Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA最新文献

{"title":"Comment on \"Prevalence and relative risk of fractures and osteoporosis in patients with ankylosing spondylitis: a systematic review and meta-analysis\".","authors":"Manish Juenja, Harshawardhan Ramteke, Rakhshanda Khan","doi":"10.1007/s00198-026-08124-0","DOIUrl":"10.1007/s00198-026-08124-0","url":null,"abstract":"","PeriodicalId":520737,"journal":{"name":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of bone fragility in duchenne muscular dystrophy: A systematic review and meta-analysis.","authors":"Chuan Liu, Dandan Yang, Ting Xu, Hang Fu, Linyuhan Zhou, Xiaotang Cai, Yingkun Guo, Huayan Xu","doi":"10.1007/s00198-026-08174-4","DOIUrl":"https://doi.org/10.1007/s00198-026-08174-4","url":null,"abstract":"<p><p>Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder that is due to mutations in the dystrophin gene which encodes the dystrophin protein. Many patients face an increased risk of bone fragility and develop secondary osteoporosis as a result of the combined effects of progressive muscle weakness, immobilization, and the osteotoxic properties of glucocorticoids (GCs). The present study showed that the prevalence of low BMD and fracture in DMD patients reached as high as 0.62 and 0.38, respectively, with contributing risk factors extending beyond GCs and loss of ambulation to include older age, vitamin D deficiency, fat mass accumulation, and hormonal imbalances. Therefore, clinical trials of bone-protective therapies and strategies to improve bone health in boys with DMD are urgently warranted.</p><p><strong>Purpose: </strong>Poor skeletal health, characterized by rapid bone mineral density decline, causes substantial morbidity in patients with Duchenne muscular dystrophy (DMD). The present systematic review and meta-analysis aimed to review comprehensive findings on the prevalence and risk factors of low bone mineral density (BMD) and fractures in DMD.</p><p><strong>Methods: </strong>PubMed, Embase, Cochrane library, and Web of Science databases were systematically searched for studies reporting prevalence of fractures, low BMD, or data on risk factors in DMD patients. Random‑effects meta‑analyses estimated pooled prevalence of low BMD and fractures. Subgroup analyses examined variations by region, GCs use, fracture location, and ambulatory stage.</p><p><strong>Results: </strong>A total of 43 studies involving 4940 patients were reviewed. The prevalence of low BMD from 0.16 to 0.93, with an overall prevalence of 0.62 (95% CI, 0.45-0.79). Fracture prevalence spanned from 0.07 to 0.87, yielding a pooled estimate of 0.38 (95% CI, 0.32-0.43). North America had the highest fracture prevalence at 0.47 (95% CI, 0.39-0.56), followed by Oceania at 0.47 (95% CI, 0.40-0.54), Europe at 0.30 (95% CI, 0.24-0.37), and Asia at the lowest 0.17 (95% CI, 0.07-0.27). Fracture prevalence was higher in glucocorticoids (GCs)-treated patients (0.39 vs. 0.23 in non-GCs) and increased with longer GCs duration, being 0.23 (95% CI, 0.11-0.35) for 3 years, 0.33 (95% CI, 0.24-0.43) for 3-6 years, and 0.59 (95% CI, 0.42-0.75) for ≥ 6 years of GCs exposure. Bone fragility in DMD is driven by multifactorial risk factors, with contributors extending beyond GCs use and loss of ambulation to include older age, vitamin D deficiency, fat mass accumulation, and hormonal imbalances.</p><p><strong>Conclusion: </strong>Low BMD and fractures are highly prevalent globally in DMD, with bone fragility driven by multifactorial mechanisms. These findings may inform the design of clinical trials for bone-protective therapies and strategies to improve bone strength in this population.</p>","PeriodicalId":520737,"journal":{"name":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with hip fracture following a fall-associated hospitalization in older adults: a retrospective cohort study.","authors":"Benoit R Lafleur, Wenshan Li, Reiko Okamoto, Chantal Backman, Stacey Fisher, Colleen Webber, Bradley Godwin, Shirley Huang, Ed Spilg","doi":"10.1007/s00198-026-08181-5","DOIUrl":"https://doi.org/10.1007/s00198-026-08181-5","url":null,"abstract":"<p><p>Among older adults hospitalized after a fall, receiving a DXA scan was associated with a decreased hazard of sustaining a hip fracture within 2 years. Older age, female sex, dementia, parkinsonism, mental health disorder and intermediate frailty were associated with a higher hazard of having a hip fracture post-discharge.</p><p><strong>Purpose: </strong>Identify factors associated with increased hazard of having a hip fracture within 2 years of discharge following a fall-related hospitalization.