Cell biomaterials最新文献

A 4D Bio-Kirigami Strategy for Engineering Complex Tissue Curvatures.

Cell biomaterials Pub Date : 2026-10-14 DOI: 10.1016/j.celbio.2026.100613

Kaelyn L Gasvoda, Aixiang Ding, Zhangli Peng, Alexandria Sterenberg, Oju Jeon, Eben Alsberg

{"title":"A 4D Bio-Kirigami Strategy for Engineering Complex Tissue Curvatures.","authors":"Kaelyn L Gasvoda, Aixiang Ding, Zhangli Peng, Alexandria Sterenberg, Oju Jeon, Eben Alsberg","doi":"10.1016/j.celbio.2026.100613","DOIUrl":"https://doi.org/10.1016/j.celbio.2026.100613","url":null,"abstract":"Native tissues exhibit intricate curvatures essential for their function yet recapitulating structural complexity and dynamic morphogenesis remains challenging. Here, we present a cytocompatible bio-Kirigami system that enables programmable transformation of cell-laden hydrogels into complex three-dimensional tissue constructs. The system consists of (1) a photocrosslinked hydrogel with tunable degradation and swelling behavior to drive shape transformation and (2) a rigid hydrogel frame to provide structural support. Spatial patterning encodes localized swelling differentials via sequential photolithography, enabling controlled deformation and diverse morphing behaviors. Stem cell-laden bio-Kirigami constructs underwent programmed shape transformation and developed into tissue-like structures with complex curvatures under tissue-specific culture conditions. Importantly, the engineered tissue constructs retained their structural integrity and shape after removal of the supporting frame. This bio-Kirigami strategy provides a versatile approach for engineering dynamically transformable tissue constructs that recapitulate the complex geometries of native tissues.","PeriodicalId":520483,"journal":{"name":"Cell biomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13730194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149329658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A long-acting injectable nanoparticle-hydrogel depot enables sustained IGF-1 delivery to reverse chronic denervation. 长效可注射纳米颗粒-水凝胶储库使持续的IGF-1递送能够逆转慢性神经丧失。

Cell biomaterials Pub Date : 2026-09-21 DOI: 10.1016/j.celbio.2026.100594

Yicheng Zhang, Thomas G W Harris, Christopher J Erb, Chenhu Qiu, Karim A Sarhane, Philip Hanwright, Benjamin R Slavin, Zhi-Cheng Yao, Jiayuan Kong, Erica B Lee, Nicholas von Guionneau, Jeffrey Khong, Rachana Suresh, Dany Y Matar, Alexander J Tinana, Moonhyung Lee, Marcos Iglesias, Connor Glass, Nicholas Hricz, Sai Pinni, Matthew Generoso, Visakha Suresh, Aysel Cetinkaya-Fisgin, Eric K Hutchinson, Jessica Izzi, Kara Segna, Sashank Reddy, Ahmet Höke, Hai-Quan Mao, Sami H Tuffaha

{"title":"A long-acting injectable nanoparticle-hydrogel depot enables sustained IGF-1 delivery to reverse chronic denervation.","authors":"Yicheng Zhang, Thomas G W Harris, Christopher J Erb, Chenhu Qiu, Karim A Sarhane, Philip Hanwright, Benjamin R Slavin, Zhi-Cheng Yao, Jiayuan Kong, Erica B Lee, Nicholas von Guionneau, Jeffrey Khong, Rachana Suresh, Dany Y Matar, Alexander J Tinana, Moonhyung Lee, Marcos Iglesias, Connor Glass, Nicholas Hricz, Sai Pinni, Matthew Generoso, Visakha Suresh, Aysel Cetinkaya-Fisgin, Eric K Hutchinson, Jessica Izzi, Kara Segna, Sashank Reddy, Ahmet Höke, Hai-Quan Mao, Sami H Tuffaha","doi":"10.1016/j.celbio.2026.100594","DOIUrl":"https://doi.org/10.1016/j.celbio.2026.100594","url":null,"abstract":"Chronic denervation following peripheral nerve injury leads to progressive muscle atrophy and Schwann cell dysfunction that severely limit functional recovery, yet no therapies effectively sustain trophic support over the prolonged regenerative period. Here, we develop a long-acting injectable (LAI) biomaterial platform that enables sustained local delivery of insulin-like growth factor-1 (IGF-1). The system encapsulates IGF-1 in poly(ethylene glycol)-b-polycaprolactone nanoparticles and embeds nanoparticles within an injectable nanofiber-hydrogel composite, enabling six-week local IGF-1 delivery with preserved bioactivity and tissue retention. In a rat chronic denervation model with delayed nerve repair, the IGF-1 LAI increased grip strength by 29.1%, myelinated axon counts by 186.2%, and myofiber cross-sectional area by 88.4%. In a non-human primate model, repeated six-week dosing maintained intramuscular IGF-1 levels and improved functional recovery by 57.0%, accompanied by reduced fibrosis and increased reinnervation. These findings establish a translational biomaterial strategy for sustained protein delivery and disease-modifying treatment of chronic denervation.","PeriodicalId":520483,"journal":{"name":"Cell biomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149248435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Focused Ultrasound is Poised to Take Non-Viral Gene Therapies to the Blood-Brain Barrier - and Beyond. 聚焦超声技术有望将非病毒基因疗法应用于血脑屏障及其他领域。

