Open medicine (Warsaw, Poland)最新文献_第2页

Delayed femoral vein ligation reduces operative time and blood loss during hip disarticulation in patients with extremity tumors. 延迟股静脉结扎术减少了手术时间和肢体肿瘤患者髋关节脱臼期间的出血量。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-10-27 eCollection Date: 2022-01-01 DOI: 10.1515/med-2021-0372

Hongwei Yu, ShuHuai Wang, Qi Song, Yan You, Junjie Bao, Meng Yao

{"title":"Delayed femoral vein ligation reduces operative time and blood loss during hip disarticulation in patients with extremity tumors.","authors":"Hongwei Yu, ShuHuai Wang, Qi Song, Yan You, Junjie Bao, Meng Yao","doi":"10.1515/med-2021-0372","DOIUrl":"https://doi.org/10.1515/med-2021-0372","url":null,"abstract":"This study aimed to evaluate the effects of delayed femoral vein ligation on the clinical outcomes of hip disarticulation. We retrospectively reviewed 20 patients with extremity tumors (10 bone tumors and 10 soft tissue sarcomas [STS]) who underwent hip disarticulation. Patients treated for hip disarticulation with synchronous femoral vein ligation (n = 10, regular surgery group) and hip disarticulation with delayed femoral vein ligation (n = 10, delayed ligation group), respectively, were enrolled in this study. The operative time and blood loss were used to evaluate the clinical outcomes. The delayed ligation group had significantly lower operative times than the regular surgery group (P < 0.05). Total, hidden, and intraoperative blood loss were all significantly lower in the delayed ligation group than in the regular surgery group (P < 0.05). However, there were no significant differences in postoperative blood loss. In conclusion, delayed femoral vein ligation could significantly reduce the operative time, hidden blood loss, and intraoperative blood loss in patients undergoing hip disarticulation.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1705-1711"},"PeriodicalIF":2.1,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40466125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital adrenal hyperplasia. Role of dentist in early diagnosis. 先天性肾上腺增生。牙医在早期诊断中的作用。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-10-27 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0524

Michele Di Cosola, Francesca Spirito, Khrystyna Zhurakivska, Riccardo Nocini, Roberto Lovero, Salvatore Sembronio, Luigi Santacroce, Edoardo Brauner, Giovanni Storto, Lorenzo Lo Muzio, Angela Pia Cazzolla

{"title":"Congenital adrenal hyperplasia. Role of dentist in early diagnosis.","authors":"Michele Di Cosola, Francesca Spirito, Khrystyna Zhurakivska, Riccardo Nocini, Roberto Lovero, Salvatore Sembronio, Luigi Santacroce, Edoardo Brauner, Giovanni Storto, Lorenzo Lo Muzio, Angela Pia Cazzolla","doi":"10.1515/med-2022-0524","DOIUrl":"https://doi.org/10.1515/med-2022-0524","url":null,"abstract":"Congenital adrenal hyperplasia (CAH) is a genetic disorder characterized by an impairment of steroid synthesis due to an altered production of 21-hydroxylase enzyme. Corticoid hormones are involved in the development and functioning of many organs. The aim of the present study was to review the international literature to collect data regarding oral manifestations of CAH. A review of the literature describing oral features of patients affected by CAH was performed using electronic databases (PubMed and Scopus). The data about number of patients, form of CAH, and oral findings were extracted and analyzed. Seven studies were included in the final analysis. The principal findings reported regarded an advanced dental development observed in patients with CAH. One paper reported amelogenesis imperfecta and periodontal issues. The dentist could be the first specialist involved in the CAH syndrome diagnosis, identifying the characteristic features described above, especially for the classical simple virilizing and non-classical form.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1699-1704"},"PeriodicalIF":2.1,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40466122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Identification of a novel necroptosis-associated miRNA signature for predicting the prognosis in head and neck squamous cell carcinoma. 一种新的预测头颈部鳞状细胞癌预后的坏死相关miRNA特征的鉴定。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-10-25 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0575

