanding of its developmental and evolutionary origins. In this study, we examined play face mimicry in human infants (n = 63), human adults (n = 36) and orangutans (Pongo pygmaeus; n = 6), using a tightly controlled design. We found that both human infants and adults reliably mimicked play faces, however, infants produced these robustly more than adults. Additionally, while adult humans did not produce as many play faces as infants, they produced reliably more smiles in response to the play face stimuli. When considering the orangutans, we found no evidence of play face mimicry, with only one instance observed across the entire experiment. This suggests that while our paradigm reliably induced mimicry across both human groups, our set-up may have been suboptimal to evoke mimicry responses in orangutans. This article is part of the theme issue 'Mechanisms, development, phylogeny and functions of emotional expressions'.","PeriodicalId":520748,"journal":{"name":"Philosophical transactions of the Royal Society of London. Series B, Biological sciences","volume":"381 1959","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of emotion regulation strategies on experiential and physiological responses to negative emotional videos. 情绪调节策略对负面情绪视频体验和生理反应的影响。

IF 4.7

Philosophical transactions of the Royal Society of London. Series B, Biological sciences Pub Date : 2026-09-24 DOI: 10.1098/rstb.2025.0138

Wilson P H Lim, Hannah S Savage, Beth F Longley, Hugo D Critchley, Tim Dalgleish, Camilla L Nord, Sarah N Garfinkel

{"title":"The impact of emotion regulation strategies on experiential and physiological responses to negative emotional videos.","authors":"Wilson P H Lim, Hannah S Savage, Beth F Longley, Hugo D Critchley, Tim Dalgleish, Camilla L Nord, Sarah N Garfinkel","doi":"10.1098/rstb.2025.0138","DOIUrl":"10.1098/rstb.2025.0138","url":null,"abstract":"Emotion regulation strategies influence how individuals experience and express emotions. Previous work suggests that self-distancing can reduce negative emotional responses, whereas self-immersion can amplify them. This study quantified how these emotion regulation strategies, applied during exposure to negative and neutral videos, shaped self-rated emotional experience across valence, arousal and intensity dimensions, influenced the free production of emotion-descriptive labels and altered measures of respiratory and cardiovascular physiology. A total of 45 participants took part in a task during which they were prompted to simply watch, or to self-distance from or self-immerse in, the emotional content of negative or neutral videos, which were presented in 12, 30-s blocks. Their rated emotional experience (valence-arousal-intensity ratings and free emotion labels) was recorded, along with cardiovascular and respiratory activity. Overall, self-distancing and self-immersing respectively attenuated and amplified aspects of subjective emotion experience relative to comparator conditions as predicted. Self-distancing reduced freely generated emotion labels corresponding to fear, but had less impact on labels corresponding to disgust, sadness and anger. The effects of emotional regulation strategies on cardiorespiratory physiology (e.g. heart rate) potentially also differ between individuals. Together, this work validates a framework for dissecting components of induced emotion, highlighting commonalities and variability in experiential and physiological reactivity and effects of regulation. This article is part of the theme issue 'Mechanisms, development, phylogeny and functions of emotional expressions'.","PeriodicalId":520748,"journal":{"name":"Philosophical transactions of the Royal Society of London. Series B, Biological sciences","volume":"381 1959","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vocal encoding of heritable sociability prevails over emotions in sheep bleats. 在羊叫声中，可遗传的社交性的声音编码胜过情感。

IF 4.7

Philosophical transactions of the Royal Society of London. Series B, Biological sciences Pub Date : 2026-09-24 DOI: 10.1098/rstb.2025.0143

Avelyne S Villain, Alain Boissy, Gaetan Bonnafé, Christian S Durand, Sébastien Douls, Paul Renaud-Goud, Marie-Madeleine Mialon, Dominique Hazard, Elodie F Briefer

{"title":"Vocal encoding of heritable sociability prevails over emotions in sheep bleats.","authors":"Avelyne S Villain, Alain Boissy, Gaetan Bonnafé, Christian S Durand, Sébastien Douls, Paul Renaud-Goud, Marie-Madeleine Mialon, Dominique Hazard, Elodie F Briefer","doi":"10.1098/rstb.2025.0143","DOIUrl":"10.1098/rstb.2025.0143","url":null,"abstract":"Vocalizations of animals are good indicators of their emotions. Temperament is known to influence the regulation and expression of emotions. However, how animal temperament affects their vocalizations and particularly their vocal expressions of emotions remains largely unexplored. Sociability is often measured as the behavioural reactivity to social separation and is a temperament trait intrinsically linked to emotional reactivity. Most social species respond to such challenging situations using contact calls. Here, we investigated whether the acoustic structure of these calls reflects sociability, emotions or both. Among 152 recorded female lambs, 42 belonged to two diverging sheep lines selected for high or low sociability. High bleats were recorded both in isolation (social challenge, all lambs) and before receiving a food treat (non-social challenge, selected lambs) to investigate the link between vocalizations, emotions and heritable sociability. The acoustic features of isolation bleats differed between lines, which was not the case for pre-food treat bleats. However, surprisingly, the genetic selection index and social behaviour explained the structure of isolation bleats better than emotional arousal per se. Last, encoding of individuality in isolation bleats was impaired by the genetic selection. Our findings show that selecting for sociable animals affects vocal signatures in calls produced during a social challenge, leading us to hypothesize a socio-acoustic co-selection. This article is part of the theme issue 'Mechanisms, development, phylogeny and functions of emotional expressions'.","PeriodicalId":520748,"journal":{"name":"Philosophical transactions of the Royal Society of London. Series B, Biological sciences","volume":"381 1959","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149033000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The expression of self-conscious emotions and their motivational and communicative function in early development. 自我意识情绪的表达及其在早期发展中的激励和交际功能。

