Clinical toxicology (Philadelphia, Pa.)最新文献

{"title":"Human plant exposures in Hungary (2012-2025): a nationwide toxicovigilance study.","authors":"Dániel Cserhalmi, Evelin Ramóna Péli","doi":"10.1080/15563650.2026.2711080","DOIUrl":"https://doi.org/10.1080/15563650.2026.2711080","url":null,"abstract":"<p><strong>Introduction: </strong>Plant intoxications represent a notable proportion of exposures reported to poison control centres worldwide, although their epidemiological patterns vary across regions. In Hungary, comprehensive data on plant-related intoxications have not previously been published. This study aims to provide a nationwide analysis of human plant intoxications, focusing on demographic characteristics, plant taxa, and causes of exposure.</p><p><strong>Methods: </strong>A retrospective analysis was conducted using data from the Hungarian National Center for Public Health and Pharmacy exposure reporting system. All recorded plant-related intoxication cases between 2012 and 2025 were included. Data collected included age, sex, exposure characteristics, plant taxa, and type of exposure. Severity data were available from 2015 onward. Taxonomic nomenclature was standardized.</p><p><strong>Results: </strong>A total of 2,720 cases were recorded, of which 2,582 involved identifiable plant taxa. Children accounted for nearly 90% of cases. Most exposures were accidental (91.9%), while suicide attempts (4.3%) and recreational use (1.4%) were less frequent. Severity data (<i>n</i> = 1,794) showed that most cases were asymptomatic (65.9%) or mild (25.6%), with severe (1.0%) and fatal (0.2%) outcomes being rare. The most prevalent species were <i>Convallaria majalis</i> and <i>Taxus baccata</i>.</p><p><strong>Discussion: </strong>Plant intoxications in Hungary predominantly affect children and are mainly accidental. Although most cases are mild, certain species are associated with severe outcomes. These findings support toxicovigilance and may improve prevention and clinical management.</p><p><strong>Conclusion: </strong>Plant intoxications in Hungary predominantly affect children and are usually accidental, with ornamental plants representing the main source of exposure.</p>","PeriodicalId":520593,"journal":{"name":"Clinical toxicology (Philadelphia, Pa.)","volume":" ","pages":"1-7"},"PeriodicalIF":3.3,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iatrogenic botulism induced by cosmetic injection requiring mechanical ventilation: clinical characteristics and outcomes.","authors":"Ping Yang, Yu Du, Songbai He, Xia Rong, Tongyao Li, Wensi Hu, Huimin Shi, Jiangmei Peng, Na Wang, Junzhao Liu","doi":"10.1080/15563650.2026.2703260","DOIUrl":"https://doi.org/10.1080/15563650.2026.2703260","url":null,"abstract":"<p><strong>Introduction: </strong>Cosmetic iatrogenic botulism is increasingly reported, but data on severe cases complicated by neuromuscular respiratory failure requiring mechanical ventilation remain limited. This study aims to characterize clinical features, treatment, and outcomes of such cases.</p><p><strong>Methods: </strong>A retrospective analysis was performed on mechanically ventilated patients with severe iatrogenic botulism following cosmetic botulinum toxin injection from April 2024 to September 2025. Data on clinical characteristics, treatment and three-month outcomes were analyzed.</p><p><strong>Results: </strong>Fifteen patients (14 females, mean age of 36.40 years) were included. The face was the most common injection site (12 cases, 80.00%), primarily for wrinkle reduction, calf reduction, and jawline contouring. Seven patients (46.67%) received unlicensed or unknown-brand botulinum neurotoxin, and six (40.00%) were injected in non-authorized institutions. All patients presented with ptosis, dysarthria, dysphagia, limb weakness, and abdominal distension. The duration of mechanical ventilation was 329.93 ± 162.81 hours. Seven patients (46.67%) underwent tracheotomy, and two (13.33%) required reintubation within 48 hours after extubation. The cumulative dose of botulinum antitoxin was 34.33 ± 13.32 × 10⁴ international units, with one patient experiencing a mild allergic reaction that resolved with management. Mean intensive care unit stay duration was 28.53 ± 13.27 days. At the three-month follow-up, one patient reported residual facial paresis and dysphagia.