American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists最新文献

{"title":"Response to \"Artificial intelligence and the future of the pharmacist's role in drug information\".","authors":"Elizabeth Unni, Batoul Senhaji-Tomza, Henry Cohen","doi":"10.1093/ajhp/zxag258","DOIUrl":"10.1093/ajhp/zxag258","url":null,"abstract":"","PeriodicalId":520552,"journal":{"name":"American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of a passive bin-based perpetual medication inventory model within ambulatory clinics at an academic medical center.","authors":"Elly Glazier, Jared Gabbert, Grayson Peek","doi":"10.1093/ajhp/zxag246","DOIUrl":"https://doi.org/10.1093/ajhp/zxag246","url":null,"abstract":"<p><strong>Purpose: </strong>Ambulatory clinics manage high-cost medications with little visibility into quantity or movement, leaving unrealized opportunities for inventory optimization. Automated dispensing cabinets, common in inpatient settings, address this issue but require significant capital investment, forcing clinics into complex workflows to balance demand for high-cost medications with minimizing waste. This study evaluated a passive bin-based inventory model that tracked clinic transactions in real time using light sensors to log product removal and replacement. The model uses artificial intelligence and various algorithms to recommend inventory optimizations based on transaction data and notably requires no electronic health record integration.</p><p><strong>Methods: </strong>This 10-week study included select medications at 2 ambulatory locations and assessed whether the utilization of a passive bin-based inventory model allowed a decrease in inventory on-hand valuation. Inventory valuation was assessed before implementation and following implementation of system recommendations at the conclusion of the pilot. The primary outcome was the change in inventory on-hand valuation. The accuracy of the system was validated via twice-weekly manual cycle count.</p><p><strong>Results: </strong>The assessed model recorded 3,454 dispenses during the study period. The average days on hand varied widely, and the total inventory valuation decreased by $34,000 of average wholesale price, although this cannot be extrapolated due to volume. The results of the modified MAS-NAS nursing satisfaction survey were mixed and not generalizable.</p><p><strong>Conclusion: </strong>In this prospective pre- vs postimplementation study, the utilization of a passive bin-based perpetual inventory model reduced inventory valuation but the difference was not statistically significant. While the model enhanced visibility in a challenging setting, further studies are necessary.</p>","PeriodicalId":520552,"journal":{"name":"American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing analysis to understand prescription drug expenditure trends.","authors":"James M Hoffman, Mina Tadrous, Glen Schumock, Matthew H Rim, Eric Tichy","doi":"10.1093/ajhp/zxag256","DOIUrl":"https://doi.org/10.1093/ajhp/zxag256","url":null,"abstract":"","PeriodicalId":520552,"journal":{"name":"American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From national projections to local decisions: Making drug-spend forecasts audit-ready for health-system pharmacy.","authors":"Rajesh Prasad Jayaswal","doi":"10.1093/ajhp/zxag249","DOIUrl":"https://doi.org/10.1093/ajhp/zxag249","url":null,"abstract":"","PeriodicalId":520552,"journal":{"name":"American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent and anticipated novel drug approvals (3Q 2026 through 2Q 2027).","authors":"Lauren Endriukaitis, Justin Han, Thuy Tran, Ashley Choi, Andrew M Levitsky, Matthew H Rim","doi":"10.1093/ajhp/zxag244","DOIUrl":"https://doi.org/10.1093/ajhp/zxag244","url":null,"abstract":"<p><strong>Purpose: </strong>Health-system pharmacists play a crucial role in monitoring the pharmaceutical pipeline to manage formularies, allocate resources, and optimize clinical programs for new therapies. This article aims to support pharmacists by sharing new and anticipated novel drug approvals.</p><p><strong>Summary: </strong>Selected drug approvals anticipated in the 12-month period covering the third quarter of 2026 through the second quarter of 2027 are reviewed. The analysis emphasizes drugs expected to have significant clinical and financial impact in hospitals and clinics selected from 66 novel drugs awaiting US Food and Drug Administration (FDA) approval. This year's pipeline features novel therapies for various disease states including rare and inherited genetic disorders, immunology and inflammatory diseases, and continued advancements in both targeted oncology therapies and gene therapies.</p><p><strong>Conclusion: </strong>Novel therapies continue to strengthen the current drug pipeline.</p>","PeriodicalId":520552,"journal":{"name":"American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148858067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving beyond a tale of two genes: Strides in management of metastatic gastrointestinal stromal tumors and their supportive care.","authors":"Clement Chung, Anthony Albayeh","doi":"10.1093/ajhp/zxag245","DOIUrl":"https://doi.org/10.1093/ajhp/zxag245","url":null,"abstract":"<p><strong>Purpose: </strong>This article evaluates and summarizes key therapeutic advances and supportive care considerations for metastatic gastrointestinal stromal tumors (GISTs).