Esophagus : official journal of the Japan Esophageal Society最新文献

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Correction: Robotic repair of an esophago-left main bronchial fistula using a pedicled autologous pericardial patch and latissimus dorsi muscle flap: a novel technique after chemoradiotherapy for cT4b esophageal cancer. 校正:机器人使用带蒂自体心包贴片和背阔肌瓣修复食管-左主支气管瘘:cT4b食管癌放化疗后的新技术。
IF 3.8
Esophagus : official journal of the Japan Esophageal Society Pub Date : 2026-10-13 DOI: 10.1007/s10388-026-01258-4
Tomoki Makino, Shigeto Nakai, Tomohira Takeoka, Kotaro Yamashita, Kazuya Kuroda, Koji Tanaka, Takashi Kanou, Tateki Kubo, Yasushi Shintani, Shigeru Miyagawa, Hidetoshi Eguchi, Yuichiro Doki
{"title":"Correction: Robotic repair of an esophago-left main bronchial fistula using a pedicled autologous pericardial patch and latissimus dorsi muscle flap: a novel technique after chemoradiotherapy for cT4b esophageal cancer.","authors":"Tomoki Makino, Shigeto Nakai, Tomohira Takeoka, Kotaro Yamashita, Kazuya Kuroda, Koji Tanaka, Takashi Kanou, Tateki Kubo, Yasushi Shintani, Shigeru Miyagawa, Hidetoshi Eguchi, Yuichiro Doki","doi":"10.1007/s10388-026-01258-4","DOIUrl":"https://doi.org/10.1007/s10388-026-01258-4","url":null,"abstract":"","PeriodicalId":520612,"journal":{"name":"Esophagus : official journal of the Japan Esophageal Society","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: First-line pembrolizumab plus chemotherapy versus chemotherapy alone for advanced esophageal cancer: 5-year extended follow-up in the Japanese subgroup of KEYNOTE-590. 修正:一线派姆单抗联合化疗与单独化疗治疗晚期食管癌:KEYNOTE-590日本亚组的5年延长随访。
IF 3.8
Esophagus : official journal of the Japan Esophageal Society Pub Date : 2026-10-04 DOI: 10.1007/s10388-026-01249-5
Ken Kato, Takashi Kojima, Hiroki Hara, Akihito Tsuji, Hisateru Yasui, Kei Muro, Taroh Satoh, Naoyoshi Yatsuzuka, Tomoko Sakata, Shirong Han, Toshihiko Doi
{"title":"Correction: First-line pembrolizumab plus chemotherapy versus chemotherapy alone for advanced esophageal cancer: 5-year extended follow-up in the Japanese subgroup of KEYNOTE-590.","authors":"Ken Kato, Takashi Kojima, Hiroki Hara, Akihito Tsuji, Hisateru Yasui, Kei Muro, Taroh Satoh, Naoyoshi Yatsuzuka, Tomoko Sakata, Shirong Han, Toshihiko Doi","doi":"10.1007/s10388-026-01249-5","DOIUrl":"https://doi.org/10.1007/s10388-026-01249-5","url":null,"abstract":"","PeriodicalId":520612,"journal":{"name":"Esophagus : official journal of the Japan Esophageal Society","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Heterogeneity of adjuvant therapy effectiveness across post-neoadjuvant pathologic strata in esophageal squamous cell carcinoma: a retrospective cohort study. 修正:食管癌新辅助后病理层间辅助治疗效果的异质性:一项回顾性队列研究。
IF 3.8
Esophagus : official journal of the Japan Esophageal Society Pub Date : 2026-09-25 DOI: 10.1007/s10388-026-01250-y
Qiuchen Ge, Xuanzhi Feng, Chenglong Guo, Jindong Li, Jianhong Lian, Tao Lu
{"title":"Correction: Heterogeneity of adjuvant therapy effectiveness across post-neoadjuvant pathologic strata in esophageal squamous cell carcinoma: a retrospective cohort study.","authors":"Qiuchen Ge, Xuanzhi Feng, Chenglong Guo, Jindong Li, Jianhong Lian, Tao Lu","doi":"10.1007/s10388-026-01250-y","DOIUrl":"https://doi.org/10.1007/s10388-026-01250-y","url":null,"abstract":"","PeriodicalId":520612,"journal":{"name":"Esophagus : official journal of the Japan Esophageal Society","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149067096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of educational pamphlet in achalasia care: education as therapy among Pakistani patients. 教育小册子对失弛缓症护理的影响:教育在巴基斯坦患者中的治疗作用。
IF 3.8
Esophagus : official journal of the Japan Esophageal Society Pub Date : 2026-09-20 DOI: 10.1007/s10388-026-01253-9
Sameen Abbas, Tayyab Saeed Akhtar, Kiran Hameed, Gul Nisar, Saima Mushtaq, Amjad Khan
