Geriatrics (Basel, Switzerland)最新文献_第3页

Cataract Surgery during the COVID-19 Pandemic: Insights from a Greek Tertiary Hospital. COVID-19大流行期间的白内障手术:来自希腊三级医院的见解。

IF 2.3

Geriatrics (Basel, Switzerland) Pub Date : 2022-07-26 DOI: 10.3390/geriatrics7040077

Sevasti Tsironi, Dimitrios Kavvadas, Georgios Delis, Alexandra Bekiaridou, Viktoria Kapourani, Frageskos Loizou, Panagiota-Sofia Apostolidou, Konstantina Misiou, Efstratios Theofrastou, Thaleia Panakleridou, Eleni Psimenidou, Anastasia Sarafi, Elie Fadel, Sofia Karachrysafi

{"title":"Cataract Surgery during the COVID-19 Pandemic: Insights from a Greek Tertiary Hospital.","authors":"Sevasti Tsironi, Dimitrios Kavvadas, Georgios Delis, Alexandra Bekiaridou, Viktoria Kapourani, Frageskos Loizou, Panagiota-Sofia Apostolidou, Konstantina Misiou, Efstratios Theofrastou, Thaleia Panakleridou, Eleni Psimenidou, Anastasia Sarafi, Elie Fadel, Sofia Karachrysafi","doi":"10.3390/geriatrics7040077","DOIUrl":"https://doi.org/10.3390/geriatrics7040077","url":null,"abstract":"Background: COVID-19 has affected everyday clinical practice, having an impact on the quality of healthcare provided, even in eye clinic departments. The aim of this study is to evaluate the consequences of this worldwide pandemic on cataract surgery in a Greek tertiary university hospital.Methods: A total of 805 patients were included in this study. The number of cataract surgeries (CS), the type, the unilateral or bilateral appearance as well as the stage of cataract were recorded for the months between January and June 2019 (pre-COVID period) and compared with the same period in 2021 (during the pandemic outbreak) in the Department of Ophthalmology of Thessaloniki General Hospital G. Papanikolaou.Results: A significant reduction in the number of CS as well as a significant increase in advanced and/or bilateral cataracts in 2021 compared to the pre-COVID period were observed.Conclusion: The COVID-19 pandemic has affected equally the value of ophthalmic interventions as well as the patients' quality of life, being a powerful reminder of the significant physical and psychological benefits of CS, especially for older adults and patients with comorbidities.","PeriodicalId":520631,"journal":{"name":"Geriatrics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40635905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The Prevalence of Low Handgrip Strength and Its Predictors among Outpatient Older Adults in a Tertiary Care Setting: A Cross-Sectional Study. 三级医疗机构门诊老年人握力不足的患病率及其预测因素:一项横断面研究。

IF 2.3

Geriatrics (Basel, Switzerland) Pub Date : 2022-07-08 DOI: 10.3390/geriatrics7040074

Manchumad Manjavong, Apichart So-Ngern, Panita Limpawattana, Natapong Manomaiwong, Thanisorn Kamsuanjig, Chudapha Khammak, Pongsak Chokkhatiwat, Kamolthorn Srisuwannakit

