Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine最新文献

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ICU-acquired Candidemia in COVID-19 Patients: An Experience from a Tertiary Care Hospital in Kerala, South India. COVID-19患者的icu获得性念珠菌:来自印度南部喀拉拉邦一家三级医院的经验
IF 2
Vettakkara Km Niyas, Sivankom D Rahulan, Rajalakshmi Arjun, Aswathy Sasidharan
{"title":"ICU-acquired Candidemia in COVID-19 Patients: An Experience from a Tertiary Care Hospital in Kerala, South India.","authors":"Vettakkara Km Niyas,&nbsp;Sivankom D Rahulan,&nbsp;Rajalakshmi Arjun,&nbsp;Aswathy Sasidharan","doi":"10.5005/jp-journals-10071-23980","DOIUrl":"https://doi.org/10.5005/jp-journals-10071-23980","url":null,"abstract":"<p><p><b>How to cite this article:</b> Niyas VKM, Rahulan SD, Arjun R, Sasidharan A. ICU-acquired Candidemia in COVID-19 Patients: An Experience from a Tertiary Care Hospital in Kerala, South India. Indian J Crit Care Med 2021;25(10):1207-1208.</p>","PeriodicalId":520643,"journal":{"name":"Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine","volume":" ","pages":"1207-1208"},"PeriodicalIF":2.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c3/15/ijccm-25-1207.PMC8645825.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39733794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Effect of Early Administration of Vitamin D on Clinical Outcome in Critically Ill Sepsis Patients: A Randomized Placebo-controlled Trial. 早期给予维生素D对危重脓毒症患者临床结局的影响:一项随机安慰剂对照试验。
IF 2
Amrita Bhattacharyya, Rajeshwari Subramaniam, Dalim K Baidya, Praveen Aggarwal, Naveet Wig
{"title":"Effect of Early Administration of Vitamin D on Clinical Outcome in Critically Ill Sepsis Patients: A Randomized Placebo-controlled Trial.","authors":"Amrita Bhattacharyya,&nbsp;Rajeshwari Subramaniam,&nbsp;Dalim K Baidya,&nbsp;Praveen Aggarwal,&nbsp;Naveet Wig","doi":"10.5005/jp-journals-10071-23993","DOIUrl":"https://doi.org/10.5005/jp-journals-10071-23993","url":null,"abstract":"<p><strong>Background: </strong>Administration of vitamin D to unselected heterogeneous critically ill patients did not demonstrate outcome benefit. The current study was undertaken to identify if early administration of vitamin D can reduce intensive care unit (ICU) length of stay and improve clinical outcomes in critically ill patients with sepsis.</p><p><strong>Methods: </strong>This single-center randomized double-blind placebo-controlled trial was done in the ICU and emergency inpatient ward of a tertiary care teaching institute in New Delhi, India. A total of 126 adult patients aged 18 to 80 years of either sex diagnosed to have sepsis were included within 24 hours of admission to the hospital and randomized into vitamin D or placebo groups. The patients in the intervention group received vitamin D3 540,000 units dissolved in 45 mL of milk. The placebo group received 45 mL of milk.</p><p><strong>Results: </strong>The median length of ICU stay (8 vs 9 days; <i>p</i> = 0.32), median length of hospital stay (12 vs 12 days; <i>p</i> = 0.33), median duration of vasopressors requirement (4 vs 3 days; <i>p</i> = 0.84), median duration of mechanical ventilation (5 vs 7 days; <i>p</i> = 0.23), requirement of tracheostomy (34 vs 39%; <i>p</i> = 0.71), and 90-day mortality [35 vs 46%; <i>p</i> = 0.29; HR 0.72 (0.42-1.24)] were similar in vitamin D and placebo arm.A subgroup analysis in patients with severe vitamin D deficiency (vitamin D <12 ng/mL) revealed a significantly decreased incidence of tracheostomy (28 vs 57%; <i>p</i> = 0.04), a trend toward decreased 90-day mortality [34 vs 66%; <i>p</i> = 0.08; HR 0.44 (0.19-1.01)], and duration of mechanical ventilation (6 vs 11 days; <i>p</i> = 0.05) in patients receiving vitamin D.</p><p><strong>Conclusion: </strong>Administration of large-dose vitamin D within 24 hours of admission does not reduce the length of ICU stay in critically ill sepsis patients.