European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery最新文献

{"title":"Early recurrence patterns after neoadjuvant chemoradiotherapy and chemoimmunotherapy in esophageal squamous cell carcinoma: A multicenter study.","authors":"Cien Sun, Chunji Chen, Hua Sun, Hao Liu, Qianyi Chen, Zimin Wang, Jiawen Chen, William C Cho, Zhigang Li, Zhichao Liu, Dehua Ma, Minhua Ye, Chunguo Wang, QinYa Wang, Xuefeng Leng, Yongtao Han, Qifeng Wang, Jiahua Lv, Hainan Chen, Jinbo Zhao, Xiaolong Yan, Huilai Lv, Ziqiang Tian, Changchun Wang, Liwei Xu, Youhua Jiang, Zhengyang Zhang, Qihong Zhong, Jiangbo Lin, Xinyu Mei, Xiaoyang Li, Dong Qian, Chengchu Zhu, Xufeng Guo, Jianfei Shen","doi":"10.1093/ejcts/ezag219","DOIUrl":"https://doi.org/10.1093/ejcts/ezag219","url":null,"abstract":"<p><strong>Objective: </strong>To compare early recurrence patterns and survival outcomes between neoadjuvant chemoimmunotherapy (NCIT) and neoadjuvant chemoradiotherapy (NCRT) in patients with locally advanced esophageal squamous cell carcinoma (ESCC).</p><p><strong>Methods: </strong>This retrospective cohort study included 1428 patients with stage IIB-IVA ESCC who underwent NCIT or NCRT followed by radical surgery. Outcomes included overall survival (OS), recurrence-free survival (RFS), locoregional recurrence, distant metastasis, and post-recurrence survival (PRS). Propensity score matching (1:1 ratio, 0.1 caliper; balance threshold: standardized mean difference <0.10) and multivariable Cox regression were utilized.</p><p><strong>Results: </strong>After propensity score matching (532 patients per group), the NCIT group exhibited better 3-year OS (72.2% vs 60.9%; hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.56-0.85; P < .001) and RFS (67.8% vs. 59.3%; HR, 0.70; 95% CI, 0.57-0.86; P < .001) than the NCRT group. The NCIT group also had lower rates of early overall recurrence (131 [24.6%] vs. 196 [36.8%]; P < .001) and early distant metastasis (73 [13.7%] vs. 125 [23.5%]; P < .001) than the NCRT group. Multivariable regression analysis identified NCRT (vs NCIT), higher ypN stage, and not achieving a major pathological response as independent risk factors for both early overall recurrence and early distant metastasis. Among patients who experienced early recurrence, PRS did not differ between the two modalities (HR, 0.81; 95% CI, 0.63-1.04; P = .086). Although the NCRT group had a higher major pathological response rate, NCIT was associated with better early recurrence control even among patients achieving major pathological response (HR, 0.61; 95% CI, 0.47-0.84; P < .001).</p><p><strong>Conclusions: </strong>Compared with NCRT, NCIT is associated with a lower incidence of early recurrence, particularly distant metastasis, which may contribute to the observed OS advantage. The poor prognosis after early recurrence highlights the need for intensified postoperative surveillance in high-risk patients.</p>","PeriodicalId":520617,"journal":{"name":"European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial Conduits for Myocardial Revascularization: My 35-Year Journey.","authors":"Antonio Maria Calafiore","doi":"10.1093/ejcts/ezag217","DOIUrl":"10.1093/ejcts/ezag217","url":null,"abstract":"","PeriodicalId":520617,"journal":{"name":"European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reparative Surgery for Regurgitant Bicuspid Aortic Valves.","authors":"Ruggero De Paulis, Gianpiero Italiano, Giulio Folino, Giulia Ciccarelli, Raffaele Scaffa, Andrea Salica","doi":"10.1093/ejcts/ezag215","DOIUrl":"10.1093/ejcts/ezag215","url":null,"abstract":"","PeriodicalId":520617,"journal":{"name":"European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Composite Endpoints Confuse More Than Clarify.","authors":"Bjorn Redfors","doi":"10.1093/ejcts/ezag214","DOIUrl":"https://doi.org/10.1093/ejcts/ezag214","url":null,"abstract":"","PeriodicalId":520617,"journal":{"name":"European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery","volume":"68 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-thrombotic Therapy After Mitral Valve Surgery.","authors":"Bilal H Kirmani, A Marc Gillinov, Luke J Rogers, Rebecca Maier, Raimondo Ascione, Sanjay Asopa, Enoch Akowuah","doi":"10.1093/ejcts/ezag204","DOIUrl":"10.1093/ejcts/ezag204","url":null,"abstract":"<p><p>The European and American guidelines offer recommendations for the management of antithrombotic medication following mitral valve interventions. Evidence to support recommendations is frequently extrapolated from studies of aortic valve procedures, despite thrombotic risk being substantially higher in mitral valve disease and mitral valve procedures. This review examines the pathophysiological basis for thrombosis in mitral valve conditions, the recommendations and evidence from the guidelines, and current uncertainties.