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Homeodomain Transcription Factors Nkx2.2 and Pax6 as Novel Biomarkers for Meningioma Tumor Treatment. 作为脑膜瘤治疗新生物标志物的同源基因转录因子 Nkx2.2 和 Pax6
IF 2.1
Immigrants and Minorities Pub Date : 2024-01-01 Epub Date: 2022-08-30 DOI: 10.1007/s12291-022-01085-1
Shirin Farheen, Mubeena Mariyath Pm, Suhailur Rehman, Md Fakhrul Hoda, Yakhlesh Gupta, Asif Ali, Kunzang Chosdol, Mehdi H Shahi
{"title":"Homeodomain Transcription Factors Nkx2.2 and Pax6 as Novel Biomarkers for Meningioma Tumor Treatment.","authors":"Shirin Farheen, Mubeena Mariyath Pm, Suhailur Rehman, Md Fakhrul Hoda, Yakhlesh Gupta, Asif Ali, Kunzang Chosdol, Mehdi H Shahi","doi":"10.1007/s12291-022-01085-1","DOIUrl":"10.1007/s12291-022-01085-1","url":null,"abstract":"<p><p>Meningioma is a common brain tumour which has neither a specific detection nor treatment method. The Sonic hedgehog (Shh) cell signaling pathway is a crucial regulatory pathway of mammalian organogenesis and tumorigenesis including meningioma. Shh cell signalling pathway cascade function by main transcription factor Gli1 and which further regulates in its downstream to Pax6 and Nkx2.2. This current study is aimed to explore the regulation of the Sonic hedgehog-Gli1 cell signaling pathway and its potential downstream targets in meningioma samples. A total of 24 surgically resected meningioma samples were used in this current study.Cytological changes were assessed using electron microscopic techniques as well as hematoxylin & eosin and DAPI staining. The expression pattern of Gli1, Nkx2.2 and Pax6 transcription factors were determined by using immunohistochemistry. The mRNA expression was assessed using RT-qPCR assays. Later, the whole transcriptome analysis of samples was performed with the amploseq technique. Results were compared with those obtained in normal human brain tissue (or normal meninges). Compared to the normal human brain tissue, meningioma samples showed crowded nuclei with morphological changes. Transcription factor Nkx2.2 expressed highly in all samples (24/24, 100%). Twenty-one of the 24 meningiomas (88%) showed high Gli1 and Pax6 expression. Whole transcriptome analysis of two meningioma samples also exhibited a very high increase in Gli1 expression signal in meningioma samples as compare to normal control. Hence, we may conclude that the Shh-Gli1 pathway is aberrantly activated in meningioma cells and is canonically upregulating the expression of transcription factors Pax6 and Nkx2.2.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12291-022-01085-1.</p>","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"15 1","pages":"47-59"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10784245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81269842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aliens: the chequered history of Britain’s wartime refugees Aliens: the chequered history of Britain’s wartime refugees , Paul Dowswell, London, Biteback Publishing, 2023, 292 pp., £25 (hardback), ISBN: 978-1-78590-793-7 《异形:英国战时难民的曲折历史》，保罗·道斯威尔，伦敦，Biteback出版社，2023年，292页，25英镑(精装本)，ISBN: 978-1-78590-793-7
Immigrants and Minorities Pub Date : 2023-10-16 DOI: 10.1080/02619288.2023.2267951
Kenneth Lunn
{"title":"Aliens: the chequered history of Britain’s wartime refugees <b>Aliens: the chequered history of Britain’s wartime refugees</b> , Paul Dowswell, London, Biteback Publishing, 2023, 292 pp., £25 (hardback), ISBN: 978-1-78590-793-7","authors":"Kenneth Lunn","doi":"10.1080/02619288.2023.2267951","DOIUrl":"https://doi.org/10.1080/02619288.2023.2267951","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"220 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136114140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chinese Sojourners in Wartime Raj 战时的中国侨民
IF 0.1
Immigrants and Minorities Pub Date : 2023-08-16 DOI: 10.1080/02619288.2023.2238400
H. Lopes
{"title":"Chinese Sojourners in Wartime Raj","authors":"H. Lopes","doi":"10.1080/02619288.2023.2238400","DOIUrl":"https://doi.org/10.1080/02619288.2023.2238400","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"12 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75008794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Returning to Ireland from Australia 1880-1925 1880-1925年从澳大利亚返回爱尔兰
