Journal of neural transmission (Vienna, Austria : 1996)最新文献_第10页

Application of tRNS to improve multiple sclerosis fatigue: a pilot, single-blind, sham-controlled study. tRNS在改善多发性硬化疲劳中的应用:一项试点、单盲、假对照研究。

IF 3.3

Journal of neural transmission (Vienna, Austria : 1996) Pub Date : 2019-06-01 Epub Date: 2019-05-03 DOI: 10.1007/s00702-019-02006-y

Giuseppe Salemi, Giulia Vazzoler, Paolo Ragonese, Alessia Bianchi, Giuseppe Cosentino, Giuseppe Croce, Massimo Gangitano, Erika Portera, Sabrina Realmuto, Brigida Fierro, Filippo Brighina

引用次数: 13

Peripheral levels of the anti-aging hormone Klotho in patients with depression. 抑郁症患者抗衰老激素Klotho的外周水平。

IF 3.3

Journal of neural transmission (Vienna, Austria : 1996) Pub Date : 2019-06-01 Epub Date: 2019-05-04 DOI: 10.1007/s00702-019-02008-w

Alexander Sartorius, Maria Gilles, Anna-Maria Pfeifer, Michael Deuschle, Carolin Hoyer, Dieter Haffner, Maren Leifheit-Nestler, Laura Kranaster

{"title":"Peripheral levels of the anti-aging hormone Klotho in patients with depression.","authors":"Alexander Sartorius, Maria Gilles, Anna-Maria Pfeifer, Michael Deuschle, Carolin Hoyer, Dieter Haffner, Maren Leifheit-Nestler, Laura Kranaster","doi":"10.1007/s00702-019-02008-w","DOIUrl":"https://doi.org/10.1007/s00702-019-02008-w","url":null,"abstract":"Klotho is a humoral factor with pleiotropic effects. Most notably, Klotho deficiency is associated with a phenotype comprising organ manifestations accompanying aging including atherosclerosis and cognitive impairment. Research on the role of Klotho in affective disorder is scarce, which is surprising in light of the fact that depression is associated with accelerated cellular aging as well as aging-related phenotypes and comorbidity observed in Klotho deficiency. Soluble α-Klotho (sKlotho) serum levels in patients with a major depressive episode and either undergoing electroconvulsive therapy (n = 16) or a monotherapy with an antidepressant (n = 37) were investigated. We measured the sKlotho serum levels in those patients before and after treatment and compared the baseline levels with those of age-matched healthy controls (n = 39). No group differences were found between the baseline sKlotho levels of patients and controls (573.5 pg/ml vs. 563.8 pg/ml; p = 0.80) and between pre- and post-treatment in the patients with depression (563.8 pg/ml vs. 561.8 pg/ml; p = 0.15), when treated either with electroconvulsive therapy or antidepressant. The major limitation of our study might be that peripheral material such as serum might not reliably reflect processes in the central nervous system. In sum, this first study on peripheral sKlotho levels in a clinical sample cannot confirm a global Klotho dysregulation in depression as it has been already suggested by others. Nonetheless, further preclinical and clinical studies on the involvement of Klotho in affective disorders should be carried out.","PeriodicalId":520679,"journal":{"name":"Journal of neural transmission (Vienna, Austria : 1996)","volume":" ","pages":"771-776"},"PeriodicalIF":3.3,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00702-019-02008-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37214625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Using wearables to assess bradykinesia and rigidity in patients with Parkinson's disease: a focused, narrative review of the literature. 使用可穿戴设备评估帕金森病患者的运动迟缓和僵硬:对文献的重点叙述回顾。

IF 3.3

Journal of neural transmission (Vienna, Austria : 1996) Pub Date : 2019-06-01 Epub Date: 2019-05-22 DOI: 10.1007/s00702-019-02017-9

Itay Teshuva, Inbar Hillel, Eran Gazit, Nir Giladi, Anat Mirelman, Jeffrey M Hausdorff

