GHM open最新文献

{"title":"The academic research organization model in universityindustry collaboration: Policy evolution and institutional reform in Japan's university hospitals.","authors":"Kensuke Yoshimura, Ryuji Suzuka, Yoichi Sakurai","doi":"10.35772/ghmo.2025.01015","DOIUrl":"10.35772/ghmo.2025.01015","url":null,"abstract":"<p><p>Japan's university hospitals face a decisive reform phase driven by demographic aging, fiscal constraints, and intensifying innovation cycles. While effective universityindustry collaboration (UIC) has become essential, partnerships often face challenges because companies prioritize rapid implementation, whereas universities emphasize scientific rigor and public accountability. In 2025, Japan's Ministry of Health, Labour and Welfare (MHLW) required all advanced treatment hospitals to establish academic research organizations (AROs) as part of basic institutional standards, integrating research governance with collaborative capability. Drawing on national policy and practical experience of Chiba University Hospital, this paper examines the rationale, governance, and implications of the ARO mandate. Institutionalizing AROs reframes university hospitals as engines of both scientific credibility and socio-economic innovation.</p>","PeriodicalId":520484,"journal":{"name":"GHM open","volume":"6 1","pages":"44-47"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic unroofing for hepatic cysts compressing the left portal vein, partial TIPE ALPPS, and hepatic vein deprivation to overcome a small future liver remnant before right hemihepatectomy.","authors":"Hirokazu Momose, Shohei Kudo, Ryosuke Miyauchi, Nobuhiro Hasui, Ryota Matsuki, Masaharu Kogure, Shiro Onozawa, Yoshihiro Sakamoto","doi":"10.35772/ghmo.2026.01001","DOIUrl":"10.35772/ghmo.2026.01001","url":null,"abstract":"<p><p>Preoperative portal vein embolization (PVE) is widely used to induce hypertrophy of the future liver remnant (FLR) before major hepatectomy. However, in cases of impaired portal flow in the FLR, conventional preoperative PVE may fail to achieve sufficient hypertrophy. A 76-year-old woman presented with intrahepatic cholangiocarcinoma involving the right Glissonean sheath. The FLR volume was 21.9% of the total liver volume, indicating the need for preoperative liver regeneration before right hemihepatectomy. However, the left portal vein (LPV) was narrowed by hepatic cysts in the Spiegel lobe; thus, sufficient left liver regeneration could not be expected after conventional PVE. Laparoscopic unroofing of hepatic cysts, partial liver partitioning, and transileocecal PVE were therefore performed as the first stage of partial transileocecal portal vein embolization with associated liver partition and portal vein ligation for staged hepatectomy (partial TIPE ALPPS). The pressure gradient between the main portal trunk and LPV was 1.5 cm. Two and four weeks after the first stage, the FLR volume increased to 39.0% and 41.5%, respectively; however, the indocyanine green (ICG) retention rate at 15 min and ICG clearance of remnant liver values were 17.8% and 0.047 (lower than the safe criterion [≥ 0.05]), respectively. To overcome the slightly insufficient FLR volume, right hemihepatectomy was performed after additional right hepatic vein deprivation (HVD) without any signs of posthepatectomy liver failure. This case illustrates a novel strategy that combines laparoscopic unroofing, partial TIPE ALPPS, and right HVD to achieve functional liver regeneration in cases of LPV stenosis.</p>","PeriodicalId":520484,"journal":{"name":"GHM open","volume":"6 1","pages":"48-51"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic impacts of COVID-19 lockdown and support for slum dwellers and homeless individuals in Ho Chi Minh City, Vietnam: A cross-sectional study.","authors":"Khuat Thi Hai Oanh, Nguyen Thuy Linh, Masami Fujita, Lam Ngoc Thuy, Nguyen Hong Phuc, Kieu Thi Mai Huong, Le Tuan Anh, Pham Thi Ngoc Mai, Hitoshi Murakami","doi":"10.35772/ghmo.2025.01008","DOIUrl":"10.35772/ghmo.2025.01008","url":null,"abstract":"<p><p>This study assessed social vulnerabilities, serious psychological distress (SPD), and socioeconomic impacts of the COVID-19 