</p><p><strong>How to cite this article: </strong>Bhattacharyya A, Subramaniam R, Baidya DK, Aggarwal P, Wig N. Effect of Early Administration of Vitamin D on Clinical Outcome in Critically Ill Sepsis Patients: A Randomized Placebo-controlled Trial. Indian J Crit Care Med 2021;25(10):1147-1154.</p>","PeriodicalId":520643,"journal":{"name":"Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine","volume":" ","pages":"1147-1154"},"PeriodicalIF":2.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bd/be/ijccm-25-1147.PMC8645802.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39821272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Phlegmonous Gastritis and Streptoccocal Toxic Shock Syndrome: An Almost Lethal Combination. 痰性胃炎和链球菌中毒性休克综合征:几乎致命的组合。
IF 2
Paramythiotou Elisabeth, Mitrakou Cornelia, Savva Athinna, Antoniadou Anastasia, Armaganidis Apostolos, Dimopoulos George
{"title":"Phlegmonous Gastritis and Streptoccocal Toxic Shock Syndrome: An Almost Lethal Combination.","authors":"Paramythiotou Elisabeth,&nbsp;Mitrakou Cornelia,&nbsp;Savva Athinna,&nbsp;Antoniadou Anastasia,&nbsp;Armaganidis Apostolos,&nbsp;Dimopoulos George","doi":"10.5005/jp-journals-10071-23997","DOIUrl":"https://doi.org/10.5005/jp-journals-10071-23997","url":null,"abstract":"<p><p>We report a case of phlegmonous gastritis in a 70-year-old woman without any predisposing factors, presenting with high fever, epigastric pain, and vomiting complicated by septic shock and multi-organ failure. The ultrasound and the computed tomography scan showed thickening of the stomach wall. <i>Streptococcus pyogenes</i> was isolated in the blood, thereby establishing the diagnosis of streptococcal toxic shock syndrome. An exploratory laparotomy excluded the need for a gastrectomy, and the patient was successfully treated with antibiotics. A short review of phlegmonous gastritis caused by <i>S. pyogenes</i> during the last 12 years is also presented. <b>How to cite this article:</b> Elisabeth P, Cornelia M, Athinna S, Anastasia A, Apostolos A, George D. Phlegmonous Gastritis and Streptoccocal Toxic Shock Syndrome: An Almost Lethal Combination. Indian J Crit Care Med 2021;25(10):1197-1200.</p>","PeriodicalId":520643,"journal":{"name":"Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine","volume":" ","pages":"1197-1200"},"PeriodicalIF":2.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/72/ijccm-25-1197.PMC8645801.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39733790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Reanalyzing the Mortality Analysis of COVID-19 Deaths in a Tertiary Care Center in India. 重新分析印度三级医疗中心COVID-19死亡病例的死亡率分析
IF 2
Abhijeet Anand, Reecha Panghal, Paridhi Kaler, Saurabh Saigal, Rajesh Panda, Saiteja Kodamanchili, Krishnkant Bhardwaj, T B Gowthaman
{"title":"Reanalyzing the Mortality Analysis of COVID-19 Deaths in a Tertiary Care Center in India.","authors":"Abhijeet Anand,&nbsp;Reecha Panghal,&nbsp;Paridhi Kaler,&nbsp;Saurabh Saigal,&nbsp;Rajesh Panda,&nbsp;Saiteja Kodamanchili,&nbsp;Krishnkant Bhardwaj,&nbsp;T B Gowthaman","doi":"10.5005/jp-journals-10071-23982","DOIUrl":"https://doi.org/10.5005/jp-journals-10071-23982","url":null,"abstract":"<p><p><b>How to cite this article:</b> Anand A, Panghal R, Kaler P, Saigal S, Panda R, Kodamanchili S, <i>et al</i>. Reanalyzing the Mortality Analysis of COVID-19 Deaths in a Tertiary Care Center in India. Indian J Crit Care Med 2021; 25(10):1211.</p>","PeriodicalId":520643,"journal":{"name":"Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine","volume":" ","pages":"1211"},"PeriodicalIF":2.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/dd/ijccm-25-1211.PMC8645815.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39733796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Characteristics and Outcomes of Critically Ill Neurological Patients with COVID-19 Infection in Neuro-intensive Care Unit: A Retrospective Study. 神经重症监护病房新冠肺炎感染神经危重症患者临床特点及转归回顾性研究
