Diabetic medicine : a journal of the British Diabetic Association最新文献

{"title":"Opportunities to improve perioperative glycaemia in hospital inpatients with diabetes and hyperglycaemia.","authors":"Florence Ho, Mervyn Kyi, Spiros Fourlanos, Rahul D Barmanray","doi":"10.1111/dme.70482","DOIUrl":"https://doi.org/10.1111/dme.70482","url":null,"abstract":"","PeriodicalId":520603,"journal":{"name":"Diabetic medicine : a journal of the British Diabetic Association","volume":" ","pages":"e70482"},"PeriodicalIF":3.4,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149003071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When dose follows response: Interpreting lower-dose semaglutide effectiveness in clinical practice.","authors":"Sevtap Kılınç","doi":"10.1111/dme.70479","DOIUrl":"https://doi.org/10.1111/dme.70479","url":null,"abstract":"","PeriodicalId":520603,"journal":{"name":"Diabetic medicine : a journal of the British Diabetic Association","volume":" ","pages":"e70479"},"PeriodicalIF":3.4,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between prior wasting malnutrition and indices of insulin secretion and sensitivity among six cohorts from Asia and Africa: The SAMPA study.","authors":"Sharon E Cox, Sana Ahmed, Dixi Paglinawan Modoc, Riddhi Dasgupta, Christina Christoffersen, Molly Chisenga, Julius Patrick Ferrer, Ruth Frikke-Schmidt, Rikke Krogh-Madsen, Belinda Kweka, Nanette Lee, Evangelista Malindisa, Mizinga J Tembo, Patrick Ngoya, Dorothea Nitsch, Daniel Faurholt-Jepsen, George PrayGod, Geeta Trilok-Kumar, Suzanne Filteau, James A M Shaw","doi":"10.1111/dme.70465","DOIUrl":"https://doi.org/10.1111/dme.70465","url":null,"abstract":"<p><strong>Aims: </strong>The role of prior wasting malnutrition (PM) in determining insulin sensitivity and secretion in low- and middle-income countries (LMICs) remains unclear. We investigated associations of insulin indices with PM and whether these were modified by current body mass index (BMI).</p><p><strong>Methods: </strong>Participants were enrolled from child and adult cohorts in Zambia, Tanzania, India and the Philippines with previously documented PM or no prior wasting malnutrition (NPM). Plasma glucose, insulin and C-peptide were measured during an oral glucose tolerance test. Static (HOMA2 %S, HOMA2 %B) and dynamic (Matsuda index, insulinogenic index, disposition index) insulin indices were calculated. Adjusted linear regression models compared indices between PM and NPM groups.</p><p><strong>Results: </strong>In 2172 participants analysed, those with PM had lower current BMI. Children with PM had reduced insulin sensitivity (Matsuda index 20%-24% lower in PM vs. NPM). Adults with PM in early life (36-37 years before) many of whom had high adult BMI, also exhibited lower insulin sensitivity after adjustment for current BMI (Matsuda Index 18% lower in PM vs. NPM). Adults with more recent PM (3-17 years previously), many of whom remained underweight, had low insulin secretion (HOMA2 %B 10%-20% lower in PM vs. NPM) but greater insulin sensitivity associated with their lower BMI (Matsuda index 21%-47% higher in PM vs. NPM). Insulin secretion generally compensated for insulin sensitivity differences, maintaining comparable disposition index and diabetes and prediabetes prevalence between PM and NPM groups.</p><p><strong>Conclusions: </strong>PM affects glucose metabolism differently according to current BMI. Remaining underweight is associated with low insulin secretion and weight gain following PM is linked to reduced insulin sensitivity. Our results further inform understanding of the relative roles of reduced insulin secretion and sensitivity in diabetes pathogenesis in LMICs.</p>","PeriodicalId":520603,"journal":{"name":"Diabetic medicine : a journal of the British Diabetic Association","volume":" ","pages":"e70465"},"PeriodicalIF":3.4,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family meals for future health: A life-course approach to type 2 diabetes risk reduction after gestational diabetes.","authors":"Eloise Litterbach, Alison C Spence, Georgia Middleton, Jane Speight, Elizabeth Holmes-Truscott","doi":"10.1111/dme.70476","DOIUrl":"https://doi.org/10.1111/dme.70476","url":null,"abstract":"<p><strong>Aims: </strong>Gestational diabetes (GDM) more than doubles maternal and child risk of type 2 diabetes (T2D). Post-GDM, a life-course approach to T2D risk reduction includes family nutrition-focused health promotion. This study explores mothers' perceptions of the role of family meals in T2D risk reduction post-GDM, and brief messages to promote optimal nutrition-related behaviours during family meals.