Clinical transplantation and research最新文献_第4页

A walk through the development of human leukocyte antigen typing: from serologic techniques to next-generation sequencing. 人类白细胞抗原分型的发展：从血清学技术到下一代测序。

Clinical transplantation and research Pub Date : 2024-12-31 Epub Date: 2024-12-11 DOI: 10.4285/ctr.24.0055

Haeyoun Choi, Eun-Jeong Choi, Hyoung-Jae Kim, In-Cheol Baek, Aegyeong Won, Su Jin Park, Tai-Gyu Kim, Yeun-Jun Chung

{"title":"A walk through the development of human leukocyte antigen typing: from serologic techniques to next-generation sequencing.","authors":"Haeyoun Choi, Eun-Jeong Choi, Hyoung-Jae Kim, In-Cheol Baek, Aegyeong Won, Su Jin Park, Tai-Gyu Kim, Yeun-Jun Chung","doi":"10.4285/ctr.24.0055","DOIUrl":"10.4285/ctr.24.0055","url":null,"abstract":"Human leukocyte antigen (HLA) is a group of glycoproteins encoded by the major histocompatibility complex (MHC) that plays a pivotal role in the host's immune defense. Given that the MHC represents the most polymorphic region in the human genome, HLA typing is crucial in organ transplantation. It significantly influences graft rejection, graft-versus-host disease, and the overall patient outcome by mediating the discrimination between self and nonself. HLA typing technology began with serological methods and has evolved rapidly alongside advances in molecular technologies, progressing from DNA-based typing to next- or third-generation sequencing. These advancements have increased the accuracy of HLA typing and reduced ambiguities, leading to marked improvements in transplantation outcomes. Additionally, numerous novel HLA alleles have been identified. In this review, we explore the developmental history and future prospects of HLA typing technology, which promises to further benefit the field of transplantation.","PeriodicalId":519901,"journal":{"name":"Clinical transplantation and research","volume":" ","pages":"294-308"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting T helper 17 cells: emerging strategies for overcoming transplant rejection. 靶向T辅助17细胞：克服移植排斥反应的新策略

Clinical transplantation and research Pub Date : 2024-12-31 DOI: 10.4285/ctr.24.0058

Young Joon Lee, Mi-La Cho

引用次数: 0

Contribution of long-lived plasma cells to antibody-mediated allograft rejection. 长寿命浆细胞对抗体介导的异体移植排斥反应的贡献。

Clinical transplantation and research Pub Date : 2024-12-31 Epub Date: 2024-12-18 DOI: 10.4285/ctr.24.0047

Eunkyeong Jang, Jeehee Youn

{"title":"Contribution of long-lived plasma cells to antibody-mediated allograft rejection.","authors":"Eunkyeong Jang, Jeehee Youn","doi":"10.4285/ctr.24.0047","DOIUrl":"10.4285/ctr.24.0047","url":null,"abstract":"Persistent alloantigens derived from allograft tissues can be recognized by the host's alloreactive immune system. This process enables cognate B cells to differentiate into plasma cells, which secrete donor-specific antibodies that are key drivers of antibody-mediated allograft rejection. A subset of these plasma cells can survive for extended periods in a suitable survival niche and mature into long-lived plasma cells (LLPCs), which are a cellular component of humoral memory. The current understanding of LLPCs is limited due to their scarcity, heterogeneity, and absence of unique markers. However, accumulating evidence indicates that LLPCs, unlike conventional short-lived plasma cells, can respond to extrinsic signals from their survival niches and can resist cell death associated with intracellular stress through cell-intrinsic mechanisms. Notably, they are refractory to traditional immunosuppressants and B cell depletion therapies. This resistance, coupled with their longevity, may explain why current treatments targeting antibody-mediated rejection are often ineffective. This review offers insights into the biology of LLPCs and discusses ongoing therapeutic trials that target LLPCs in the context of antibody-mediated allograft rejection.","PeriodicalId":519901,"journal":{"name":"Clinical transplantation and research","volume":" ","pages":"341-353"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Animal models for transplant immunology: bridging bench to bedside. 移植免疫学动物模型：从工作台到床边的桥梁。

Clinical transplantation and research Pub Date : 2024-12-31 Epub Date: 2024-09-05 DOI: 10.4285/ctr.24.0029

Minseok Kang, Hwon Kyum Park, Kyeong Sik Kim, Dongho Choi

引用次数: 0

Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival. 移植中的Belatacept和调节性T细胞：免疫耐受和移植物存活的协同策略。

Clinical transplantation and research Pub Date : 2024-12-31 Epub Date: 2024-12-18 DOI: 10.4285/ctr.24.0057

Gil-Ran Kim, Kyung-Ho Nam, Je-Min Choi

引用次数: 0

Beyond the icebox: modern strategies in organ preservation for transplantation. 超越冰箱：移植器官保存的现代策略。

Clinical transplantation and research Pub Date : 2024-12-31 DOI: 10.4285/ctr.24.0039