Jiezhong Guan, Xinyu Liu, Kang Wang, Yiqun Jia, Bo Yang

{"title":"Identification of a novel necroptosis-associated miRNA signature for predicting the prognosis in head and neck squamous cell carcinoma.","authors":"Jiezhong Guan, Xinyu Liu, Kang Wang, Yiqun Jia, Bo Yang","doi":"10.1515/med-2022-0575","DOIUrl":"https://doi.org/10.1515/med-2022-0575","url":null,"abstract":"Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive malignancies that have a poor prognosis. Necroptosis has been demonstrated in recent years to be a form of inflammatory cell death occurring in multicellular organism, which plays complex roles in cancer. However, the expression of necroptosis-related miRNAs and genes in HNSCC and their correlations with prognosis remain unclear. In this study, R software was used to screen differentially expressed miRNAs downloaded from The Cancer Genome Atlas. A prognostic model containing six necroptosis-related miRNAs (miR-141-3p, miR-148a-3p, miR-331-3p, miR-543, miR-425-5p, and miR-7-5p) was generated, whose risk score was validated as an independent prognostic factor for HNSCC. Target genes of the key miRNAs were obtained from TargetScan, miRDB, and miRTarBase, and 193 genes in the intersection of the three databases were defined as consensus genes. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses indicated that the composition of the tumor microenvironment as well as specific pathways may be closely related to necroptosis in HNSCC. Nine key genes were also obtained by the MCODE and cytoHubba plug-ins of Cytoscape: PIK3CD, NRAS, PTK2, IRS2, IRS1, PARP1, KLF4, SMAD2, and DNMT1. A prognostic model formed by the key gene was also established, which can efficiently predict the overall survival of HNSCC patients. In conclusion, necroptosis-related miRNAs and genes play important roles in tumor development and metastasis and can be used to predict the prognosis of HNSCC.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1682-1698"},"PeriodicalIF":2.1,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40475219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Silencing of CPSF7 inhibits the proliferation, migration, and invasion of lung adenocarcinoma cells by blocking the AKT/mTOR signaling pathway. CPSF7的沉默通过阻断AKT/mTOR信号通路抑制肺腺癌细胞的增殖、迁移和侵袭。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-10-21 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0570

Weishao An, Fang Yu

{"title":"Silencing of CPSF7 inhibits the proliferation, migration, and invasion of lung adenocarcinoma cells by blocking the AKT/mTOR signaling pathway.","authors":"Weishao An, Fang Yu","doi":"10.1515/med-2022-0570","DOIUrl":"https://doi.org/10.1515/med-2022-0570","url":null,"abstract":"Cleavage and polyadenylation specific factor 7 (CPSF7) is an important participator in the cleavage and polyadenylation of pre-mRNAs. This study aims to uncover the function and underlying mechanism of CPSF7 in lung adenocarcinoma (LUAD). CPSF7 expression in LUAD cells was measured using real time-quantitative polymerase chain reaction and Western blotting. Our results showed that CPSF7 expression was upregulated in LUAD cell lines (A549, H1299, and HCC827). To explore the function of CPSF7 on LUAD, CPSF7 was silenced by the si-CPSF7 transfection and overexpressed by the oe-CPSF7 transfection in A549 cells. Cell proliferation was measured using cell counting kit-8 and colony formation assays. Cell migration and invasion were measured by wound healing and Transwell assays, respectively. Our data revealed that CPSF7 silencing inhibited the viability, colony formation, migration, and invasion of LUAD cells. On the contrary, CPSF7 overexpression enhanced the malignant characteristics of LUAD cells. Additionally, expression of AKT/mTOR pathway-related proteins was detected using Western blotting. CPSF7 silencing blocked the AKT/mTOR signaling pathway. The intervention of SC79 (an activator of the AKT/mTOR pathway) weakened the antitumor effects of CPSF7 silencing in LUAD cells. Silencing of CPSF7 inhibits the malignant characteristics of LUAD cells by blocking the AKT/mTOR signaling pathway.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1655-1663"},"PeriodicalIF":2.1,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40455141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound-guided lumbar plexus block versus transversus abdominis plane block for analgesia in children with hip dislocation: A double-blind, randomized trial. 超声引导下腰丛阻滞与腹平面阻滞对髋脱位儿童镇痛的对照:一项双盲随机试验。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-10-21 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0581