lockdown on slum dwellers and homeless individuals in Ho Chi Minh City (HCMC), Vietnam. It also examined the coverage and sources of cash and food support provided, community actors who assisted with such support, and the continuation of medication for chronic diseases. A cross-sectional survey of 415 participants (383 slum dwellers and 32 homeless individuals) was conducted using a structured questionnaire. Many participants faced social vulnerabilities, and 19.8% exhibited SPD. Job insecurity affected 58.8% of participants, and 60.7% reported income reductions due to the lockdown. During this period, 78.8% received cash support and 84.8% received food support; however, the coverage was significantly lower among homeless individuals, particularly for government-provided assistance. Community actors, most notably neighborhood heads, played key roles in assisting with the provision of cash and food support. The vast majority of patients with chronic illnesses were able to continue their medications during the lockdown, primarily through household drug storage and visits to health facilities. Receiving sufficient food support was significantly associated with reduced odds of SPD. These findings highlight the profound socioeconomic effects of the COVID-19 lockdown on populations with unstable housing in HCMC. The cash and food support, predominantly sourced from the government and donors, achieved high coverage through effective delivery by various community actors. Prescription regulations should be adjusted during lockdowns to allow patients with chronic conditions to stockpile sufficient medication. Mental health support is crucial for populations with unstable housing during pandemics.</p>","PeriodicalId":520484,"journal":{"name":"GHM open","volume":"6 1","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening infectious disease surveillance and control through long-term international collaboration: Insights from the Ghana- Japan partnership.","authors":"Kaede Tashiro, Naoaki Shinzawa, Tomoko Ishino, Ryoichi Saito, Yuta Shirogane, Toshihiko Suzuki","doi":"10.35772/ghmo.2025.01014","DOIUrl":"10.35772/ghmo.2025.01014","url":null,"abstract":"<p><p>West Africa remains a global epicenter for emerging and re-emerging infectious diseases, yet data on pathogen diversity and transmission dynamics remain fragmented. This communication summarizes 21 years of longitudinal research collaboration between the Institute of Science Tokyo (formerly Tokyo Medical and Dental University) and the Noguchi Memorial Institute for Medical Research (NMIMR) in Ghana. Our integrated surveillance framework encompasses: <i>i</i>) defining environmental virulence factors for <i>Mycobacterium ulcerans</i> to refine Buruli ulcer risk assessment; <i>ii</i>) uncovering the \"masked\" circulation of Dengue and SARS-CoV-2 through molecular epidemiology; <i>iii</i>) investigating biological determinants, including gut microbiome profiles, of reduced Rotavirus vaccine efficacy in low-income settings; <i>iv</i>) characterizing the environmental reservoirs and fitness costs of carbapenemase-producing <i>Enterobacteriaceae</i>; and <i>v</i>) analysis of the interaction of malaria parasites between symbionts in vector mosquitoes and vaccine development. By aligning basic research on infectious diseases with clinical data and human resource development, this partnership provides a scalable model for strengthening global health security and addressing the unique infectious disease challenges of the \"post-viral\" era.</p>","PeriodicalId":520484,"journal":{"name":"GHM open","volume":"6 1","pages":"40-43"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the retention of health professionals in Lao People's Democratic Republic: A cross-sectional survey analysis.","authors":"Sengthida Sivilay, Khampasong Theppanya, Bertrand Martinez-Aussel, Mick Soukavong, Mayfong Mayxay","doi":"10.35772/ghmo.2025.01012","DOIUrl":"10.35772/ghmo.2025.01012","url":null,"abstract":"<p><p>Retention of qualified health professionals is critical for achieving universal health coverage (UHC) in Lao People's Democratic Republic (Lao PDR). Despite policy commitments, the public health sector continues