{"title":"Impact of educational pamphlet in achalasia care: education as therapy among Pakistani patients.","authors":"Sameen Abbas, Tayyab Saeed Akhtar, Kiran Hameed, Gul Nisar, Saima Mushtaq, Amjad Khan","doi":"10.1007/s10388-026-01253-9","DOIUrl":"https://doi.org/10.1007/s10388-026-01253-9","url":null,"abstract":"<p><strong>Background: </strong>Achalasia, a rare disease, requires symptomatic self-management that can be achieved by educating patients. Pakistan continues to struggle with low health literacy, resulting in a meagre understanding of disease management, for which educational materials have shown promising improvements in knowledge and symptom resolution. This study aims to investigate the impact of educational intervention on Pakistani achalasia patients, for their disease and associated symptoms management.</p><p><strong>Methodology: </strong>A prospective observational study involving 84 Pakistani achalasia patients was conducted at Center for Liver and Digestive Diseases, Holy Family Hospital, Rawalpindi. Participants received educational pamphlet covering disease information, diagnostic tests, treatment options, and dietary recommendations. Baseline data, including demographic details and health measures, were collected, followed by an educational session. One month later, follow-up assessments evaluated changes in symptoms, HRQoL, and feasibility of pamphlet. Data analysis was performed using SPSS version 25.0.</p><p><strong>Results: </strong>The educational pamphlets significantly improved health outcomes post-follow-up. Subgroup analysis suggested that intervention was broadly effective across demographic groups, while regression analysis confirmed that pamphlet intervention was strong predictor of symptom improvement (p < 0.001) and patient satisfaction. Correlation analyses revealed that higher education levels were associated with greater improvements in both Eckardt and ASQ scores, while employment status showed weak associations with health outcomes.</p><p><strong>Conclusion: </strong>The educational pamphlet had a significant impact on improving symptom management and patient satisfaction with achalasia, demonstrating its effectiveness in enhancing disease understanding and self-management. Future research should focus on the long-term effects and explore additional strategies to enhance disease self-management in diverse populations.</p>","PeriodicalId":520612,"journal":{"name":"Esophagus : official journal of the Japan Esophageal Society","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Local triamcinolone acetonide injection for the prevention of pharyngeal deformity following endoscopic submucosal dissection of superficial pharyngeal neoplasms. 局部注射曲安奈德预防咽部浅表肿瘤内镜下粘膜下夹层术后咽畸形。
IF 3.8
Esophagus : official journal of the Japan Esophageal Society Pub Date : 2026-09-20 DOI: 10.1007/s10388-026-01252-w
Yugo Suzuki, Minoru Oda, Junji Tanaka, Daisuke Kikuchi, Toshiro Iizuka, Shu Hoteya
{"title":"Local triamcinolone acetonide injection for the prevention of pharyngeal deformity following endoscopic submucosal dissection of superficial pharyngeal neoplasms.","authors":"Yugo Suzuki, Minoru Oda, Junji Tanaka, Daisuke Kikuchi, Toshiro Iizuka, Shu Hoteya","doi":"10.1007/s10388-026-01252-w","DOIUrl":"https://doi.org/10.1007/s10388-026-01252-w","url":null,"abstract":"<p><strong>Background: </strong>Extensive mucosal resection following endoscopic submucosal dissection (ESD) for hypopharyngeal neoplasms can result in scar contracture and pharyngeal deformity, potentially increasing the risk of aspiration pneumonia. This study aimed to evaluate the efficacy and safety of local triamcinolone acetonide (TA) injection for preventing post-ESD pharyngeal deformity.</p><p><strong>Methods: </strong>This retrospective cohort study included 388 patients who underwent ESD for hypopharyngeal neoplasms between 2011 and 2026. Patients were divided into those who received local TA injection after ESD (TA group, n = 65) and those who did not (control group, n = 323). Post-ESD pharyngeal deformity was classified into four grades based on endoscopic findings. The piriform sinus was subdivided into three subfields according to the extent of the mucosal defect.</p><p><strong>Results: </strong>The TA group had a significantly lower deformity severity and fewer grade ≥ 2 deformities than the control group (both p < .001). Significant preventive effects were observed only in the piriform sinus (both p < .001). Among mucosal defects involving multiple piriform sinus subfields, both outcomes were significantly lower in the TA group for mucosal defects involving two (p < .001 and p = .046, respectively) and three (both p < .001) subfields. Similar findings were observed after propensity score matching. No adverse events related to TA injection were observed.</p><p><strong>Conclusions: </strong>Local TA injection may be an effective and safe strategy for preventing post-ESD pharyngeal deformity, particularly in mucosal defects involving multiple piriform sinus subfields.</p>","PeriodicalId":520612,"journal":{"name":"Esophagus : official journal of the Japan Esophageal Society","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improved operative mortality after esophagectomy in patients aged ≥ 75 years over a decade: a nationwide Japanese retrospective cohort study. ≥75岁患者食管切除术后10年生存率的改善:一项日本全国回顾性队列研究
