{"title":"Quantum limit cycles and synchronization from a measurement perspective","authors":"Tobias Nadolny, Christoph Bruder","doi":"10.1103/c5wj-4s73","DOIUrl":"https://doi.org/10.1103/c5wj-4s73","url":null,"abstract":"Limit-cycle oscillators are the basic building blocks for synchronization; yet, the notion of a quantum limit cycle has remained unclear. Here, we study quantum limit cycles and synchronization in the presence of continuous heterodyne measurement. The resulting quantum trajectories, i.e., time evolutions of the quantum state conditioned on the measurement outcome, make the quantum limit cycles apparent. We focus on the paradigmatic model of the quantum van der Pol oscillator and on two-level systems. Our work provides insights into limit cycles in quantum systems, emphasizing their similarity to classical limit cycles subject to noise. Additionally, we connect theoretical measures of quantum synchronization to quantities experimentally accessible via heterodyne detection.","PeriodicalId":520315,"journal":{"name":"Physical review research","volume":"8 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Amplifying microwave pulses with a single qubit engine fueled by quantum measurements","authors":"Rémy Dassonneville, Cyril Elouard, Romain Cazali, Réouven Assouly, Audrey Bienfait, Alexia Auffèves, Benjamin Huard","doi":"10.1103/rygc-bc3c","DOIUrl":"https://doi.org/10.1103/rygc-bc3c","url":null,"abstract":"Recent progress in manipulating individual quantum systems enables the exploration of engines exploiting nonclassical resources. One of the most appealing is the energy provided by the inherent backaction of quantum measurements. While a handful of experiments have investigated the inner dynamics of engines fueled by measurement backaction, powering a task by such an engine is missing. Here, we demonstrate the amplification of microwave signals by an engine fueled by repeated quantum measurements of a superconducting transmon qubit. Using feedback, the engine acts as a quantum Maxwell demon operating without a hot thermal source. Measuring the gain of this amplification constitutes a direct probing of the work output of the engine, in contrast to inferring the work by measuring the qubit state along its evolution. Observing a good agreement between both work estimation methods, our experiment validates the accuracy of the indirect method. We characterize the long-term stability of the engine as well as its robustness to transmon decoherence, loss, and drifts. Our experiment exemplifies the use of energy brought by quantum measurement backaction.","PeriodicalId":520315,"journal":{"name":"Physical review research","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olivier Witteveen, Samuel J Rosen, Ryan S Lach, Maxwell Z Wilson, Marianne Bauer
{"title":"Optimizing information transmission in optogenetic Wnt signaling.","authors":"Olivier Witteveen, Samuel J Rosen, Ryan S Lach, Maxwell Z Wilson, Marianne Bauer","doi":"10.1103/f7qj-f7qy","DOIUrl":"10.1103/f7qj-f7qy","url":null,"abstract":"<p><p>Populations of cells regulate gene expression in response to external signals, but their ability to make reliable collective decisions is limited by both intrinsic noise in molecular signaling and variability between individual cells. In this work, we use optogenetic control of the canonical Wnt pathway as an example to study how reliably information about an external signal is transmitted to a population of cells, and determine an optimal encoding strategy to maximize information transmission from Wnt signals to gene expression. We find that it is possible to reach an information capacity beyond 1 bit only through an appropriate, discrete encoding of signals: using no Wnt, a short Wnt pulse, or a sustained Wnt signal. By averaging over an increasing number of outputs, we systematically vary the effective noise in the pathway. As the effective noise decreases, the optimal encoding comprises more discrete input signals. These signals do not need to be fine-tuned to achieve near-optimal information transmission. The optimal code transitions into a continuous code in the small-noise limit, which can be shown to be consistent with the Jeffreys prior. We visualize the performance of different signal encodings using decoding maps. Our results suggest that optogenetic Wnt signaling allows for regulatory control beyond a simple binary switch and provide a framework to apply ideas from information processing to single-cell <i>in vitro</i> experiments.