Cell biomaterials Pub Date : 2026-09-15 Epub Date: 2026-05-20 DOI: 10.1016/j.celbio.2026.100461

Eden N Gordon, Anna C Debski, Victoria R Breza, Matthew R Hoch, Nareen Z Anwar, Khondamir Imomnazarov, Alec J Batts, Matthew R DeWitt, Natasha D Sheybani, Richard J Price

{"title":"Focused Ultrasound is Poised to Take Non-Viral Gene Therapies to the Blood-Brain Barrier - and Beyond.","authors":"Eden N Gordon, Anna C Debski, Victoria R Breza, Matthew R Hoch, Nareen Z Anwar, Khondamir Imomnazarov, Alec J Batts, Matthew R DeWitt, Natasha D Sheybani, Richard J Price","doi":"10.1016/j.celbio.2026.100461","DOIUrl":"10.1016/j.celbio.2026.100461","url":null,"abstract":"The blood-brain barrier (BBB) offers a highly specialized protective boundary for the brain, but severely limits therapeutic delivery, posing major challenges for treating neurological diseases and solid tumors. Focused ultrasound (FUS) has emerged as a powerful tool to noninvasively and transiently disrupt the BBB to enable localized delivery of drugs and gene therapies. More commonly paired with viral vectors like adeno-associated virus (AAV), FUS is now being explored with non-viral vectors such as polymeric and lipid nanoparticles, which offer tunable chemistry, repeat dosing potential, and capability to deliver varying cargos. Upon promising advances, future directions aim to improve safety, target immune modulation, and integrate diagnostic imaging for theranostic potential. Overall, the convergence of FUS and non-viral nanocarrier technologies represents a transformative approach for precise, minimally invasive, and accessible gene delivery to the central nervous system.","PeriodicalId":520483,"journal":{"name":"Cell biomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Light Processing 3D Printing Enables Versatile Fabrication of Human Engineered Heart Tissues. 数字光处理3D打印实现了人类工程心脏组织的多功能制造。

Cell biomaterials Pub Date : 2026-09-15 Epub Date: 2026-03-12 DOI: 10.1016/j.celbio.2026.100405

Abhishek P Dhand, Miranda A Juarros, Thomas G Martin, Manuela Garay-Sarmiento, Christina Alamana, Dakota R Hunt, Gabriel J Rodriguez-Rivera, Mackenzie C Obenreder, Cody O Crosby, Bianca Meurer-Zeman, Quentin McAfee, Henry Valle-Ayala, Hannah M Zlotnick, Declan N Goddard, Christopher C Ebmeier, Jason A Burdick, Leslie A Leinwand