Ke Sun, Mei Jin, Xiaoguang Zhang

{"title":"Ultrasound-guided lumbar plexus block versus transversus abdominis plane block for analgesia in children with hip dislocation: A double-blind, randomized trial.","authors":"Ke Sun, Mei Jin, Xiaoguang Zhang","doi":"10.1515/med-2022-0581","DOIUrl":"https://doi.org/10.1515/med-2022-0581","url":null,"abstract":"Lumbar plexus block is often used as analgesia for adult hip surgery, but it is rarely used in pediatric patients. This study aimed to compare the efficacy and feasibility of ultrasound-guided lumbar plexus block versus transversus abdominis plane block for postoperative analgesia in children with hip dislocation. Eighty children undergoing unilateral hip dislocation surgeries at our hospital from October 2019 to February 2021 were randomized to the lumbar plexus block group (group L) and transversus abdominis plane block group (group T). Compared with group L, the regional block time in group T was lower (8.0 ± 2.5 vs 11.5 ± 2.3 min, P < 0.05), and the ultrasound image definition was better (P < 0.05). There were no significant differences in mean blood pressure and heart rate within 24 h (all P > 0.05). Children's Hospital of Eastern Ontario Pain Scale scores were lower in group L than in group T at 18-24 h only (all P < 0.05). The satisfying analgesia rate in group L was higher than in group T (87.5 vs 65%, P < 0.05). No regional block-related complications were found in both groups. Ultrasound-guided lumbar plexus block showed a longer postoperative analgesic effect in children with hip dislocation compared with transversus abdominis plane block.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1664-1673"},"PeriodicalIF":2.1,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40455139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm. 血浆MBP和8-氧-脱氧葡萄糖与早产儿脑损伤的关系。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-10-21 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0566

Yuwei Zhao, Guanghui Liu, Lei Liang, Zaiwei Yu, Jian Zhang, Hong Zheng, Liying Dai

{"title":"Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm.","authors":"Yuwei Zhao, Guanghui Liu, Lei Liang, Zaiwei Yu, Jian Zhang, Hong Zheng, Liying Dai","doi":"10.1515/med-2022-0566","DOIUrl":"https://doi.org/10.1515/med-2022-0566","url":null,"abstract":"Preterm infants face a significant risk of brain injury in the perinatal period, as well as potential long-term neurodevelopmental disabilities. However, preterm children with brain injury lack specific clinical manifestations in the early days. Therefore, timely and accurate diagnosis of brain injury is of vital importance. This study was to explore the diagnostic efficiency of myelin basic protein (MBP) and 8-oxo-deoxyguanosine (8-oxo-dG) serum levels in brain injury of premature infants. A total of 75 preterm infants with gestational age between 28 and 32 weeks and birth weight higher than 1,000 g were prospectively included. MBP serum levels were significantly higher in premature infants with white matter injury (WMI). 8-oxo-dG serum levels were significantly increased in both WMI and periventricular-intraventricular hemorrhages (PIVH). MBP and 8-oxo-dG were significantly correlated. The area under the curve was 0.811 [95% confidence interval (CI) 0.667-0.955; p = 0.002] in MBP and 0.729 (95% CI 0.562-0.897; p = 0.020) in 8-oxo-dG. Therefore, the results showed that high MBP levels indicated a possibility of WMI in the premature brain during the early postnatal period, while high 8-oxo-dG levels were closely related to both WMI and PIVH, thus suggesting that MBP and 8-oxo-dG could be used as potential neuro-markers of preterm brain injury.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1674-1681"},"PeriodicalIF":2.1,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40475220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serpin family A member 1 is an oncogene in glioma and its translation is enhanced by NAD(P)H quinone dehydrogenase 1 through RNA-binding activity. Serpin家族A成员1是胶质瘤中的致癌基因，NAD(P)H醌脱氢酶1通过rna结合活性促进其翻译。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-10-20 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0572

