European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology最新文献

{"title":"Sentinel lymph node biopsy in breast cancer--is lymphoscintigraphy really necessary?","authors":"S S Upponi,&nbsp;S A McIntosh,&nbsp;G C Wishart,&nbsp;K K Balan,&nbsp;A D Purushotham","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The role of lymphoscintigraphy in sentinel node biopsy in breast cancer remains debatable. This study assesses the value of lymphoscintigraphy in axillary sentinel node biopsy in women undergoing surgery for breast cancer. Sixty-two patients underwent sentinel node biopsy using a combination of technetium-labelled nanocolloid, lympho-scintigraphy and patent blue dye. Lymphoscintigraphy was successful in 84% of patients. Axillary sentinel nodes were identified intraoperatively in all these patients. Internal mammary nodes were identified on lymphoscintigraphy in 19%. Despite lymphoscintigraphy being unsuccessful in 10 patients, axillary sentinel nodes were found intraoperatively in eight of these patients. Lymphoscintigraphy did not increase the detection rate of axillary sentinel nodes and a negative scan did not preclude identification of an axillary sentinel node intraoperatively. This study questions the contribution of lymphoscintigraphy in axillary sentinel node biopsy, however its value may lie in the detection of extra-axillary nodes.</p>","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"28 5","pages":"479-80"},"PeriodicalIF":3.8,"publicationDate":"2002-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22047295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative radiotherapy and external beam radiation therapy in gastric adenocarcinoma with R0-R1 surgical resection.","authors":"O Glehen,&nbsp;A C Beaujard,&nbsp;P Romestaing,&nbsp;I Sentenac,&nbsp;Y François,&nbsp;P Peyrat,&nbsp;G Braillon,&nbsp;J Vignal,&nbsp;J P Gérard,&nbsp;F N Gilly","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The aims of this study were to evaluate the results of intraoperative radiotherapy (IORT) and external beam therapy (EBRT) in the treatment of gastric adenocarcinoma.</p><p><strong>Methods: </strong>From 1986 to 1999, 87 patients who underwent surgical resection for gastric adenocarcinoma combined with IORT were reviewed. A R0 surgical resection was performed in 82 patients and five underwent R1 resection. The stage was: pT1 in 12, pT2 in 19, pT3 in 44 and pT4 in seven. Thirteen patients were pN1 and 43 were pN2, The IORT dose ranged from 12 to 23 Gy. Patients with pT3 and/or pN tumours underwent EBRT with a standard dose of 44-46 Gy.</p><p><strong>Results: </strong>The post-operative mortality and morbidity rates were 2.3 and 6.8%, respectively. The 5-year survival rate for R0 patients was 60%, for R0-pN0 was 90% and for R0-pN+ patients was 55%. The local failure rate in the 19 pN+ patients was 21%.</p><p><strong>Conclusion: </strong>IORT and EBRT combined with surgical resection may provide overall survival, improving the local control after gastrectomy.</p>","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"26 Suppl A ","pages":"S10-2"},"PeriodicalIF":3.8,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21953442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal tissue tolerance to intraoperative radiotherapy.","authors":"H J Hoekstra,&nbsp;H J Heijmans,&nbsp;M Cromheecke,&nbsp;B G Szabo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"26 Suppl A ","pages":"S5-9"},"PeriodicalIF":3.8,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21953447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative radiotherapy for primary and locally recurrent soft tissue sarcoma: morbidity and long-term prognosis.","authors":"T Lehnert,&nbsp;M Schwarzbach,&nbsp;F Willeke,&nbsp;M Treiber,&nbsp;U Hinz,&nbsp;M M Wannenmacher,&nbsp;C Herfarth","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Soft tissue sarcoma has a high risk of local recurrence. Therefore, extensive surgical resection has been combined with radiotherapy to improve long-term results. Because external beam radiation doses may be limited by adjacent radiosensitive tissue, intraoperative boost radiation has been devised to achieve a higher total radiation dose in combination with external beam radiotherapy. We report our experience with this multimodal approach for primary and recurrent soft tissue sarcoma.</p><p><strong>Methods: </strong>Clinical and pathological data were extracted from a prospective data base including all patients with a diagnosis of soft tissue sarcoma treated at the Department of Surgery, University of Heidelberg between 1988 and 1999. Intraoperative radiotherapy dosages were 12-15 Gy for the extremities and 15-18 Gy for the trunk and the retroperitoneum. Additional external beam radiotherapy was given at 40 Gy, whenever possible.</p><p><strong>Results: </strong>Between 1988 and 1999, a total of 251 patients with primary or recurrent soft tissue sarcoma of the extremities, the trunk or the retroperitoneum were treated. The mean (+/- SD) age of 136 men and 115 women was 53+/-16 years. Five of 251 patients died post-operatively, giving a mortality rate of 2.0%. Intraoperative radiotherapy (IORT) was used in 92 patients (37%). Surgical complications were more frequent in IORT patients (30 of 92; 33%) compared to non-IORT patients (36 of 159; 23% P=0.1). Infectious complications were significantly more frequent in patients receiving IORT (P=0.03). Two hundred and four patients were macroscopically tumour-free (R0, R1 resection). For these patients multivariate analysis identified grading (relative risk (RR) 3.1-6.6; P<0.001), age (over 55 years; (RR) 1.8: P<0.008) and tumour location in the retroperitoneum (RR 2.2; P<0.004) as independently associated with recurrence-free survival. The use of IORT (P<0.02) reduced the relative risk of death or recurrence by 40% (RR 0.6; P<0.02). Sex, primary vs. recurrent tumour, T classification and R-status (R0 vs. R1) were not significantly related to recurrence-free survival.