European psychiatry : the journal of the Association of European Psychiatrists最新文献

{"title":"The association between glutamate, GABA, and anterior cingulate connectivity in schizophrenia spectrum disorders: Implications for symptom domains.","authors":"Jonatan Malmros, Simon Cervenka, Linda Steinholtz, Jan Weis, Robert Bodén, Jonas Persson","doi":"10.1192/j.eurpsy.2026.12212","DOIUrl":"https://doi.org/10.1192/j.eurpsy.2026.12212","url":null,"abstract":"","PeriodicalId":520621,"journal":{"name":"European psychiatry : the journal of the Association of European Psychiatrists","volume":" ","pages":"1-22"},"PeriodicalIF":6.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the burden of cognitive impairment associated with schizophrenia: results from the international LUCIA study.","authors":"Christoph U Correll, Silvana Galderisi, Maite Artés, Ana Fernández, Bregt Kappelhoff, Walter D Lawhorn, Sébastien Tulliez, Satoru Ikezawa, Åsa Konradsson-Geuken, Sheykhi Hagaieg Morgane, Kari Skau, Monique van der Weijden-Germann, Robert A McCutcheon","doi":"10.1192/j.eurpsy.2026.12208","DOIUrl":"https://doi.org/10.1192/j.eurpsy.2026.12208","url":null,"abstract":"","PeriodicalId":520621,"journal":{"name":"European psychiatry : the journal of the Association of European Psychiatrists","volume":" ","pages":"1-38"},"PeriodicalIF":6.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and Clinical Baseline Characteristics from the Spanish SURVIVE Prospective Cohort Study on Suicide Attempts.","authors":"Victor Perez, Matilde Elices, Carlos Schmidt, Jorge Andreo-Jover, Wala Ayad-Ahmed, Maria Teresa Bobes-Bascarán, María Ángeles Botí, Ana Isabel Cebria Meca, Manuel Canal-Rivero, Irene Canosa, Benedicto Crespo-Facorro, Alejandro de la Torre-Luque, Marina Díaz-Marsá, Jennifer Fernández-Fernández, Ainoa García-Fernandez, Iria Grande, Luis Jiménez-Treviño, Ana González-Pinto, Diego J Palao Vidal, Ángela Palao-Tarrero, Andres Pemau, Ivan Perez-Diez, Beatriz Orgaz, Natalia Roberto, Pilar Alejandra Saiz","doi":"10.1192/j.eurpsy.2025.10143","DOIUrl":"https://doi.org/10.1192/j.eurpsy.2025.10143","url":null,"abstract":"","PeriodicalId":520621,"journal":{"name":"European psychiatry : the journal of the Association of European Psychiatrists","volume":" ","pages":"1-24"},"PeriodicalIF":6.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Medicine in Mental Health: Applications, Challenges, and Recommendations.","authors":"Celso Arango, Eduard Vieta, Lourdes Fañañás, Philippe Courtet, Livia De Picker, Martien J H Kas, Peter Kéri, Pavel Mohr, Inez Myin-Germeys, Brenda Wjh Penninx, Andreas Reif, Martina Rojnic Kuzman, Marion Leboyer, Andrea Fiorillo, Ana Catalan","doi":"10.1192/j.eurpsy.2026.12210","DOIUrl":"https://doi.org/10.1192/j.eurpsy.2026.12210","url":null,"abstract":"","PeriodicalId":520621,"journal":{"name":"European psychiatry : the journal of the Association of European Psychiatrists","volume":" ","pages":"1-30"},"PeriodicalIF":6.7,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing Participation of People with Thought Disorder in Clinical Research.","authors":"Lena Palaniyappan, Sylvain Baillet, Valentina Bambini, Etienne Barou-Laforie, Marta Bosia, Oli Delgaram-Nejad, Hashwin Ganesh, Ranjini Garani, Neil Harrison, Vegas Hodgins, Ridha Joober, Gina Kuperberg, Tilo Kircher, Chantal Murthy, Susan Rossell, Krish D Singh, Iris E Sommer, Sunny X Tang, Debra Titone, Alban Voppel, Tosh Watson, Irnes Zeljkovic","doi":"10.1192/j.eurpsy.2026.12211","DOIUrl":"https://doi.org/10.1192/j.eurpsy.2026.12211","url":null,"abstract":"","PeriodicalId":520621,"journal":{"name":"European psychiatry : the journal of the Association of European Psychiatrists","volume":" ","pages":"1-36"},"PeriodicalIF":6.7,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life in early-phase schizophrenia patients