IF 2
Rohini M Surve, Rajeeb K Mishra, Soumya R Malla, Sriganesh Kamath, Dhritiman R Chakrabarti, Karthik Kulanthaivelu, Mahendranath Musunuru
{"title":"Clinical Characteristics and Outcomes of Critically Ill Neurological Patients with COVID-19 Infection in Neuro-intensive Care Unit: A Retrospective Study.","authors":"Rohini M Surve,&nbsp;Rajeeb K Mishra,&nbsp;Soumya R Malla,&nbsp;Sriganesh Kamath,&nbsp;Dhritiman R Chakrabarti,&nbsp;Karthik Kulanthaivelu,&nbsp;Mahendranath Musunuru","doi":"10.5005/jp-journals-10071-23989","DOIUrl":"https://doi.org/10.5005/jp-journals-10071-23989","url":null,"abstract":"<p><strong>Background: </strong>There are insufficient data about clinical outcomes in critically ill neurological patients with concomitant coronavirus disease (COVID-19). This study describes the clinical characteristics, predictors of mortality, and clinical outcomes in COVID-19-positive neurological patients managed in a dedicated COVID-19 neurointensive care unit (CNICU).</p><p><strong>Methods: </strong>This single-center, retrospective cohort study was conducted in critically ill neurological and neurosurgical patients with concomitant COVID-19 infection admitted to the CNICU at the National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, from July to November 2020. Patients' demographic, clinical, laboratory, imaging, treatment, and outcome data were retrieved from the manual and electronic medical records. Predictors of mortality and neurological outcome were identified using logistic regression.</p><p><strong>Results: </strong>During the study period, 50 COVID-19-positive neurological patients were admitted to the CNICU. Six patients were excluded from the analysis as they were managed in the CNICU for <24 hours. A poor outcome, defined as death or motor Glasgow Coma Scale <5 at hospital discharge, was observed in 34 of 44 patients (77.27%) with inhospital mortality in 26 of 44 patients (59%). Worst modified sequential organ failure assessment (MSOFA) score, lactate dehydrogenase maximum levels (LDH<sub>max</sub>), and lymphocyte count were predictors of inhospital mortality with an odds ratio (OR) of 1.88, 1.01, and 0.87, respectively, whereas worst MSOFA and LDH<sub>max</sub> levels were predictors for poor neurological outcome with OR of 1.99 and 1.01, respectively.</p><p><strong>Conclusions: </strong>Mortality is high in neurological patients with concomitant COVID-19 infection. Elevated inflammatory markers of COVID-19 suggest the role of systemic inflammation on clinical outcomes. Predictors of mortality and poor outcome were higher MSOFA score and elevated LDH levels. Additionally, lymphopenia was associated with mortality.</p><p><strong>How to cite this article: </strong>Surve RM, Mishra RK, Malla SR, Kamath S, Chakrabarti DR, Kulanthaivelu K, et al. Clinical Characteristics and Outcomes of Critically Ill Neurological Patients with COVID-19 Infection in Neuro-intensive Care Unit: A Retrospective Study. Indian J Crit Care Med 2021;25(10):1126-1132.</p>","PeriodicalId":520643,"journal":{"name":"Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine","volume":" ","pages":"1126-1132"},"PeriodicalIF":2.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/39/ijccm-25-1126.PMC8645809.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39821269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Plasma Exchange in Pediatric Intensive Care Unit: A Single-center Experience. 儿科重症监护病房的治疗性血浆交换:单中心经验。
IF 2
Serkan Özsoylu, Adem Dursun, Binnaz Çelik