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of all Ontario adults aged 65 + hospitalized after a fall between November 1, 2015 and October 31, 2020 using administrative health databases. We compared individuals who did or did not experience a hip fracture within 2 years of discharge based on socio-demographics, frailty, comorbidities, receipt of a dual-energy X-ray absorptiometry (DXA) scan, and family physician or geriatrician visits. We performed a Cox proportional hazard regression to identify factors associated with having a subsequent hip fracture, accounting for death as a competing risk.</p><p><strong>Results: </strong>Among the 88,140 individuals who were discharged after a fall-related hospitalization, 4.6% suffered a hip fracture within 2 years. Older age (hazard ratio [HR] 1.04 per year, 95% confidence interval [CI] 1.04-1.05), female sex (HR 1.16, 95% CI 1.08-1.24), parkinsonism (HR 1.42, 95% CI 1.19-1.70), dementia (HR 1.28, 95% CI 1.17-1.41), mental health disorders (HR 1.10, 95% CI 1.01-1.20), and intermediate frailty risk by HFRS score (HR 6.68, 95% CI 3.28-13.7) were associated with a higher hazard of having a hip fracture. Post-discharge DXA scanning was associated with a decreased hip fracture hazard (HR 0.75, 95% CI 0.66-0.86), yet only 15% of the study population underwent this assessment.</p><p><strong>Conclusion: </strong>Timely fall risk reduction and bone health optimization efforts should focus on the high-risk groups identified in this study to help prevent hip fractures following fall-related hospitalizations.</p>","PeriodicalId":520737,"journal":{"name":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systemwide approach to secondary fracture prevention-the New South Wales Osteoporosis Refracture Prevention Initiative was associated with reduced refractures and was economically sustainable.","authors":"Aedan G K Roberts, Peter K K Wong, Jennifer Williamson, Jacqueline Center, Roderick Clifton-Bligh, Carlos El-Haddad, Matthew Jennings, Jayne Hyde, Craig Knox, Gabor Major, Lyn March, Chris Needs, Julia Thompson, Liz Hay","doi":"10.1007/s00198-026-08140-0","DOIUrl":"https://doi.org/10.1007/s00198-026-08140-0","url":null,"abstract":"<p><p>We assessed the effectiveness and efficiency of the Osteoporosis Refracture Prevention Initiative, which involved widespread Fracture Liaison Service (FLS) implementation throughout New South Wales (NSW), Australia's most populous state. Systemwide FLS implementation was cost-effective and associated with a reduction in minimal trauma refractures requiring hospital admission.</p><p><strong>Introduction: </strong>The Osteoporosis Refracture Prevention (ORP) Initiative involved widespread Fracture Liaison Service (FLS) implementation throughout New South Wales (NSW), Australia's most populous state.</p><p><strong>Purpose: </strong>To determine the effectiveness and efficiency of the NSW Osteoporosis Refracture Prevention (ORP) Initiative.</p><p><strong>Methods: </strong>Linked administrative data on inpatient admissions, outpatient attendances, Emergency Department (ED) presentations, deaths, and cost was performed. Business-as-usual projections for the expected number of refractures and health service utilisation were generated by extrapolating historical trends. Cost data was measured as National Weighted Activity Units, and an economic analysis included a cost-benefit analysis.</p><p><strong>Results: </strong>Following ORP implementation in financial year (FY) 2017-2018, 5 years later, in FY 2022-2023, there were 1246 fewer minimal trauma refractures that year which required hospital admission (17% reduction) with 3030 fewer inpatient separations/admissions for refractures (21.4% reduction) compared to expected. Over the 5-year study period, there was a cumulative total of 5329 fewer minimal trauma refractures that required hospital admission (13.6% reduction; p = 0.018) and 11,070 fewer inpatient admissions for refractures (14.7% reduction; p = 0.002) than expected. Probability of a minimal trauma refracture requiring hospital admission within 2 years following an initial minimal trauma fracture decreased from 9.2% to 8.5% (p < 0.0001). For every dollar spent on ORP, an economic return of AUD1.60 was achieved.</p><p><strong>Conclusion: </strong>Systemwide FLS implementation was associated with a reduction in minimal trauma refractures requiring hospital admission. While there are limitations with using \"business-as usual\" projections as historical controls may have been affected by unknown factors, systemwide FLS implementation was cost-effective and a realistic systemwide model of care to address the burden of osteoporotic fractures.