</p><p><strong>Methods: </strong>Fourteen qualitative, semi-structured online interviews were conducted with mothers aged 18+ years, living in Australia, with prior GDM and at least one child aged <3 years, recruited via social media. Interviews explored perceptions of family meals and T2D risk and included cognitive debriefing and refinement of health-promoting family mealtime messages. Reflexive thematic analysis was applied to transcripts.</p><p><strong>Results: </strong>Mothers indicated awareness of elevated T2D risk. Four themes included: Mothers place high value and expectations on family meals; Balancing individual and collective health and well-being needs post-GDM; an opportunity for family health beyond T2D risk reduction; and supports required to engage in family meals for future health. Mothers perceived the messages as relevant and mostly acceptable. Mothers liked how messages normalised mealtime challenges, though some suggested adaptations conflicted with best-practice guidelines. Mothers preferred online or physical message delivery (e.g. videos, posters), via credible sources (e.g. health professionals) and with practical resources (e.g. recipes).</p><p><strong>Conclusions: </strong>Post-GDM, mealtimes appear feasible and acceptable for supporting T2D risk reduction in families. Acceptability and relevance of messages highlight their potential for supporting family health, although how to support best practice remains challenging. Implementation pathways and ways to action messages may require the inclusion of practical resources.</p>","PeriodicalId":520603,"journal":{"name":"Diabetic medicine : a journal of the British Diabetic Association","volume":" ","pages":"e70476"},"PeriodicalIF":3.4,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental monitoring and therapeutic adherence in adolescents and young adults with type 1 diabetes mellitus: Systematic review with meta-analysis.","authors":"Juan Carlos Muñoz-Cruz, Catalina López-Martínez, Rafael Del-Pino-Casado","doi":"10.1111/dme.70477","DOIUrl":"https://doi.org/10.1111/dme.70477","url":null,"abstract":"<p><strong>Aim: </strong>To synthesise and quantify the association between parental monitoring and therapeutic adherence in adolescents and young adults (10-24 years) with Type 1 Diabetes Mellitus (T1DM).</p><p><strong>Methods: </strong>We conducted a systematic review with meta-analysis following PRISMA guidelines (PROSPERO: CRD420251231615). Searches were conducted in PubMed, CINAHL, SCOPUS, and PsycINFO up to June 2026. Observational studies examining the association between parental monitoring (active supervision of diabetes self-management) and multidimensional therapeutic adherence in individuals aged 10-24 years with T1DM were included. Random-effects models were used to pool correlation coefficients. Heterogeneity (I²), publication bias (Egger's test and trim-and-fill method), and sensitivity analyses were assessed. Methodological quality and certainty of evidence were evaluated using predefined criteria and GRADE principles.</p><p><strong>Results: </strong>Eight studies (8 independent samples; N = 1209) met inclusion criteria. All the studies were cross-sectional and conducted in the United States. The pooled analysis showed a significant positive association between parental monitoring and therapeutic adherence (r = 0.286; 95% CI: 0.232-0.337), with no statistical heterogeneity. Findings were consistent across informants (parent- or adolescent-reported) and remained robust in sensitivity analyses. Risk of publication bias was low and did not materially affect the estimates. Overall certainty of evidence was moderate.