{"title":"The Prevalence of Low Handgrip Strength and Its Predictors among Outpatient Older Adults in a Tertiary Care Setting: A Cross-Sectional Study.","authors":"Manchumad Manjavong, Apichart So-Ngern, Panita Limpawattana, Natapong Manomaiwong, Thanisorn Kamsuanjig, Chudapha Khammak, Pongsak Chokkhatiwat, Kamolthorn Srisuwannakit","doi":"10.3390/geriatrics7040074","DOIUrl":"https://doi.org/10.3390/geriatrics7040074","url":null,"abstract":"Background: Low muscle strength is linked to several adverse health outcomes. However, there are limited data regarding its prevalence and associated factors in Thai older adults. This study aimed to fill that gap. Methods: This cross-sectional study was conducted with patients aged ≥ 60 years at the outpatient clinic of the internal medicine department of a tertiary care hospital from April 2020 to December 2021. Patient characteristics were collected, and a handgrip dynamometer was used to measure handgrip strength (HGS). Low HGS was defined according to the 2019 recommendations of the Asian Working Group for Sarcopenia. Results: In total, 198 patients were recruited. The prevalence of low HGS was 51%. Median HGS was 17.8 kg and 27.7 kg in women and men, respectively. Every age per year increase, greater number of medications of any type, and lower Montreal Cognitive Assessment (MoCA) score were independent factors associated with low HGS, with adjusted odds ratios of 1.1, 1.2, and 0.9, respectively. Conclusions: Low HGS was prevalent among older patients in this setting, indicating a high degree of possible sarcopenia. As there were some modifiable factors associated with low HGS, routine measurement, medication review, and cognitive evaluation are recommended for early diagnosis and management.","PeriodicalId":520631,"journal":{"name":"Geriatrics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40634394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Role of Cognitive Performance and Physical Functions in the Association between Age and Gait Speed: A Mediation Study. 认知表现和身体功能在年龄和步态速度之间的作用:一项中介研究。

IF 2.3

Geriatrics (Basel, Switzerland) Pub Date : 2022-07-07 DOI: 10.3390/geriatrics7040073

Marcelo de Maio Nascimento, Élvio Rúbio Gouveia, Bruna R Gouveia, Adilson Marques, Priscila Marconcin, Cíntia França, Andreas Ihle

{"title":"The Role of Cognitive Performance and Physical Functions in the Association between Age and Gait Speed: A Mediation Study.","authors":"Marcelo de Maio Nascimento, Élvio Rúbio Gouveia, Bruna R Gouveia, Adilson Marques, Priscila Marconcin, Cíntia França, Andreas Ihle","doi":"10.3390/geriatrics7040073","DOIUrl":"https://doi.org/10.3390/geriatrics7040073","url":null,"abstract":"Introduction: With vulnerable aging, gait speed (GS) undergoes progressive changes, becoming slower. In this process, cognitive performance (CP) and physical function (PF) both play an important role. This study aims (1) to investigate the association between CP and PF with GS and (2) to examine whether CP and PF mediate the association between age and GS in a large sample of Brazilian older adults.Methods: A cross-sectional study analyzed 697 individuals (mean age 70.35 ± 6.86 years) from the state of Amazonas. The CP was evaluated by the COGTEL test battery, PF by the Senior Fitness Test battery, and GS with the 50-foot Walk Test.Results: Older adults with a lower CP and PF had a 70% and 86% chance of slow GS, respectively. When CP and PF were placed simultaneously as mediators, the direct effect estimated by the model revealed a non-significant relationship between age and GS. Specifically, CP and PF mediated the association between age and GS, at approximately 12% and 98%, respectively.Conclusions: CP and PF show the potential to estimate GS performance among older adults. Moreover, CP and PF indicated a negative and direct association between age and slow GS, especially PF.","PeriodicalId":520631,"journal":{"name":"Geriatrics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40634393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Influencing the Data Communication Equipment Competence in Korean Older People. 影响韩国老年人数据通信设备使用能力的因素。

IF 2.3

Geriatrics (Basel, Switzerland) Pub Date : 2022-06-17 DOI: 10.3390/geriatrics7030070