to experience high turnover, especially among non-permanent staff. This study examined key factors influencing health professionals' intention to remain in government service. A cross-sectional survey was conducted from June to August 2023 among 1,873 public-sector health professionals in five provinces representing high and low-turnover areas. A structured questionnaire developed with the Department of Health Personnel (DHP) and administered <i>via</i> KoboToolbox collected data on demographics, employment status, income, motivation, and job satisfaction. Descriptive, bivariate, and multivariate logistic-regression analyses identified predictors of attrition intention. Overall, 37.4% of respondents reported having considered leaving the public sector. Contractual (AOR = 2.24, 95% CI: 1.573.21) and volunteer (AOR = 2.90, 95% CI: 1.904.44) staff were significantly more likely to intend departure than civil servants. Late salary or bonus payments (AOR = 2.25, 95% CI: 1.543.31) strongly increased attrition intent. Conversely, perceiving salary incentives and career-development opportunities as effective was protective (AOR = 0.35, 95% CI: 0.210.58, for moderately effective). Health professionals outside Vientiane Capital showed 3540% lower odds of intending to leave. Retention in Lao PDR is driven by employment security, financial predictability, and professional-development opportunities. Regularizing contractual and volunteer positions, ensuring timely remuneration, and expanding career pathways are critical to implementing the national Human Resources for Health (HRH) Development Strategy 20212030 and achieving UHC by 2025.</p>","PeriodicalId":520484,"journal":{"name":"GHM open","volume":"6 1","pages":"30-39"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148311266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective evaluation of the effectiveness of flomoxef against infections with extended-spectrum β-lactamase-producing <i>Enterobacterales</i>.","authors":"Ryuji Koizumi, Yukihiro Hamada, Kazuhisa Mezaki, Norio Ohmagari, Kayoko Hayakawa","doi":"10.35772/ghmo.2025.01005","DOIUrl":"10.35772/ghmo.2025.01005","url":null,"abstract":"<p><p>This retrospective, observational study evaluated the effectiveness and optimal dosage of flomoxef (FMOX) against infections with extended-spectrum β-lactamase (ESBL)-producing <i>Enterobacterales</i> (ESBLPE) by performing pharmacokinetic/pharmacodynamic analysis. Patients with ESBLPE infections treated using FMOX for ≥ 4 days were included. The time above the minimum inhibitory concentration (MIC) (TAM) was calculated using the FMOX MIC for ESBLPE and simulated FMOX concentration. Ten patients including six women (median age: 76 years, interquartile range: 6191) were included. Most ESBLPE infections were urinary tract infections (UTIs, 60%). Among the ESBLPE isolates, eight were of <i>Escherichia coli</i>, one was of <i>Klebsiella pneumoniae</i>, and one was of <i>Proteus mirabilis</i>. Four patients had bacteremia secondary to ESBLPE infection. The most frequent MIC for FMOX was ≤ 0.12 mg/L (50%), followed by 0.25 mg/L and 0.5 mg/L. Clinical effectiveness was noted in 77.8% of cases. Regarding UTIs, effectiveness was noted in all five cases. Regarding non-UTIs, only 50% of cases showed clinical effectiveness. Regarding microbiological effectiveness, both cases in which evaluation was possible showed effectiveness. Despite the use of different doses, TAM was 100% in most cases. FMOX may be a potentially effective option for UTIs caused by ESBLPE, though larger studies are needed. FMOX effectiveness in non-UTI cases needs further evaluation.