</p><p><strong>Conclusion: </strong>Parental monitoring is consistently and positively associated with therapeutic adherence in adolescents and young adults with T1DM. Although effect sizes were small to moderate and studies were cross-sectional, the findings support the clinical relevance of collaborative and non-intrusive parental supervision. Family-centred interventions promoting adaptive monitoring may help mitigate the decline in adherence during adolescence.</p>","PeriodicalId":520603,"journal":{"name":"Diabetic medicine : a journal of the British Diabetic Association","volume":" ","pages":"e70477"},"PeriodicalIF":3.4,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148972966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Participant and physician perspectives on the use of SGLT2 inhibitors in type 1 diabetes.","authors":"Julia Fielden, Pam Leblanc, Chloe Parezanovic, Vikas S Sridhar, Bruce A Perkins, David Z Cherney, David J T Campbell","doi":"10.1111/dme.70463","DOIUrl":"https://doi.org/10.1111/dme.70463","url":null,"abstract":"<p><strong>Aims: </strong>Sodium-glucose co-transporter inhibitors (SGLT2i) have proven cardiorenal benefits in type 2 diabetes and are promising as adjunct-to-insulin therapy in participants with type 1 diabetes (T1D). However, clinical use in T1D has been limited owing to a lack of regulatory approval and the augmented risk of diabetic ketoacidosis (DKA). Participant and physician input is critical in understanding how and when the risk-benefit ratio with these therapies is perceived to be favourable for users. This study aimed to explore how risks and benefits of SGLT2i are considered by participants with T1D and physicians who treat the condition.</p><p><strong>Methods: </strong>We used a qualitative descriptive study design, in which we conducted semi-structured interviews with people with T1D and physicians who treat this population. Participants were sampled from multiple Canadian sites via online recruitment. Transcripts were analysed inductively using conventional qualitative content analysis to identify themes.</p><p><strong>Results: </strong>We interviewed 24 participants with long-standing T1D, whose duration of living with diabetes ranged from 8 to 62 years. We also interviewed 7 physicians, including endocrinologists and nephrologists with a range of 4 to 20+ years in practice. Our analysis revealed five major themes: (i) A prevailing inclination to 'stay in the safe zone', reflecting hesitancy to move beyond established therapeutic boundaries; (ii) A sense of 'feeling the disconnect', characterized by divergent lenses between patients and clinicians, and tension regarding who holds expertise in T1D care; (iii) Ongoing efforts to reconcile the trade-offs between risks and benefits when considering new therapeutic strategies; (iv) A cautiously optimistic search for a path forward, marked by both anticipation and restraint; and (v) The need for personalization of care-the overarching theme.</p><p><strong>Conclusions: </strong>While there is great interest and motivation toward the use of SGLT2i among people with T1D and the physicians who treat them, there is also a clear understanding of the need for personalization of therapy and support for robust evidence to inform care.</p>","PeriodicalId":520603,"journal":{"name":"Diabetic medicine : a journal of the British Diabetic Association","volume":" ","pages":"e70463"},"PeriodicalIF":3.4,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underrepresentation of females and the elderly with type 1 diabetes in clinical exercise trials: A call to action.","authors":"Clara Solà, Marietta Kokla, Jasmin von Zezschwitz, Chloe Nicholas, Sandra Tawfik, Richard M Bracken, Signe Schmidt, Kirsten Nørgaard, Olivia Mary McCarthy","doi":"10.1111/dme.70468","DOIUrl":"https://doi.org/10.1111/dme.70468","url":null,"abstract":"<p><strong>Aims: </strong>The aims of this review were to (1) estimate the ratio of male and female participants with type 1 diabetes (T1D) in clinical exercise studies, (2) ascertain the degree to which menstruation has been considered and (3) characterize the number of studies in which the elderly have been included.