{"title":"Digital Light Processing 3D Printing Enables Versatile Fabrication of Human Engineered Heart Tissues.","authors":"Abhishek P Dhand, Miranda A Juarros, Thomas G Martin, Manuela Garay-Sarmiento, Christina Alamana, Dakota R Hunt, Gabriel J Rodriguez-Rivera, Mackenzie C Obenreder, Cody O Crosby, Bianca Meurer-Zeman, Quentin McAfee, Henry Valle-Ayala, Hannah M Zlotnick, Declan N Goddard, Christopher C Ebmeier, Jason A Burdick, Leslie A Leinwand","doi":"10.1016/j.celbio.2026.100405","DOIUrl":"10.1016/j.celbio.2026.100405","url":null,"abstract":"Investigations into cardiac biology and drug discovery benefit from in vitro models that replicate human cardiac physiology. Current engineered heart tissue (EHT) models recapitulate aspects of this physiology but are limited by scalability, cost, and reproducibility. We report a one-step method to fabricate hydrogel molds using digital light processing (DLP) 3D printing to support EHT formation from human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). DLP enables rapid tuning of mold size, aspect ratio, and stiffness, while increasing scalability for high-throughput experiments without compromising EHT quality. DLP-fabricated EHTs show aligned extracellular matrix and display improvements in maturity versus 2D cultures, including a shift to fatty acid metabolism, increased myofilament density, and improved sarcomere organization. These EHTs also display expected responses to pathological stimuli (e.g., adrenergic agonism, increased stiffness), enabling disease modeling applications. Overall, 3D DLP-printed EHT molds provide versatile, scalable cardiac tissue platforms for both mechanistic studies and large-scale drug screening.","PeriodicalId":520483,"journal":{"name":"Cell biomaterials","volume":"2 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148979023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PEG-lipid shedding and biodistribution are shaped by nanocarrier morphology and lipid chemistry. 聚乙二醇脂质脱落和生物分布是由纳米载体形态和脂质化学决定的。

Cell biomaterials Pub Date : 2026-09-15 Epub Date: 2026-03-23 DOI: 10.1016/j.celbio.2026.100419

Ethan P Cisneros, Caroline C Hoy, Constadina Arvanitis, Ben Kinzelberg, Aadya S Wijesekera, Lisa R Volpatti

{"title":"PEG-lipid shedding and biodistribution are shaped by nanocarrier morphology and lipid chemistry.","authors":"Ethan P Cisneros, Caroline C Hoy, Constadina Arvanitis, Ben Kinzelberg, Aadya S Wijesekera, Lisa R Volpatti","doi":"10.1016/j.celbio.2026.100419","DOIUrl":"10.1016/j.celbio.2026.100419","url":null,"abstract":"Targeting moieties are often attached to nanocarriers (NCs) using poly(ethylene glycol)-lipids (PEG-lipids) to direct uptake to target cells and organs. However, nanoparticles (NPs) can interact with proteins during systemic circulation, causing PEG-lipids to dissociate or \"shed,\" which limits targeting efficiency. Here, we investigate how lipid chemistry and poly(ethylene glycol)-b-poly(propylene sulfide) (PEG-PPS) NC morphology affect PEG-lipid shedding. We conjugated one fluorophore to the NC and another to the PEG-lipid to track shedding over time. By coupling Förster resonance energy transfer (FRET) and total internal reflection fluorescence microscopy (TIRF) with biological systems, we found that PEG-lipids with stable anchors shed slowly and are consistent across NC morphologies. In contrast, weakly anchored PEG-lipids exhibit morphology-dependent shedding and biodistribution in vivo. These findings underscore how PEG-lipids can have different biodistribution from their NCs, highlighting the importance of this phenomenon in the design of new targeted nanomedicines.","PeriodicalId":520483,"journal":{"name":"Cell biomaterials","volume":"2 9","pages":"100419"},"PeriodicalIF":0.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optoelectronic Biohybrid Platform Enables Light-Controlled Cardiac Structural and Functional Feedback. 光电生物混合平台实现光控心脏结构和功能反馈。

Cell biomaterials Pub Date : 2026-09-15 Epub Date: 2026-03-24 DOI: 10.1016/j.celbio.2026.100416

Yuyao Kuang, Ze-Fan Yao, Catherine Salgado, Emil M Lundqvist, Nadeen Morsi, Natalie Celt, Juan Manuel Urueña, Chelsea M Phillips, Michael J Zeitz, James W Smyth, Dmitry A Fishman, Herdeline Ann M Ardoña