{"title":"Therapeutic Plasma Exchange in Pediatric Intensive Care Unit: A Single-center Experience.","authors":"Serkan Özsoylu,&nbsp;Adem Dursun,&nbsp;Binnaz Çelik","doi":"10.5005/jp-journals-10071-23985","DOIUrl":"https://doi.org/10.5005/jp-journals-10071-23985","url":null,"abstract":"<p><strong>Aim and objective: </strong>To examine the clinical characteristics, indications, and complications of patients undergoing therapeutic plasma exchange (TPE) in our pediatric intensive care unit (PICU).</p><p><strong>Materials and methods: </strong>Patients who underwent therapeutic plasma exchange between January 2018 and January 2020 in the PICU were included in the study. Demographic, clinical, and laboratory data of patients were obtained retrospectively from medical records. A venous catheter was placed into subclavian, femoral, or jugular veins. The number of plasmapheresis sessions for each patient was determined by observing the course of the disease and clinical improvement. Patients were monitored for vital signs during the plasmapheresis process. Complications directly associated with TPE were recorded.</p><p><strong>Results: </strong>During the 2-year study period, 105 TPE sessions were performed in 25 patients (15 males/10 females). The median age was 84 months (6-204), and the median body weight was 32 kg (8-75). Renal disorders and sepsis were the most common group, and about 48% of patients were in these groups. The most common diagnoses were sepsis with multi-organ dysfunction syndrome in seven patients and followed by hemolytic uremic syndrome (five patients) and Guillain-Barre syndrome (three patients). Nausea (6.7%) and hypocalcemia (6.7%) were the most common complications of patients associated with the procedure. Premature discontinuation of the procedure were not seen due to complications. Complications were treated with symptomatic therapy.</p><p><strong>Conclusion: </strong>TPE is an effective treatment that can be safely used for pediatric patients with developments in PICUs. Nevertheless, TPE should be performed by experienced staff at a specialized center to minimize the risk of complications.</p><p><strong>How to cite this article: </strong>Özsoylu S, Dursun A, <i>Ç</i>elik B<i>.</i> Therapeutic Plasma Exchange in Pediatric Intensive Care Unit: A Single-center Experience. Indian J Crit Care Med 2021;25(10):1189-1192.</p>","PeriodicalId":520643,"journal":{"name":"Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine","volume":" ","pages":"1189-1192"},"PeriodicalIF":2.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/6a/ijccm-25-1189.PMC8645823.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39732342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
INDICAPS II: A Bird's Eye View of the Indian Intensive Care Landscape. INDICAPS II:鸟瞰印度重症监护景观。
IF 2
Raj K Mani
{"title":"INDICAPS II: A Bird's Eye View of the Indian Intensive Care Landscape.","authors":"Raj K Mani","doi":"10.5005/jp-journals-10071-24003","DOIUrl":"https://doi.org/10.5005/jp-journals-10071-24003","url":null,"abstract":"<p><p><b>How to cite this article:</b> Mani RK. INDICAPS II: A Bird's Eye View of the Indian Intensive Care Landscape. Indian J Crit Care Med 2021; 25(10):1087-1088.</p>","PeriodicalId":520643,"journal":{"name":"Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine","volume":" ","pages":"1087-1088"},"PeriodicalIF":2.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/f7/ijccm-25-1087.PMC8645803.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39732958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Epidemiology and Predictors of Hospital Outcomes of Critically Ill Pediatric Oncology Patients: A Retrospective Study. 儿科肿瘤危重患者的流行病学和预后预测因素:一项回顾性研究。
IF 2
Shilpushp J Bhosale, Malini Joshi, Vijaya P Patil, Amol T Kothekar, Sheila Nainan Myatra, Jigeeshu V Divatia, Atul P Kulkarni