</p><p><strong>Discussion: </strong>Neuromuscular respiratory failure in severe iatrogenic botulism was associated with prolonged mechanical ventilation. The use of unlicensed products, injection in unauthorized institutions, and delayed medical care might contribute to severe systemic toxicity. The prolonged clinical course reflected the underlying mechanism of botulinum neurotoxin‑induced neuromuscular junction blockade and nerve terminal regeneration.</p><p><strong>Conclusion: </strong>Among hospitalized patients with severe iatrogenic botulism, respiratory failure may necessitate prolonged mechanical ventilation, difficult weaning, and extended intensive care unit stay. Unlicensed products, non-authorized institution injection, excessive botulinum neurotoxin dosage, and delayed hospital presentation may be associated with disease progression.</p>","PeriodicalId":520593,"journal":{"name":"Clinical toxicology (Philadelphia, Pa.)","volume":" ","pages":"1-8"},"PeriodicalIF":3.3,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic low-dose methotrexate toxicity with vasoplegic shock.","authors":"Arihant Jain, Rahul Jain, Nayer Jamshed","doi":"10.1080/15563650.2026.2703875","DOIUrl":"https://doi.org/10.1080/15563650.2026.2703875","url":null,"abstract":"","PeriodicalId":520593,"journal":{"name":"Clinical toxicology (Philadelphia, Pa.)","volume":" ","pages":"1-2"},"PeriodicalIF":3.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148703215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspiration-induced lung injury in acute drug and ethanol poisoning: incidence, risk factors, and clinical predictors.","authors":"Rebecca Dieminger, Franziska Helfrich, Florian Eyer, Tobias Zellner","doi":"10.1080/15563650.2026.2638395","DOIUrl":"10.1080/15563650.2026.2638395","url":null,"abstract":"<p><strong>Introduction: </strong>Aspiration-induced lung injury complicates acute poisoning due to impaired airway reflexes. This study aims to identify risk factors for aspiration-induced lung injury in acutely poisoned patients and evaluate the predictive value of the CRB-65 score, a tool for assessing the severity of community-acquired pneumonia in poisoning.</p><p><strong>Methods: </strong>We performed a retrospective review of patients presenting with acute poisoning due to recreational drug use at one hospital between January 2019 and June 2021. Clinical data, laboratory findings, and radiological reports were analyzed. Logistic regression analysis was performed to identify independent risk factors. Additionally, the CRB-65 score was assessed for its ability to predict aspiration-induced lung injury in poisoned patients.</p><p><strong>Results: </strong>Of 497 cases included, 34 patients (6.8%) diagnosed with aspiration-induced lung injury. The logistic regression model identified fever (OR 39.4, 95% CI: 3.0-522.3), dysrhythmia (OR 20.5, 95% CI: 1.4-290.5), respiratory insufficiency (OR 18.7, 95% CI: 2.9-119.4), sedation (OR 4.6, 95% CI: 1.5-14.3), long-term medication (OR 4.5, 95% CI: 1.3-15.9), and neuroleptic administration (OR 4.1, 95% CI: 1.3-13.7) as independent predictors. Aspiration-induced lung injury was also associated with confusion (<i>P <0</i>.001) and lower Glasgow Coma Scale scores (<i>P <0</i>.001). The CRB-65 score demonstrated a high negative predictive value (96.6%) but low specificity (46.1%).</p><p><strong>Discussion: </strong>The observed incidence was lower than in comparable studies, likely due to varying diagnostic criteria, as no standardized definition exists. A negative CRB-65 score may help rule out aspiration-induced lung injury, but it is insufficient as a standalone diagnostic tool.</p><p><strong>Conclusion: </strong>In acutely poisoned patients, aspiration-induced lung injury is associated with impaired consciousness, cardiovascular instability, and administration of neuroleptics or sedatives. While the CRB-65 score can help exclude aspiration-induced lung injury in low-risk patients, further diagnostic tools such as clinical examination, laboratory testing, and imaging remain necessary for confirmation.