IF 3.8
Esophagus : official journal of the Japan Esophageal Society Pub Date : 2026-09-20 DOI: 10.1007/s10388-026-01251-x
Akihiko Sano, Hideki Endo, Hiroyuki Yamamoto, Yoshihiko Kawaguchi, Tomoki Makino, Kengo Kuriyama, Makoto Sakai, Yasue Kimura, Hiroya Takeuchi, Hideki Ueno, Ken Shirabe, Hiroshi Saeki
{"title":"Improved operative mortality after esophagectomy in patients aged ≥ 75 years over a decade: a nationwide Japanese retrospective cohort study.","authors":"Akihiko Sano, Hideki Endo, Hiroyuki Yamamoto, Yoshihiko Kawaguchi, Tomoki Makino, Kengo Kuriyama, Makoto Sakai, Yasue Kimura, Hiroya Takeuchi, Hideki Ueno, Ken Shirabe, Hiroshi Saeki","doi":"10.1007/s10388-026-01251-x","DOIUrl":"https://doi.org/10.1007/s10388-026-01251-x","url":null,"abstract":"<p><strong>Background: </strong>Esophagectomy is associated with substantial morbidity and mortality, particularly in older patients. Although minimally invasive surgery (MIS) has been widely adopted, its contribution to improve operative outcomes in this population remains unclear. This study aimed to evaluate temporal trends in short-term outcomes after esophagectomy in patients aged ≥ 75 years and determine whether the increasing adoption of MIS contributed to improved operative mortality.</p><p><strong>Methods: </strong>Using the Japanese National Clinical Database, we analyzed patients aged ≥ 75 years who underwent radical esophagectomy for esophageal cancer between 2014 and 2024. The primary and secondary endpoints were operative mortality and severe postoperative complications (Clavien-Dindo grade ≥IIIa), respectively. Multivariable logistic regression analyses were performed, including sensitivity analyses additionally adjusted for MIS.</p><p><strong>Results: </strong>Among 7,678 patients, patient complexity increased over time, with higher proportions of octogenarians, patients with American Society of Anesthesiologists Physical Status ≥ 3, and patients receiving preoperative chemotherapy. Open thoracotomy decreased from 53.1% to 6.5%, whereas robot-assisted esophagectomy increased from 0% to 34.8%. Operative mortality decreased from 4.7% to 2.4%, with a risk-adjusted odds ratio (OR) of 0.49 (95% confidence interval [CI] 0.35-0.67; P < 0.001). Risk of severe postoperative complications remained unchanged (adjusted OR = 1.12, 95% CI 0.98-1.29; P = 0.11). Mortality reduction remained significant after adjustment for MIS (OR = 0.58, 95% CI 0.41-0.83; P = 0.003).</p><p><strong>Conclusions: </strong>Despite increasing patient complexity, operative mortality after esophagectomy in older patients improved substantially over the past decade. This improvement was unlikely to be explained by the increasing use of MIS alone and may reflect broader advances in perioperative management and other system-level factors. These findings have important implications for surgical care in aging populations worldwide.</p>","PeriodicalId":520612,"journal":{"name":"Esophagus : official journal of the Japan Esophageal Society","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Respiratory function recovery after esophagectomy: a retrospective analysis of surgical approaches. 食管切除术后呼吸功能恢复的比较:手术入路的回顾性分析。
IF 3.8
Esophagus : official journal of the Japan Esophageal Society Pub Date : 2026-09-20 DOI: 10.1007/s10388-026-01241-z
Naohito Sai, Kazushi Miyata, Takahiro Imaizumi, Yasukazu Kanie, Yuki Murata, Shizuki Sugita, Atsushi Ogura, Tomoki Ebata