{"title":"Using wearables to assess bradykinesia and rigidity in patients with Parkinson's disease: a focused, narrative review of the literature.","authors":"Itay Teshuva, Inbar Hillel, Eran Gazit, Nir Giladi, Anat Mirelman, Jeffrey M Hausdorff","doi":"10.1007/s00702-019-02017-9","DOIUrl":"https://doi.org/10.1007/s00702-019-02017-9","url":null,"abstract":"The potential of using wearable technologies for the objective assessment of motor symptoms in Parkinson's disease (PD) has gained prominence recently. Nonetheless, compared to tremor and gait impairment, less emphasis has been placed on the quantification of bradykinesia and rigidity. This review aimed to consolidate the existing research on objective measurement of bradykinesia and rigidity in PD through the use of wearables, focusing on the continuous monitoring of these two symptoms in free-living environments. A search of PubMed was conducted through a combination of keyword and MeSH searches. We also searched the IEEE, Google Scholar, Embase, and Scopus databases to ensure thorough results and to minimize the chances of missing relevant studies. Papers published after the year 2000 with sample sizes greater than five were included. Studies were assessed for quality and information was extracted regarding the devices used and their location on the body, the setting and duration of the study, the \"gold standard\" used as a reference for validation, the metrics used, and the results of each paper. Thirty-one and eight studies met the search criteria and evaluated bradykinesia and rigidity, respectively. Several studies reported strong associations between wearable-based measures and the gold-standard references for bradykinesia, and, to a lesser extent, rigidity. Only a few, pilot studies investigated the measurement of bradykinesia and rigidity in the home and free-living settings. While the current results are promising for the future of wearables, additional work is needed on their validation and adaptation in ecological, free-living settings. Doing so has the potential to improve the assessment and treatment of motor fluctuations and symptoms of PD more generally through real-time objective monitoring of bradykinesia and rigidity.","PeriodicalId":520679,"journal":{"name":"Journal of neural transmission (Vienna, Austria : 1996)","volume":" ","pages":"699-710"},"PeriodicalIF":3.3,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00702-019-02017-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37261653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Long-term effect of subthalamic and pallidal deep brain stimulation for status dystonicus in children with methylmalonic acidemia and GNAO1 mutation. 甲基丙二酸血症和GNAO1突变儿童状态障碍的长期影响:丘脑底和白脑深部脑刺激。

IF 3.3

Journal of neural transmission (Vienna, Austria : 1996) Pub Date : 2019-06-01 Epub Date: 2019-05-10 DOI: 10.1007/s00702-019-02010-2

Alberto Benato, Miryam Carecchio, Alberto Burlina, Francesco Paoloni, Stefano Sartori, Margherita Nosadini, Domenico d'Avella, Andrea Landi, Angelo Antonini

{"title":"Long-term effect of subthalamic and pallidal deep brain stimulation for status dystonicus in children with methylmalonic acidemia and GNAO1 mutation.","authors":"Alberto Benato, Miryam Carecchio, Alberto Burlina, Francesco Paoloni, Stefano Sartori, Margherita Nosadini, Domenico d'Avella, Andrea Landi, Angelo Antonini","doi":"10.1007/s00702-019-02010-2","DOIUrl":"https://doi.org/10.1007/s00702-019-02010-2","url":null,"abstract":"Status dystonicus (SD) is a rare and potentially life-threatening condition requiring intensive care management. Deep brain stimulation (DBS) has emerged as an effective treatment for SD refractory to medical management, but its application in this field is still limited. Here, we report the long-term outcome of four pediatric patients treated with DBS at the University Hospital of Padua, Italy, for SD refractory to medications. In addition, we present the results of a systematic literature review aimed at identifying published cases of SD treated with DBS, with focus on motor outcome. In our cohort, two children were affected by methylmalonic acidemia and suffered acute basal ganglia lesions, while the other two carried a pathogenic mutation in GNAO1 gene. DBS target was subthalamic nucleus (STN) in one case and globus pallidus internus (GPi) in three. All patients experienced SD resolution within 8-19 days after surgery. Mean post-operative follow-up was 5 years. We identified in the literature 53 additional SD cases treated with DBS (median age at DBS implantation: 12 years) with reported positive outcome in 51 and resolution of SD in a mean of 17 days after surgery. Our findings indicate that DBS is an effective treatment for SD refractory to medications, even in patients with acute basal ganglia lesions; STN can be an appropriate target when GPi is damaged. Moreover, data from long-term follow-up show that SD recurrences can be significantly reduced in frequency or abolished after DBS implantation.","PeriodicalId":520679,"journal":{"name":"Journal of neural transmission (Vienna, Austria : 1996)","volume":" ","pages":"739-757"},"PeriodicalIF":3.3,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00702-019-02010-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37406526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Why patients with multiple sclerosis perceive improvement of gait during treatment with natalizumab? 为什么多发性硬化症患者在纳他珠单抗治疗期间步态改善?