HeeYoung Kim

{"title":"Factors Influencing the Data Communication Equipment Competence in Korean Older People.","authors":"HeeYoung Kim","doi":"10.3390/geriatrics7030070","DOIUrl":"https://doi.org/10.3390/geriatrics7030070","url":null,"abstract":"The purpose of this study was to identify the most vulnerable group among older Korean adults regarding information literacy. Once that was identified, the study aimed to provide basic data for developing strategies to improve information literacy by investigating the factors that influence the ability to utilize the Data Communication Equipment (DCE). The subjects included 10,073 older adults from the 10,299 participants of the 2017 Korean National Survey of Older Adults. The mean age of the older people was 74.06 years from a range of 65 to 106 years old. This study excluded the 216 individuals who did not complete the survey. The data were analyzed using the SPSS 18.0 program. A univariate analysis was performed to identify the most vulnerable group with regard to DCE competence. To investigate the factors that influence DCE competence, a logistic regression analysis was performed on the significant variables in the univariate analysis, while the nominal variables were treated as dummies. Senior citizens in Korea were less able to utilize DCE when they had higher ages, lower education levels, were women, lived alone, lower incomes, decreased sensory function, decreased cognitive function, negative value of learning, no lifelong learning, and smaller social networks. The factors influencing DCE competence in older adults were as follows: age, education level, income level, health status, cognitive function, social networks, lifelong learning, and the value of learning. For DCE competence in older adults to be effectively improved, adequate support must be provided to the vulnerable group. Furthermore, support for personalized DCE utilization seems essential and should consider a person's age, education level, income, health status, cognitive function, social networks, lifelong learning and the value of learning.","PeriodicalId":520631,"journal":{"name":"Geriatrics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40255014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caring for Homebound Veterans during COVID-19 in the U.S. Department of Veterans Affairs Medical Foster Home Program. 在美国退伍军人事务部医疗寄养家庭计划中照顾COVID-19期间在家的退伍军人。

IF 2.3

Geriatrics (Basel, Switzerland) Pub Date : 2022-06-15 DOI: 10.3390/geriatrics7030066

Leah M Haverhals, Chelsea E Manheim, Maya Katz, Cari R Levy

{"title":"Caring for Homebound Veterans during COVID-19 in the U.S. Department of Veterans Affairs Medical Foster Home Program.","authors":"Leah M Haverhals, Chelsea E Manheim, Maya Katz, Cari R Levy","doi":"10.3390/geriatrics7030066","DOIUrl":"https://doi.org/10.3390/geriatrics7030066","url":null,"abstract":"The onset of the COVID-19 pandemic made older, homebound adults with multiple chronic conditions increasingly vulnerable to contracting the virus. The United States (US) Department of Veterans Affairs (VA) Medical Foster Home (MFH) program cares for such medically complex veterans residing in the private homes of non-VA caregivers rather than institutional care settings like nursing homes. In this qualitative descriptive study, we assessed adaptations to delivering safe and effective health care during the early stages of the pandemic for veterans living in rural MFHs. From December 2020 to February 2021, we interviewed 37 VA MFH care providers by phone at 16 rural MFH programs across the US, including caregivers, program coordinators, and VA health care providers. Using both inductive and deductive approaches to thematic analysis, we identified themes reflecting adaptations to caring for rural MFH veterans, including care providers rapidly increased communication and education to MFH caregivers while prioritizing veteran safety. Telehealth visits also increased, MFH veterans were prioritized for in-home COVID-19 vaccinations, and strategies were applied to mitigate the social isolation of veterans and caregivers. The study findings illustrate the importance of clear, regular communication and intentional care coordination to ensure high-quality care for vulnerable, homebound populations during crises like the COVID-19 pandemic.","PeriodicalId":520631,"journal":{"name":"Geriatrics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40255012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Exploring Meal Provision and Mealtime Challenges for Aged Care Residents Consuming Texture-Modified Diets: A Mixed Methods Study. 探索膳食供应和用餐时间的挑战，为老年人消费结构调整饮食:一项混合方法研究。

IF 2.3

Geriatrics (Basel, Switzerland) Pub Date : 2022-06-15 DOI: 10.3390/geriatrics7030067