IF 0.1
Immigrants and Minorities Pub Date : 2023-07-28 DOI: 10.1080/02619288.2023.2232345
D. Hall, Loretta Dynan
{"title":"Returning to Ireland from Australia 1880-1925","authors":"D. Hall, Loretta Dynan","doi":"10.1080/02619288.2023.2232345","DOIUrl":"https://doi.org/10.1080/02619288.2023.2232345","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"8 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78984337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chapters of Accidents: A Writer’s Memoir 《意外:一个作家的回忆录
IF 0.1
Immigrants and Minorities Pub Date : 2023-07-13 DOI: 10.1080/02619288.2023.2233863
Anne J. Kershen
{"title":"Chapters of Accidents: A Writer’s Memoir","authors":"Anne J. Kershen","doi":"10.1080/02619288.2023.2233863","DOIUrl":"https://doi.org/10.1080/02619288.2023.2233863","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"8 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87576008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The persistence and malleability of settlerness: Danube Swabians in Entre Rios/Guarapuava (Paraná, Brazil) 定居的持久性和延展性:多瑙河斯瓦本人在恩特雷里奥斯/瓜拉普瓦瓦(巴西帕拉纳<e:1>)
IF 0.1
Immigrants and Minorities Pub Date : 2023-06-28 DOI: 10.1080/02619288.2023.2216683
Cristian Cercel
{"title":"The persistence and malleability of settlerness: Danube Swabians in Entre Rios/Guarapuava (Paraná, Brazil)","authors":"Cristian Cercel","doi":"10.1080/02619288.2023.2216683","DOIUrl":"https://doi.org/10.1080/02619288.2023.2216683","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"3 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79715272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NS-Verfolgte nach der Befreiung: Ausgrenzungserfahrungen und Neubeginn 纳粹是从获释后学习的
IF 0.1
Immigrants and Minorities Pub Date : 2023-04-21 DOI: 10.1080/02619288.2023.2198364
Matthew Stibbe
{"title":"NS-Verfolgte nach der Befreiung: Ausgrenzungserfahrungen und Neubeginn","authors":"Matthew Stibbe","doi":"10.1080/02619288.2023.2198364","DOIUrl":"https://doi.org/10.1080/02619288.2023.2198364","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"40 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78219394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Black Handsworth: Race in 1980s Britain 《黑人汉斯沃斯:1980年代英国的种族》
IF 0.1
Immigrants and Minorities Pub Date : 2023-01-27 DOI: 10.1080/02619288.2023.2171754
Natalie Thomlinson
{"title":"Black Handsworth: Race in 1980s Britain","authors":"Natalie Thomlinson","doi":"10.1080/02619288.2023.2171754","DOIUrl":"https://doi.org/10.1080/02619288.2023.2171754","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"9 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89067696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global White Nationalism: From Apartheid to Trump 全球白人民族主义:从种族隔离到特朗普
IF 0.1
Immigrants and Minorities Pub Date : 2022-10-26 DOI: 10.1080/02619288.2022.2138170
Liam John Liburd
{"title":"Global White Nationalism: From Apartheid to Trump","authors":"Liam John Liburd","doi":"10.1080/02619288.2022.2138170","DOIUrl":"https://doi.org/10.1080/02619288.2022.2138170","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"2015 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73905515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
‘Feindliche Ausländer’ im Deutschen Reich während des Ersten Weltkrieges 你怎么样
IF 0.1
Immigrants and Minorities Pub Date : 2022-09-26 DOI: 10.1080/02619288.2022.2124732
Matthew Stibbe
{"title":"‘Feindliche Ausländer’ im Deutschen Reich während des Ersten Weltkrieges","authors":"Matthew Stibbe","doi":"10.1080/02619288.2022.2124732","DOIUrl":"https://doi.org/10.1080/02619288.2022.2124732","url":null,"abstract":"","PeriodicalId":51940,"journal":{"name":"Immigrants and Minorities","volume":"231 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76437904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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