</p><p><strong>Materials and methods: </strong>Original clinical exercise research articles in individuals with T1D from 1985 to 2025 on PubMed were screened. The number and age of participants were analysed. A standardized menstrual-status tiering system was used to assess the quality of menstrual cycle (MC) information of females: Gold, Silver and Bronze were awarded based on the level of methodological control, including verification of MC characteristics and hormonal profiling.</p><p><strong>Results: </strong>Of a total of 315 included studies, the majority (81%) contained a mixed-sex population with an overall male dominance in participant ratio (57% males vs 43% females). Since 1985, there have been six studies conducted exclusively in females compared to the 54 studies done in men, with six times fewer total participants (n = 99 vs n = 671, respectively). Across all studies, the mean age of participants was 29 ± 7 years, with only one study conducted solely in post-menopausal females. MC status was reported in 30 studies, 6 of which were graded Bronze and 3 Silver. None achieved Gold.</p><p><strong>Conclusions: </strong>Females and the elderly are under-represented in clinical exercise trials conducted in people with T1D. These data highlight the need for intensified efforts to bridge the current sex-and age-data gaps so as to improve practical implementation and clinical translation.</p>","PeriodicalId":520603,"journal":{"name":"Diabetic medicine : a journal of the British Diabetic Association","volume":" ","pages":"e70468"},"PeriodicalIF":3.4,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel deep intronic EIF2AK3 variant disrupts splicing and causes Wolcott-Rallison syndrome.","authors":"Alaa Al Assi, Georgia Bonfield, James Russ-Silsby, Suhel Ahmed, Thomas W Laver, Kadri Karaer, Bayram Özhan, Ayca Altincik, Kashyap A Patel, Jayne A L Houghton, Sarah E Flanagan, Matthew B Johnson, Elisa De Franco","doi":"10.1111/dme.70466","DOIUrl":"https://doi.org/10.1111/dme.70466","url":null,"abstract":"<p><strong>Aim: </strong>Deep intronic variants can disrupt splicing and cause monogenic disease but are missed by routine genetic testing. This study assessed the contribution of deep intronic variants to Wolcott-Rallison syndrome (WRS), a recessive disorder characterized by early-onset diabetes and progressive multisystem disease caused by loss-of-function EIF2AK3 variants.</p><p><strong>Methods: </strong>We investigated a cohort of 116 individuals referred to the Exeter Genomics Laboratory for genetic testing who had diabetes diagnosed at ≤2 years and at least one additional feature consistent with WRS: hepatic dysfunction, skeletal abnormalities or developmental delay. No genetic cause had been identified after testing all known early-onset diabetes genes. We screened genome-sequencing data for rare homozygous intronic EIF2AK3 variants. Candidate variants predicted to affect splicing by SpliceAI were assessed using a minigene exon-trapping assay.</p><p><strong>Results: </strong>We identified two rare homozygous intronic EIF2AK3 variants in two siblings. Only one variant, c.1651-180G>T, was predicted to disrupt splicing in silico. The two children, born to consanguineous parents, were diagnosed with early-onset diabetes (diagnosed at 1 year and 21 weeks), hepatic dysfunction, skeletal abnormalities, developmental delay, thyroid dysfunction, hip dysplasia and gait abnormalities. The minigene assay showed that c.1651-180G>T creates a cryptic donor splice site within intron 9, resulting in inclusion of a 79-nucleotide pseudoexon, causing a frameshift and premature stop codon. Using this evidence, the variant was reclassified as likely pathogenic according to ACMG/ACGS guidelines.</p><p><strong>Conclusions: </strong>We report the first deep intronic EIF2AK3 variant causing WRS, highlighting the need to consider systematic intronic analysis in unresolved cases.</p>","PeriodicalId":520603,"journal":{"name":"Diabetic medicine : a journal of the British Diabetic Association","volume":" ","pages":"e70466"},"PeriodicalIF":3.4,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of social determinants of health on use of diabetes-related mobile health applications in older adults with type 2 diabetes.","authors":"Damilola Adissa, Cody Makinson, Melissa A Elafros, Kara Mizokami-Stout, Eva L Feldman, Brian C Callaghan, Evan L Reynolds","doi":"10.1111/dme.70464","DOIUrl":"https://doi.org/10.1111/dme.70464","url":null,"abstract":"<p><strong>Aims: </strong>Determine associations between social determinants of health (SDOH) and use of diabetes-related mobile health (mHealth) applications in older individuals with type 2 diabetes.