Digestive diseases (Basel, Switzerland)最新文献

{"title":"Sucralfate/Sodium Alginate Capsules and Proton Pump Inhibitor-Refractory Reflux Symptoms in Nonerosive Reflux Disease and Mild Erosive Disease: A Randomized, Phase 3, Noninferiority Study.","authors":"Shaahin Shahbazi, Erfan Shahbazi, Mohammad-Hosein Shahbazi, Zahra Vahdat Shariatpanahi","doi":"10.1159/ddi/acnag002","DOIUrl":"10.1159/ddi/acnag002","url":null,"abstract":"<p><strong>Introduction: </strong>Proton pump inhibitors have failed to control symptoms in some patients with gastroesophageal reflux disease. We investigated the effect of alginate and sucralfate (ALSUC) capsules in patients who had not responded to proton pump inhibitors.</p><p><strong>Methods: </strong>From March 2024 to March 2025, 692 adult patients with mild esophagitis (Los Angeles classification grades A, B) and nonerosive reflux disease (NERD) with reflux symptoms for ≥4 days/week were randomly assigned to receive ALSUC after meals and at bedtime or a double dose of omeprazole (20 mg) twice daily for 8 weeks. Patients were asked to complete a daily questionnaire. The primary endpoint was the percentage of complete heartburn-free days, analyzed for noninferiority. The secondary endpoints were analyzed for superiority.</p><p><strong>Results: </strong>ALSUC was noninferior to omeprazole in terms of percentage of heartburn-free days (omeprazole: 50.9%, ALSUC: 49.1%, CI: -0.003, 0.039). The percentage of regurgitation-free days was significantly higher in the ALSUC group (omeprazole: 49.8%, ALSUC: 53.5%, CI: -0.059, -0.016; p = 0.001). In the subgroup analysis, no significant differences were observed between the two groups within either the NERD or esophagitis subgroups for the evaluated outcomes. The exceptions were that omeprazole offered better heartburn control in patients with esophagitis, whereas ALSUC provided better control of regurgitation in patients with NERD.</p><p><strong>Conclusion: </strong>ALSUC can be a safe approach in controlling symptoms of mild esophagitis and NERD.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived Satisfaction of Outpatients Undergoing Endoscopic Examination: A Cross-Sectional Observational Study.","authors":"Fabio Grilli, Alessio Lo Cascio, Chiara Massari, Mattia Bozzetti, Michaela Angeletti, Veronica Brandinu, Eleonora Ribaudi, Maria Luigia Candela, Giovanni Cammarota, Alfredo Papa, Cristiano Spada, Franco Scaldaferri, Antonio Gasbarrini, Daniele Napolitano","doi":"10.1159/000552790","DOIUrl":"10.1159/000552790","url":null,"abstract":"<p><strong>Introduction: </strong>Patient satisfaction is a key quality indicator in gastrointestinal endoscopy, influencing adherence, service improvement, and overall care experience. This study aimed to assess determinants of satisfaction among outpatients undergoing gastrointestinal endoscopic procedures.</p><p><strong>Methods: </strong>We conducted a cross-sectional study at the Digestive Endoscopy Service of a university hospital in Italy. Outpatients undergoing esophagogastroduodenoscopy, colonoscopy, or endoscopic ultrasound completed the Endoscopy Customer Satisfaction Questionnaire and the Perceived Stress Scale. Relevant sociodemographic and clinical data were collected. Statistical analyses included ANOVA, t-tests, Pearson's correlation, and multiple linear regression.</p><p><strong>Results: </strong>A total of 203 outpatients were enrolled. Mean overall satisfaction score was 46.4 ± 9.2 (maximum score = 60). Higher satisfaction was associated with healthcare professionals' competence, particularly nurses (p < 0.001), and with the interaction between nurse and endoscopist expertise. In multivariable analysis, gender, previous surgeries, bowel preparation timing, nurse competence, examination duration, and time spent in the endoscopy room were significant predictors of satisfaction, while perceived stress was not significantly associated with satisfaction.</p><p><strong>Conclusion: </strong>Nursing and medical expertise are crucial in shaping endoscopic patient satisfaction. Enhanced communication, reduced waiting times, and optimized procedural factors may improve patient experiences. Future research should explore strategies to increase satisfaction and adherence to follow-up procedures.