</p>","PeriodicalId":520737,"journal":{"name":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The incidence and predictors of falling in older adults: the results of follow-up in Iranian multicenter osteoporosis study (IMOS).","authors":"Mohammad Ahmadi, Maral Sargolzaeimoghaddam, Vahideh Mohseni, Mohammad Sargolzaeimoghaddam, Kazem Khalagi, Mohammad Javad Mansourzadeh, Samaneh Akbarpour, Gita Shafiee, Mahnaz Sanjari, Noushin Fahimfar, Afshin Ostovar","doi":"10.1007/s00198-026-08183-3","DOIUrl":"https://doi.org/10.1007/s00198-026-08183-3","url":null,"abstract":"<p><p>In this prospective cohort of 1,410 community-dwelling Iranian older adults, a history of falls in the previous year was the strongest independent predictor of incident falls over one-year follow-up, supporting routine fall-history assessment as part of fracture-risk stratification.</p><p><strong>Background: </strong>Osteoporosis and falls are closely interlinked, particularly among aging populations, leading to increased risks of fragility fractures and disability. Identifying fall-related risk factors is essential for guiding prevention strategies.</p><p><strong>Objective: </strong>This study aimed to investigate the incidence of falls and associated risk factors among community-dwelling older adults in Iran over a one-year follow-up period.</p><p><strong>Methods: </strong>Individuals aged ≥ 50 years, who participated in the Iranian Multicenter Osteoporosis Study were followed. Baseline data included demographics, medical history, functional assessments, and laboratory findings. Falls were tracked prospectively over 12 months through phone calls. Statistical analyses included chi-square tests for categorical variables, independent t-tests for numerical comparisons, and Cox proportional hazards regression to identify predictors of falls. Variables with p < 0.20 in univariable analyses were entered into the multivariable model.</p><p><strong>Results: </strong>Among 1,450 participants at baseline, 1,410 (54.6% women; mean age 60.7 ± 8.0 years) completed follow-up. The overall fall incidence rate was 14.27 per 1,000 person-years (95% CI: 12.64-16.09), with higher rates among women than men. In unadjusted analyses, female sex, higher BMI, dizziness, visual impairment, and prior fall history were associated with increased fall risk. After multivariable adjustment, a history of one fall during past year (HR:2.49, 95%CI:1.76-3.70), two or more falls during past year (HR:2.55, 95%CI:1.74-3.70) and visual impairment (HR:1.48,95%CI:1.05-2.08) remained independent predictors of incident falls. Those with a fall in the previous year showed more than a 2.7-fold higher risk of subsequent falls (HR = 2.70; 95% CI: 1.99-3.66; p < 0.001).</p><p><strong>Conclusion: </strong>History of previous falls was the important independent predictor of incident falls after adjustment, highlighting the importance of systematic fall-history assessment in community-dwelling older adults.</p>","PeriodicalId":520737,"journal":{"name":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and disparities in DXA testing for osteoporosis among Medicare beneficiaries, 2005-2023.","authors":"Casey E Pelzl, Anand K Narayan, Tyler M Prout, Neil C Binkley, Tarig Elhakim, Taha Lodhi, Alexandra Drake, Elizabeth Y Rula, Eric W Christensen, Dania Daye","doi":"10.1007/s00198-026-08083-6","DOIUrl":"https://doi.org/10.1007/s00198-026-08083-6","url":null,"abstract":"<p><p>DXA utilization among Medicare beneficiaries declined 35% from 2005 to 2023. Declines were disproportionately larger among racial/ethnic minorities and socioeconomically deprived groups, while use increased among highest-acuity patients. These findings highlight widening inequities in DXA testing and underscore the need for targeted policy and public health interventions.</p><p><strong>Objective: </strong>The objective of this study is to examine the association between demographic and socioeconomic (SES) factors and national trends in dual-energy X-ray absorptiometry (DXA) testing among Medicare beneficiaries.</p><p><strong>Methods: </strong>This 19-year repeated cross-sectional study used 5% Medicare fee-for-service claims (2005-2023) to assess the annual utilization of DXA. Claims missing patient ZIP code, age, or race/ethnicity were excluded. Patient acuity was measured using the Neiman Imaging Comorbidity Index (NICI). Patient residence ZIP codes were used to determine urbanicity and Area Deprivation Index. Annual DXA utilization was calculated per 100,000 beneficiaries overall and stratified by SES covariates. Covariate associations with DXA utilization were assessed using logistic regression and comparisons of adjusted odds ratios (AOR) between years quantified utilization changes.</p><p><strong>Results: </strong>We identified 5,243,098 unique beneficiaries from 2005 to 2023 (mean 2,517,265 beneficiaries per year); 1,218,904 (23.2%) beneficiaries had at least one DXA. Annual use per 100,000 beneficiaries declined 35.4% from 7255 in 2005 to 4,690 in 2023. Hispanic beneficiaries saw the largest percentage decrease (-35.3%) in AOR of DXA utilization from 2005 (AOR, 0.93) to 2023 (AOR, 0.60), while beneficiaries with NICI ≥ 7 demonstrated the largest percentage increase (+57.7%) in AOR of DXA utilization from 2005 (AOR, 1.11) to 2023 (AOR, 1.70).