Kidus Haile Yemaneberhan, Minseok Kang, Jun Hwan Jang, Jin Hee Kim, Kyeong Sik Kim, Ho Bum Park, Dongho Choi

{"title":"Beyond the icebox: modern strategies in organ preservation for transplantation.","authors":"Kidus Haile Yemaneberhan, Minseok Kang, Jun Hwan Jang, Jin Hee Kim, Kyeong Sik Kim, Ho Bum Park, Dongho Choi","doi":"10.4285/ctr.24.0039","DOIUrl":"10.4285/ctr.24.0039","url":null,"abstract":"Organ transplantation, a critical treatment for end-stage organ failure, has witnessed significant advancements due to the integration of improved surgical techniques, immunosuppressive therapies, and donor-recipient matching. This review explores the progress of organ preservation, focusing on the shift from static cold storage (SCS) to advanced machine perfusion techniques such as hypothermic (HMP) and normothermic machine perfusion (NMP). Although SCS has been the standard approach, its limitations in preserving marginal organs and preventing ischemia-reperfusion injury (IRI) have led to the adoption of HMP and NMP. HMP, which is now the gold standard for high-risk donor kidneys, reduces metabolic activity and improves posttransplant outcomes. NMP allows real-time organ viability assessment and reconditioning, especially for liver transplants. Controlled oxygenated rewarming further minimizes IRI by addressing mitochondrial dysfunction. The review also highlights the potential of cryopreservation for long-term organ storage, despite challenges with ice formation. These advances are crucial for expanding the donor pool, improving transplant success rates, and addressing organ shortages. Continued innovation is necessary to meet the growing demands of transplantation and save more lives.","PeriodicalId":519901,"journal":{"name":"Clinical transplantation and research","volume":"38 4","pages":"377-403"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of allorecognition and xenorecognition in transplantation. 移植中异体识别和异体识别的机制。

Clinical transplantation and research Pub Date : 2024-12-31 DOI: 10.4285/ctr.24.0056

Il Hee Yun, Jaeseok Yang

{"title":"Mechanisms of allorecognition and xenorecognition in transplantation.","authors":"Il Hee Yun, Jaeseok Yang","doi":"10.4285/ctr.24.0056","DOIUrl":"10.4285/ctr.24.0056","url":null,"abstract":"Foreign antigen recognition is the ability of immune cells to distinguish self from nonself, which is crucial for immune responses in both invertebrates and vertebrates. In vertebrates, T cells play a pivotal role in graft rejection by recognizing alloantigens presented by antigen-presenting cells through direct, indirect, or semidirect pathways. B cells also significantly contribute to the indirect presentation of antigens to T cells. Innate immune cells, such as dendritic cells, identify pathogen- or danger-associated molecular patterns through pattern recognition receptors, thereby facilitating effective antigen presentation to T cells. Recent studies have shown that innate immune cells, including macrophages and NK cells, can recognize allogeneic or xenogeneic antigens using immune receptors like CD47 or activating NK receptors, instead of pattern recognition receptors. Additionally, macrophages and NK cells are capable of exhibiting memory responses to alloantigens, although these responses are shorter than those of adaptive memory. T cells also recognize xenoantigens through either direct or indirect presentation. Notably, macrophages and NK cells can directly recognize xenoantigens via surface immune receptors in an antibody-independent manner, or they can be activated in an antibody-dependent manner. Advances in our understanding of the recognition mechanisms of adaptive and innate immunity against allogeneic and xenogeneic antigens may improve our understanding of graft rejection.","PeriodicalId":519901,"journal":{"name":"Clinical transplantation and research","volume":"38 4","pages":"273-293"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing immunosuppression in liver transplantation: the role of regulatory T cells in immune modulation and graft tolerance. 推进肝移植免疫抑制：调节性T细胞在免疫调节和移植物耐受中的作用。

Clinical transplantation and research Pub Date : 2024-12-31 Epub Date: 2024-12-19 DOI: 10.4285/ctr.24.0059

Ji Won Han, Su-Hyung Park

{"title":"Advancing immunosuppression in liver transplantation: the role of regulatory T cells in immune modulation and graft tolerance.","authors":"Ji Won Han, Su-Hyung Park","doi":"10.4285/ctr.24.0059","DOIUrl":"10.4285/ctr.24.0059","url":null,"abstract":"Prolonged immunosuppressive therapy in liver transplantation (LT) is associated with significant adverse effects, such as nephrotoxicity, metabolic complications, and heightened risk of infection or malignancy. Regulatory T cells (Tregs) represent a promising target for inducing immune tolerance in LT, with the potential to reduce or eliminate the need for life-long immunosuppression. This review summarizes current knowledge on the roles of Tregs in LT, highlighting their mechanisms and the impact of various immunosuppressive agents on Treg stability and function. The liver's distinct immunological microenvironment, characterized by tolerogenic antigen-presenting cells and high levels of interleukin (IL)-10 and transforming growth factor-β, positions this organ as an ideal setting for Treg-mediated tolerance. We discuss Treg dynamics in LT, their association with rejection risk, and their utility as biomarkers of transplant outcomes. Emerging strategies, including the use of low-dose calcineurin inhibitors with mammalian target of rapamycin inhibitors, adoptive Treg therapy, and low-dose IL-2, aim to enhance Treg function while providing sufficient immunosuppression. Thus, the future of LT involves precision medicine approaches that integrate Treg monitoring with tailored immunosuppressive protocols to optimize long-term outcomes for LT recipients.","PeriodicalId":519901,"journal":{"name":"Clinical transplantation and research","volume":" ","pages":"257-272"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 25-year scoping review of the organ donation system in Malaysia: past, present, and future. 马来西亚器官捐献系统 25 年范围回顾：过去、现在和未来。