IF 4.7

Philosophical transactions of the Royal Society of London. Series B, Biological sciences Pub Date : 2026-09-24 DOI: 10.1098/rstb.2025.0134

Milica Nikolić, Robert Hepach

{"title":"The expression of self-conscious emotions and their motivational and communicative function in early development.","authors":"Milica Nikolić, Robert Hepach","doi":"10.1098/rstb.2025.0134","DOIUrl":"10.1098/rstb.2025.0134","url":null,"abstract":"Self-conscious emotions, such as embarrassment, guilt, shame and pride, play a central role in managing reputation and interpersonal relationships. They are thought to emerge in the first years of life, with children's developing cognitive capacities and their growing appreciation of social norms and rules. Recent years have seen a rapid increase in research on self-conscious emotions in early life, supported by advanced methods including manual and automated micro-coding of non-verbal behaviour, depth sensor imaging and physiological measures. In this narrative review, we summarize this emerging evidence from developmental science, which suggests that self-conscious emotions may be observed earlier than previously thought-within the first months and years of life-and that they seem to serve both motivational and communicative functions from early on. Specifically, they motivate socially appropriate behaviours, such as helping others, while communicating adherence to social norms and rules. Further, we highlight current limitations in the field and recommend more experimental and longitudinal studies especially in infancy and toddlerhood, the integration of multi-modal data and the use of naturalistic tasks to advance our understanding of self-conscious emotions in early development. This article is part of the theme issue 'Mechanisms, development, phylogeny and functions of emotional expressions'.","PeriodicalId":520748,"journal":{"name":"Philosophical transactions of the Royal Society of London. Series B, Biological sciences","volume":"381 1959","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149033003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

More than just smiling: how positive emotions are expressed on the face. 不仅仅是微笑：积极的情绪是如何表达在脸上的。

IF 4.7

Philosophical transactions of the Royal Society of London. Series B, Biological sciences Pub Date : 2026-09-24 DOI: 10.1098/rstb.2025.0133

Kunalan Manokara, Irene Teulings, YongQi Cong, Roza Kamiloğlu, Agneta H Fischer, Disa A Sauter

{"title":"More than just smiling: how positive emotions are expressed on the face.","authors":"Kunalan Manokara, Irene Teulings, YongQi Cong, Roza Kamiloğlu, Agneta H Fischer, Disa A Sauter","doi":"10.1098/rstb.2025.0133","DOIUrl":"10.1098/rstb.2025.0133","url":null,"abstract":"To advance the science of positive emotional expressions, we test how 22 positive emotions are spontaneously displayed on the face, using the participant-negotiated episodic recall method. Respondents (n = 163) narrated emotional events from their lives, and we extracted facial behaviours that reflected peak expressivity (35 410 facial actions). Network models were applied to probe whether specific positive emotions would be conditionally associated with particular facial behaviours. Our results point to three sets of positive emotions: five that do not seem to have specific facial actions related to them (e.g. admiration), nine whose expressions do not significantly involve smiling (e.g. head turn for interest, raised chin for determination), and eight whose facial expressions include smiling as a unique expressive feature (e.g. positive surprise and elation). Notably, nine of these positive emotions had expressive patterns that were distinct from the other emotions in our set (e.g. raised cheeks and closed eyes for sexual desire), while eight emotions were associated with expressive patterns that were shared in pairs (e.g. raised eyebrows for both hope and inspiration). These results provide a tentative map of what specific positive emotions look like when produced on the face in a naturalistic situation. This article is part of the theme issue 'Mechanisms, development, phylogeny and functions of emotional expressions'.","PeriodicalId":520748,"journal":{"name":"Philosophical transactions of the Royal Society of London. Series B, Biological sciences","volume":"381 1959","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149033021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multi-level framework for the functions of emotions and their expressions. 情绪及其表达功能的多层次框架。

IF 4.7

Philosophical transactions of the Royal Society of London. Series B, Biological sciences Pub Date : 2026-09-24 DOI: 10.1098/rstb.2025.0150

Laith Al-Shawaf, David M G Lewis, Elias Acevedo

引用次数: 0