</p><p><strong>Conclusions: </strong>In this prospective, non-randomized study of soft tissue sarcoma IORT was associated with a higher rate of infectious complications, but the the risk of death or recurrence was reduced by 40%.</p>","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"26 Suppl A ","pages":"S21-4"},"PeriodicalIF":3.8,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21953445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative radiotherapy: 20 years of clinical experience, technological development and consolidation of results.","authors":"F A Calvo,&nbsp;H J Hoekstra,&nbsp;T Lehnert","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"26 Suppl A ","pages":"S1-4"},"PeriodicalIF":3.8,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21953441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of intraoperative radiotherapy for pancreatic carcinoma.","authors":"J A Cienfuegos,&nbsp;F A Manuel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intraoperative radiotherapy (IORT) involves the administration of higher doses of irradiation to the pancreas in patients with locally advanced disease, and to the surgical bed in patients following pancreaticoduodenectomy. IORT was initially used in patients with unresectable lesions on whom palliative surgery was being performed. In all the series local control was improved, although no parallel increase in survival has been confirmed. Various institutions have used IORT after pancreatic resection, integrated into a complementary programme of chemo-and radiotherapy. A significant reduction in the index of local recurrence has been documented in all the series. No significant improvement in survival has been documented, owing to the development of metastases.</p>","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"26 Suppl A ","pages":"S13-5"},"PeriodicalIF":3.8,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21953443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative radiotherapy for locally recurrent rectal cancer in The Netherlands.","authors":"H J Rutten,&nbsp;G H Mannaerts,&nbsp;H Martijn,&nbsp;T Wiggers","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We present our experience with intraoperative radiotherapy (IORT) multimodality treatment for patients with locally recurrent rectal cancer, but without distant metastases. Between 1994 and early 2000, 62 patients were treated according to a set protocol. Three-year survival rate was 49%. The local control rate was 63%. Total dose of irradiation and completeness of resection were significantly correlated to a better prognosis.</p>","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"26 Suppl A ","pages":"S16-20"},"PeriodicalIF":3.8,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21953444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative techniques of intraoperative radiotherapy.","authors":"R J Ellis,&nbsp;S Nag,&nbsp;T J Kinsella","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aims: </strong>The article reviews current techniques for the delivery of intraoperative radiotherapy (IORT).</p><p><strong>Methods: </strong>Various techniques have been developed to allow for IORT to be given as an adjuvant to surgical resection in the operating room during surgery. This article reviews these different techniques including: dedicated IORT units, intraoperative high dose rate brachytherapy and mobile IORT units such as the Mobetron.</p><p><strong>Results: </strong>IORT may be safely delivered by various methods during operation. Mobile linear accelerators, such as the Mobetron, may allow wider applications of IORT. Preliminary results of IORT at various institutions show promising results.</p><p><strong>Conclusions: </strong>Widespread applications for IORT are feasible due to improvements in the technology. Future studies should define the proper role for IORT at various disease sites.</p>","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"26 Suppl A ","pages":"S25-7"},"PeriodicalIF":3.8,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21953446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous unilateral parotid neoplasms of different histological types.","authors":"S D Stavrianos,&nbsp;N R McLean,&nbsp;J V Soames","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The occurrence of multiple tumours in the salivary glands is an unusual phenomenon and the simultaneous development of tumours different types is extremely rare. Two cases are presented with synchronous tumours of the parotid gland of different histological types. The first was a Warthin tumour in combination with a metastatic lung carcinoma and the second was a pleomorphic adenoma in combination with non-Hodgkin's malignant lymphoma.</p>","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"25 3","pages":"331-2"},"PeriodicalIF":3.8,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21251354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinosarcoma of the submandibular salivary gland.","authors":"J Gogas,&nbsp;C Markopoulos,&nbsp;V Karydakis,&nbsp;G Gogas,&nbsp;J Delladetsima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report a rare case of submandibular salivary gland carcinosarcoma ('true' malignant mixed tumour) which occurred in a 77-year-old man. Microscopic examination showed a neoplasm comprised of sarcomatous elements (chondrosarcoma, rhabdomyosarcoma and osteosarcoma) with tabular salivary ductal adenocarcinoma. A short review of the literature is also presented and the poor prognosis of these tumours, in spite of complete surgical removal and additional radiation therapy and chemotherapy, is discussed.</p>","PeriodicalId":519500,"journal":{"name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","volume":"25 3","pages":"333-5"},"PeriodicalIF":3.8,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21251196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}