IF 3.3

Journal of neural transmission (Vienna, Austria : 1996) Pub Date : 2019-06-01 Epub Date: 2019-05-16 DOI: 10.1007/s00702-019-02013-z

Klara Novotna, Jan Rusz, Eva Kubala Havrdova, Jana Lizrova Preiningerova

{"title":"Why patients with multiple sclerosis perceive improvement of gait during treatment with natalizumab?","authors":"Klara Novotna, Jan Rusz, Eva Kubala Havrdova, Jana Lizrova Preiningerova","doi":"10.1007/s00702-019-02013-z","DOIUrl":"https://doi.org/10.1007/s00702-019-02013-z","url":null,"abstract":"Gait impairment is one of the common manifestations of multiple sclerosis (MS) and contributes to a loss of quality of life. Natalizumab, an anti-α4 integrin monoclonal antibody, has been shown to have an effect in treatment of MS, reducing relapses and inflammatory lesions. Aim of our study was to assess how patients perceive gait impairment over the first year of treatment with natalizumab and what is the objective correlate of this change. This is an open-label prospective observational study. Subjective gait evaluation was measured by Multiple Sclerosis Walking Scale-12 (MSWS-12). Objective gait assessment included Timed 25-Foot Walk Test (T25FW) and spatiotemporal parameters of gait measured by a GAITRite instrument during a self-selected speed of walking (normal walk) and a fast speed of walking (fast walk). We analysed data of 50 patients with a relapsing-remitting form of MS, median EDSS 3.5 (range 1.5-5). MSWS-12 score significantly decreased between the baseline and month 12 of treatment (p < 0.001). Walking velocity and step length were significantly improved in Normal walk tests (p < 0.001). During the Fast walk tests, a step length and a double support time of the gait cycle were significantly improved (p = 0.001). Change in MSWS-12 score confirmed the clinically significant improvement of gait in patients with MS treated with natalizumab for 1 year. The analysis of spatiotemporal gait parameters has shown a significant improvement in self-selected gait velocity and step length.","PeriodicalId":520679,"journal":{"name":"Journal of neural transmission (Vienna, Austria : 1996)","volume":" ","pages":"731-737"},"PeriodicalIF":3.3,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00702-019-02013-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37251141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Administration of memantine reverses behavioral, histological, and electrophysiological abnormalities in rats subjected to early maternal deprivation. 给予美金刚可逆转早期母性剥夺大鼠的行为、组织学和电生理异常。

IF 3.3

Journal of neural transmission (Vienna, Austria : 1996) Pub Date : 2019-06-01 Epub Date: 2019-05-02 DOI: 10.1007/s00702-019-02007-x

Ezequiel Uribe, Leticia Fernández, Dulce Pacheco, Luis Fernandez, Nieves Nayadoleni, Antonio Eblen-Zajjur