</p>","PeriodicalId":520484,"journal":{"name":"GHM open","volume":"6 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the strengthening of nursing regulatory systems: A comparative study of Lao PDR and Mongolia.","authors":"Kazuki Miyazaki, Kyoko Koto-Shimada, Kaori Seino, Sadatoshi Matsuoka, Megumi Ikemoto, Battsooj Batchuluun, Khampasong Theppanya, Mari Nagai, Noriko Fujita","doi":"10.35772/ghmo.2025.01010","DOIUrl":"10.35772/ghmo.2025.01010","url":null,"abstract":"<p><p>Access to high-quality healthcare requires a qualified health workforce supported by a robust regulatory framework, an overarching legal structure governing regulation of health professionals. Its effectiveness depends on how well its regulatory functions are carried out. Implementing these functions requires regulatory systems that provide organizational arrangements for each health profession. This study focuses on the nursing regulatory systems in Lao PDR and Mongolia to identify key factors influencing their strengthening and extract policy insights to inform efforts to strengthen nursing regulation in low- and middle-income countries. A qualitative research design was employed, integrating literature reviews and semi-structured interviews with 24 stakeholders from ministries of health, nursing associations, nursing education institutions, clinical nursing administrators, and development partners. The development stages of the nursing regulatory systems were analyzed using Walt and Gilson's Health Policy Analysis Model and the five progressive stages. While governance, capacity building, and health workforce information systems (HWIS) are recognized as important factors in health workforce regulation, this study demonstrates how they interact across stages of development. Three key factors were identified: <i>i</i>) Strengthening governance with nursing engagement in policymaking, <i>ii</i>) Capacity building of internal stakeholders through collaboration with external partners, and <i>iii</i>) Establishing interoperable HWIS for sustainable regulatory implementation. These factors operate in a cumulative and phased process, reflecting regulatory system maturity. The findings underscore the importance of tailoring regulatory strategies to the contextwith early-stage countries focusing on governance and capacity building, and more mature systems advancing toward digital integration and institutional sustainability.</p>","PeriodicalId":520484,"journal":{"name":"GHM open","volume":"6 1","pages":"19-29"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with withholding of invasive mechanical ventilation in the early phase of the COVID-19 response and their ethical analyses.","authors":"Shinichiro Morioka, Kyoko Takashima, Yusuke Asai, Tetsuya Suzuki, Hidetoshi Nomoto, Sho Saito, Kumiko Suzuki, Setsuko Suzuki, Lubna Sato, Keiji Nakamura, Mio Nikaido, Nobuaki Matsunaga, Kayoko Hayakawa, Masanori Mori, Keiichiro Yamamoto, Norio Ohmagari","doi":"10.35772/ghmo.2025.01002","DOIUrl":"10.35772/ghmo.2025.01002","url":null,"abstract":"<p><p>End-of-life decision making regarding invasive mechanical ventilation (IMV) for patients with severe coronavirus disease (COVID-19) is challenging. We aimed to explore the factors associated with the withholding of IMV in patients with COVID-19. This retrospective study included patients registered in a nationwide COVID-19 Registry Japan. We enrolled patients with COVID-19 admitted between January 1, 2020, and June 30, 2021, and died during hospitalization. The enrolled patients were divided into two groups: those who received IMV (IMV group) and those who did not (non-IMV group). To identify the factors associated with withholding of IMV among patients with COVID-19 who died during hospitalization, we conducted a multivariate logistic regression analysis. A total of 2,401 patients were enrolled. Of these, 588 (24.5%) were in the IMV group and 1813 (75.5%) in the non-IMV group. Withholding IMV was positively associated with older age (95% confidence interval [CI]: 0.82-0.88, <i>p</i> < 0.0001), dementia (95% CI: 0.81-0.91, <i>p</i> < 0.0001), chronic lung disease (95% CI: 0.88-1.00, <i>p</i> = 0.036), and malignancy (95% CI: 0.82-0.94, <i>p</i> < 0.0004) although inversely associated with male sex (95% CI: 1.04-1.15, <i>p</i> = 0.0008), body mass index (95% CI: 1.01-1.02, <i>p</i> < 0.0001), and National Early Warning Score (95% CI: 1.01-1.03, <i>p</i> < 0.0001). We subsequently analyzed these results to inform preparedness for future emerging infectious disease pandemics by retrospectively examining the decision-making processes during the COVID-19 crisis, with particular attention to the role of multidisciplinary collaboration. Based on this study, it will be essential in future pandemics to assess decisions concerning life-sustaining treatments, including IMV, from both scientific and ethical perspectives.