Infectious diseases & clinical microbiology最新文献

{"title":"Clinical Entity Mimicking Infectious Cellulitis: Eosinophilic Cellulitis (Wells' Syndrome).","authors":"Mustafa Deniz, Kübra Demir-Önder, Yusuf Özkaraman, Zafer Adıgüzel, Kadir Balaban","doi":"10.36519/idcm.2023.279","DOIUrl":"https://doi.org/10.36519/idcm.2023.279","url":null,"abstract":"<p><p>Eosinophilic cellulitis (EC) is a skin disease characterized by pruritic, non-purulent, erythematous plaques and histologically by edema and eosinophil infiltration in the dermis. The etiopathogenesis of the disease is not fully elucidated. It differs from infectious cellulitis by being unresponsive to antibiotics and recurring. This case report presents a late-diagnosed case of EC in a patient who did not respond to long-term and broad-spectrum antibiotics. This case underscores the importance of skin biopsy and histopathological diagnosis in patients with recurrent, non-responsive, antibiotic-resistant, and cellulitis-like clinical features resembling infectious cellulitis; \"eosinophilic cellulitis\" should be considered in the differential diagnosis.</p>","PeriodicalId":519881,"journal":{"name":"Infectious diseases & clinical microbiology","volume":"5 4","pages":"376-379"},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10986720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Cause of Acute Isolated Hepatitis in a Cancer Patient Post-COVID Pneumonia: HSV-2.","authors":"Türkkan Öztürk-Kaygusuz, Ayşe Sağmak-Tartar, Ayhan Akbulut","doi":"10.36519/idcm.2022.117","DOIUrl":"https://doi.org/10.36519/idcm.2022.117","url":null,"abstract":"<p><p>Herpes simplex virus is a rare cause of hepatitis in immunosuppressed and immunocompetent individuals. It can cause clinical pictures in patients ranging from an asymptomatic course to fatal acute fulminant hepatitis. Early diagnosis and treatment may be delayed if it is not suspected because of the patients' nonspecific clinic. This study presents a case of isolated HSV-2 hepatitis in a patient with a history of cancer chemotherapy and a recent diagnosis of COVID-19 who received steroid therapy.</p>","PeriodicalId":519881,"journal":{"name":"Infectious diseases & clinical microbiology","volume":"4 3","pages":"210-213"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10986694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Gardnerella vaginalis</i>: Is it an Underestimated Cause of Urinary Symptoms in Males?","authors":"Mert Kılıç, Yeşim Beşli, Ersin Köseoğlu, Erhan Kerim Palaoğlu, Tarık Esen","doi":"10.36519/idcm.2022.172","DOIUrl":"https://doi.org/10.36519/idcm.2022.172","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the detection rate of <i>Gardnerella vaginalis</i> by multiplex PCR test in the genitourinary samples of male patients with suspected urethritis and related symptoms.</p><p><strong>Materials and methods: </strong>A total of 144 male patients who presented to our department between February 2021 and October 2021, either with urinary symptoms or concerns following unprotected sex, were included in the study.A total of 128 (88.9%) first-void urine samples, 15 (10.4%) urethral swabs, and one (0.7%) semen sample were obtained. NeoPlex STI-14 Detection Multiplex PCR Kit (GeneMatrix Inc. Seongnam, South Korea) was used to investigate any of the following pathogens: <i>Candida albicans</i>, <i>Chlamydia trachomatis</i>, <i>G. vaginalis</i>, <i>Mycoplasma genitalium</i>, <i>Mycoplasma hominis</i>, <i>Neisseria gonorrhoeae</i>, <i>Trichomonas vaginalis</i>, <i>Ureaplasma parvum</i>, <i>Ureaplasma urealyticum</i>,herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), <i>Treponema pallidum</i> , <i>Streptococcus agalactiae</i>, and <i>Haemophilus ducreyi</i>. The patients with positive results for <i>G. vaginalis</i> were retrospectively analyzed.