</p>","PeriodicalId":520315,"journal":{"name":"Physical review research","volume":"8 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inner-shell x-ray lasing in x-ray free-electron laser-driven highly ionized plasmas","authors":"Yongjun Li, Cheng Gao, Jianpeng Liu, Jiaolong Zeng, Jianmin Yuan","doi":"10.1103/7xbb-lb39","DOIUrl":"https://doi.org/10.1103/7xbb-lb39","url":null,"abstract":"We present an efficient time-dependent Maxwell-Bloch transport model for simulating inner-shell x-ray lasing (XRL) in x-ray free-electron laser-driven highly ionized and excited nonlocal thermodynamic equilibrium plasmas. The model selectively retains all coherences between lasing levels together with nonradiative coherences linking adjacent lasing transitions. This model fully accounts for all processes governing population evolution, enabling accurate and efficient simulation of complex atomic systems. Applications to neon and argon gases reveal distinct amplification behaviors across charge states. In neon, multiple lasing lines spanning low to high ionization stages are identified, where low-charge-state transitions are strongly shaped by autoionization and saturation, while high-charge-state transitions exhibit pronounced coherence signatures such as Rabi oscillations and Rabi splitting. In argon, amplification is dominated by a few strong channels, while weaker ones are suppressed by nonradiative coherence effects in <a:math xmlns:a=\"http://www.w3.org/1998/Math/MathML\"> <a:mi mathvariant=\"normal\">Λ</a:mi> </a:math> -type subsystems. Overall, our results demonstrate that laser field-induced multilevel coherent coupling plays a crucial role in shaping XRL gain and spectra. This framework provides a versatile and predictive tool for designing XRLs with tailored temporal and spectral properties, with potential applications in ultrafast science, nonlinear x-ray optics, and precision spectroscopy.","PeriodicalId":520315,"journal":{"name":"Physical review research","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147912817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phylogenetic corrections and higher-order sequence statistics in protein families: Potts vs multiple sequence alignment transformer machine learning models.","authors":"Kisan Khatri, Ronald M Levy, Allan Haldane","doi":"10.1103/g5cx-1vhj","DOIUrl":"10.1103/g5cx-1vhj","url":null,"abstract":"<p><p>Recent generative machine learning models applied to protein multiple sequence alignment (MSA) datasets include simple and interpretable physics-based Potts covariation models and other machine learning models such as MSA Transformer (MSA-T). The best models accurately reproduce MSA statistics induced by the biophysical constraints within proteins, raising the question of which functional forms best model the underlying physics. The Potts model is usually specified by an effective potential including pairwise residue-residue interaction terms, but it has been suggested that MSA-T can capture the effects induced by effective potentials that include more than pairwise interactions and implicitly account for phylogenetic structure in the MSA. Here, we compare the ability of the Potts model and MSA-T to reconstruct higher-order sequence statistics reflecting complex biophysical sequence constraints. We show how the model performance depends greatly on the treatment of phylogenetic relationships between the sequences, which can induce nonbiophysical mutational covariation in MSAs. When using explicit corrections for phylogenetic dependencies, we find that the Potts model outperforms MSA-T in detecting epistatic interactions of biophysical origin. Furthermore, the sequences generated by the models we studied here are predicted to fold into nativelike structures, as indicated by AlphaFold predictions.</p>","PeriodicalId":520315,"journal":{"name":"Physical review research","volume":"7 4","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13251796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148230444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kousuke Kumasaki, Toshihiro Yada, Ken Funo, Takahiro Sagawa