Clinical transplantation and research Pub Date : 2024-09-30 Epub Date: 2024-08-05 DOI: 10.4285/ctr.24.0020

Lay See Khoo, Chloë Ballesté

{"title":"A 25-year scoping review of the organ donation system in Malaysia: past, present, and future.","authors":"Lay See Khoo, Chloë Ballesté","doi":"10.4285/ctr.24.0020","DOIUrl":"10.4285/ctr.24.0020","url":null,"abstract":"Organ donation and transplantation are integral components of modern medicine. This scoping review thoroughly explores the historical evolution, current status, and future prospects of organ donation and transplantation in Malaysia. Historically, Malaysia faced significant challenges in establishing a robust organ transplantation system, with various factors hindering organ donation efforts. Currently, Malaysia continues to struggle with stagnant donation rates despite collaborative efforts from various sectors. There is an urgent need to amend the 50-year-old Human Tissue Act to strengthen the legal framework for organ donation and address ethical concerns. Looking to the future, Malaysia could adopt a soft opt-out system and prioritize advancements in organ preservation techniques by exploring new sources of organs through the donation after circulatory death program. Continued efforts are necessary to enhance education programs for professionals and the public, dispelling myths about organ donation and effectively educating on the concepts of brain death. Malaysia strives to create a more accessible future for organ transplantation, aligning with the Sustainable Development Goals to reduce the burden of organ failure and improve the population's health and well-being.","PeriodicalId":519901,"journal":{"name":"Clinical transplantation and research","volume":" ","pages":"163-187"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of fluid responsiveness after tidal volume challenge in renal transplant recipients: a nonrandomized prospective interventional study. 肾移植受者潮气量挑战后的液体反应性评估：一项非随机前瞻性干预研究。

Clinical transplantation and research Pub Date : 2024-09-30 Epub Date: 2024-09-09 DOI: 10.4285/ctr.24.0025

Ganesh Ramaji Nimje, Vipin Kumar Goyal, Pankaj Singh, Praveenkumar Shekhrajka, Akash Mishra, Saurabh Mittal

{"title":"Assessment of fluid responsiveness after tidal volume challenge in renal transplant recipients: a nonrandomized prospective interventional study.","authors":"Ganesh Ramaji Nimje, Vipin Kumar Goyal, Pankaj Singh, Praveenkumar Shekhrajka, Akash Mishra, Saurabh Mittal","doi":"10.4285/ctr.24.0025","DOIUrl":"10.4285/ctr.24.0025","url":null,"abstract":"Background: When applying lung-protective ventilation, fluid responsiveness cannot be predicted by pulse pressure variation (PPV) or stroke volume variation (SVV). Functional hemodynamic testing may help address this limitation. This study examined whether changes in dynamic indices such as PPV and SVV, induced by tidal volume challenge (TVC), can reliably predict fluid responsiveness in patients undergoing renal transplantation who receive lung-protective ventilation.Methods: This nonrandomized interventional study included renal transplant recipients with end-stage renal disease. Patients received ventilation with a 6 mL/kg tidal volume (TV), and the FloTrac system was attached for continuous hemodynamic monitoring. Participants were classified as responders or nonresponders based on whether fluid challenge increased the stroke volume index by more than 10%.Results: The analysis included 36 patients, of whom 19 (52.8%) were responders and 17 (47.2%) were nonresponders. Among responders, the mean ΔPPV6-8 (calculated as PPV at a TV of 8 mL/kg predicted body weight [PBW] minus that at 6 mL/kg PBW) was 3.32±0.75 and ΔSVV6-8 was 2.58±0.77, compared to 0.82±0.53 and 0.70±0.92 for nonresponders, respectively. ΔPPV6-8 exhibited an area under the curve (AUC) of 0.97 (95% confidence interval [CI], 0.93-1.00; P≤0.001), with an optimal cutoff value of 1.5, sensitivity of 94.7%, and specificity of 94.1%. ΔSVV6-8 displayed an AUC of 0.93 (95% CI, 0.84-1.00; P≤0.001) at the same cutoff value of 1.5, with a sensitivity of 94.7% and a specificity of 76.5%.Conclusions: TVC-induced changes in PPV and SVV are predictive of fluid responsiveness in renal transplant recipients who receive intraoperative lung-protective ventilation.","PeriodicalId":519901,"journal":{"name":"Clinical transplantation and research","volume":" ","pages":"188-196"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0