Frontiers of hormone research最新文献_第2页

Medical Treatment of Acromegaly: What's New? 肢端肥大症的医学治疗：有什么新进展？

Frontiers of hormone research Pub Date : 2024-01-01 DOI: 10.1159/000539945

Pietro Maffei, Francesca Dassie

引用次数: 0

Perioperative Mobility Assessment of Acromegalic Patients Undergoing Endoscopic Endonasal Resection of Pituitary Adenomas Using Digital Phenotyping. 利用数字表型技术评估接受内窥镜下垂体腺瘤切除术的肢体瘫痪患者围手术期的活动能力

Frontiers of hormone research Pub Date : 2024-01-01 DOI: 10.1159/000539989

Christopher S Hong, Jakob V E Gerstl, Krish Maniar, John L Kilgallon, Le Min, Jukka-Pekka Onnela, Carleton E Corrales, Timothy R Smith

{"title":"Perioperative Mobility Assessment of Acromegalic Patients Undergoing Endoscopic Endonasal Resection of Pituitary Adenomas Using Digital Phenotyping.","authors":"Christopher S Hong, Jakob V E Gerstl, Krish Maniar, John L Kilgallon, Le Min, Jukka-Pekka Onnela, Carleton E Corrales, Timothy R Smith","doi":"10.1159/000539989","DOIUrl":"10.1159/000539989","url":null,"abstract":"Methods to assess quality of life and recovery after endoscopic endonasal surgery (EES) for sellar lesions are limited and often biased by subjective patient-reported assessments. Objective in-situ assessments are lacking. Smartphone-based digital phenotyping has been increasingly studied across a variety of pathologies, utilizing built-in technologies to measure behavioral patterns pertaining to sleep, physical mobility, social interactions, and cognitive functioning, among others. We report our experience with smartphone-based digital phenotyping in two acromegalic patients treated with EES. Beiwe application was applied pre-operatively to passively collect global position system data in the pre- and postoperative period, including daily distance traveled, maximal distance traveled from home, number of separate places visited outside of home, and overall time spent at home. This study demonstrates the feasibility of DP for a small sample of acromegalic patients undergoing EES based on passively collected smartphone global position system data during the peri-operative period. This is part of a larger, ongoing study enrolling surgical patients as well as non-operative controls for comparison aimed at predicting postoperative outcomes with in-situ tool.","PeriodicalId":520300,"journal":{"name":"Frontiers of hormone research","volume":"55 ","pages":"215-225"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of GH Deficiency and Excess on Men Sexual Health and Fertility. GH 缺乏和过剩对男性性健康和生育能力的影响。

Frontiers of hormone research Pub Date : 2024-01-01 DOI: 10.1159/000540048

Giovanni Corona, Clotilde Sparano, Nicola Bianchi, Olga Prontera, Alessandra Sforza, Mario Maggi

{"title":"Impact of GH Deficiency and Excess on Men Sexual Health and Fertility.","authors":"Giovanni Corona, Clotilde Sparano, Nicola Bianchi, Olga Prontera, Alessandra Sforza, Mario Maggi","doi":"10.1159/000540048","DOIUrl":"10.1159/000540048","url":null,"abstract":"A fair shred of evidence supports the mutual relationship between the hypothalamus-pituitary testis axis and the growth hormone (GH) pathway. Nevertheless, the role of GH on male sexual function and fertility is controversial, due to conflicting data from literature. The present review summarizes the available andrological consequences of two pathological extremes, i.e., either GH excess or deficiency. GH excess drives different disorders of male sexual health. On one hand, it indirectly favors the onset of erectile dysfunction (40.2% of cases) mostly by its detrimental vascular and metabolic effects, while testosterone levels don't appear as a key factor. On the other hand, GH excess directly impairs fertility, leading to secondary hypogonadism. Of note, compared to controls, this condition adversely affects the main sperm parameters, i.e., sperm concentration (p = 0.00), progressive motility (p = 0.03), and normal morphology (p = 0.02). Although with limited evidence, GH deficiency also fosters erectile dysfunction, while its effect on fertility is still unclear. On the whole, the available literature shows that any GH disorder plays a negative role in both male general and sexual health. Nevertheless, the potential benefit of testosterone replacement therapy in this population has not yet been explored.","PeriodicalId":520300,"journal":{"name":"Frontiers of hormone research","volume":"55 ","pages":"226-237"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone, Metabolic and Mental Detrimental Effects of GHD: Reasons Underlying Replacement Therapy in Adults. 多动障碍对骨骼、新陈代谢和心理的不利影响：成人替代疗法的根本原因。

Frontiers of hormone research Pub Date : 2024-01-01 DOI: 10.1159/000540046

Oana Ruxandra Cotta, Maria Bonsangue, Salvatore Cannavò

引用次数: 0

GH Replacement in Children and Adolescent following Surgery for Hypothalamic-Pituitary Neoplasia. 下丘脑-垂体肿瘤手术后儿童和青少年的 GH 替代治疗。

Frontiers of hormone research Pub Date : 2024-01-01 DOI: 10.1159/000539937

Marco Cappa

引用次数: 0

Preface. 序言

Frontiers of hormone research Pub Date : 2024-01-01 DOI: 10.1159/000539936

Federica Guaraldi, Diego Mazzatenta

引用次数: 0

Growth Hormone Deficiency in the Transitional Age. 过渡时期的生长激素缺乏症。

Frontiers of hormone research Pub Date : 2024-01-01 DOI: 10.1159/000539985

Marina Caputo, Samuele Costelli, Martina Romanisio, Francesca Pizzolitto, Valentina Antoniotti, Rosa Pitino, Gianluca Aimaretti, Flavia Prodam

{"title":"Growth Hormone Deficiency in the Transitional Age.","authors":"Marina Caputo, Samuele Costelli, Martina Romanisio, Francesca Pizzolitto, Valentina Antoniotti, Rosa Pitino, Gianluca Aimaretti, Flavia Prodam","doi":"10.1159/000539985","DOIUrl":"10.1159/000539985","url":null,"abstract":"Transition is the time encompassing the achievement of full height and complete somatic development, representing a period of physical, psychological, and social changes. Considering the beginning of social adaptation, the research of independence, and the desire to manage health conditions, the acceptance of chronic care should be poor. Patients affected by growth hormone deficiency (GHD), characterized by heterogeneity in diagnosis, high comorbidity burden, need for daily injections, and lack of biological markers during follow-up, could have a high drop-out rate. Replacement treatment is meaningful because, even if GHD is not life-threatening, it could represent a risk for long-term metabolic, cardiovascular, bone, and psychosocial complications with, eventually, a reduction in quality of life. Moreover, the diagnosis is not always straightforward, since the studies on stimulation tests are limited, or molecules are lacking, cutoffs are often not validated in transition patients, and follow-up requires attention in specific cases (i.e., cancer survivors). The present review aims to describe the features of GHD during transition, focusing on etiologies, pitfalls in diagnosis, GH replacement therapy, and follow-up issues.","PeriodicalId":520300,"journal":{"name":"Frontiers of hormone research","volume":"55 ","pages":"29-48"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0