{"title":"Epidemiology and Predictors of Hospital Outcomes of Critically Ill Pediatric Oncology Patients: A Retrospective Study.","authors":"Shilpushp J Bhosale,&nbsp;Malini Joshi,&nbsp;Vijaya P Patil,&nbsp;Amol T Kothekar,&nbsp;Sheila Nainan Myatra,&nbsp;Jigeeshu V Divatia,&nbsp;Atul P Kulkarni","doi":"10.5005/jp-journals-10071-23984","DOIUrl":"https://doi.org/10.5005/jp-journals-10071-23984","url":null,"abstract":"<p><strong>Background: </strong>The number of pediatric oncology patients admitted to the intensive care unit (ICU) has increased, and their hospital outcomes are improving. Since scarce data are available about this patient population, we conducted this retrospective study to evaluate the epidemiology and predictors of hospital outcomes.</p><p><strong>Materials and methods: </strong>We included all children with cancers who were admitted to our ICU over 1 year. We excluded children admitted after elective surgery and those following bone marrow transplant. We collected data about demographics, admission diagnosis, type of malignancies, and ICU interventions. The primary outcome was the hospital outcome. The secondary outcomes were ICU length of stay (LOS), and ICU and hospital mortality. We analyzed the predictors of hospital outcome.</p><p><strong>Results: </strong>Two hundred pediatric oncology patients were admitted from November 1, 2014 to October 30, 2015. Seventy-eight children had solid organ malignancies, and the rest had hematological malignancies. Hematooncology malignancy patients had significantly higher hospital mortality than those with solid organ malignancies. (61.5 vs 34.6%, <i>p</i> = 0.015). On multivariate regression analysis, mechanical ventilation [odds ratio (OR), 14.64; 95% confidence interval (CI): 1.23-165.05; <i>p</i> <0.030], inotropes (OR, 9.81; 95% CI: 1.222-78.66; <i>p</i> <0.032), and the presence of coagulopathy (OR, 3.86; 95% CI: 1.568-9.514; <i>p</i> <0.003) were independent predictors of hospital mortality.</p><p><strong>Conclusion: </strong>In this retrospective cohort of 200 children with malignancies, we found that children with hematologic cancer had significantly higher hospital mortality as compared to those with solid tumors. The need for mechanical ventilation, use of inotrope infusion, and coagulopathy were independent predictors of mortality.</p><p><strong>How to cite this article: </strong>Bhosale SJ, Joshi M, Patil VP, Kothekar AT, Myatra SN, Divatia JV, <i>et al</i>. Epidemiology and Predictors of Hospital Outcomes of Critically Ill Pediatric Oncology Patients: A Retrospective Study. Indian J Crit Care Med 2021;25(10):1183-1188.</p>","PeriodicalId":520643,"journal":{"name":"Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine","volume":" ","pages":"1183-1188"},"PeriodicalIF":2.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/b8/ijccm-25-1183.PMC8645808.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39732341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Factors Affecting the Time to First Dose Antibiotic in Sepsis in Acute Emergency. 影响急性急诊脓毒症患者首次给药时间的因素。
IF 2
Joshua Vijay Joseph, Mamta Madhiyazhagan, Ramgopal Roshan, Sudhakar Geratala Dhanapal, Sivanandan Arul, Kundavaram Paul Prabhakar Abhilash