Wenjun Liu, Min Du, Hongping Wan, Hao Yang, Xiaorong Deng, Yu Chen, Qian Zhang

{"title":"Serpin family A member 1 is an oncogene in glioma and its translation is enhanced by NAD(P)H quinone dehydrogenase 1 through RNA-binding activity.","authors":"Wenjun Liu, Min Du, Hongping Wan, Hao Yang, Xiaorong Deng, Yu Chen, Qian Zhang","doi":"10.1515/med-2022-0572","DOIUrl":"https://doi.org/10.1515/med-2022-0572","url":null,"abstract":"Serpin family A member 1 (SERPINA1) is expressed abundantly in gliomas and can predict unfavorable prognosis of patients with glioma. Studies have shown that nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1 (NQO1) can promote the proliferation of glioblastoma multiforme cells and enhance the expression of SERPINA1, but its effects on glioma cells remain unknown. In this study, we explored the functions of SERPINA1 in glioma tumorigenesis in vitro and then investigated whether NQO1 affects the protein expression of SERPINA1 and its mRNA level. The results showed that the translation of SERPINA1 was suppressed while its mRNA level had no significant changes under the condition of NQO1 silencing. Luciferase reporter assay and biotin pull-down assay further indicated that NQO1 bond with SERPINA1 3' untranslated region. miR-1321 was also identified to target SERPINA1, repressing its mRNA and protein levels. SERPINA1 and NQO1 promoted glioma cell proliferation and suppressed cell apoptosis. Moreover, SERPINA1 rescued the effects of sh-NQO1 in glioma cell malignant phenotypes. In conclusion, our findings showed that oncogene NQO1 and antioncogene miR-1321 bind to oncogene SERPINA1 to affect proliferation and apoptosis of glioma cells, which can bring new solution of antitumor treatments for glioma in the future.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1645-1654"},"PeriodicalIF":2.1,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40455140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

lncRNA-AC130710/miR-129-5p/mGluR1 axis promote migration and invasion by activating PKCα-MAPK signal pathway in melanoma. lncRNA-AC130710/miR-129-5p/mGluR1轴通过激活PKCα-MAPK信号通路促进黑色素瘤的迁移和侵袭。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-10-18 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0587

Zhi Xie, Chen Wang, Li Li, Xianfeng Chen, Guanjing Wei, Yan Chi, Yanping Liang, Lizhen Lan, Jiqiong Hong, Lili Li

{"title":"lncRNA-AC130710/miR-129-5p/mGluR1 axis promote migration and invasion by activating PKCα-MAPK signal pathway in melanoma.","authors":"Zhi Xie, Chen Wang, Li Li, Xianfeng Chen, Guanjing Wei, Yan Chi, Yanping Liang, Lizhen Lan, Jiqiong Hong, Lili Li","doi":"10.1515/med-2022-0587","DOIUrl":"https://doi.org/10.1515/med-2022-0587","url":null,"abstract":"Invasion and metastasis of melanoma are a series of complicated biological events regulated by multiple factors. The coregulation of many molecules involved in the development and progression of melanoma contributes to invasion and migration. mGluR1 is a metabotropic glutamate receptor that is overexpressed in melanocytes and is sufficient to induce melanoma. In our study, we found that mGluR1 was obviously increased in melanoma. Furthermore, we found that miR-129-5p could directly target and regulate mGluR1 mRNA, which was significantly reduced in A375 cells. Overexpression of miR-129-5p inhibited cell migration, invasion and clonal formation. lncRNA-AC130710 directly targeted and suppressed miR-129-5p in A375 cells. Downregulation of lncRNA-AC130710 suppressed the levels of mGluR1 mRNA by promoting miR-129-5p expression and further inhibiting migration, invasion and colony formation in A375 cells, which was associated with the activation of the PKCα-MAPK signaling pathway. Taken together, our study showed that the lncRNA-AC130710/miR-129-5p/mGluR1 axis plays an important role in the invasion and metastasis of melanoma.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1612-1622"},"PeriodicalIF":2.1,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40465514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SNRPB promotes cell cycle progression in thyroid carcinoma via inhibiting p53. SNRPB通过抑制p53促进甲状腺癌细胞周期进展。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-10-18 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0531