{"title":"Administration of memantine reverses behavioral, histological, and electrophysiological abnormalities in rats subjected to early maternal deprivation.","authors":"Ezequiel Uribe, Leticia Fernández, Dulce Pacheco, Luis Fernandez, Nieves Nayadoleni, Antonio Eblen-Zajjur","doi":"10.1007/s00702-019-02007-x","DOIUrl":"https://doi.org/10.1007/s00702-019-02007-x","url":null,"abstract":"Schizophrenia (SCZ) is a severe and chronic neurodevelopmental disorder with onset occurring during adolescence or early adulthood; notwithstanding, the brain dysfunction occurs before the disease and is not clinically evident. Recently, memantine (MEM) had been postulated as an effective preventive treatment in rats. In this study, was performed the Early Maternal Deprivation (EMD) protocol in Sprague-Dawley rats, establishing four groups (control, EMD, EMD treated with MEM, and MEM treatment). Behavioral parameters such as active linking (AL) and T maze were evaluated as well as quantitative brain histological changes at 3, 7, and 10 weeks of age, to understand the longitudinal demeanor of the disease. Prefrontal evoked potentials (PFEPs) were recorded to study functional synaptic connectivity and neuronal synchronicity changes. The results showed that EMD induces a decrease of AL and poor performance of T maze, in addition to volumetric changes of cortical and subcortical brain structures and abnormalities in PFEPs. The majority of this changes were absent by neonatal MEM administration. Taking into account that all these abnormalities are associated to SCZ, we propose to MEM as a potential preventive treatment.","PeriodicalId":520679,"journal":{"name":"Journal of neural transmission (Vienna, Austria : 1996)","volume":" ","pages":"759-770"},"PeriodicalIF":3.3,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00702-019-02007-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37209336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Novel putative mechanisms to link circadian clocks to healthy aging. 新的假定机制将生物钟与健康衰老联系起来。

IF 3.3

Journal of neural transmission (Vienna, Austria : 1996) Pub Date : 2015-08-01 Epub Date: 2013-12-03 DOI: 10.1007/s00702-013-1128-4

Aurel Popa-Wagner, Bogdan Catalin, Ana-Maria Buga

引用次数: 4

Lenticular nucleus hyperechogenicity in Wilson's disease reflects local copper, but not iron accumulation. 威尔逊氏病的透镜状核高回声反映了局部铜的积累，而不是铁的积累。

IF 3.3

Journal of neural transmission (Vienna, Austria : 1996) Pub Date : 2014-10-01 Epub Date: 2014-03-11 DOI: 10.1007/s00702-014-1184-4

Uwe Walter, Marta Skowrońska, Tomasz Litwin, Grażyna Maria Szpak, Katarzyna Jabłonka-Salach, David Skoloudík, Ewa Bulska, Anna Członkowska