{"title":"Factors Affecting the Time to First Dose Antibiotic in Sepsis in Acute Emergency.","authors":"Joshua Vijay Joseph,&nbsp;Mamta Madhiyazhagan,&nbsp;Ramgopal Roshan,&nbsp;Sudhakar Geratala Dhanapal,&nbsp;Sivanandan Arul,&nbsp;Kundavaram Paul Prabhakar Abhilash","doi":"10.5005/jp-journals-10071-23994","DOIUrl":"https://doi.org/10.5005/jp-journals-10071-23994","url":null,"abstract":"<p><strong>Background: </strong>The Surviving Sepsis Campaign recommends the administration of antibiotics within 1 hour of triage time in sepsis patients. The purpose of this study was to determine the factors affecting the time to first dose antibiotics in sepsis patients presenting to the emergency department (ED).</p><p><strong>Methods: </strong>We conducted a prospective observational study on factors affecting the time to first dose antibiotics in patients with sepsis presenting to the ED over a period of 7 months (July 2019 to January 2020). The purpose of this study was to determine the factors affecting the time to first dose antibiotics in sepsis patients.</p><p><strong>Results: </strong>During the study period, a total of 410 patients with a mean age of 51.6 years were presented to the ED with sepsis. Majority was triaged to priority 1 (84.8%). The median door to antibiotic time was 50 minutes (IQR, 40-90). Two-thirds (68%) of the patients (279) received antibiotics within 60 minutes. The blood culture positivity rate was 22.9%, and the contamination rate was 6%. The most common factors for the delay were atypical presentation (36.6%) and unknown focus of infection (36.6%). Triage to non-acute areas of the ED (priority 2) was associated with delayed antibiotic administration [odds ratio (OR), 7.3; 95% confidence interval (CI), 4.03-13.36; <i>p</i>-value <0.001]. Patients presented with cellulitis and necrotizing soft tissue infection (NSTI) had received antibiotics within an hour compared to other diagnoses (18.3 vs 8.4%; OR, 2.4; 95% CI, 1.2-4.9; <i>p</i> = 0.009).</p><p><strong>Conclusion: </strong>Two-thirds of our patients received their first dose of antibiotics within an hour of presentation to the ED. Triage to lower priorities was an independent risk factor for delay in first-dose antibiotic administration, and patients presented with an obvious focus of infections like cellulitis and NSTI received their first dose of antibiotic much earlier when compared to other diagnoses.</p><p><strong>How to cite this article: </strong>Joseph JV, Madhiyazhagan M, Roshan R, Dhanapal SG, Arul S, Abhilash KPP. Factors Affecting the Time to First Dose Antibiotic in Sepsis in Acute Emergency. Indian J Crit Care Med 2021;25(10):1155-1160.</p>","PeriodicalId":520643,"journal":{"name":"Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine","volume":" ","pages":"1155-1160"},"PeriodicalIF":2.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b6/46/ijccm-25-1155.PMC8645811.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39732336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Autoimmune Hemolytic Anemia in Intensive Care Unit and Blood Transfusion: Lesson Learnt-A Case Report. 重症监护病房自身免疫性溶血性贫血和输血:经验教训- 1例报告
IF 2
Sunil K Garg, Pragya Garg
{"title":"Autoimmune Hemolytic Anemia in Intensive Care Unit and Blood Transfusion: Lesson Learnt-A Case Report.","authors":"Sunil K Garg,&nbsp;Pragya Garg","doi":"10.5005/jp-journals-10071-23999","DOIUrl":"https://doi.org/10.5005/jp-journals-10071-23999","url":null,"abstract":"<p><p>Clinicians are often in a difficult situation while managing severe anemia due to autoimmune hemolysis in intensive care unit (ICU). It is hard to get properly cross-matched blood due to the presence of autoantibody in the patient's serum. Still, such patients should not be devoid of transfusion. <b>How to cite this article:</b> Garg SK, Garg P. Autoimmune Hemolytic Anemia in Intensive Care Unit and Blood Transfusion: Lesson Learnt-A Case Report. Indian J Crit Care Med 2021;25(10):1201-1202.</p>","PeriodicalId":520643,"journal":{"name":"Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine","volume":" ","pages":"1201-1202"},"PeriodicalIF":2.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7e/22/ijccm-25-1201.PMC8645826.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39733791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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