Xiaojing Wu, Lina Yousif, Anna Miles, Andrea Braakhuis

{"title":"Exploring Meal Provision and Mealtime Challenges for Aged Care Residents Consuming Texture-Modified Diets: A Mixed Methods Study.","authors":"Xiaojing Wu, Lina Yousif, Anna Miles, Andrea Braakhuis","doi":"10.3390/geriatrics7030067","DOIUrl":"https://doi.org/10.3390/geriatrics7030067","url":null,"abstract":"Dysphagia has become more prevalent with age. Thus, the demand for texture-modified diets (TMDs) has increased. While the nutritional perspectives have been studied, the provision of TMDs and mealtime practice has received less attention. This study aimed to explore the TMD provision and mealtime challenges of residents requiring TMDs in aged care facilities. The study was conducted across five aged care facilities using a mixed methods design involving 14 TMD menu audits by a foodservice dietitian, 15 mealtime observations, and semi-structured interviews with residents and staff (n = 18). TMD menus failed to meet all nutrition requirements and foodservice and clinical standards based on the dietitian NZ foodservice and nutrition audit tool. A content analysis offered three main themes: (1) Foodservice production. Inconsistent quality and meal portions were observed. The variety, choice, and portion size of TMDs required improvement based on the residents' preferences; (2) Serving procedures. There was a lack of standardisation of meal distribution and feeding assistance; and (3) Dining environment. The dining room set-up varied across facilities, and residents expressed different preferences towards the dining environment. There is a need to improve staff awareness of mealtime consistency and optimise feeding assistance. The dining environment should be individualised to accommodate residents' psychosocial needs. Standardised policies and continuous training can facilitate quality mealtime implementation.","PeriodicalId":520631,"journal":{"name":"Geriatrics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40255013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Impact of Perioperative and Predisposing Risk Factors on the Development of Postoperative Delirium and a Possible Gender Difference. 围手术期及诱发因素对术后谵妄发生的影响及可能的性别差异。

IF 2.3

Geriatrics (Basel, Switzerland) Pub Date : 2022-06-14 DOI: 10.3390/geriatrics7030065

Maria Wittmann, Andrea Kirfel, Diane Jossen, Andreas Mayr, Jan Menzenbach

{"title":"The Impact of Perioperative and Predisposing Risk Factors on the Development of Postoperative Delirium and a Possible Gender Difference.","authors":"Maria Wittmann, Andrea Kirfel, Diane Jossen, Andreas Mayr, Jan Menzenbach","doi":"10.3390/geriatrics7030065","DOIUrl":"https://doi.org/10.3390/geriatrics7030065","url":null,"abstract":"(1) Background: Postoperative delirium (POD) is an undesirable event especially for older patients after surgery. Perioperative risks for POD development are multiple, but gender differences are still poorly considered. In this observational study, predisposing and precipitating risk factors of POD and the possible gender influence are distinguished. (2) Methods: This observational prospective trial enrolled 1097 patients in a tertiary hospital from September 2018 until October 2019. POD was considered positive, if one of the tests Confusion Assessment Method for ICU (CAM-ICU) or Confusion Assessment Method (CAM), 4 'A's Test (4AT) or Delirium Observation Screening (DOS) scale was positive on one of five assessment days. (3) Results: POD incidence was 23.5% and the mean age of study population was 72.3 ± 7.3 years. The multiple logistic regression model showed a significant impact of age (Odds Ratio (OR) 1.74; 95% Confidence Interval (CI): 1.37-2.22), American Society of Anesthesiologists (ASA) (OR 1.67; 95% CI: 1.25-2.26), surgery risk (OR 2.10; 95% CI: 1.52-2.95) and surgery duration (OR 1.17; 95% CI: 1.07-1.28), ventilation time (OR 1.64; 95% CI: 1.27-2.24), as well as the male sex (OR 1.74; 95% CI: 1.37-2.22) on POD risk. (4) Conclusions: Perioperative and predisposing risk factors had an impact on the development of POD. The influence of male sex should be considered in future research.","PeriodicalId":520631,"journal":{"name":"Geriatrics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40255011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Impact of Hydrotherapy on Antioxidant Enzyme Activity in an Elderly Population. 水疗对老年人抗氧化酶活性的影响。

IF 2.3

Geriatrics (Basel, Switzerland) Pub Date : 2022-06-13 DOI: 10.3390/geriatrics7030064

Ana Valado, Stephanie Fortes, Márcia Morais, Rogério Barreira, João Paulo Figueiredo, Armando Caseiro