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"1-13"},"PeriodicalIF":2.1,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148805144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using GLP-1 Receptor Agonists in Patients with Inflammatory Bowel Disease: A Systematic Review and Single-Arm Meta-Analysis.","authors":"Omar Khasawneh, Kyrillos Mahrous Gerges, Islam Khasawneh, Edoardo V Savarino, Brigida Barberio, Ahmed Farid Gadelmawla, Basma Mansor Elhabbasi, Maram Albandak, Abdelmoneim Taher Mohamed, Hala Abubkr Shlibek, Bisher Sawaf, Miguel Regueiro, Muhammed Elhadi","doi":"10.1159/000553479","DOIUrl":"10.1159/000553479","url":null,"abstract":"<p><p><p>Introduction: This study aimed to investigate the effects of GLP-1 receptor agonists (GLP-1 RAs) on weight, metabolic, and inflammatory bowel disease (IBD) activity parameters in patients with IBD.</p><p><strong>Methods: </strong>We conducted a systematic search for studies using GLP-1 RAs in IBD patients. The primary outcomes included weight (body mass index, total body weight, total weight loss percentage [TWL%], and >5 and >10 weight loss [WL]) and metabolic parameters (lipid panel and glycated hemoglobin [HbA1c]), while IBD-activity parameters and adverse events were secondary outcomes.</p><p><strong>Results: </strong>Ten studies were included (n = 7,831). Weight parameters showed reductions, with a TWL% of -7.55% (95% confidence interval [CI]: -3.99 to -11.12), with 60% achieving WL >5% (95% CI: 53 to 67) and 40% achieving WL >10% (95% CI: 33 to 47). Metabolic parameters showed improved and stabilized levels, of which LDL decreased from 94.96 mg/dL (95% CI: 79.91 to 110.00) to 90.45 mg/dL (95% CI: 81.58 to 99.33), and HbA1c, in diabetics, from 7.11% (95% CI: 6.62 to 7.59) to 6.76% (95% CI: 6.35 to 7.16). GLP-1 RAs seem not to exacerbate IBD activity, with improved fecal calprotectin from 289.46 μg/g (95% CI: 62.88 to 516.04) to 210.59 μg/g (95% CI: 75.45 to 345.73), with 11% and 6% requiring IV steroids and advanced therapy, respectively. Adverse events occurred at lower rates, with nausea/vomiting being the most common.</p><p><strong>Conclusion: </strong>Our findings suggest that GLP-1 RAs may be promising for reducing weight and improving metabolic parameters without exacerbating activity, and may be a safe option for IBD patients. However, larger randomized controlled trials are needed to assess causal inference and long-term effects. </p>.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"1-24"},"PeriodicalIF":2.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13485284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148805213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety and Depression in Pancreatitis: Mechanisms, Assessment, and Treatment.","authors":"Changyou Xiong, Zesen Zheng, Weiguang Qiao, Yutang Ren","doi":"10.1159/ddi/acnag001","DOIUrl":"10.1159/ddi/acnag001","url":null,"abstract":"<p><strong>Background: </strong>Numerous studies have detailed that patients with pancreatitis frequently experience comorbid anxiety and depression, which may arise from physiological factors or psychosocial influences, and these conditions adversely affect daily functioning and quality of life. However, there is still a lack of reviews on epidemiological and mechanistic studies of anxiety and depression in patients with pancreatitis.</p><p><strong>Summary: </strong>Patients with pancreatitis commonly present with comorbid anxiety and depression, with chronic pancreatitis patients being more susceptible than those with acute pancreatitis. The mechanisms underlying this comorbidity are complex and likely multifactorial. Biological factors encompass inflammation-driven cytokine signaling to the brain, hypothalamic-pituitary-adrenal axis hyperactivity, gut microbiome dysbiosis, and altered central nervous system plasticity. Psychosocial factors include the emotional burden of pancreatitis, persistent sleep disturbances, substance abuse, and diminished family and social support. Assessment primarily relies on various types of scales, while treatment encompasses a comprehensive approach involving medication, psychological interventions, and family and social support.</p><p><strong>Key messages: </strong>This paper reviews the epidemiological characteristics of anxiety and depression in patients with pancreatitis, explores their biological and psychosocial mechanisms, and summarizes key points for the assessment and treatment of this comorbidity.