Journal of AIDS and HIV treatment最新文献

{"title":"The Performance of a New Multidimensional Frailty Index in Comparison to the Frailty Phenotype to Assess Frailty in People Living with HIV 50 Years of Age and Older in an Urban HIV Clinic.","authors":"Uzoamaka A Eke, Katie Wasserstein, Carolyn Susman, Ahizechukwu C Eke, Kareshma Mohanty, Sarah Schmalzle, Nicole Viviano, Jennifer D Hoffmann, Neha S Pandit, Robyn Palmeiro, Judith Lee, Alice S Ryan, Kristen A Stafford, Ann Gruber-Baldini","doi":"10.33696/aids.7.058","DOIUrl":"10.33696/aids.7.058","url":null,"abstract":"<p><strong>Background: </strong>Frailty is increasingly recognized in older people living with HIV (PLWH), but optimal diagnostics are yet to be determined. Frailty indices (FI) represent an accumulation of health deficits shown to correlate better with mortality and adverse effects of aging than the frailty phenotype or chronological age.</p><p><strong>Methods: </strong>This is a retrospective cohort study of frailty assessments in PLWH aged ≥ 50 years in a multidisciplinary urban HIV clinic. Frailty was assessed using Frailty Phenotype (FP) and a new 40-variable clinical composite FI derived from routine clinical and laboratory data (CCFI). CCFI scores were categorized into robust (≤ 0.15), pre-frail (>0.15-0.4), and frail (>0.4). CCFI frailty and its association with frailty-related factors were analyzed using logistic regression.</p><p><strong>Results: </strong>The 165 participants were mostly black (94%) and male (56%), with median age 59 years (IQR 55-63), CD4 count 606 cells/μl (IQR 393-873), and 78% had HIV viral load ≤ 40 copies/ml. 70% had multimorbidity, 38% falls, 25% poor cognition, and 24% polypharmacy. By FP, 2% were frail, 65% prefrail, and 33% robust. By CCFI, 26% were frail, 67% prefrail, and 7% robust (range 0.08-0.57; mean 0.34 ±0.11). For FP categorized as robust, prefrail and frail, the mean CCFI was 0.31 ± 0.1, 0.35 ± 0.11 and 0.38 ± 0.08 respectively (P=0.06). Cognition (OR 3.64, p=0.003), falls (OR 5.09, p<0.001), polypharmacy of 6-9 medications (OR 3.07, p=0.03) and ≥ 10 medications (OR 4.25, p=0.009) and >3 comorbidities (OR 3.06, p=0.03) were associated with CCFI frailty, adjusted for age and sex.</p><p><strong>Conclusion: </strong>The majority of older PLWH were pre-frail or frail. The CCFI identified more patients as frail and had significant clinical associations compared to FP.</p>","PeriodicalId":519937,"journal":{"name":"Journal of AIDS and HIV treatment","volume":"7 1","pages":"27-37"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Advantages of a Well-balanced Nutrition Regimen for People Living with Human Immunodeficiency Virus Type -1.","authors":"Daniele Basta, Olga S Latinovic, Yutaka Tagaya, Giovannino Silvestri","doi":"10.33696/aids.6.048","DOIUrl":"10.33696/aids.6.048","url":null,"abstract":"<p><p>This review underscores the important role of nutrition in enhancing the management of Human Immunodeficiency Virus type 1 (HIV-1). Highlighting the efficacy of dietary interventions, including, the importance of omega-3 fatty acids, vitamins D and B-12, and the Mediterranean diet, we delineate how these beneficial nutritional strategies can improve the effectiveness of combined antiretroviral therapy (cART), mitigate its side effects, and ameliorate metabolic disorders in people living with HIV-1 (PLWH). Our review advocates for the integration and implementation of personalized nutritional assessments into the care plan for PLWH, proposing actionable strategies for healthcare providers in HIV-1 field. Summarizing the current standing of the relevance of the nutritional and well-planned diet recommended for the PLWH and emphasizing on the future research directions, this review establishes a foundation for nutrition as a cornerstone in comprehensive HIV-1 management. Our review aims to improve patients' health outcomes and overall quality of life for PLWH.</p>","PeriodicalId":519937,"journal":{"name":"Journal of AIDS and HIV treatment","volume":"6 1","pages":"11-27"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11155617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}