Clinical advances in hematology & oncology : H&O最新文献

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Energy balance in advanced breast cancer: extending beyond the curative setting. 晚期乳腺癌的能量平衡:超出治疗范围。
IF 1
Tarah J Ballinger, Martha A Cancilla, Che Young Lee, Jennifer A Ligibel
{"title":"Energy balance in advanced breast cancer: extending beyond the curative setting.","authors":"Tarah J Ballinger,&nbsp;Martha A Cancilla,&nbsp;Che Young Lee,&nbsp;Jennifer A Ligibel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Outcomes in early-stage breast cancer, including quality of life, body composition, physical functioning, physiologic biomarkers, cancer recurrence, and mortality, are associated with body weight, diet, and physical activity. These same endpoints may also be relevant in patients with metastatic breast cancer; however, few studies have evaluated the role of energy balance in this setting. Future work is needed to determine how body weight, nutrition, and exercise or other physical activity might affect the disease course of metastatic breast cancer, and whether energy balance may be a component of beneficial supportive or therapeutic interventions for specific patient populations living with metastatic breast cancer.</p>","PeriodicalId":520589,"journal":{"name":"Clinical advances in hematology & oncology : H&O","volume":" ","pages":"727-733"},"PeriodicalIF":1.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35209950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on pure red cell aplasia: etiology, diagnosis, and treatment. 纯红细胞发育不全的最新进展:病因、诊断和治疗。
IF 1
Robert T Means
{"title":"Update on pure red cell aplasia: etiology, diagnosis, and treatment.","authors":"Robert T Means","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":520589,"journal":{"name":"Clinical advances in hematology & oncology : H&O","volume":" ","pages":"18-21"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39959483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changing paradigms in the treatment of acute myeloid leukemia in older patients. 老年急性髓性白血病治疗模式的改变。
IF 1
Alexandre Bazinet, Tapan M Kadia
{"title":"Changing paradigms in the treatment of acute myeloid leukemia in older patients.","authors":"Alexandre Bazinet,&nbsp;Tapan M Kadia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Standard therapy for acute myeloid leukemia (AML) has long consisted of intensive chemotherapy followed by allogeneic hematopoietic stem cell transplant. Older individuals (≥60 years), who constitute the majority of patients with AML, may not always benefit from such intensive approaches owing to increasing frailty, comorbidities, and a higher incidence of adverse-risk disease features. Recent years have seen major advances in the development of effective low-intensity therapies for AML. Low-intensity induction regimens based on hypomethylating agents, venetoclax, and nucleoside analogues are highly effective and safe. A greater emphasis is being placed on the importance of an accurate genetic classification of AML to identify patients who may benefit from novel targeted therapies, such as FLT3 and IDH inhibitors. Genomic classification also highlights a group of patients with high-risk disease (TP53-mutated), for whom improved treatments are urgently needed. Finally, given that relapse is the major cause of treatment failure in elderly patients with AML, innovative maintenance strategies incorporating targeted therapy are being investigated to delay or prevent relapse. In this article, we provide an updated review of the treatment of AML in older patients.</p>","PeriodicalId":520589,"journal":{"name":"Clinical advances in hematology & oncology : H&O","volume":" ","pages":"37-46"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39845608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The next targets for small cell lung cancer. 小细胞肺癌的下一个目标。
IF 1
Ravi Salgia
{"title":"The next targets for small cell lung cancer.","authors":"Ravi Salgia","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":520589,"journal":{"name":"Clinical advances in hematology & oncology : H&O","volume":" ","pages":"35-36"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39959485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent data for acalabrutinib in chronic lymphocytic leukemia. 阿卡拉布替尼治疗慢性淋巴细胞白血病的最新数据。
IF 1
Paolo Ghia
{"title":"Recent data for acalabrutinib in chronic lymphocytic leukemia.","authors":"Paolo Ghia","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":520589,"journal":{"name":"Clinical advances in hematology & oncology : H&O","volume":" ","pages":"27-29"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39959484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to choose second-line treatment for hepatocellular carcinoma. 肝细胞癌如何选择二线治疗。
IF 1
Catherine Frenette
{"title":"How to choose second-line treatment for hepatocellular carcinoma.","authors":"Catherine Frenette","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":520589,"journal":{"name":"Clinical advances in hematology & oncology : H&O","volume":" ","pages":"726-729"},"PeriodicalIF":1.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39646443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The evolving use of CAR T-cell therapy in follicular lymphoma. CAR - t细胞治疗滤泡性淋巴瘤的进展。
IF 1
Loretta J Nastoupil
{"title":"The evolving use of CAR T-cell therapy in follicular lymphoma.","authors":"Loretta J Nastoupil","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":520589,"journal":{"name":"Clinical advances in hematology & oncology : H&O","volume":" ","pages":"684-686"},"PeriodicalIF":1.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39646048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of ADAMTS13 assays in thrombotic microangiopathies. ADAMTS13检测在血栓性微血管病变中的应用
IF 1
Spero Cataland
{"title":"The use of ADAMTS13 assays in thrombotic microangiopathies.","authors":"Spero Cataland","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":520589,"journal":{"name":"Clinical advances in hematology & oncology : H&O","volume":" ","pages":"687-689"},"PeriodicalIF":1.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39646050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New data for sacituzumab govitecan-hziy in the treatment of metastatic triple-negative breast cancer. sacituzumab govitecan-hziy治疗转移性三阴性乳腺癌的新数据
IF 1
Aditya Bardia
{"title":"New data for sacituzumab govitecan-hziy in the treatment of metastatic triple-negative breast cancer.","authors":"Aditya Bardia","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":520589,"journal":{"name":"Clinical advances in hematology & oncology : H&O","volume":" ","pages":"723-725"},"PeriodicalIF":1.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39646442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DA-R-EPOCH vs R-CHOP in DLBCL: How do we choose? DA-R-EPOCH vs R-CHOP治疗DLBCL:我们如何选择?
IF 1
Ajay Major, Sonali M Smith
{"title":"DA-R-EPOCH vs R-CHOP in DLBCL: How do we choose?","authors":"Ajay Major,&nbsp;Sonali M Smith","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The emerging molecular and prognostic characterization of diffuse large B-cell lymphoma (DLBCL) has challenged the rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) treatment paradigm in recent years, with the identification of several DLBCL subtypes associated with significantly inferior survival after standard R-CHOP therapy. Efforts to improve upon the R-CHOP backbone have included dose intensification as well as the addition of new agents; the infusional dose-adjusted rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-R-EPOCH) regimen has been identified as a potential replacement for R-CHOP in high-risk DLBCL. In this review, we provide a historical perspective on the R-CHOP and DA-R-EPOCH regimens and summarize the clinical trial literature regarding the efficacy of each regimen in various risk groups of DLBCL. Further, we propose clinical management scenarios in which DA-R-EPOCH may be preferred, including some for patient populations in which the use of R-CHOP vs DA-R-EPOCH is controversial.</p>","PeriodicalId":520589,"journal":{"name":"Clinical advances in hematology & oncology : H&O","volume":" ","pages":"698-709"},"PeriodicalIF":1.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036549/pdf/nihms-1799433.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39646049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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