</p><p><strong>Methods: </strong>We identified participants that self-reported having type 2 diabetes who completed the National Poll on Healthy Aging, a nationally representative survey of older adults in the United States. Co-primary outcomes were use of mHealth applications to (1) track diabetes medications and (2) track blood glucose levels. SDOH factors included household income, education, health insurance, lack of companionship or social isolation, homeownership and access to technology. Logistic regression models determine associations between SDOH factors and use of mHealth applications, adjusted for age.</p><p><strong>Results: </strong>There were 348 participants with type 2 diabetes that completed the survey (mean [SD] age: 65.4 [7.9] years, 44.0% female, 69.5% White). We found 12.4% used mHealth applications to track blood glucose and 5.5% to track diabetes medications. Regression revealed higher income associated with a greater use of mHealth applications to track diabetes medications (OR: 4.3, 95% CI: 1.3-15.3) and blood glucose levels (OR: 52.0, 95% CI: 6.3-716.9). Additionally, older age (OR: 0.9, 95% CI: 0.8-0.99) was associated with decreased odds of using mHealth applications to track medications, whereas having graduate education (OR: 3.9, 95% CI: 1.2-12.8) was associated with increased odds of using mHealth applications to track blood glucose levels.</p><p><strong>Conclusions: </strong>We found that few older adults with type 2 diabetes use mHealth applications to assist in diabetes care, particularly among those with lower income. Future studies are needed to identify barriers and facilitators of mHealth use in these populations to develop and tailor future interventions.</p>","PeriodicalId":520603,"journal":{"name":"Diabetic medicine : a journal of the British Diabetic Association","volume":" ","pages":"e70464"},"PeriodicalIF":3.4,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of sex and ethnicity in the variability of estimated glomerular filtration rate (eGFR) in people with type 1 diabetes.","authors":"Salma Ayis, Murat Ozdede, Luigi Gnudi, Thamer Alobaid, Panagiotis Pavlou, Anastasios Mangelis, Nikolaos Fountoulakis, Aicha Goubar, Janaka Karalliedde","doi":"10.1111/dme.70469","DOIUrl":"https://doi.org/10.1111/dme.70469","url":null,"abstract":"<p><strong>Aims: </strong>To examine sex-based differences in estimated glomerular filtration rate (eGFR) trajectories for people with type 1 diabetes (T1D) over 10 years and to test the hypothesis that sex and ethnicity interaction predicts eGFR decline.</p><p><strong>Methods: </strong>A cohort of 1495 individuals, 48% men (81% White, 12% African-Caribbean and 7% Other) and baseline eGFR ≥45 mL/min/1.73 m² was analysed. Group-based trajectory modelling (GBTM) was used to identify eGFR sex-specific trajectories, and linear mixed models were used to evaluate the role of sex and ethnicity interaction in predicting eGFR heterogeneity.</p><p><strong>Results: </strong>Five eGFR trajectories were identified in both women and men. Rapid decline (>3 mL/min/1.73 m²/year) occurred in 5.75% of women and 10% of men. Among women, the group included 12.3% of the African-Caribbean and 4.8% of the White; among men, it included 24.3% of the African-Caribbean, 22.2% of the Asian and 8.3% of the White. Mild/Stable decline was observed in 16% of women and 27% of men. Mean eGFR was lower by (-20 [95% CI -25, -15] mL/min/1.73 m²/year) in African-Caribbean women and (-15 [-21, -9]) in men, compared to White women and men respectively. The lowest eGFR sex gap observed in African-Caribbeans, and the highest in 'Other'.</p><p><strong>Conclusions: </strong>Interactions between sex and ethnicity may determine the heterogeneity in kidney function decline.</p>","PeriodicalId":520603,"journal":{"name":"Diabetic medicine : a journal of the British Diabetic Association","volume":" ","pages":"e70469"},"PeriodicalIF":3.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}