Intestinal Failure (New York, N.Y.)最新文献

{"title":"Extensive mesenteric dystrophic calcification in a patient with chronic enterocutaneous fistula.","authors":"Gabriela A Calcano, Mohamed H Khalaf, Kishore R Iyer","doi":"10.1016/j.intf.2025.100322","DOIUrl":"10.1016/j.intf.2025.100322","url":null,"abstract":"<p><p>A 42-year-old male developed a complex entero-cutaneous fistula (ECF) after surgery for diverticulitis, followed by multiple complications, ten additional procedures and total parenteral nutrition (TPN) dependence. Despite these interventions, the complex ECF persisted, and he was transferred to our care. Imaging revealed extensive mesenteric dystrophic calcifications, though lab values were normal. Intraoperatively, dense calcifications were found infiltrating mesenteric vessels and bowel serosa without perforation. The calcifications were carefully excised, preserving blood supply. A second-look surgery confirmed bowel viability, and continuity was restored with 190 cm of small bowel. Pathology showed dystrophic calcification and bone formation without malignancy. This rare case underscores the challenges of managing chronic ECF with extensive calcification and validates a conservative approach to ischemic bowel.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"7 ","pages":"100322"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of sarcopenia in patients with chronic intestinal failure due to short bowel syndrome.","authors":"Solar Héctor, Ortega Mariana Laura, Ramisch Diego, Marinucci Franco, Paladini Hugo","doi":"10.1016/j.intf.2025.100321","DOIUrl":"10.1016/j.intf.2025.100321","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is a progressive and generalized loss of muscle mass and function. Patients with chronic intestinal failure due to short bowel syndrome (CIF-SBS) could develop sarcopenia due to malabsorption, inflammatory states and/or physical inactivity. The aims of this study were to determine the prevalence of sarcopenia in a cohort of adult patients with CIF-SBS and its association with demographic and nutritional parameters.</p><p><strong>Material and methods: </strong>Adult CIF-SBS patients were included. SARC-F questionnaire was performed. Age, sex, anatomy type, time on parenteral nutrition (PN), current weight, height, Body Mass Index (BMI) and hand grip strength were assessed. In all patients a CT scan was done. Bivariate analysis was carried out to study variable associations. Chi-squared was used for categorical variables. Statistical analyses were performed in R; significance was considered when p < 0.05.</p><p><strong>Results: </strong>From June 2019 to March 2024, 63 adult CIF-SBS patients were included. Mean age was 51.6 ± 16.4 years and 52.4 % were female. Anatomy type was 1 in 95.2 % of the patients. Mean BMI was 23.2 ± 5.5 kg/m2 and 53.9 % had less than 6 months on PN. SARC-F was ≥ 4 in all patients. Hand grip strength was low in 55.5 % and CT muscle mass was low in 77.8 %. There was no association with less than 6 months of time on PN or low BMI. The prevalence of sarcopenia was 44.4 .</p><p><strong>Conclusion: </strong>Sarcopenia was diagnosed in less than half patients with CIF-SBS The majority of the patients had low muscle mass. However low handgrip was not as high.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"7 ","pages":"100321"},"PeriodicalIF":0.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alpha1-antitrypsin protects the intestine from ischemia-reperfusion injury in a rat intestinal clamping model.","authors":"Antoine Dubois, Mathias Clarysse, Ricard Farré, Tine Wylin, Veerle Heetfeld, Emilio Canovai, Tim Vanuytsel, Gert De Hertogh, Jacques Pirenne, Laurens J Ceulemans","doi":"10.1016/j.intf.2025.100314","DOIUrl":"10.1016/j.intf.2025.100314","url":null,"abstract":"<p><strong>Background: </strong>Ischemia-reperfusion injury (IRI) remains a significant hurdle when blood flow is restored to ischemic tissue. Alpha1-antitrypsin (AAT), a serine protease inhibitor, has demonstrated strong anti-inflammatory properties, including inhibition of neutrophil recruitment and activation. In this study we aim to investigate its potential to mitigate intestinal IRI (IIRI).</p><p><strong>Material and methods: </strong>The experimental protocol included two phases, performed in male Sprague-Dawley rats (250-350 g). Intravenous treatment was administered 10 min before ischemia induced by 60 min of superior mesenteric artery clamping. In the first phase, groups (N = 7/group) were: sham (PBS), AAT/60 (AAT60mg/kg+IRI), and AAT/100 (AAT100mg/kg+IRI), with 7-day survival as primary endpoint. Selecting AAT dose based on Phase 1 results, Phase 2 included three groups (N = 6/group): sham (PBS), control (PBS+IRI), and AAT (AAT+IRI). Reperfusion lasted 60 min, followed by animals sacrifice for sampling. Endpoints were transepithelial electrical resistance (TEER, villus length-adjusted), histological injury (Park-Chiu score), neutrophil infiltration (MPO immunohistochemistry), ileal cytokine levels (IL-6,IL-10,IL-1β,TNFα), and arterial blood analysis (blood gas, endotoxin, IL-6).