{"title":"Thermodynamic approach to quantum cooling limit of continuous Gaussian feedback","authors":"Kousuke Kumasaki, Toshihiro Yada, Ken Funo, Takahiro Sagawa","doi":"10.1103/5cz5-n6jt","DOIUrl":"https://doi.org/10.1103/5cz5-n6jt","url":null,"abstract":"Feedback cooling plays a critical role in stabilizing quantum systems and achieving low temperatures, where a key question is to determine the fundamental thermodynamic limits on cooling performance. We establish a fundamental bound on quantum feedback cooling in Gaussian systems, by deriving a generalized second law of thermodynamics involving the kinetic temperatures of the system and a measure of quantum information flow obtained by continuous measurement. In contrast to previously known bounds, the obtained bound can be saturated by experimentally feasible situations using the quantum Kalman filter with a large feedback gain, where the cooling efficiency approaches its maximum. Our theoretical result is numerically demonstrated using parameters from an experiment of levitated nanoparticles. Our theory provides a general framework for understanding the thermodynamic constraints on quantum feedback cooling.","PeriodicalId":520315,"journal":{"name":"Physical review research","volume":"7 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147917998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christoph Hellings, Nathan Lacroix, Ants Remm, Richard Boell, J. Herrmann, Stefania Lazăr, Sebastian Krinner, François Swiadek, Christian Kraglund Andersen, Christopher Eichler, Andreas Wallraff
{"title":"Calibrating magnetic flux control in superconducting circuits by compensating distortions on timescales from nanoseconds up to tens of microseconds","authors":"Christoph Hellings, Nathan Lacroix, Ants Remm, Richard Boell, J. Herrmann, Stefania Lazăr, Sebastian Krinner, François Swiadek, Christian Kraglund Andersen, Christopher Eichler, Andreas Wallraff","doi":"10.1103/1qhb-r4fb","DOIUrl":"https://doi.org/10.1103/1qhb-r4fb","url":null,"abstract":"Fast tuning of the transition frequency of superconducting qubits using magnetic flux is essential, for example, for realizing high-fidelity two-qubit gates with low leakage or for reducing errors in dispersive qubit readout. To apply accurately shaped flux pulses, signal distortions induced by the flux control lines need to be carefully compensated for. This requires their characterization at the reference plane of the qubit. However, many existing approaches are limited in time resolution or in pulse duration. Here, we overcome these limitations and demonstrate accurate flux control with subpermille residual frequency errors on timescales ranging from nanoseconds to tens of microseconds. We achieve this by combining two complementary methods to characterize and compensate for pulse distortions. We have deployed this approach successfully in a quantum error correction experiment calibrating 24 flux-activated two-qubit gates. Reliable calibration methods, as the ones presented here, are essential in experiments scaling up superconducting quantum processors.","PeriodicalId":520315,"journal":{"name":"Physical review research","volume":"7 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147913232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gene expression cycles drive non-exponential bacterial growth.","authors":"Arianna Cylke, Shiladitya Banerjee","doi":"10.1103/24rx-sxcw","DOIUrl":"10.1103/24rx-sxcw","url":null,"abstract":"<p><p>Bacterial populations typically exhibit exponential growth under resource-rich conditions, yet individual cells often deviate from this pattern. Recent work has shown that the elongation rates of <i>Escherichia coli</i> and <i>Caulobacter crescentus</i> increase throughout the cell cycle (super-exponential growth), while <i>Bacillus subtilis</i> displays a mid-cycle minimum (convex growth), and <i>Mycobacterium tuberculosis</i> grows linearly. Here, we develop a single-cell model linking gene expression, proteome allocation, and mass growth to explain these diverse growth trajectories. By calibrating model parameters with experimental data, we show that DNA-proportional mRNA transcription produces near-exponential growth, whereas deviations from this proportionality yield the observed non-exponential growth patterns. Analysis of gene expression perturbations reveals that ribosome expression primarily controls dry mass growth rate, whereas cell envelope protein expression more strongly affects cell elongation rate. We show that cell-cycle-dependent transcription dynamics give rise to convex, super-exponential, and linear modes of cell elongation observed experimentally, demonstrating how the timing of cell envelope and ribosomal protein expressions drive cell-cycle-specific behaviors. These findings provide a mechanistic basis for non-exponential single-cell growth and offer insights into how bacterial cells dynamically regulate elongation rates within each generation.</p>","PeriodicalId":520315,"journal":{"name":"Physical review research","volume":"7 3","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12700632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}