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Proton Pump Inhibitor and <i>Clostridioides difficile</i> Risk in ICU Patients: A Systematic Review and Meta-Analysis of Clinical Outcomes.","authors":"Abdul Rafeh Awan, Muniba Ijaz, Meher Ayyazuddin, Anoosh Farooqui, Puneet Kaur Bansal, Mudasar Nisar, Zuhaa Rehman, Abdelrahman M Yousef, Abdullah Ahmad, Jibran Ikram, Antonio Giuseppuci, Sapana Verma, Amir Humza Sohail, Asad Ullah, Muhammad Ahmad Nadeem, Abu Baker Sheikh","doi":"10.1159/000553518","DOIUrl":"10.1159/000553518","url":null,"abstract":"<p><strong>Introduction: </strong>Clostridioides difficile infection (CDI) is a leading cause of antibiotic-associated diarrhea in critically ill patients. This meta-analysis evaluated whether proton pump inhibitor-based stress ulcer prophylaxis increases CDI risk and examined associated outcomes, including mortality, gastrointestinal bleeding, and other clinical effects in ICU patients.</p><p><strong>Methods: </strong>The study was prospectively registered on PROSPERO (CRD420251176540). Following PRISMA guidelines, PubMed, Scopus, Cochrane, and Google Scholar were searched (2007 - March 2025) for randomized controlled trials and observational studies comparing PPIs with H₂ receptor antagonists (H₂RAs) or placebo in ICU patients. Data were pooled using a random-effects model, and heterogeneity was assessed using the I2 statistic.</p><p><strong>Results: </strong>Eight studies (∼58,000 patients) met inclusion criteria. PPI use did not significantly increase CDI risk (OR 1.12; p = 0.49, I2 = 73%) or mortality (RR 1.01; p = 0.70) but significantly reduced gastrointestinal bleeding risk (RR 0.60; p = 0.02), particularly versus H₂RAs (RR 0.72; p = 0.0008). No significant differences were found in ICU or hospital length of stay as well as for mechanical ventilation duration.</p><p><strong>Conclusion: </strong>In ICU patients, PPI prophylaxis was associated with reduced gastrointestinal bleeding but showed no clear benefit for mortality, ICU or hospital length of stay, or duration of mechanical ventilation. The available evidence does not allow firm conclusions regarding CDI risk because of substantial heterogeneity and very low certainty of evidence. Compared with H2RAs, PPIs provide greater bleeding protection, although possible signals of longer ICU stay and slightly higher mortality require further investigation.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13498313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148475759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Incident High-Risk Varices in Patients with Hepatitis B-Related Cirrhosis Receiving Nucleos(t)ide Analog Therapy.","authors":"Yu-Chia Chiu, Hsin-Ju Tsai, Chia-Chang Chen, Ying-Cheng Lin, Shou-Wu Lee, Teng-Yu Lee","doi":"10.1159/000553519","DOIUrl":"10.1159/000553519","url":null,"abstract":"<p><strong>Introduction: </strong>In patients receiving nucleos(t)ide analog (NA) therapy for chronic hepatitis B (CHB)-related cirrhosis, routine endoscopic surveillance may be deferred in the absence of high-risk varices (HRV). We aimed to identify predictors of incident HRV in this population.</p><p><strong>Methods: </strong>This retrospective cohort study included patients with CHB-related cirrhosis who initiated NA therapy between March 2008 and June 2020 and were followed through May 2024. Eligible patients underwent baseline and on-treatment upper endoscopy. Patients with baseline HRV, prior variceal ligation, use of nonselective β-blockers, other viral hepatitis, alcohol overuse, or malignancy were excluded. The cumulative incidence of HRV and adjusted subdistribution hazard ratios (aSHRs) were estimated using competing-risk methods. A point-based risk prediction model was derived from multivariable regression coefficients.</p><p><strong>Results: </strong>Among the 110 included patients, 14 (12.7%) developed HRV over a median follow-up of 3.6 years (IQR, 2.0-5.6). In multivariable analysis, fibrosis-4 (FIB-4) ≥4.0 (aSHR 9.77; 95% CI, 1.45-65.7), coexisting metabolic dysfunction-associated steatotic liver disease (MASLD) (aSHR 6.37; 95% CI, 1.84-22.0), and albumin-bilirubin (ALBI) grade >1 (aSHR 3.02; 95% CI, 1.21-7.55) were independently associated with incident HRV and were assigned 3, 2, and 1 point, respectively, in the prediction model. At 3 years, the cumulative incidence of HRV was 1.5% (95% CI, 0-4.5) in the low-risk group (0-3 points) and 21.4% (95% CI, 8.0-34.8) in the high-risk group (4-6 points) (p = 0.001).