{"title":"Comparison of Respiratory function recovery after esophagectomy: a retrospective analysis of surgical approaches.","authors":"Naohito Sai, Kazushi Miyata, Takahiro Imaizumi, Yasukazu Kanie, Yuki Murata, Shizuki Sugita, Atsushi Ogura, Tomoki Ebata","doi":"10.1007/s10388-026-01241-z","DOIUrl":"https://doi.org/10.1007/s10388-026-01241-z","url":null,"abstract":"<p><strong>Background: </strong>Esophagectomy for patients with esophageal cancer is a highly invasive procedure that can lead to substantial postoperative pulmonary impairment. Minimally invasive approaches, such as video-assisted thoracoscopic surgery (VATS) and robot-assisted minimally invasive esophagectomy (RAMIE), have been introduced to improve postoperative outcomes. This study aimed to assess the impact of surgical approach on postoperative pulmonary function recovery.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients who underwent esophagectomy between 2006 and 2023. Patients were categorized into three groups: open esophagectomy (OE), VATS, and RAMIE. Pulmonary function was assessed using vital capacity (VC) and forced expiratory volume in one second (FEV1.0) at one, three, six, and 12 months postoperatively. Multivariate logistic regression was performed to identify independent factors influencing respiratory function decline.</p><p><strong>Results: </strong>In all approaches, the VC and FEV1.0 decreased at one month postoperatively, followed by gradual recovery. Compared with OE, RAMIE showed a significantly better VC than OE at one month postoperatively (p = 0.04), whereas VATS showed a significantly better FEV1.0 at one month (p = 0.03). By 12 months, respiratory function recovery was comparable among all groups. Postoperative pulmonary complications (PPCs) were identified as a significant risk factor for long-term pulmonary function decline (p = 0.044).</p><p><strong>Conclusions: </strong>Minimally invasive approaches, particularly RAMIE and VATS, contribute to preserving postoperative respiratory function at one month. However, respiratory function recovery is similar across all surgical techniques at one year. Preventing PPCs is crucial for improving respiratory function outcomes. Further prospective studies are needed to validate these findings and refine surgical strategies.</p>","PeriodicalId":520612,"journal":{"name":"Esophagus : official journal of the Japan Esophageal Society","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term nutritional outcomes after esophagectomy following induction chemotherapy versus chemoradiotherapy for T4b esophageal cancer. T4b食管癌诱导化疗后食管切除术与放化疗后的长期营养结局
IF 3.8
Esophagus : official journal of the Japan Esophageal Society Pub Date : 2026-09-20 DOI: 10.1007/s10388-026-01256-6
Keijiro Sugimura, Koji Tanaka, Takahito Sugase, Kota Momose, Takashi Kanemura, Kotaro Yamashita, Tomoki Makino, Osamu Shiraishi, Masaaki Motoori, Atsushi Takeno, Hiroshi Miyata, Motohiro Hirao, Kazumasa Fujitani, Takushi Yasuda, Masahiko Yano, Hidetoshi Eguchi, Yuichiro Doki
{"title":"Long-term nutritional outcomes after esophagectomy following induction chemotherapy versus chemoradiotherapy for T4b esophageal cancer.","authors":"Keijiro Sugimura, Koji Tanaka, Takahito Sugase, Kota Momose, Takashi Kanemura, Kotaro Yamashita, Tomoki Makino, Osamu Shiraishi, Masaaki Motoori, Atsushi Takeno, Hiroshi Miyata, Motohiro Hirao, Kazumasa Fujitani, Takushi Yasuda, Masahiko Yano, Hidetoshi Eguchi, Yuichiro Doki","doi":"10.1007/s10388-026-01256-6","DOIUrl":"https://doi.org/10.1007/s10388-026-01256-6","url":null,"abstract":"<p><strong>Background: </strong>The long-term impact of preoperative treatment on nutritional recovery after esophagectomy remains unclear. Although neoadjuvant chemotherapy (NAC) and neoadjuvant chemoradiotherapy (NACRT) followed by surgery are established strategies for advanced esophageal cancer, their differential effects on postoperative weight loss have not been well characterized. This study aimed to compare long-term nutritional outcomes between esophagectomy after induction chemotherapy and after induction chemoradiotherapy in patients with T4b esophageal cancer.</p><p><strong>Methods: </strong>We retrospectively analyzed 86 patients with T4b esophageal cancer who underwent conversion surgery after induction treatment at six institutions between 2009 and 2021. Patients were categorized into a chemotherapy group (CT group, n = 51) and a chemoradiotherapy group (CRT group, n = 35). Longitudinal changes in body weight, lymphocyte counts, serum albumin levels, and prognostic nutritional index (PNI) were evaluated up to 24 months postoperatively.