starting treatment with long-acting injectable vs. oral antipsychotic drugs: data from the European Long-acting Antipsychotics in Schizophrenia Trial (EULAST).","authors":"Anna-Theresa Schulze, Lena Tschiderer, Fabienne Post, Beatrice Frajo-Apor, Wolfgang Fleischhacker, Michael Davidson, Alex Hofer","doi":"10.1192/j.eurpsy.2026.12209","DOIUrl":"https://doi.org/10.1192/j.eurpsy.2026.12209","url":null,"abstract":"","PeriodicalId":520621,"journal":{"name":"European psychiatry : the journal of the Association of European Psychiatrists","volume":" ","pages":"1-27"},"PeriodicalIF":6.7,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental alcohol supply in early childhood and adolescent drinking: Evidence from a prospective cohort - ADDENDUM.","authors":"Albert J Ksinan, Pavla Brennan Kearns, Zuzana Mohrová, Zsófia Csajbók, Jana Klánová, Hynek Pikhart, Martin Bobák","doi":"10.1192/j.eurpsy.2026.12207","DOIUrl":"10.1192/j.eurpsy.2026.12207","url":null,"abstract":"","PeriodicalId":520621,"journal":{"name":"European psychiatry : the journal of the Association of European Psychiatrists","volume":"69 1","pages":"e48"},"PeriodicalIF":6.7,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic sensitivity to the environment moderates the impact of positive and negative childhood experiences on psychological adjustment \"for good and for bad\".","authors":"Pilar Torrecilla, Valeria Lavín, Angelo Arias-Magnasco, Bochao Danae Lin, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Every Thiery, Nele Jacobs, Jim van Os, Bart Rutten, Sinan Guloksuz, Neus Barrantes-Vidal","doi":"10.1192/j.eurpsy.2026.10176","DOIUrl":"10.1192/j.eurpsy.2026.10176","url":null,"abstract":"<p><strong>Background: </strong>The vulnerability-stress framework guiding gene-environment interaction (GxE) research overlooks the role of positive experiences. The Differential Susceptibility (DS) model offers a broader perspective, suggesting that individuals vary in sensitivity to <i>both</i> negative and positive environments. This study aimed at replicating previous DS research by examining interactions between polygenic scores for environmental sensitivity (PGS-ES) and positive and negative early exposures on subclinical psychosis and internalizing psychopathology, functioning, and wellbeing.</p><p><strong>Methods: </strong>The sample consisted of 638 twins from the first wave of the TwinssCan study, a general population twin cohort. PGS-ES and adversity, bullying and positive experiences in childhood were collected, along with assessments of psychotic, affective, functioning, and positive mental health. GxE interactions were tested under a competitive-confirmatory approach.</p><p><strong>Results: </strong>DS effects were found for the interactions between PGS-ES and all environmental exposures on schizotypic eccentricity and functioning. Adolescents with high genetic sensitivity were rated as more eccentric and less functional under childhood adversity but were rated as less eccentric and better adjusted under childhood favorable conditions. DS also resulted from the interaction between PGS-ES and positive childhood on social coping. No significant models emerged for internalizing or wellbeing.</p><p><strong>Conclusion: </strong>Findings overall supported DS, indicating that genetic sensitivity to the environment operates in a \"for better and for worse\" manner depending on the quality of environmental exposures. It extends initial evidence that DS applies to nonclinical psychosis expression and highlights the importance of considering the full spectrum of environmental conditions to understand both risk and opportunity factors in GxE.