</p>","PeriodicalId":520484,"journal":{"name":"GHM open","volume":"5 1","pages":"30-36"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The frequency of peripheral blood eosinophilia and its clinical significance in patients with dermatomyositis.","authors":"Kayoko Tabata, Yutaka Inaba, Tomoyuki Hara, Kayo Kunimoto, Yuki Yamamoto, Ryo Matsumiya, Masatoshi Jinnin, Takao Fujii","doi":"10.35772/ghmo.2023.01027","DOIUrl":"10.35772/ghmo.2023.01027","url":null,"abstract":"<p><p>In connective tissue diseases, eosinophil is thought to varying extents to be involved in the pathogenesis. Increased eosinophils in the skin tissues of patients with dermatomyositis (DM) have been reported, but there have been no investigations of blood eosinophilia in patients with DM. This study is the aim of determining the frequency of peripheral blood eosinophilia and elucidating its clinical significance. We retrospectively collected the clinical records of 48 patients (15 men and 35 women) who were diagnosed with classical DM (<i>n</i> = 34), ADM (<i>n</i> = 13), and JDM (<i>n</i> = 1), on the basis of the 2017 EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies. Eosinophil count ≥ 400/mm³ was observed in 14.6% (<i>n</i> = 7) of the patients, while 4.2% (<i>n</i> = 2) of patients had eosinophil counts >1,000/mm³. Regarding the clinical significance of peripheral blood eosinophilia in DM patients, in seven patients with increased blood eosinophil counts, the prevalence of Gottron's sign/papules, heliotrope rash, V-neck sign, shawl sign, pruritus, internal malignancy, and positive anti-TIF1-γ antibody were more frequent than in those without (85.7% , 85.7%, 71.4%, 71.4%, 85.7%, 42.9%, 28.6% <i>vs.</i> 92.7% <i>p</i> = 0.48, 61.0% <i>p</i> = 0.40, 36.6% <i>p</i> = 0.11, 39.0% <i>p</i> = 0.22, 36.6% <i>p</i> = 0.034, 19.5% <i>p</i> = 0.33, and 19.5% <i>p</i> = 0.63, respectively). Among them, pruritus was more common in patients with elevated eosinophil counts with statistical significance. The activity of eosinophilia and severity of skin eruptions also tended to be correlated. In summary, our study suggests that blood eosinophilia is correlated with the presence of pruritus, but not disease-associated autoantibodies or internal malignancy.</p>","PeriodicalId":520484,"journal":{"name":"GHM open","volume":"5 1","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fatal case of pyogenic spondylitis rapidly progressing to epidural abscess caused by a novel ST-type methicillin-susceptible <i>Staphylococcus aureus</i> ST9378.","authors":"Takeru Inoue, Tomoe Setoguchi, Michiaki Akashi, Nobuyuki Shimono, Yasuhisa Iwao, Shoko Kutsuno, Junzo Hisatsune","doi":"10.35772/ghmo.2025.01001","DOIUrl":"10.35772/ghmo.2025.01001","url":null,"abstract":"<p><p>Pyogenic spondylitis can be life-threatening; however, its diagnosis remains challenging because of the initial presentation of nonspecific symptoms. Given the vulnerability of the infected site, patients are highly at risk for severe complications, such as epidural abscesses or bacterial meningitis, which can considerably worsen the prognosis. Herein, we report a case of lumbar pyogenic spondylitis initially identified through methicillin-susceptible <i>Staphylococcus aureus</i> bacteremia, which subsequently progressed to an epidural abscess. The abscess rapidly ascended to the cervical region, causing bacterial meningitis and ultimately, a fatal outcome. The strain (JARB-OU3818) was positive for the virulence factor genes of the enterotoxin gene cluster (<i>seg</i>, <i>sei</i>, <i>sem</i>, <i>sen</i>, and <i>seo</i>) but negative for the Panton-Valentine leucocidin (PVL) and toxic shock syndrome toxin-1 (TSST-1) coding genes. Additionally, JARB-OU3818 was ST9378 belonging to the clonal complex 45 lineage. Clinicians should recognize that pyogenic spondylitis may follow an aggressively progressive clinical course, as demonstrated by this case.</p>","PeriodicalId":520484,"journal":{"name":"GHM open","volume":"5 1","pages":"47-51"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}