</p><p><strong>Results: </strong>Postoperative weight loss was significantly greater in the CRT group than in the CT group, particularly at 9 and 12 months postoperatively (-13.4% vs. -9.6%, P = 0.011; -13.8% vs. -9.3%, P = 0.022). Weight loss persisted until 12 months after esophagectomy in the CRT group, whereas gradual recovery was observed after 6 months in the CT group. Lymphocyte counts were consistently lower in the CRT group from preoperation through 24 months postoperatively (all P < 0.05). Serum albumin levels did not differ significantly between groups. One year after surgery, deterioration in PNI was significantly greater in the CRT group (P < 0.001).</p><p><strong>Conclusions: </strong>Esophagectomy following induction chemoradiotherapy was associated with greater long-term weight loss and impaired nutritional recovery compared with surgery following chemotherapy alone. These findings highlight the need for intensified nutritional surveillance and intervention in patients treated with preoperative CRT.</p>","PeriodicalId":520612,"journal":{"name":"Esophagus : official journal of the Japan Esophageal Society","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor-associated calcium signal transducer 2 expression as a promising therapeutic target in esophageal squamous cell carcinoma: a combined the Cancer Genome Atlas and an institutional cohort. 肿瘤相关钙信号传感器2表达作为食管鳞状细胞癌的一个有希望的治疗靶点:癌症基因组图谱和机构队列的结合
IF 3.8
Esophagus : official journal of the Japan Esophageal Society Pub Date : 2026-09-20 DOI: 10.1007/s10388-026-01257-5
Chiaki Inagaki, Hisato Kawakami, Seiichiro Mitani, Hiroshi Iijima, Ryo Matoba, Akihiko Ito, Osamu Shiraisi, Takushi Yasuda, Hidetoshi Hayashi
{"title":"Tumor-associated calcium signal transducer 2 expression as a promising therapeutic target in esophageal squamous cell carcinoma: a combined the Cancer Genome Atlas and an institutional cohort.","authors":"Chiaki Inagaki, Hisato Kawakami, Seiichiro Mitani, Hiroshi Iijima, Ryo Matoba, Akihiko Ito, Osamu Shiraisi, Takushi Yasuda, Hidetoshi Hayashi","doi":"10.1007/s10388-026-01257-5","DOIUrl":"https://doi.org/10.1007/s10388-026-01257-5","url":null,"abstract":"<p><strong>Background: </strong>Esophageal squamous cell carcinoma (ESCC) has a poor prognosis, and new therapeutic targets are required. Antibody-drug conjugates (ADCs) are a promising therapeutic modality that selectively delivers cytotoxic payloads to tumors via cell-surface antigens. Tumor-associated calcium signal transducer 2 (TROP2, TACSTD2) has shown therapeutic potential as an ADC target in several malignancies; however, its clinical significance in ESCC remains unclear.</p><p><strong>Methods: </strong>An institutional cohort of ESCC patients treated at Kindai University was retrospectively evaluated by immunohistochemistry (n=70) and RNA sequencing (n=27). TACSTD2 copy number alterations, RNA expression, and survival were analyzed using the Cancer Genome Atlas (TCGA) ESCC dataset. IHC was assessed in both resected and biopsy specimens, including metastatic lesions. Survival analyses were performed, stratifying patients by cohort-specific median TACSTD2 expression levels.</p><p><strong>Results: </strong>Immunohistochemistry analysis demonstrated uniformly strong TROP2 expression in all evaluable primary and metastatic lesions. In the TCGA dataset, TACSTD2 mRNA expression was consistently high, irrespective of copy-number status, and was comparable to or higher than that observed in non-small cell lung cancer and breast cancer, tumor types in which TROP2-targeted ADCs are clinically active. The TACSTD2 high-expression group showed a trend toward worse overall survival in both the institutional and the TCGA cohort, whereas disease-free survival was similar.</p><p><strong>Conclusions: </strong>TROP2/TACSTD2 is strongly and consistently expressed in ESCC at the protein and RNA levels, despite infrequent gene amplification, supporting its feasibility as a therapeutic target. High expression shows a trend toward poorer overall survival, warranting validation in larger cohorts.</p>","PeriodicalId":520612,"journal":{"name":"Esophagus : official journal of the Japan Esophageal Society","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Randomized trial comparing esophageal resection versus substitution alone for corrosive esophageal strictures. 比较食管切除术与单独替代治疗腐蚀性食管狭窄的随机试验。
IF 3.8
Esophagus : official journal of the Japan Esophageal Society Pub Date : 2026-09-20 DOI: 10.1007/s10388-026-01254-8
Nihar Ranjan Dash, Lokesh Agarwal, Sujoy Pal, Alok Thakar, Chirom Amit Singh, Kumble Seetharama Madhusudhan, Saurav Sharma
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