{"title":"Lenticular nucleus hyperechogenicity in Wilson's disease reflects local copper, but not iron accumulation.","authors":"Uwe Walter, Marta Skowrońska, Tomasz Litwin, Grażyna Maria Szpak, Katarzyna Jabłonka-Salach, David Skoloudík, Ewa Bulska, Anna Członkowska","doi":"10.1007/s00702-014-1184-4","DOIUrl":"https://doi.org/10.1007/s00702-014-1184-4","url":null,"abstract":"In patients with Wilson's disease (WD) transcranial brain sonography typically reveals areas of increased echogenicity (hyperechogenicity) of the lenticular nucleus (LN). Correlation with T2-hypointensity on magnetic resonance images suggested that LN hyperechogenicity in WD is caused by trace metal accumulation. Accumulation of both, copper and iron, in the brain of WD patients has been reported. The present study was designed to elucidate whether LN hyperechogenicity in WD reflects accumulation of copper or iron. Post-mortem brains of 15 WD patients and one non-WD subject were studied with ultrasonography in an investigator-blinded fashion. LN hyperechogenicity was measured planimetrically by manual tracing as well as using digitized image analysis. The putaminal copper content was determined in samples of 11 WD brains and the non-WD brains using inductively coupled plasma mass spectrometry, and iron content was assessed using flame atomic absorption spectroscopy. LN was normal on ultrasonography only in the non-WD brain, but abnormal (hyperechogenic) in all WD brains. Digitized image analysis measures of LN hyperechogenicity and, by trend, manual measures correlated with putaminal copper content (Pearson test; digitized: r = 0.77, p = 0.04; manual: r = 0.57, p = 0.051) but not with iron content (each, p > 0.18). LN hyperechogenicity measures were unrelated to age at death of patients, age at onset of WD, WD duration, age of brain specimen, serum copper or serum ceruloplasmin (each, p > 0.1). We conclude that LN hyperechogenicity in WD reflects copper, but not iron accumulation. Further studies are warranted to elucidate the use of transcranial brain sonography for monitoring therapeutic effects of chelating agents in WD patients.","PeriodicalId":520679,"journal":{"name":"Journal of neural transmission (Vienna, Austria : 1996)","volume":" ","pages":"1273-9"},"PeriodicalIF":3.3,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00702-014-1184-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40298587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression? 谷氨酸介导的兴奋性毒性在炎症性抑郁中是否起作用?

IF 3.3

Journal of neural transmission (Vienna, Austria : 1996) Pub Date : 2014-08-01 Epub Date: 2014-03-15 DOI: 10.1007/s00702-014-1187-1

Robert Dantzer, Adam K Walker

引用次数: 107

Glutamatergic autoencephalitides: an emerging field. 谷氨酸能自体脑肽:一个新兴领域。

IF 3.3

Journal of neural transmission (Vienna, Austria : 1996) Pub Date : 2014-08-01 Epub Date: 2014-01-09 DOI: 10.1007/s00702-013-1152-4

Jessica A Panzer, Amy J Gleichman, David R Lynch

{"title":"Glutamatergic autoencephalitides: an emerging field.","authors":"Jessica A Panzer, Amy J Gleichman, David R Lynch","doi":"10.1007/s00702-013-1152-4","DOIUrl":"https://doi.org/10.1007/s00702-013-1152-4","url":null,"abstract":"Autoimmune responses targeting synaptic proteins are associated with a wide range of neurologic symptoms. Among these disorders are those associated with antibodies to ionotropic glutamate receptors, including the NMDAR (N-methyl-D-aspartate receptor) and AMPAR (α-amino-3-hydrozy-5-methyl-4-isoxazolepropionic acid receptor). Patients with anti-NMDAR encephalitis present with psychiatric symptoms, seizures, movement disorders, impaired consciousness, and autonomic derangements; half of patients have an associated ovarian teratoma, and most patients respond to immunosuppressive therapies. Patients' antibodies bind to the amino terminal domain of the NMDAR, and result in loss of NMDARs from synapses with subsequent NMDAR hypofunction. Anti-NMDAR antibodies have now been reported in other neuropsychiatric conditions, including psychosis, dementia, and HSV encephalitis. The pathophysiologic relevance of anti-NMDAR antibodies in these disorders is not yet clear, but their presence may indicate a role for immunotherapy in some patients. Although considerable work remains to be done, our understanding of disorders associated with anti-glutamate receptor antibodies has grown exponentially since they were first described just over 7 years ago, revolutionizing neurology. These antibodies, by interfering with synaptic function, readily link basic science and clinical medicine, and have revealed the impact of sudden but sustained loss of specific neurotransmitter receptors in humans. Improved understanding of their pathophysiology will lead to better treatments for these diseases while providing novel insights regarding the roles of glutamate receptors in learning, memory, and neuropsychiatric disease.","PeriodicalId":520679,"journal":{"name":"Journal of neural transmission (Vienna, Austria : 1996)","volume":" ","pages":"957-68"},"PeriodicalIF":3.3,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00702-013-1152-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32011161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20