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Pain and pessimism affect calves' play behaviours post-disbudding. 疼痛和悲观情绪会影响小牛犊的玩耍行为。

Discover animals Pub Date : 2025-01-01 Epub Date: 2025-07-31 DOI: 10.1007/s44338-025-00105-7

Amelia St John Wallis, Suzanne D E Held, Michael T Mendl, Marina A G von Keyserlingk, Daniel M Weary, Benjamin Lecorps

{"title":"Pain and pessimism affect calves' play behaviours post-disbudding.","authors":"Amelia St John Wallis, Suzanne D E Held, Michael T Mendl, Marina A G von Keyserlingk, Daniel M Weary, Benjamin Lecorps","doi":"10.1007/s44338-025-00105-7","DOIUrl":"10.1007/s44338-025-00105-7","url":null,"abstract":"Calves are expected to play less when in pain, and more pessimistic individuals may be more affected by painful events, such as hot-iron disbudding (i.e., horn-bud removal). We explored 1) the impact of disbudding on different play behaviours, predicting that those involving the head (e.g., play-fighting) may be more sensitive to disbudding due to the injury location, and 2) the effect of 'pessimism' (assessed using the judgement bias test) on changes in play post-disbudding. Holstein female calves (n = 19) were housed in groups of 10, individually tested for judgement bias at 25 days old, and disbudded following the farm's standards (including sedation and local anaesthesia) at 45 days old. Individual and parallel locomotor play and play-fighting were recorded for 4 h/day (from 1800 to 2200 h) for 5 days before disbudding, on disbudding day, and for 7 days after. Play-fighting reduced after disbudding compared to baseline and did not recover over 7 days. Locomotor play did not change on disbudding day and increased on the day after compared to baseline. More pessimistic calves did not show greater changes in play post-disbudding, but they showed a smaller increase in locomotor play on the day after disbudding, suggesting they did not recover as well as the others. Overall, play-fighting (i.e., pushing with the head) may be a more sensitive indicator of disbudding pain than other play behaviours, likely reflecting calves avoiding evoked pain, which may persist for at least 7 days. Our results also add to the growing literature demonstrating that pessimistic expectations affect animals' ability to cope with stressors.Supplementary information: The online version contains supplementary material available at 10.1007/s44338-025-00105-7.","PeriodicalId":520282,"journal":{"name":"Discover animals","volume":"2 1","pages":"50"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress induces nucleobindin-1 mRNA and nesfatin-1-like peptide stimulates cortisol secretion in goldfish. 应激诱导金鱼的核吲哚-1 mRNA 和内司蛋白-1 样肽刺激皮质醇分泌。

Discover animals Pub Date : 2024-01-01 Epub Date: 2024-11-06 DOI: 10.1007/s44338-024-00031-0

Lakshminarasimhan Sundarrajan, Umar Farouk Mustapha, Suraj Unniappan

{"title":"Stress induces nucleobindin-1 mRNA and nesfatin-1-like peptide stimulates cortisol secretion in goldfish.","authors":"Lakshminarasimhan Sundarrajan, Umar Farouk Mustapha, Suraj Unniappan","doi":"10.1007/s44338-024-00031-0","DOIUrl":"10.1007/s44338-024-00031-0","url":null,"abstract":"Stress is a state of disrupted homeostasis triggered by physical or psychological stimuli that elicit adaptive responses at the molecular and cellular levels. In fish, the hypothalamus-pituitary-interrenal (HPI) axis mediates stress responses. Nesfatin-1 and a nesfatin-1-like peptide (NLP), derived from nucleobindin-1 (NUCB1), have been implicated in stress hormone regulation in mammals. This study investigated the cell-specific expression of NUCB1/NLP in HPI tissues and its effects on stress response in goldfish (Carassius auratus). NUCB1 mRNA is abundant in the hypothalamus, pituitary, and several other peripheral tissues of goldfish. NUCB1/NLP-like immunoreactivity was found in the brain and pituitary, co-localized with corticotropin-releasing factor receptor 1 (CRF-R1) in the hypothalamus, and with adrenocorticotrophic hormone (ACTH) in the pituitary. In vivo netting and restraint stress increased nucb1 and crf-r1 mRNAs in the brain and acth mRNA in the pituitary, as determined by RT-qPCR. Intraperitoneal injection of NLP increased cortisol in circulation, crf-r1 mRNA in the brain and acth mRNA in the pituitary. These findings suggest that NUCB1/NLP is a new player in mediating the endocrine stress response of goldfish through the HPI axis.","PeriodicalId":520282,"journal":{"name":"Discover animals","volume":"1 1","pages":"32"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0