</p><p><strong>Conclusions: </strong>Underserved populations have seen greater declines in DXA utilization compared with the observed national decline from 2005 to 2023. Future studies should identify the underlying factors associated with these disparities to inform public health interventions that enhance equitable utilization of DXA testing across the nation.</p>","PeriodicalId":520737,"journal":{"name":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low alkaline phosphatase in adults: implications for the diagnosis of hypophosphatasia during evaluation for osteoporosis.","authors":"Leonhard S Hummel, Martina Blaschke, Annette Lamersdorf, Gabriele Lehmann, Uwe Kornak, Heide Siggelkow","doi":"10.1007/s00198-026-08161-9","DOIUrl":"https://doi.org/10.1007/s00198-026-08161-9","url":null,"abstract":"<p><p>Hypophosphatasia (HPP) occurs in patients referred for suspected osteoporosis. In our cohort, ALP below 25 IU/L predicted a positive genetic diagnosis, yet higher values did not rule out the clinical diagnosis of HPP. Lower ALP correlated with increased fracture risk independent of genetic results, underscoring the clinical importance of recognising HPP to prevent use of contraindicated treatments.</p><p><strong>Purpose: </strong>Hypophosphatasia (HPP) is a rare inherited metabolic disorder affecting bone and teeth, characterised by osteomalacia, stress fractures, and pseudofractures. It remains underdiagnosed and may coexist with osteoporosis, risking inappropriate anti-resorptive therapy. This study characterised the biochemical, clinical, and densitometric features of adults with low alkaline phosphatase (ALP) and identified predictors of genetically confirmed HPP.</p><p><strong>Methods: </strong>We retrospectively analysed adults referred to our centre for thyroid, endocrine, osteoporosis, or rheumatological conditions in whom low ALP was identified. Data extracted included fracture history, dual-energy X-ray absorptiometry (DXA), trabecular bone score (TBS), biochemical parameters including pyridoxal-5-phosphate (PLP), and ALPL variant testing. ALPL-positive and ALPL-negative groups were compared using regression analyses.</p><p><strong>Results: </strong>Of 33 patients, 20 carried pathogenic ALPL variants. All individuals with ALP ≤ 25 IU/L had a detectable disease-causing variant, though ALP was often higher in variant-positive patients. PLP levels differed significantly between groups, whereas bone-specific ALP, standard biochemical markers, and DXA T-scores did not. Overall fracture prevalence was similar between groups; however, each 7.8 IU/L decrease in ALP significantly increased fracture probability, independent of genotype. Peripheral fractures predominated, consistent with adult HPP. One patient received bisphosphonates before diagnosis.</p><p><strong>Conclusion: </strong>Very low ALP strongly indicates HPP, yet the clinical spectrum extends beyond strict biochemical thresholds. ALP level-independent of genetic status-predicts fracture risk, suggesting residual enzyme activity is clinically relevant. These findings highlight the limitations of DXA and FRAX in HPP and underscore the need for thorough biochemical evaluation and broader clinical awareness to prevent contraindicated osteoporosis treatments.</p>","PeriodicalId":520737,"journal":{"name":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone-based patient-reported outcome of acute phase reaction after zoledronic acid infusion and prediction algorithm: a multicenter, prospective cohort study.","authors":"Sung Joon Cho, Sang Wouk Cho, Min Heui Yu, Seng Chan You, Seong Hee Ahn, Yumie Rhee, Namki Hong","doi":"10.1007/s00198-026-08172-6","DOIUrl":"https://doi.org/10.1007/s00198-026-08172-6","url":null,"abstract":"<p><p>Acute phase reaction (APR) after zoledronic acid infusion impairs adherence and treatment outcomes. Using smartphone-based ePRO monitoring, we developed a simple prediction model for severe APR incorporating age, sex, and day-1 symptoms. This algorithm showed good discrimination and may enable early identification and personalized prevention of severe APR.</p><p><strong>Purpose: </strong>Zoledronic acid (ZOL) is an effective antiresorptive therapy for osteoporosis, but acute phase reaction (APR) after initial infusion may impair adherence and outcomes. Identifying individuals at high risk for severe APR is essential for personalized prevention.