</p><p><strong>Results: </strong>The patients' median age was 37 (range: 21 to 71 years old). <i>G. vaginalis</i> was the most frequently detected microorganism (n=23; 15.9%). Other microorganisms found in order of frequency were <i>U. urealyticum</i> (n=19; 13.2%), <i>U. parvum</i> (n=15; 10.4%), <i>C. trachomatis</i> (n=11; 7.6%), <i>M. genitalium</i> (n=8; 5.6%), HSV-2 (n= 7; 4.9%), <i>N. gonorrhoeae</i> (n=6; 4.2), HSV-1 (n=2; 1.4%), <i>M. hominis</i> (n=1, 0.7%), and <i>C. albicans</i> (n=1, 0.7%). Fifteen patients (65%) were positive for one or two microbial agents together with <i>G. vaginalis</i>, while in eight patients (35%), <i>G. vaginalis</i> was the only isolated agent. Six of these eight patients and 14 of the remaining 15 were symptomatic.</p><p><strong>Conclusion: </strong>With the introduction of multiplex PCR tests, including those for <i>G. vaginalis</i>, we can expect a higher detection rate of these species of bacteria in male genitourinary samples, which could be the cause of unexplained urinary/urethral symptoms.</p>","PeriodicalId":519881,"journal":{"name":"Infectious diseases & clinical microbiology","volume":"4 3","pages":"172-177"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10986695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel SARS-CoV-2 Omicron variants in İstanbul; Rapid Preponderance of BA.2 and BA.5.","authors":"Yeşim Tuyji-Tok, Ebru Yücebağ, Ayşe Betül Keleş, Ayşe Ceylan Kılınçarslan, Okan Kadir Nohut, Seda Salman-Yılmaz, Mert Ahmet Kuşkucu, Kenan Midilli","doi":"10.36519/idcm.2022.143","DOIUrl":"https://doi.org/10.36519/idcm.2022.143","url":null,"abstract":"<p><strong>Objective: </strong>In Turkey, the fourth wave of SARS-CoV-2 started in December 2021 and peaked in mid-January 2022. Afterward, peaks were seen in the number of COVID-19 cases because of Omicron BA.2 and BA.5 variants. Our study aimed to observe the prevalence and viral load-related transmissibility rates of the Omicron BA.2 and BA.5 variant infections in our region between January 21 and July 01, 2022, using an easy and cost-effective PCR screening method.</p><p><strong>Methods: </strong>The frequency of BA.2 and BA.5 were determined by the two-stage allele-specific and drop-out RT-PCR method targeting NSP6 105-107del, spike 69-70del, and spike L452R mutation-specific primers. Transmissibility of the Omicron variants was assessed using cycle threshold (Ct) values (a proxy for SARS-CoV-2 viral load and infectivity). Also, using the next generation sequencing (NGS) method, existing mutations were analyzed by generating full-length sequences of the representative, randomly selected samples from the Omicron variants determined by PCR screening test.</p><p><strong>Results: </strong>We defined the first case of BA.2 on January 19, 2022, in İstanbul University-Cerrahpaşa School of Medicine COVID-19 Molecular Diagnosis Laboratory. Following this, it was observed that BA.1 lost its dominance due to the increased transmissibility of BA.2. On May 5, we defined the first case of BA.5, and as of July this Omicron variant rapidly became preponderant, with a frequency of more than 85%. Compared with BA.1, BA.2 and BA.5 were associated with 2.82 (95% CI: 2.33-4.12) and 2.49 (95% CI: 2.16-3.55) fewer cycles, respectively, meaning higher transmissibility. As confirmed by the NGS results, it was concluded that screening with NSP6 105-107del, spike 69-70del and spike L452R mutation targeted PCR method, which is used uniquely in our hospital in Turkey, can be an easy and cost-effective method in the follow-up of Omicron variants.</p><p><strong>Conclusion: </strong>The higher viral load detection in infections with BA.2 and BA.5 reflects a prolonged disease period, and increased transmissibility, so rapid expansion of these Omicron variants in Turkey is inevitable. Even though the prevalence of the Omicron variants in the population can be monitored in near real-time by the PCR screening method, more sequencing studies are needed for the early identification of new mutations that will emerge.</p>","PeriodicalId":519881,"journal":{"name":"Infectious diseases & clinical microbiology","volume":"4 3","pages":"192-198"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}