</p><p><strong>Summary: </strong>GISTs comprise a highly aggressive, heterogeneous group of soft tissue sarcomas that span multiple anatomic origins. Following surgical resection, GISTs often recur locally or metastasize to the liver. Collectively, GISTs represent the first group of solid malignancies that was elucidated as a mutation-driven neoplasm more than 2 decades ago. The treatment landscape for GISTs shifted with the advent of kinase inhibitors (eg, imatinib and sunitinib) targeting the constitutive activation of the cognate receptor kinase encoded by the proto-oncogene KIT or PDGFRA, which enables tumor cells to proliferate in a ligand-independent manner. The critical relevance of these oncogenic signaling pathways and, most recently, the introduction of novel kinase inhibitors (eg, avapritinib) that target a common mutation (PDGFRA D842V) associated with primary resistance to imatinib, sunitinib, and regorafenib or development of secondary resistance (eg, to regorafenib or ripretinib) have refined the management of GISTs, including so-called \"wild-type\" GISTs. Although these results are promising, tumor heterogeneity and varied resistance mechanisms to kinase inhibitors across different tumor locations limit the efficacy of these therapies, highlighting the therapeutic need to develop novel therapies and the important role of supportive care in mitigating treatment-related adverse effects and prolonging life by minimizing treatment interruptions for a group of malignancies that are highly dependent on oncogenic signaling.</p><p><strong>Conclusion: </strong>Studies of the genomic and epigenetic landscape of GISTs have contributed to an understanding of their key molecular features and subsequent therapeutic advances. Supportive care is vital in optimizing treatment outcomes with these novel therapies.</p>","PeriodicalId":520552,"journal":{"name":"American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of an electronic documentation system on timeliness and ancillary task completion.","authors":"Samuel Strong, Judy Huang, Heather Nelkin, Amar Ramudhin, Claudia M Goldblatt, Craig A Greszler","doi":"10.1093/ajhp/zxag254","DOIUrl":"https://doi.org/10.1093/ajhp/zxag254","url":null,"abstract":"<p><strong>Purpose: </strong>This study was conducted to compare the completion rate of ancillary tasks associated with sterile compounding and the timeliness of documentation before and after implementation of a technology-assisted workflow (TAWF) and electronic documentation software solution.</p><p><strong>Methods: </strong>This mixed methods, pre-post study was conducted at 3 related facilities (sites A, B, and C). Sterile and nonsterile compounding records were evaluated using both electronic data and ethnographic observations over two 90-day periods. The workflow before and after implementation was assessed for percentage of ancillary tasks completed, timeliness of completion, percentage of storage area inspections completed, and time required to document compliance activities.</p><p><strong>Results: </strong>Analysis indicated that while sites B and C saw significant improvement in on-time completion of ancillary activities, site A did not. Site B increased its on-time completion from 42.3% of all activities to 79.1%, while site C increased the completion rate from 72.1% to 98.1% (P < 0.0001 for both comparisons). Similarly, sites B and C increased the percentage of completed medication storage area inspections both overall and across the majority of evaluated subcategories. Timely completion of inspections remained relatively consistent at all 3 sites; site A saw a slight increase. Finally, the total time that staff used to document ancillary compounding activities declined by 6 to 92 seconds at each of the 3 sites during the postimplementation period.</p><p><strong>Conclusion: </strong>Implementation of mobile technology with a new TAWF system can meaningfully increase timeliness and visibility of documentation of ancillary compounding tasks, leading to improvements in standardization, documentation, and operational efficiency.</p>","PeriodicalId":520552,"journal":{"name":"American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thigh abscess following alternate-site continuous glucose monitoring sensor placement.","authors":"Kristy M Shaeer, Raechel T White, Benjamin Lord, Tina L Pham, Sarah Kimble, Erin L Reynolds, Jennifer Teeters, Kevin Cowart","doi":"10.1093/ajhp/zxag252","DOIUrl":"https://doi.org/10.1093/ajhp/zxag252","url":null,"abstract":"<p><strong>Purpose: </strong>To describe a methicillin-susceptible Staphylococcus aureus (MSSA) thigh abscess following alternate-site placement of a continuous glucose monitor (CGM) sensor and to highlight safety considerations associated with off-label device use in patients with poorly controlled diabetes.