Yan Deng, Xin Li, Wenlei Jiang, Jindan Tang

{"title":"SNRPB promotes cell cycle progression in thyroid carcinoma via inhibiting p53.","authors":"Yan Deng, Xin Li, Wenlei Jiang, Jindan Tang","doi":"10.1515/med-2022-0531","DOIUrl":"https://doi.org/10.1515/med-2022-0531","url":null,"abstract":"Papillary thyroid carcinoma (PTC) accounts for more than 80% of all thyroid carcinoma cases. Small nuclear ribonucleoprotein polypeptides B and B1 (SNRPB) has been indicated to be carcinogenic in several cancers; however, its function and mechanism in PTC are unclarified. Real time quantitative polymerase chain reaction and western blotting revealed the upregulation of SNRPB and downregulation of tumor protein p53 in PTC tissues compared with the normal tissues. Flow cytometry and western blotting displayed that SNRPB silencing induced cell cycle arrest at G1 phase and suppressed the expression levels of Cyclin family proteins in PTC cells. In vivo experiments suggested that SNRPB silencing inhibited PTC tumor growth in mice. Bioinformatics analysis revealed that the expression of SNRPB and cell cycle-associated genes in thyroid carcinoma tissues is positively correlated. Immunofluorescence staining and co-immunoprecipitation demonstrated that SNRPB directly interacted with p53 and suppressed its expression in PTC cells. In conclusion, SNRPB facilitates cell cycle progression in PTC by inhibiting p53 expression.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1623-1631"},"PeriodicalIF":2.1,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40465513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Xylooligosaccharides and aerobic training regulate metabolism and behavior in rats with streptozotocin-induced type 1 diabetes. 低聚木糖和有氧训练调节链脲佐菌素诱导的1型糖尿病大鼠的代谢和行为。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-10-18 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0579

Mariya Choneva, Michaela Shishmanova-Doseva, Ivica Dimov, Krasimir Boyanov, Iliyan Dimitrov, Tatyana Vlaykova, Katerina Georgieva, Petar Hrischev, Anelia Bivolarska

{"title":"Xylooligosaccharides and aerobic training regulate metabolism and behavior in rats with streptozotocin-induced type 1 diabetes.","authors":"Mariya Choneva, Michaela Shishmanova-Doseva, Ivica Dimov, Krasimir Boyanov, Iliyan Dimitrov, Tatyana Vlaykova, Katerina Georgieva, Petar Hrischev, Anelia Bivolarska","doi":"10.1515/med-2022-0579","DOIUrl":"https://doi.org/10.1515/med-2022-0579","url":null,"abstract":"Type 1 diabetes mellitus is characterized with decreased microbial diversity. Gut microbiota is essential for the normal physiological functioning of many organs, especially the brain. Prebiotics are selectively fermentable oligosaccharides [xylooligosaccharides (XOS), galactooligosaccharides, etc.] that promote the growth and activity of gut microbes and influence the gut-brain axis. Aerobic exercise is a non-pharmacological approach for the control of diabetes and could improve cognitive functions. The potential beneficial effect of XOS and/or aerobic training on cognition, the lipid profile and oxidative stress markers of experimental rats were evaluated in this study. Male Wistar rats were randomly divided into three streptozotocin-induced diabetic groups and a control group. Some of the rats, either on a XOS treatment or a standard diet, underwent aerobic training. The results showed that the aerobic training independently lowered the total cholesterol levels compared to the sedentary diabetic rats (p = 0.032), while XOS lowers the malondialdehyde levels in the trained diabetic rats (p = 0.034). What is more the exercise, independently or in combination with XOS beneficially affected all parameters of the behavioral tests. We conclude that aerobic exercises alone or in a combination with the prebiotic XOS could ameliorate the dyslipidemia, oxidative stress, and cognitive abilities in experimental type 1 diabetic animals.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1632-1644"},"PeriodicalIF":2.1,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40446190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0