</p>","PeriodicalId":520593,"journal":{"name":"Clinical toxicology (Philadelphia, Pa.)","volume":" ","pages":"661-670"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute unintentional single-substance pediatric exposures to direct factor Xa inhibitors reported to US Poison Centers, 2011-2019.","authors":"Matthew Kolbeck, Deirdre Regan, Michael Hodgman, Vincent Calleo","doi":"10.1080/15563650.2026.2634753","DOIUrl":"10.1080/15563650.2026.2634753","url":null,"abstract":"<p><strong>Introduction: </strong>Direct factor Xa inhibitors are widely used anticoagulants. Safety in adults is well studied, however limited data exist for pediatric exposures. The objective of this study is to describe referral patterns, clinical outcomes, and treatment modalities for unintentional pediatric single-substance ingestion of factor Xa inhibitors as reported to the National Poison Data System^®.</p><p><strong>Methods: </strong>This is a retrospective review of cases reported to the National Poison Data System^® from January 1, 2011 to December 31, 2019. Inclusion criteria were age <6 years with single-substance, unintentional ingestion of a direct factor Xa inhibitor. Cases were excluded if the medical outcome was coded as unrelated effect, confirmed non-exposure, not followed (non-toxic/minimal toxicity), unable to follow (potentially toxic), or outcome not provided. Data abstracted included medical outcomes, level of care, clinical effects, and therapies.</p><p><strong>Results: </strong>A total of 744 cases met inclusion criteria. Among 350 cases managed at home, outcomes included 346 cases with \"no effect\" and four cases with \"minor effect\". Among 394 cases treated/evaluated at a healthcare facility, reported medical outcomes included 337 (85.5%) cases with \"no effect\", 33 (8.4%) with \"minor effect\", 22 (5.6%) with \"moderate effect\", and two (0.5%) with \"major effect\". No clinical effects related to bleeding were reported. One hundred twenty-two patients received activated charcoal. One of the two cases with major effect involved ingestion of up to 500 mg rivaroxaban with laboratory coagulopathy, but bleeding was not coded as a clinical effect.</p><p><strong>Discussion: </strong>In this cohort of patients less than six years of age with acute, unintentional single-substance ingestion of direct factor Xa inhibitors, no cases had bleeding coded as a clinical effect. These findings are consistent with the previously described low toxicity profile of acute ingestions of these medications in children.</p><p><strong>Conclusions: </strong>These data suggest that asymptomatic, unintentional, single substance exposures to factor Xa inhibitors in patients <6 years of age are unlikely to develop clinically significant bleeding.</p>","PeriodicalId":520593,"journal":{"name":"Clinical toxicology (Philadelphia, Pa.)","volume":" ","pages":"685-690"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between laboratory indicators and severity of viper snakebite and limb swelling: a retrospective study in southwestern China.","authors":"Nan Xie, Tao Cheng, Jianna Zhang, Zhenfei Yuan","doi":"10.1080/15563650.2026.2639578","DOIUrl":"10.1080/15563650.2026.2639578","url":null,"abstract":"<p><strong>Introduction: </strong>Snakebite envenomation remains a significant public health concern, with viper bites in southwestern China posing substantial clinical challenges due to complications such as coagulopathy and tissue swelling. The objective is investigate the correlation between laboratory indicators and the degree of limb swelling in patients with acute viper snakebites and to identify laboratory indicators for understanding the mechanisms involved in severity and swelling.</p><p><strong>Methods: </strong>This retrospective study included patients presenting with confirmed viper snakebites to the emergency department of a regional medical center in southwest China between January 1, 2023, and December 31, 2023. Clinical data and laboratory results were collected and analyzed. Spearman's correlation and receiver operating characteristic curve analysis were performed to identify predictive indicators.</p><p><strong>Results: </strong>A total of 105 patients with a mean (±SD) age of 48.9 ± 16.6 years (61.0% male) were included. The neutrophil-to-lymphocyte ratio, white blood cell count, lactate dehydrogenase activity, creatine kinase activity, magnesium concentration, hydroxybutyrate dehydrogenase activity, and absolute neutrophil count were positively correlated with severity. Platelet count, low-density lipoprotein concentration, total cholesterol concentration, absolute lymphocyte count, eosinophil count, and albumin concentration were negatively correlated. For limb swelling, the D-dimer concentration, neutrophil-to-lymphocyte ratio, white blood cell count, absolute neutrophil count, and total cholesterol concentration showed positive correlations, while activated partial thromboplastin time, albumin concentration, absolute lymphocyte count, eosinophil count, low-density lipoprotein concentration, and magnesium concentration were negatively correlated.