Cornelia S Link-Rachner, A. Göbel, Nikolai P Jaschke, T. D. Rachner
{"title":"Endocrine health in survivors of adult-onset cancer.","authors":"Cornelia S Link-Rachner, A. Göbel, Nikolai P Jaschke, T. D. Rachner","doi":"10.1016/s2213-8587(24)00088-3","DOIUrl":"https://doi.org/10.1016/s2213-8587(24)00088-3","url":null,"abstract":"","PeriodicalId":519532,"journal":{"name":"The lancet. Diabetes & endocrinology","volume":"90 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140797708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Fleseriu, Fabienne Langlois, Dawn Shao Ting Lim, Elena V Varlamov, Shlomo Melmed
{"title":"Acromegaly: pathogenesis, diagnosis, and management.","authors":"Maria Fleseriu, Fabienne Langlois, Dawn Shao Ting Lim, Elena V Varlamov, Shlomo Melmed","doi":"10.1016/S2213-8587(22)00244-3","DOIUrl":"https://doi.org/10.1016/S2213-8587(22)00244-3","url":null,"abstract":"<p><p>Growth hormone-secreting pituitary adenomas that cause acromegaly arise as monoclonal expansions of differentiated somatotroph cells and are usually sporadic. They are almost invariably benign, yet they can be locally invasive and show progressive growth despite treatment. Persistent excess of both growth hormone and its target hormone insulin-like growth factor 1 (IGF-1) results in a wide array of cardiovascular, respiratory, metabolic, musculoskeletal, neurological, and neoplastic comorbidities that might not be reversible with disease control. Normalisation of IGF-1 and growth hormone are the primary therapeutic aims; additional treatment goals include tumour shrinkage, relieving symptoms, managing complications, reducing excess morbidity, and improving quality of life. A multimodal approach with surgery, medical therapy, and (more rarely) radiation therapy is required to achieve these goals. In this Review, we examine the epidemiology, pathogenesis, diagnosis, complications, and treatment of acromegaly, with an emphasis on the importance of tailoring management strategies to each patient to optimise outcomes.</p>","PeriodicalId":519532,"journal":{"name":"The lancet. Diabetes & endocrinology","volume":" ","pages":"804-826"},"PeriodicalIF":44.5,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33514237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rise in diabetic ketoacidosis during the COVID-19 pandemic: several questions remain.","authors":"Shivani Misra","doi":"10.1016/S2213-8587(22)00272-8","DOIUrl":"https://doi.org/10.1016/S2213-8587(22)00272-8","url":null,"abstract":"","PeriodicalId":519532,"journal":{"name":"The lancet. Diabetes & endocrinology","volume":" ","pages":"763-765"},"PeriodicalIF":44.5,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33491856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jean Claude Katte, Laurien Sibomana, Given Hapunda, Justin Cirhuza Cikomola, Carol A Abidha
{"title":"Diabetes in sub-Saharan Africa: what are the next steps?","authors":"Jean Claude Katte, Laurien Sibomana, Given Hapunda, Justin Cirhuza Cikomola, Carol A Abidha","doi":"10.1016/S2213-8587(22)00274-1","DOIUrl":"https://doi.org/10.1016/S2213-8587(22)00274-1","url":null,"abstract":"","PeriodicalId":519532,"journal":{"name":"The lancet. Diabetes & endocrinology","volume":" ","pages":"766-768"},"PeriodicalIF":44.5,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33505344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New metrics to support diabetes education and advocacy.","authors":"Bruce B Duncan","doi":"10.1016/S2213-8587(22)00271-6","DOIUrl":"https://doi.org/10.1016/S2213-8587(22)00271-6","url":null,"abstract":"","PeriodicalId":519532,"journal":{"name":"The lancet. Diabetes & endocrinology","volume":" ","pages":"765-766"},"PeriodicalIF":44.5,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40386000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}