</p><p><strong>Results: </strong>In phase 1, AAT/60 <i>vs</i> control 7-day survival was 100 % <i>vs</i> 14 % (p = 0.001)(AAT/100: 86 %), selecting AAT/60 for Phase 2. For AAT/60 <i>vs</i> control, mean(SD) TEER values were 18.87(8.36) <i>vs</i> 12.00(3.43)Ω·cm² (p = 0.991). Park-Chiu scores were 2(1) <i>vs</i> 4(1)(p = 0.029), with neutrophil infiltration of 0.61(0.14)% <i>vs</i> 1.28(0.64)% (p = 0.028). Lactate acidosis was reduced (lactate: 2.02(0.72) <i>vs</i> 4.00(0.70)mmol/L, p < 0.001; pH: 7.36(0.04) <i>vs</i> 7.28(0.02), p = 0.004), whereas arterial endotoxin levels, arterial IL-6 levels, and ileal cytokine expression were similar.</p><p><strong>Conclusion: </strong>By modulating neutrophil activity, AAT appears to reduce IIRI local/systemic effects, leading to improved 7-day survival.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"7 ","pages":"100314"},"PeriodicalIF":0.0,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The discarded donor intestine: A review of donor criteria, availability and utilization, and current efforts to expand the donor pool.","authors":"Carolyn P Smullin, Ami Hayashi, Robert S Venick, Douglas G Farmer","doi":"10.1016/j.intf.2025.100311","DOIUrl":"10.1016/j.intf.2025.100311","url":null,"abstract":"<p><strong>Background: </strong>Intestinal transplantation (ITx) remains the least performed abdominal organ transplant. Despite increasing indications for intestinal transplantation, annual case volume remains fewer than 150 in the U.S., with waitlist mortality exceeding 30-40 %. This study summarizes current intestine donor criteria, availability, and utilization, and explores evidence-based strategies to expand the donor pool.</p><p><strong>Methods: </strong>This study included registry analysis of Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients (OPTN/SRTR) and STAR, as well as a literature review of emerging donor expansion efforts. Predictors of organ discard, simulation modeling of donor criteria, temporal trends and geographic variation were examined.</p><p><strong>Results: </strong>Approximately 1 % of eligible donors proceeded to intestine procurement from 1980 to 2025, of which ∼ 90 % were transplanted. Most discards are due to listing/evaluation, organ quality, or anatomic concerns. No single donor variable significantly predicted discard. Higher donor creatinine and age were associated with increased graft failure (p = 0.001, p < 0.001, respectively). Relaxing donor criteria-defined by less stringent cutoffs for age, body mass index (BMI), creatinine, and medical comorbidities-was not associated with higher graft failure (p = 0.394). Simulation modeling suggests that relaxing criteria could double eligible donors and increase transplant volume by ∼ 60 %, potentially saving over 100 lives annually. Regional disparities in usage further suggest that standardization may improve equity.</p><p><strong>Conclusion: </strong>A small number of modifiable barriers-particularly strict donor criteria and center-level variability-limit intestinal graft utilization. Expanding donor eligibility, implementing machine perfusion, and targeting discard drivers could substantially improve transplant access and outcomes.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"6 ","pages":"100311"},"PeriodicalIF":0.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivisceral Transplantation as curative Treatment for patients with Diffuse Splanchnic Arterial Ischemia: a case report.","authors":"Caroline Boelhouwer, Aksharaa Iyer, Antoine Dubois, Lawrence Bonne, Geert Maleux, Inge Fourneau, Sabrina Houthoofd, Albert Wolthuis, Philippe Nafteux, Hans Van Veer, Mauricio Sainz, Diethard Monbaliu, Lucas Wauters, Tim Vanuytsel, Laurens J Ceulemans, Jacques Pirenne","doi":"10.1016/j.intf.2025.100313","DOIUrl":"10.1016/j.intf.2025.100313","url":null,"abstract":"<p><strong>Background: </strong>Criteria for multivisceral transplantation (MVTx) have broadened. However, diffuse splanchnic arterial ischemia secondary to visceral arterial thrombosis has only been described once.</p><p><strong>Case report: </strong>A 46-year-old woman with acute-on-chronic diffuse splanchnic ischemia received a MVTx from a 14-year-old braindead donor. Cold ischemia time was 6h29, warm ischemia time 0h36. Pre-operative embolization of inferior mesenteric artery was performed and the patient was placed on continuous veno-venous hemofiltration. An aortic conduit was constructed. Non-vascularized-rectus-fascia transplantation was performed. Postoperative course was hindered by kinking of superior mesenteric artery (SMA) (requiring stenting), acute cellular rejection of intestine (early) and liver (late) (requiring high-dose solumedrol) and esophagogastric anastomotic leakage (requiring endoscopic vacuum assisted closure). At 11 months, she is alive and well. She is able to have oral intake.</p><p><strong>Conclusion: </strong>MVTx is a curative treatment for diffuse arterial splanchnic ischemia secondary to thrombosis of both the coeliac trunk and the SMA, a condition otherwise rapidly fatal.