{"title":"Optoelectronic Biohybrid Platform Enables Light-Controlled Cardiac Structural and Functional Feedback.","authors":"Yuyao Kuang, Ze-Fan Yao, Catherine Salgado, Emil M Lundqvist, Nadeen Morsi, Natalie Celt, Juan Manuel Urueña, Chelsea M Phillips, Michael J Zeitz, James W Smyth, Dmitry A Fishman, Herdeline Ann M Ardoña","doi":"10.1016/j.celbio.2026.100416","DOIUrl":"10.1016/j.celbio.2026.100416","url":null,"abstract":"Cardiac tissues naturally respond to an autoregulatory loop of electrical and mechanical cues, which often influence signal transduction pathways in synergism rather than in isolation. Here, we present a mechanically compliant biointerface fabricated with cardiomyocytes aligned atop a photocurrent-generating elastomeric substrate. Cardiac tissue contractions were optically paced within a normal human heartbeat frequency range without requiring gene modification. Using this biohybrid system as an in vitro model, we investigate how pulsed light input potentiates mechanical tissue response via contractility, and in turn, how contraction-induced tissue strain affects the structure and expression of cellular features responsible for intercellular communication. More specifically, we quantified the effects of this photostimulation approach, with and without the additional influence of actuation, on cytoskeletal/ sarcomeric orientation and gap junction expression. In summary, this biohybrid platform based on an optoelectronic polymer interface enables light-controlled electromechanical feedback useful for in vitro mechanistic investigations of the cardiac structure-function continuum.","PeriodicalId":520483,"journal":{"name":"Cell biomaterials","volume":"2 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticle-Hydrogel Composites for Precision Medicine. 用于精准医疗的纳米颗粒-水凝胶复合材料。

Cell biomaterials Pub Date : 2026-09-15 Epub Date: 2026-02-13 DOI: 10.1016/j.celbio.2026.100372

Sadiyah Parveen, Suleyman B Bozal, Jordan S Pober, W Mark Saltzman

{"title":"Nanoparticle-Hydrogel Composites for Precision Medicine.","authors":"Sadiyah Parveen, Suleyman B Bozal, Jordan S Pober, W Mark Saltzman","doi":"10.1016/j.celbio.2026.100372","DOIUrl":"10.1016/j.celbio.2026.100372","url":null,"abstract":"Nanoparticle-hydrogel composites hold significant potential for precision medicine. They effectively combine the molecular programming capabilities of nanoparticles and the macroscopic spatial management properties of hydrogels. This review examines the material composition of nanoparticles and hydrogels, the methods used to create composite structures, and the design elements that facilitate therapeutic customization. In theory, these systems can be engineered to target patient-specific biomarkers and coordinate multi-agent release with disease progression while adapting therapeutic dosing to individual treatment contexts that are critical for precision medicine applications. Through analysis of recent advances in cancer immunotherapy, drug delivery, gene therapy, tissue engineering, and personalized vaccination, we emphasize that clinical success demands equal focus on mechanistic sophistication along with practical considerations including manufacturing reproducibility, standardized material characterization, and evaluation frameworks that assess clinically relevant outcomes beyond traditional laboratory metrics. This review discusses the key approaches to strategically design nanoparticle-hydrogel composites to bridge the gap between preclinical studies and clinical translation in precision medicine.","PeriodicalId":520483,"journal":{"name":"Cell biomaterials","volume":"2 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148979163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Approaches for recapitulating the extracellular matrix in organs-on-chip. 芯片上器官细胞外基质的再现方法。

Cell biomaterials Pub Date : 2026-09-08 DOI: 10.1016/j.celbio.2026.100577

Madeline W Singletary, Ryan N Stack, McKenzie Garcia, Sarina Schmoyer, Sreenidhi Elayaperumal, William J Polacheck

{"title":"Approaches for recapitulating the extracellular matrix in organs-on-chip.","authors":"Madeline W Singletary, Ryan N Stack, McKenzie Garcia, Sarina Schmoyer, Sreenidhi Elayaperumal, William J Polacheck","doi":"10.1016/j.celbio.2026.100577","DOIUrl":"https://doi.org/10.1016/j.celbio.2026.100577","url":null,"abstract":"Recent initiatives to reduce animal use in preclinical research have accelerated the development of organs-on-chip (OoC) for modeling human physiology. While OoCs have advanced structural and cellular complexity beyond 2D culture, strategies to reproduce the extracellular matrix (ECM) remain limited. This review synthesizes emerging strategies to recapitulate native ECM within OoCs, emphasizing both solid and fluid phases of the microenvironment. We define key mechanical parameters governing cell-matrix interactions and outline how these properties are engineered in biomimetic hydrogels. Natural polymers, their modified derivatives, and synthetic polymers are discussed alongside top-down methods using ECM from xenogeneic and human tissues, highlighting tradeoffs among biochemical and biomechanical fidelity, reproducibility, and compatibility with OoC fabrication. By comparing these strategies across tissues and disease models, we identify design principles for engineering ECM that balance physiological relevance with manufacturability, guiding the next generation of OoC platforms toward improved physiological relevance and translational utility.","PeriodicalId":520483,"journal":{"name":"Cell biomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxygen-generating cryogel vaccines help overcome tumor antigen tolerance and induce durable antitumor immunity in prostate cancer. 产氧低温凝胶疫苗有助于克服肿瘤抗原耐受性和诱导持久的抗肿瘤免疫在前列腺癌。