</p><p><strong>Discussion: </strong>These findings suggest that laboratory indicators can provide a rapid and objective assessment of both systemic severity and local swelling in viper snakebites, although heterogeneity in patient presentation and the retrospective, single-center design may limit generalizability.</p><p><strong>Conclusions: </strong>Admission laboratory indicators may provide useful adjunctive information and mechanistic insight into the severity and swelling associated with viper envenomation, but they cannot replace rapid bedside clinical assessment for early swelling evaluation. These biomarkers should therefore be regarded as supportive tools, and future prospective studies are needed to validate their predictive value for clinical decision-making.</p>","PeriodicalId":520593,"journal":{"name":"Clinical toxicology (Philadelphia, Pa.)","volume":" ","pages":"671-677"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pneumatosis intestinalis and portal venous gas mimicking intestinal necrosis in organophosphate poisoning.","authors":"Yutaro Shinzato, Masahiro Kashiura, Takashi Moriya","doi":"10.1080/15563650.2026.2681094","DOIUrl":"10.1080/15563650.2026.2681094","url":null,"abstract":"<p><strong>Introduction: </strong>Organophosphate poisoning typically induces gastrointestinal hypermotility. Pneumatosis intestinalis and portal venous gas are rare, ominous signs often associated with intestinal necrosis.</p><p><strong>Case summary: </strong>A 46-year-old woman ingested fenitrothion and malathion. Despite receiving a minimal cumulative dose of atropine (4.5 mg), she developed abdominal distension on day five. An emergency exploratory laparotomy revealed severe, diffuse intestinal edema without necrosis or perforation. The patient recovered with conservative decompression.</p><p><strong>Images: </strong>Abdominal computed tomography performed on day five demonstrated severe small intestinal dilatation accompanied by pneumatosis intestinalis and gas within the portal vein branches.</p><p><strong>Conclusion: </strong>These radiological findings can result from direct chemical injury to the gut mucosa and dysbiosis, mimicking irreversible necrosis. In the absence of frank infarction, such cases may be successfully managed conservatively, independent of atropine toxicity.</p>","PeriodicalId":520593,"journal":{"name":"Clinical toxicology (Philadelphia, Pa.)","volume":" ","pages":"732-734"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148255542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlabeled kratom alkaloids detected in products marketed as kava.","authors":"Stacy Marshall, Leah Leisch, Karen S Scott, Jessica Rivera, Jennifer Whiddon, Davis Bradford, Katherine Frost, Siva Rama Raju Kanumuri, Abhisheak Sharma, Christopher R McCurdy","doi":"10.1080/15563650.2026.2688238","DOIUrl":"10.1080/15563650.2026.2688238","url":null,"abstract":"<p><strong>Introduction: </strong>In October 2025, the Alabama Poison Information Center and local addiction medicine providers identified a cluster of cases involving liquid products marketed as containing kava associated with opioid-like withdrawal symptoms. Kava is not typically associated with physical dependence, raising concern for opioid-active substances.</p><p><strong>Methods: </strong>Five unique retail products were submitted for laboratory analysis. Three underwent quantitative ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) testing for kavalactones, kratom alkaloids, and related semisynthetic derivatives, with additional screening for 260 substances. Two products underwent qualitative gas chromatography-mass spectrometry (GC-MS) testing for mitragynine and kavalactones.</p><p><strong>Results: </strong>Qualitative GC-MS detected both mitragynine and kavalactones in one product, while another contained mitragynine with no detectable kavalactones. Quantitative UPLC-MS/MS identified both kavalactones and kratom alkaloids in three products, with mitragynine pseudoindoxyl predominating at concentrations of 0.16-0.21 mg per bottle.