</p><p><strong>Conclusion: </strong>MASLD, FIB-4, and ALBI grade predict incident HRV in NA-treated CHB cirrhosis, enabling risk-stratified endoscopic surveillance.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148475739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgE-Mediated Food Allergy in Patients with Celiac Disease.","authors":"Eli Magen, Eugene Merzon, Israel Magen, Akim Geishin, Ilan Green, Avivit Golan-Cohen, Shlomo Vinker, Ariel Israel","doi":"10.1159/000551435","DOIUrl":"10.1159/000551435","url":null,"abstract":"<p><strong>Introduction: </strong>Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten in genetically predisposed individuals. While CD is associated with various autoimmune and allergic conditions, the prevalence of IgE-mediated food allergies among CD patients remains underexplored. This study aimed to investigate the prevalence of specific IgE-mediated food allergies in individuals with CD and to assess associated clinical features.</p><p><strong>Methods: </strong>This retrospective observational study utilized anonymized electronic health record data from Leumit Health Care Services, a nationwide healthcare provider in Israel. Adult patients with a documented diagnosis of CD (ICD-9 code 579.0) were identified. A control group was randomly selected at a 1:10 ratio, matched for age category, sex, geographic region, ethnic background, and socioeconomic status. The prevalence of physician-diagnosed IgE-mediated food allergies and related clinical outcomes was compared between groups.</p><p><strong>Results: </strong>The study included 3,389 CD patients and 33,890 matched controls. The mean age was 18 years; 64% were female. The cumulative incidence of IgE-mediated food allergies was significantly higher in CD patients (4.75%) than in controls (2.25%) with an odds ratio (OR) of 2.16 (95% CI: 1.82-2.57, p < 0.001). Milk allergy was most common (1.95% vs. 1.25%, OR 1.56, 95% CI: 1.18-2.04). CD patients had significantly increased odds of allergies to eggs (OR 4.01), peanuts (OR 4.29), tree nuts (OR 3.34), and food-related dermatitis (OR 3.68). Anaphylaxis rates were higher but not statistically significant.</p><p><strong>Conclusion: </strong>CD is associated with an increased risk of IgE-mediated food allergies. Further studies are warranted to elucidate the immunopathological links and clinical implications of this association.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148428598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trembling Technique for Improving Colonic Adenoma Detection Rate by Enhancing Mucosal Exposure during Withdrawal: A Prospective, Non-Randomized Single-Center Study.","authors":"Hyun-Ho Choi, Kyung Jin Seo, Sang Woo Kim, Hyung-Keun Kim, Seung Ho Sin, Bo-In Lee, In-Sik Cho, Hiun Suk Chae","doi":"10.1159/000553418","DOIUrl":"10.1159/000553418","url":null,"abstract":"<p><strong>Introduction: </strong>Exposure of the hidden colon mucosa is essential for improving the adenoma detection rate (ADR). For enlarging the visual field, we innovated a unique trembling technique (trembling colonoscopy [TC]) by shaking the operating hand slightly during colonoscope withdrawal, and compared the ADR of TC with that of a standard colonoscopy (SC).</p><p><strong>Methods: </strong>This prospective study was performed between October 2017 and October 2019 by four experienced endoscopists. A total of 426 patients who had not undergone colonoscopy within the previous 3 years were enrolled (TC = 225, SC = 201).</p><p><strong>Results: </strong>No differences were observed in age, sex, or indications between TC and SC. The bowel preparation scores were higher in the TC group than in the SC group. Mean withdrawal time of TC (18.5 ± 6.3 min) was over two-fold longer than that of SC (8.5 ± 3.3 min) (p < 0.001). The TC group showed a significantly higher ADR and polyp detection rate than the SC group (TC 65.3% vs. SC 47.8%; p < 0.001:TC 78.7% vs. SC 65.7%; p = 0.003). TC also showed higher APC (adenomas per colonoscopy) than SC (p < 0.001). In multivariate analysis, the factors associated with ADR were male sex (p = 0.020), age (p < 0.001), and TC (p = 0.043). Hyperplastic polyps (HPs) were more frequently detected in the TC group than in the SC group (p = 0.001).