Cell biomaterials Pub Date : 2026-09-01 DOI: 10.1016/j.celbio.2026.100578

Alexandra Nukovic, Khushbu Bhatt, Thibault Colombani, Emilia Todorovic, Lucy M Williamson, Brittany Noonan, Enrique M Chang, Laura Losada Miguens, Michail Sitkovsky, Sidi A Bencherif, Stephen M Hatfield

{"title":"Oxygen-generating cryogel vaccines help overcome tumor antigen tolerance and induce durable antitumor immunity in prostate cancer.","authors":"Alexandra Nukovic, Khushbu Bhatt, Thibault Colombani, Emilia Todorovic, Lucy M Williamson, Brittany Noonan, Enrique M Chang, Laura Losada Miguens, Michail Sitkovsky, Sidi A Bencherif, Stephen M Hatfield","doi":"10.1016/j.celbio.2026.100578","DOIUrl":"10.1016/j.celbio.2026.100578","url":null,"abstract":"Therapeutic cancer vaccines represent a promising approach to boost patients' own immune system to fight cancer; however, they have shown limited success in clinical trials largely due to insufficient antigen delivery to overcome tolerance and hypoxia-mediated immunosuppression. Cryogel-based delivery scaffolds offer a promising platform for cancer vaccines due to their biocompatibility and macroporous structure, enabling effective delivery to infiltrating antigen-presenting cells. However, these systems are limited by rapid, diffusion-mediated burst release of encapsulated proteins and local hypoxia-driven immunosuppression. Click conjugation of a tumor-associated protein within cryogel-based vaccines, combined with an O2-generating platform (Click O2-CryogelVAX), overcomes immunosuppression and weak antigenicity, and primes effective antitumor immunity. Sustained antigen delivery promotes cellular memory and Th1-driven responses, while O2 release enhances humoral immunity. Together, Click O2-CryogelVAX supports a robust antitumor response and prolongs survival in a therapeutic prostate cancer model, supporting further investigation as an effective delivery platform for cancer vaccines.","PeriodicalId":520483,"journal":{"name":"Cell biomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reverse the progression of Alzheimer's disease through Nano-ERASER-based adult neuroregeneration. 通过基于纳米eraser的成人神经再生逆转阿尔茨海默病的进展。

Cell biomaterials Pub Date : 2026-08-26 DOI: 10.1016/j.celbio.2026.100575

Mingming Wang, Brandon VanderVeen, Zhixuan Annie Xu, Ying Xu, Jacobo Mintzer, Angela Murphy, Quanguang Zhang, Peisheng Xu

{"title":"Reverse the progression of Alzheimer's disease through Nano-ERASER-based adult neuroregeneration.","authors":"Mingming Wang, Brandon VanderVeen, Zhixuan Annie Xu, Ying Xu, Jacobo Mintzer, Angela Murphy, Quanguang Zhang, Peisheng Xu","doi":"10.1016/j.celbio.2026.100575","DOIUrl":"https://doi.org/10.1016/j.celbio.2026.100575","url":null,"abstract":"Alzheimer's disease (AD) remains irreversible largely because the adult brain cannot replace lost neurons. Here, we present a Nano-ERASER-based Trim-Away system (TN-PTBP1) that enables adult neuroregeneration in the AD brain, offering a new strategy to counteract AD progression. TN-PTBP1 penetrates the blood-brain barrier, delivers anti-PTBP1 antibodies into astrocytes, and triggers rapid TRIM21-mediated PTBP1 degradation. This non-genomic protein depletion induces astrocyte-to-neuron conversion, generates functional neurons in vitro and in human brain organoids, and restores hippocampal neurogenesis in AD mice. Importantly, TN-PTBP1 treatment significantly improves cognition, learning, and memory, demonstrating true functional reversal of AD-associated deficits. By resolving the long-standing controversy surrounding PTBP1 reprogramming and establishing a translational biomaterials-based platform for in situ neuronal regeneration, this work introduces a transformative therapeutic paradigm aimed not only at slowing AD but at rebuilding the neuronal circuitry it destroys.","PeriodicalId":520483,"journal":{"name":"Cell biomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0