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"6 ","pages":"100313"},"PeriodicalIF":0.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cocoon Syndrome as a Cause of Intestinal Failure and Indication for Combined Liver-Intestine-Kidney Transplantation.","authors":"M V Gentilini, M Doeyo, Santillán Marco, P Lc Illidge, F Pattin, A Fraile, D Ramisch, M Rumbo, H Solar, G E Gondolesi","doi":"10.1016/j.intf.2025.100310","DOIUrl":"10.1016/j.intf.2025.100310","url":null,"abstract":"<p><strong>Background: </strong>Cocoon Syndrome, or sclerosing encapsulating peritonitis, is a rare but severe complication of long-term peritoneal dialysis. It can lead to progressive fibrotic encapsulation of the intestines, causing intestinal obstruction due to a fibrous membrane encasing the abdominal organs.</p><p><strong>Case report: </strong>We present a complex case of a 29-year-old male with history of nephronophthisis and four years on peritoneal dialysis who developed Cocoon Syndrome, leading to intestinal perforation and total enterectomy, resulting in irreversible intestinal failure. After prolonged dependence on parenteral nutrition, he developed intestinal failure-associated liver disease, ultimately becoming a candidate for combined liver-intestine and kidney transplantation.</p><p><strong>Conclusion: </strong>This case illustrates how advanced Cocoon Syndrome can lead to severe and progressive complications that may ultimately require combined liver-intestine and kidney transplantation. It underscores the importance of early recognition and appropriate multidisciplinary management to improve patient outcomes.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"6 ","pages":"100310"},"PeriodicalIF":0.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term outcomes of no gut syndrome in children - A multicentre study.","authors":"Elena Cernat, Susan Hill, Rachel Wood, Assad Butt, Sally Buxton, Jeng Cheng, Jenny Goldthorpe, Jonathan Hind, Jutta Koglmeier, Nkem Onyeador, Sue Protheroe, Sunita Rajani, Catherine Richards, Camilla Salvestrini, Chris Smith, Arun Urs, Akshay Batra","doi":"10.1016/j.intf.2025.100309","DOIUrl":"10.1016/j.intf.2025.100309","url":null,"abstract":"<p><strong>Background: </strong>Children with extreme short bowel syndrome, including those who have undergone resection of the entire jejunum and ileum-termed \"No Gut Syndrome\" (NGS) in the adult literature-are now surviving due to advancements in parenteral nutrition (PN) and medical care. This study aims to describe the population characteristics and long-term outcomes of children with NGS.</p><p><strong>Material and methods: </strong>A questionnaire was distributed to the paediatric intestinal failure (IF) centres in the UK to identify patients with NGS discharged home on PN. Inclusion criteria: infants/children < 18 years with duodenum plus up to 5 cm jejunum and colon (total/partial). Follow-up data was collected two years after the initial recruitment. A multicentre Health Research Authority approval was obtained.</p><p><strong>Results: </strong>19/20 (95 %) IF centres managing 379 HPN patients responded - 27/379 (7 %) had ultrashort-bowel syndrome (U-SBS) and an additional 14/379 (4 %) NGS. Aetiology of NGS was - midgut volvulus (64 %), bowel ischaemia (22 %), necrotising enterocolitis (7 %), jejuno-ileal atresia (7 %).Nine patients had a colonic remnant in continuity. Thirteen/14 patients (93 %) remained stable on PN with one weaned off following small bowel transplant. Nine/13 (69 %) patients received > 80 % of EAR as PN and 4/13 (31 %), 30-80 %. Eight/13 (61 %) tolerated some form of enteral nutrition. There were no deaths during the follow-up period. Educational outcomes were positive showing that 11/14 (79 %) are attending school, 2/14 (14 %) nurseries with 1 awaiting enrollment (7 %).</p><p><strong>Conclusion: </strong>Advances in PN and health care have improved the long-term survival of patients with NGS. In addition, these children are attending school and participating in daily activities without significant limitation.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"6 ","pages":"100309"},"PeriodicalIF":0.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of intestinal transplantation in Australia.","authors":"Katrina Tan, Brooke Chapman, Darren Wong, Jason Yap, Graham Starkey, Adam Testro","doi":"10.1016/j.intf.2025.100072","DOIUrl":"10.1016/j.intf.2025.100072","url":null,"abstract":"<p><p>Intestinal transplantation was introduced into Australia in 2010 to meet the need of a small number of patients with irreversible intestinal failure who would otherwise need to travel abroad to access this life-saving therapy. Due to small case numbers, a single center based in Melbourne, Victoria, services all of Australia and New Zealand. Centralization of clinical activity has resulted in excellent patient outcomes, with 5-year graft and patient survival matching that of the more experienced international centers. However, on the path to establishing a successful service, multiple significant challenges were encountered, including training of staff, surgical and immunosuppression protocol development, and donor organ acceptance and recipient allocation based on the vast geography of Australia. Deficiencies in intestinal failure management on a national level have posed some further concerns regarding timely access to and referral for transplantation. Herein we discuss the establishment of an intestinal transplant service in Australia, how challenges were overcome and what barriers remain.