</p><p><strong>Conclusion: </strong>TC was associated with higher ADR and APC than SC, mainly through increased detection of diminutive adenomas and HPs, whereas sessile serrated lesion detection and clinically significant serrated polyp detection rate were not significantly improved.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus Recommendations for the Management of <i>Helicobacter pylori</i> in Egypt: A 2026 Report.","authors":"Mohamed Alboraie, Walied Elhossary, Sherief Abdel-Salam, Muhammad Abdel-Gawad, Mohammed Ahmed Medhat, Ahmed Bahaa, Doaa Ghaith, Ahmed El Ray, Bahaa Abbas, Ebada M Said, Osama Aboelfetouh, Maysaa A Saeed, Samy Zaky, Ashraf Aboubakr, Mohamed Eltaher Ibrahim, Gamal Esmat","doi":"10.1159/000553178","DOIUrl":"10.1159/000553178","url":null,"abstract":"<p><p>Helicobacter pylori infection is highly prevalent in Egypt and plays a central role in peptic ulcer disease, gastric cancer, and several extra-gastrointestinal disorders. Growing antibiotic resistance and emerging treatment options necessitate an updated national consensus to guide diagnosis and management strategies. We aimed to develop updated, evidence-based consensus recommendations for the management of H. pylori infection in Egypt, reflecting current international guidelines and regional clinical realities. A multidisciplinary expert panel reviewed studies on H. pylori published since 2018, including Egyptian data and updated global guidelines. Statements were developed across five domains: epidemiology, diagnosis, treatment, gastric cancer, and extra-gastroduodenal associations. Each statement was discussed and voted upon; consensus was defined as ≥70% agreement. This 2026 Egyptian consensus provides practical guidance on optimizing H. pylori diagnosis and eradication. Key updates include support for high-dose PPIs and vonoprazan-based therapy, expanded use of bismuth regimens, and validation of high-dose dual therapy as an effective option. Adoption of these recommendations aims to improve eradication success, reduce complications, and guide future public health strategies in Egypt.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"1-14"},"PeriodicalIF":2.1,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatitis in Familial Dysautonomia Patients.","authors":"Ariel A Benson, Adi Cohen, Guy Peskin, David Hakimian, Alon Groisman, Rebecca Brooks, Harold Jacob, Channa Maayan","doi":"10.1159/000552342","DOIUrl":"10.1159/000552342","url":null,"abstract":"<p><p><p>Introduction: Familial dysautonomia (FD) is characterized by abnormal function of autonomic and sensory nervous systems. Gastrointestinal (GI) symptoms are extremely prevalent in FD patients, but the impact of FD on the pancreas is less well described. We aimed to elucidate the incidence and characteristics of acute pancreatitis (AP) in a population of FD patients and to identify potential risk factors.</p><p><strong>Methods: </strong>A retrospective review was performed on FD patients treated at a single tertiary center between 1981 and 2020. FD patients were included in the study, except those who died before 6 months. Data collected included demographics, FD symptoms, medication use, laboratory results, imaging results, and surgical and hospitalization history. Statistical analysis was performed to determine prevalence of AP in FD patients and FD-related symptoms.</p><p><strong>Results: </strong>Out of 192 FD patients, 49% were male, and average age at the time of evaluation was 25.3 years (range: 1-59 years). Most patients had GI (n = 179, 96.8%) and respiratory (n = 166, 88.3%) FD manifestations. More than 33% of patients had an FD crisis frequency of more than four times/year. The incidence of AP among this FD population was 288.5 cases per 100,000 person-years, 8.5 times higher than the incidence in the general population. There was no significant difference in the prevalence of pancreatitis risk factors when comparing FD patients who developed AP to FD patients who did not.</p><p><strong>Conclusions: </strong>There is a significantly increased risk for pancreatitis among FD patients that is not explained by traditional pancreatitis risk factors. This increased risk may be due to sphincter of Oddi dysfunction as part of their autonomic nervous system abnormalities. </p>.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"1-7"},"PeriodicalIF":2.1,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148335277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}