{"title":"Impact of Hydrotherapy on Antioxidant Enzyme Activity in an Elderly Population.","authors":"Ana Valado, Stephanie Fortes, Márcia Morais, Rogério Barreira, João Paulo Figueiredo, Armando Caseiro","doi":"10.3390/geriatrics7030064","DOIUrl":"https://doi.org/10.3390/geriatrics7030064","url":null,"abstract":"Oxidative stress is defined as the imbalance between reactive species and antioxidant agents. One of the effects of oxidative stress is the normal process of cellular aging that stems from the accumulation of tissue damage. Epidemiological studies show that regular physical exercise prevents the injuries caused by aging. The objective was to evaluate whether the practice of hydrotherapy, in an elderly population, positively influenced the activity of the enzymes superoxide dismutase, glutathione peroxidase and reductase that act by reducing reactive species in the body. The study involved 37 participants aged ≥ 60 years, of both sexes, divided into experimental and control groups. The experimental group performed 15 hydrotherapy sessions. Enzyme activity was evaluated in two moments: T0-before the first session, and T1-after the last session, with blood collections conducted in both. In T1, there was a significant increase vs. T0 of glutathione peroxidase activity (57.72 ± 19.99 vs. 48.14 ± 17.22 U/g Hb) and glutathione reductase activity (100.18 ± 30.85 vs. 78.44 ± 21.26 U/L). Both sexes tended to show higher values at T1. We concluded that hydrotherapy proved to be a positive stimulus for the enzymatic antioxidant activity of the elderly, suggesting that a regular and moderate practice of physical exercise induces better and higher quality of life.","PeriodicalId":520631,"journal":{"name":"Geriatrics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40253505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Nurses' Death Anxiety and Ageism towards Older Adults Amid the COVID-19 Pandemic: The Moderating Role of Symbolic Immortality. COVID-19大流行期间护士的死亡焦虑和对老年人的年龄歧视:象征性不朽的调节作用

IF 2.3

Geriatrics (Basel, Switzerland) Pub Date : 2022-06-09 DOI: 10.3390/geriatrics7030063

Mohammad Rababa, Shatha Al-Sabbah, Dania Bani-Hamad

引用次数: 1

Cognitive Decline in Older People with Multiple Sclerosis-A Narrative Review of the Literature. 老年多发性硬化症患者认知能力下降——文献综述

IF 2.3

Geriatrics (Basel, Switzerland) Pub Date : 2022-06-05 DOI: 10.3390/geriatrics7030061

Hsueh-Sheng Chiang, Alka Khera, Barbara E Stopschinski, Olaf Stuve, John Hart, Brendan Kelley, Trung Nguyen

{"title":"Cognitive Decline in Older People with Multiple Sclerosis-A Narrative Review of the Literature.","authors":"Hsueh-Sheng Chiang, Alka Khera, Barbara E Stopschinski, Olaf Stuve, John Hart, Brendan Kelley, Trung Nguyen","doi":"10.3390/geriatrics7030061","DOIUrl":"https://doi.org/10.3390/geriatrics7030061","url":null,"abstract":"Several important questions regarding cognitive aging and dementia in older people with multiple sclerosis (PwMS) are the focus of this narrative review: Do older PwMS have worse cognitive decline compared to older people without MS? Can older PwMS develop dementia or other neurodegenerative diseases such as Alzheimer's disease (AD) that may be accelerated due to MS? Are there any potential biomarkers that can help to determine the etiology of cognitive decline in older PwMS? What are the neural and cellular bases of cognitive aging and neurodegeneration in MS? Current evidence suggests that cognitive impairment in MS is distinguishable from that due to other neurodegenerative diseases, although older PwMS may present with accelerated cognitive decline. While dementia is prevalent in PwMS, there is currently no consensus on defining it. Cerebrospinal fluid and imaging biomarkers have the potential to identify disease processes linked to MS and other comorbidities-such as AD and vascular disease-in older PwMS, although more research is required. In conclusion, one should be aware that multiple underlying pathologies can coexist in older PwMS and cause cognitive decline. Future basic and clinical research will need to consider these complex factors to better understand the underlying pathophysiology, and to improve diagnostic accuracy.","PeriodicalId":520631,"journal":{"name":"Geriatrics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40253503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2