</p><p><strong>Methods: </strong>This multicenter, prospective observational study collected electronic patient-reported outcome (ePRO) data via a smartphone application after a single 5-mg ZOL infusion. Adults aged ≥ 19 years reported the severity of nine APR symptoms daily for four days using a 5-point scale. Daily scores were summed to calculate a total APR score. Severity was categorized as mild-to-moderate or severe based on the median of total APR score. A prediction algorithm for severe APR was developed using age, sex, and day-1 symptoms.</p><p><strong>Results: </strong>Among 685 participants (mean age 70.6 years; 83.7% women), 222 (32.4%) experienced APR, and 118 (17.2%) developed severe APR. APR scores peaked on day 2 and declined by day 4. Severe APR showed earlier onset, longer duration, and greater symptom burden than mild-to-moderate APR. Younger age and female sex were associated with severe APR. Five day-1 symptoms (myalgia, arthralgia, chills, headache, and back pain) were identified as core predictors. A compact model incorporating age, sex, and the number of day-1 core symptoms demonstrated good discrimination for severe APR (AUROC 0.81).</p><p><strong>Conclusion: </strong>Smartphone-based ePRO effectively captured APR severity following ZOL. A simple clinical algorithm using age, sex, and day-1 symptoms accurately identified individuals at high risk for severe APR, enabling personalized preventive strategies.</p>","PeriodicalId":520737,"journal":{"name":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author response to original letter, manuscript no. OSIN-D-26-01474, \"Pre-teriparatide anti-osteoporosis medication therapy and fracture-related hospitalization in patients at very high fracture risk\".","authors":"Shao-Chi Fu, Chen-Yu Wang, Shau-Huai Fu","doi":"10.1007/s00198-026-08173-5","DOIUrl":"10.1007/s00198-026-08173-5","url":null,"abstract":"","PeriodicalId":520737,"journal":{"name":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","volume":" ","pages":"2155-2156"},"PeriodicalIF":5.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148703396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased fracture risk associated with iron-deficiency anemia: a population-based propensity score matched cohort study.","authors":"Andrea M Burden, Adrian Martinez-De la Torre, Maria Immoos, Theresa Burkard, Lorenz C Hofbauer, Martina Rauner, Andrea U Steinbicker","doi":"10.1007/s00198-026-08002-9","DOIUrl":"10.1007/s00198-026-08002-9","url":null,"abstract":"<p><p>Anemia seems to be associated with an increased risk of fracture. This cohort study of the UK primary care data shows in 84,932 anemic patients and 158,731 controls an increased fracture risk in anemic patients, also including patients < 50 years of age. Severe anemia was associated with 2 × vertebral fracture risk. Awareness of this clinically relevant association should increase.</p><p><strong>Purpose: </strong>In this study, we evaluated the risk of fracture among adult patients with anemia, compared to propensity score matched controls, stratifying by fracture site, age, and severity of anemia.</p><p><strong>Methods: </strong>We conducted a cohort study using the UK IQVIA Medical Research Database (IMRD), incorporating The Health Improvement Network (THIN), a Cegedim database. Adults with a diagnosis of anemia and an eligible hemoglobin value (< 13 g/dL (men) or < 12 g/dL (women)) were matched to controls using propensity score matching. Cox proportional hazard models estimated the hazard ratios (HRs) for the risk of any fracture (stratified by fracture site, sex, and age (defined < 50 years and >  = 50 years)).</p><p><strong>Results: </strong>84,932 anemic patients were matched to 158,731 controls. Overall, anemia was associated with a significant 20% risk of any fracture (driven by a 32% (HR 1.32, 1.20-1.47) increase among males, no difference among females). When stratified by sex, males had a significant risk at all fracture sites (27% (HR 1.27, 1.03-1.58) risk for vertebral, 89% (HR 1.89, 1.52-2.34) risk for humerus fractures). In females, only hip (HR 1.14, 1.05-1.25) and vertebral fractures (HR 1.24, 1.07-1.43) were significantly associated with anemia. Patients ≥ 50 years had elevated risks for all sites. In patients < 50 years, only hip fracture was elevated (HR 1.86, 1.04-3.33).</p><p><strong>Conclusion: </strong>Anemia was associated with a significant 20% increase of any fracture; however, this was driven by the elevated risk among males and those over the age of 50 years. Among females, only hip and vertebral fracture risk was elevated, while males had an elevated risk at all sites.</p>","PeriodicalId":520737,"journal":{"name":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","volume":" ","pages":"2037-2049"},"PeriodicalIF":5.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147871350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}