</p><p><strong>Discussion: </strong>Detection of kratom alkaloids and related semisynthetic derivatives in products labeled as kava may explain the observed opioid-like withdrawal. Mitragynine pseudoindoxyl, which has greater opioid activity than mitragynine and 7-hydroxymitragynine, was identified as the predominant kratom-related compound.</p><p><strong>Conclusion: </strong>Unrecognized exposure to opioid-active kratom compounds may occur through products marketed as kava, highlighting the need for improved surveillance and increased awareness.</p>","PeriodicalId":520593,"journal":{"name":"Clinical toxicology (Philadelphia, Pa.)","volume":" ","pages":"728-731"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute pharmaceutical poisoning as a cause of seizure events: a database analysis (2011-2023).","authors":"Florian Hauser, Cornelia Reichert, Gerd A Kullak-Ublick, Alexander Jetter","doi":"10.1080/15563650.2026.2643396","DOIUrl":"10.1080/15563650.2026.2643396","url":null,"abstract":"<p><strong>Introduction: </strong>Supratherapeutic exposures to pharmaceuticals are a considerable cause of seizures, often leading to severe complications. This study aimed to identify the drugs most frequently associated with seizures in overdose and to evaluate their seizure potential, focusing on dosage and age-related differences.</p><p><strong>Methods: </strong>A retrospective analysis of single-agent pharmaceutical exposures, mostly overdoses, reported to Tox Info Suisse from 1 January 2011 to 31 December 2023 was conducted. Cases with seizures were compared to all cases (\"seizure rate\") and to all cases involving the same substance (\"seizure potential\"). The median ingested dose was compared to the maximum approved daily dosage (\"relative overdose\"), and relative overdose in seizure versus non-seizure cases with the same substance was compared (\"seizure overdose ratio\").</p><p><strong>Results: </strong>There were 20,176 single-agent pharmaceutical exposures, with seizures reported in 233 cases (1.2%). Antidepressants were the most frequently implicated drug class (34.3%). Mefenamic acid (15.7%), quetiapine (10%), and bupropion (10%) were most commonly associated with seizures. Cefepime (37.5%) and bupropion (23.7%) showed the highest seizure potentials. Seizures occurred at low relative overdoses for clozapine, chlorprothixene, and trimipramine (1.3×, 2.0×, 2.8×, respectively). Tricyclic antidepressants (notably trimipramine), mefenamic acid, tolperisone, and bupropion exhibited low seizure overdose ratios (1.4, 2.0, 2.1, 2.1, respectively). Age-related seizure rates did not differ significantly between adolescents (1.7%) and adults (1.5%).</p><p><strong>Discussion: </strong>Besides the established seizure association of antidepressants, this analysis confirmed the high seizure risk of overdoses of mefenamic acid and bupropion. A comparative assessment using relative overdoses and seizure overdose ratios revealed that even mild overdoses of clozapine or chlorprothixene induce seizures. For mefenamic acid, tolperisone and bupropion, seizures occurred at overdoses only about twice those not associated with seizures. Seizures from intravenously administered cefepime were caused by not adapting the posology to decreased kidney function.</p><p><strong>Conclusion: </strong>Overdoses of mefenamic acid, quetiapine, bupropion, venlafaxine and tramadol, respectively, were most commonly associated with seizures. Cefepime exhibited the highest seizure potential, in patients with impaired renal function. Tricyclic antidepressants (trimipramine, amitriptyline), tolperisone, mefenamic acid and bupropion were associated with seizures at relatively small overdoses compared to respective non-seizure cases.</p>","PeriodicalId":520593,"journal":{"name":"Clinical toxicology (Philadelphia, Pa.)","volume":" ","pages":"705-714"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioid toxicity from impaired oxycodone metabolism associated with adagrasib.","authors":"Lily Sloan, Colleen P Cowdery, Courtney Temple","doi":"10.1080/15563650.2026.2675038","DOIUrl":"10.1080/15563650.2026.2675038","url":null,"abstract":"","PeriodicalId":520593,"journal":{"name":"Clinical toxicology (Philadelphia, Pa.)","volume":" ","pages":"737-738"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148255507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}