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"6 ","pages":"100072"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life in pediatric intestinal failure: A scoping review.","authors":"Fatima Wasif, Dylan Johnson, Anna Gold","doi":"10.1016/j.intf.2025.100071","DOIUrl":"10.1016/j.intf.2025.100071","url":null,"abstract":"<p><strong>Background: </strong>Interest in quality of life (QoL) of children with intestinal failure (IF) has increased in recent years, driven by improved survival rates. Conceptualization and measurement of QoL remains understudied. As such, we conducted a scoping review to systemically catalogue measures of QoL, collate existing findings about QoL among IF patients, and examine risk and protective factors.</p><p><strong>Methods: </strong>A systemic search was conducted across four databases (MEDLINE, EMBASE, PsychINFO, CINAHL) from inception to May 6, 2024. Included articles had to explicitly operationalize and measure QoL among pediatric IF patients (< 18 years of age).</p><p><strong>Results: </strong>Thirty-three articles met inclusion criteria from an initial screen of 2124. Across studies, QoL was most frequently measured through standardized questionnaires, with the PedsQL most frequently employed. On self-report, patients reported worse health-related QoL, as well as lower physical, social, and school functioning, compared to controls. Adolescents with IF reported worse QoL than children. Youth and caregivers diverged in their reporting on QoL, with caregivers reporting worse overall QoL outcomes than children. Medical (bowel functioning), social (participation in activities with peers), and familial (parental stress and anxiety) risk and protective factors also emerged.</p><p><strong>Conclusions: </strong>IF has been found to have a negative impact on QoL for children and caregivers. It will be important to establish a standardized IF-specific QoL questionnaire to capture IF-relevant medical and treatment parameters, as well as include an evaluation of physical, emotional, social, psychological, and school functioning. Our findings help lay groundwork for establishing clinical guidelines for patient assessment and monitoring.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"6 ","pages":"100071"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal foreign body removal in children with intestinal failure: A single center ten-year retrospective review^☆.","authors":"Kieley L Chapman, Paul Crowley, Evan Brociner, Enju Liu, Brenna Fullerton, Biren P Modi, Tom Jaksic, Lissette Jimenez, Christopher P Duggan, Alexandra N Carey","doi":"10.1016/j.intf.2025.100315","DOIUrl":"10.1016/j.intf.2025.100315","url":null,"abstract":"<p><strong>Background: </strong>The significance of foreign body (FB) ingestion in children with Intestinal Failure (IF) is unknown. We aimed to characterize differences in procedural management and clinical outcomes related to gastrointestinal FB removal in pediatric patients with IF compared to children without this condition.</p><p><strong>Material and methods: </strong>This ten-year retrospective review utilized electronic healthcare data from a single pediatric center. We evaluated patients who underwent post-esophageal gastrointestinal FB removal procedures between 2011 and 2020 and compared medical history, presentation, procedure type, and procedure outcomes in children with and without IF.</p><p><strong>Results: </strong>There were 12 patients with IF and 185 controls. All FBs ingested by IF patients carried low intrinsic risk of perforation or obstruction. Esophagogastroduodenoscopy (EGD) was the most common removal procedure in both groups. Patients with IF were more likely to have FBs removed from a post-pyloric location (100 vs. 20.5 %, p < 0.0001), require lower endoscopy (41.7 vs. 9.7 %, p = 0.006), require multiple procedures for definitive removal (41.7 vs. 8.6 %, p = 0.0041), involve > 1 endoscopist or pediatric surgeon (66.7 vs. 7.0 %, p < 0.0001), and require hospital admission (83.3 vs. 28.6 %, p < 0.0001).</p><p><strong>Conclusion: </strong>FB ingestion by children with IF is associated with increased risk of procedural complexity and hospital admission, even when the object's intrinsic risk of gastrointestinal hazard is low. These differences may be related to altered intestinal anatomy and dysmotility. Physicians should consider involvement of an advanced proceduralist during removal. Education to prevent ingestion should be part of routine IF care.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"7 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12768488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}