</p>","PeriodicalId":520621,"journal":{"name":"European psychiatry : the journal of the Association of European Psychiatrists","volume":"69 1","pages":"e41"},"PeriodicalIF":6.7,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147583538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Antidepressant Use in Geriatric Depression: Expert Consensus from French societies of geriatrics, old age psychiatry and clinical pharmacy (SFGG, SF3PA and SFPC).","authors":"Morgane Houix, Alexis Lepetit, Christophe Arbus, Sophie Armand-Branger, Sylvie Bonin-Guillaume, Benjamin Calvet, Mathieu Corvaisier, Ismael Conejero, Anne-Laure Debruyne, Sandrine Louchart de la Chapelle, Gérald Deschietere, Thomas Desmidt, Jean-Michel Dorey, Olivier Drunat, Jean-Pascal Fournier, Quentin Gallet, Jacques Gauillard, Cécile Hanon, Nicolas Hoertel, Ilia Humbert, Isabelle Jalenques, Aline Lepelletier, Frédéric Limosin, Nicolas Marie, Stéphanie Miot, Jean Olivier, Laurence Petit, Beatriz Pozuelo Moyano, Maximilien Redon, Gabriel Robert, Jean Roche, Tanguy Taillefer de Laportaliere, Pierre Vandel, Sonia Prot-Labarthe, Samuel Bulteau","doi":"10.1192/j.eurpsy.2026.12206","DOIUrl":"https://doi.org/10.1192/j.eurpsy.2026.12206","url":null,"abstract":"","PeriodicalId":520621,"journal":{"name":"European psychiatry : the journal of the Association of European Psychiatrists","volume":" ","pages":"1-37"},"PeriodicalIF":6.7,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A network analysis of obsessive-compulsive patients in intensive outpatient treatment.","authors":"Valerie S Swisher, Kate Rogers, Sandra Hadlock, Michelle G Newman","doi":"10.1192/j.eurpsy.2026.10184","DOIUrl":"10.1192/j.eurpsy.2026.10184","url":null,"abstract":"<p><strong>Background: </strong>The network theory of mental disorders posits that associations between symptoms activate other symptoms to maintain a disorder over time. Network analytic approaches therefore may inform treatment targets. In the present study, we compared baseline OCD symptom networks among treatment responders to non-responders and examined how network structure and connectivity changed from before to after exposure and response prevention (ERP) treatment.</p><p><strong>Methods: </strong>Community adults with OCD (<i>n</i> = 712) who underwent intensive outpatient treatment were assessed using the Yale-Brown Obsessive Compulsive Scale (YBOCS) at admission and discharge. Network comparison tests were used to (a) examine differences in baseline symptom network structures between treatment responders versus non-responders and (b) examine changes in network structures from pre- to post-treatment.</p><p><strong>Results: </strong>Pre-treatment network structures and global connectivity did not differ significantly between treatment responders and non-responders. However, post-treatment networks exhibited greater global strength (i.e., stronger associations between OCD symptoms) and significantly different network structure (i.e., different patterns of associations between OCD symptoms) relative to the pre-treatment network.</p><p><strong>Conclusions: </strong>Findings showed that network structure and connectivity in OCD may be more informative as a marker of therapeutic change than in discriminating treatment responders from nonresponders using baseline symptoms. After ERP treatment, associations between obsessions and compulsions demonstrated significantly greater global network strength and altered network structure, thus underscoring the potential for network approaches to identify mechanisms of change throughout OCD treatment. Future studies incorporating session-by-session data may clarify when and how these network shifts occur over the course of therapy to help identify treatment targets.</p>","PeriodicalId":520621,"journal":{"name":"European psychiatry : the journal of the Association of European Psychiatrists","volume":" ","pages":"e46"},"PeriodicalIF":6.7,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}