</p>","PeriodicalId":520617,"journal":{"name":"European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: Lung Volume Reduction Surgery for Cannabis-Associated Emphysema: Expanding Indication With Functional and Quality of Life Improvements.","authors":"","doi":"10.1093/ejcts/ezag218","DOIUrl":"https://doi.org/10.1093/ejcts/ezag218","url":null,"abstract":"","PeriodicalId":520617,"journal":{"name":"European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery","volume":"68 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149027402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Methods for Intersegmental Plane Preparation: Supplemental Analysis of JCOG0802/WJOG4607L.","authors":"Yoshinori Handa, Yasuhiro Tsutani, Akira Hamada, Norifumi Tsubokawa, Takahiro Mimae, Yoshihiro Miyata, Masashi Wakabayashi, Masaya Yotsukura, Yoshihisa Shimada, Kazuo Nakagawa, Aritoshi Hattori, Tomohiro Miyoshi, Mitsuhiro Isaka, Makoto Endo, Hiroshige Yoshioka, Tetsuya Isaka, Tomohiro Maniwa, Ryu Nakajima, Kenji Suzuki, Keiju Aokage, Hisashi Saji, Masahiro Tsuboi, Hisao Asamura, Yuta Sekino, Kenichi Nakamura, Haruhiko Fukuda, Shun-Ich Watanabe, Morihito Okada","doi":"10.1093/ejcts/ezag216","DOIUrl":"https://doi.org/10.1093/ejcts/ezag216","url":null,"abstract":"","PeriodicalId":520617,"journal":{"name":"European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery","volume":"68 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"My Journey of Internal Thoracic Artery Grafting.","authors":"Bruce Lytle","doi":"10.1093/ejcts/ezag195","DOIUrl":"10.1093/ejcts/ezag195","url":null,"abstract":"","PeriodicalId":520617,"journal":{"name":"European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148475653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transapical Transcatheter Valve Implantation for Aortic Regurgitation: A Multicentre, Prospective Trial.","authors":"Bowen Xiao, Ming Li, Lulu Liu, Jun Shi, Haibo Zhang, Xu Meng, Liangwan Chen, Xiquan Zhang, Liang Ma, Nianguo Dong, Xiaoke Shang, Jian Yang, Yang Liu, Pingfan Wang, Yingbin Xiao, Xiangbin Pan, Jian'an Wang, Dan Zhu, Huiming Guo, Jian Liu, Dongjin Wang, Zhiyun Xu, Zhigang Song, Yingqiang Guo","doi":"10.1093/ejcts/ezag065","DOIUrl":"10.1093/ejcts/ezag065","url":null,"abstract":"<p><strong>Objectives: </strong>We evaluated the safety and efficacy of transcatheter aortic valve replacement (TAVR) up to 1-year follow-up for patients with severe pure aortic valve regurgitation (AR) or mixed severe aortic valve regurgitation and aortic valve stenosis (AR+AS) using a novel self-expandable bioprosthesis.</p><p><strong>Methods: </strong>From 2021 to 2022, transapical TAVR using Ken-Valve (Jenscare Biotechnology Ltd, Ningbo, China) was performed in 142 symptomatic patients (mean age 70.3 ± 5.5 years) with pure AR (n = 109) or AR+AS (n = 33) across 15 hospitals in China. All patients were considered high-risk or inoperable after heart team evaluation, with a mean Society of Thoracic Surgeons score of 5.9 ± 3.0%, and 99.3% in NYHA class III/IV. Procedural characteristics, echocardiography data, and clinical outcomes up to 1-year were analysed.</p><p><strong>Results: </strong>Technical success was achieved in 97.2% of cases. Two (1.4%) patients were converted to open surgery due to unsuitable anatomy or valve migration during the procedure. New permanent pacemakers were implanted in 20 (14.1%) patients. Three (2.1%) patients had stroke, and 3 (2.1%) patients had major bleeding. Thirty-day mortality was 2.1%, and all-cause mortality at 1-year was 5.6% (8/142). Mean aortic valve gradient and effective orifice area (EOA) at 1-year postoperatively were 9.4 ± 5.4 mmHg and 1.9 ± 0.6 cm2, respectively. Significant improvement in clinical symptoms, positive left ventricular remodelling, and quality of life were observed up to 1-year. There was no significant difference in mortality, complications, and haemodynamic performance between patients with pure AR and AR+AS at 1-year.</p><p><strong>Conclusions: </strong>TAVR using the Ken-Valve was safe and effective in patients with pure AR or mixed AR+AS in mid-term.</p><p><strong>Clinical registration number: </strong>NCT03788590.</p>","PeriodicalId":520617,"journal":{"name":"European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the Evidence Catches up With Practice: Intercostal Nerve Cryoablation for the Nuss Procedure.","authors":"Kyle J Van Arendonk, Peter J Kneuertz","doi":"10.1093/ejcts/ezag212","DOIUrl":"10.1093/ejcts/ezag212","url":null,"abstract":"","PeriodicalId":520617,"journal":{"name":"European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}