</p><p><strong>Summary: </strong>A 49-year-old man with uncontrolled type 2 diabetes (glycated hemoglobin, 11.3%) was referred to an ambulatory care pharmacist for diabetes management. The patient placed the sensor on his upper thigh due to prior dislodgement from the upper arm. Three days later, the patient presented with a painful, erythematous, fluctuant 4.5 x 5 cm abscess at the sensor insertion site. Initial incision and drainage (I&D) was performed and oral sulfamethoxazole/trimethoprim was prescribed. Four days later, he returned with worsening pain and impaired ambulation requiring repeat I&D. Wound cultures grew MSSA. Management additionally included wound packing, topical mupirocin, and continuation of sulfamethoxazole/trimethoprim, with clinical improvement noted after the second I&D procedure. Cutaneous complications with CGM use are typically mild, infrequent, and most often involve contact or irritant dermatitis rather than infection. Reports of CGM-associated skin infections are rare, and none have been reported following sensor placement at unapproved insertion sites.</p><p><strong>Conclusion: </strong>This case underscores the potential for a skin and soft tissue infection following off-label CGM placement, especially in patients with uncontrolled hyperglycemia. Pharmacists play a critical role in reinforcing appropriate device use, identifying early signs of infection, and coordinating interdisciplinary care to mitigate device-related complications.</p>","PeriodicalId":520552,"journal":{"name":"American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of pharmacy in advancing evidence-based tobacco use treatment in the Veterans Health Administration.","authors":"Timothy C Chen, Mark C Geraci, Mark G Myers, Dana E Christofferson, Jennifer Knoeppel, Michael H Tran, Kim W Hamlett-Berry, Pamela S Belperio","doi":"10.1093/ajhp/zxag248","DOIUrl":"https://doi.org/10.1093/ajhp/zxag248","url":null,"abstract":"<p><strong>Purpose: </strong>Pharmacy has been a key driver of enhanced patient access to tobacco use treatment in the Veterans Health Administration (VHA). The purpose of this article is to describe steps taken by VHA, particularly in integrating pharmacy expertise, to improve tobacco use treatment among veterans and their impact on pharmacotherapy prescribing.</p><p><strong>Summary: </strong>Over the past 15 years, VHA policy has expanded patient access to tobacco use treatment medications and developed clinical practice models and training programs that integrate clinical pharmacist practitioners (CPPs) in the delivery of evidence-based tobacco use treatment. As a result of these policies and programs, prescribing of tobacco use treatment medications by CPPs increased almost 3-fold from 2014 to 2023 and over 50% of CPPs prescribe tobacco use treatment medications. CPPs accounted for approximately 30% of varenicline, nicotine nasal spray, and nicotine inhaler prescriptions in VHA in 2020, despite making up only 14% of all prescribers in VHA.</p><p><strong>Conclusion: </strong>With significant support from pharmacy providers, VHA has made great strides in increasing access to evidence-based care. The lessons learned from VHA may support other healthcare systems in increasing tobacco use treatment through use of pharmacy-led clinical programs.</p>","PeriodicalId":520552,"journal":{"name":"American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of an automated robotic syringe-filling device in a hospital-based sterile products cleanroom.","authors":"Trevor Rice, Alexsandra Nilges, Lindsey Amerine, Angela Yaniv","doi":"10.1093/ajhp/zxag255","DOIUrl":"https://doi.org/10.1093/ajhp/zxag255","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the implementation of an automated robotic syringe-filling device within a hospital-based sterile products cleanroom.</p><p><strong>Summary: </strong>Automated intravenous (IV) compounding can reduce compounded product variability, decrease human error, and improve patient and staff safety outcomes. An automated robotic syringe-filling device was implemented to automate sterile syringe preparation. Staff training, workflow redesign, and batching optimization were required for effective implementation. Syringe preparation volume increased from 5,290 syringes in the first month to an average of 22,640 syringes per month by the end of the first year following implementation. Staffing needs decreased from approximately 2.5 full-time equivalents (FTEs) dedicated to manual syringe and automated bagged preparation compounding to 1.7 FTEs for combined staffing of both robots. This labor shift enabled reallocation of technician time to other high-priority tasks. Continuous process improvements increased syringe production efficiency while maintaining similar labor demands.</p><p><strong>Conclusion: </strong>Robotic syringe filling significantly improved operational efficiency and capacity while reducing staff dedicated to syringe compounding. Successful implementation required thorough planning, education, and continuous improvement. As system optimization progressed, throughput gains and labor savings were realized, demonstrating the value of automation in a high-volume sterile compounding environment.</p>","PeriodicalId":520552,"journal":{"name":"American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148835874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}