2024 IEEE Applied Sensing Conference (APSCON)最新文献_第3页

Electrospun SnO2 nanofibers-based electrochemical sensor using AB (1-40) for early detection of Alzheimer’s 使用 AB (1-40) 的电纺 SnO2 纳米纤维电化学传感器用于早期检测阿尔茨海默氏症

2024 IEEE Applied Sensing Conference (APSCON) Pub Date : 2024-01-22 DOI: 10.1109/APSCON60364.2024.10466169

Patta Supraja, R. Gangwar, Suryasnata Tripathy, S. Vanjari, S. Singh

{"title":"Electrospun SnO2 nanofibers-based electrochemical sensor using AB (1-40) for early detection of Alzheimer’s","authors":"Patta Supraja, R. Gangwar, Suryasnata Tripathy, S. Vanjari, S. Singh","doi":"10.1109/APSCON60364.2024.10466169","DOIUrl":"https://doi.org/10.1109/APSCON60364.2024.10466169","url":null,"abstract":"An early diagnosis of Alzheimer’s disease (AD) is challenging and affects millions worldwide. AB(1-40), a potential biomarker found in cerebrospinal fluid, blood, and its derivatives, is utilized as an alternative for an early diagnosis of Alzheimer’s. This work presents an early detection of AD with the help of label-free electrochemical transduction mechanisms using AB(1-40) as a biomarker. To increase the diversity of decision-making parameters that inherently improve the disease’s diagnostic accuracy, the detection was carried out with the help of DPV and EIS analysis. The sensing platform utilized electrospun tin-oxide (SnO2) nanofibers modified carbon electrodes as a transducing element comprising covalently immobilized AB(1-40) antibodies on which the target AB(1-40) binds specifically. The sensing platform detected the target analyte concentrations prepared in real-time human blood plasma in the linear detection range of 1 fg/mL – 10 ng/mL and 1 fg/mL – 100 pg/mL obtained from DPV and EIS, respectively. It also accounted for an extremely low detection limit of 0.785 and 0.573 fg/mL and a very high sensitivity of 4.095 (μA/(ng/mL))/cm2 and 285.94 (kΩ/(ng/mL))/cm2 obtained from DPV and EIS, respectively. Further, the proposed sensing platform showed excellent selectivity, repeatability, reproducibility and high interference resistance.","PeriodicalId":518961,"journal":{"name":"2024 IEEE Applied Sensing Conference (APSCON)","volume":"258 11","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140531022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MEMS Thermo-Nanomechanical Membrane Flexure (T-NMF) Device for Temperature Sensing 用于温度传感的 MEMS 热纳米机械膜挠性 (T-NMF) 设备

2024 IEEE Applied Sensing Conference (APSCON) Pub Date : 2024-01-22 DOI: 10.1109/APSCON60364.2024.10466145

Uma D Santhosh, V. Seena

{"title":"MEMS Thermo-Nanomechanical Membrane Flexure (T-NMF) Device for Temperature Sensing","authors":"Uma D Santhosh, V. Seena","doi":"10.1109/APSCON60364.2024.10466145","DOIUrl":"https://doi.org/10.1109/APSCON60364.2024.10466145","url":null,"abstract":"A promising choice for mechanical sensing applications is the nanomechanical cantilever sensor (NMC), which converts physical change on the cantilever surface into nanomechanical motion that may be detected by suitable transduction techniques. Structural modification of this device into an optimized membrane-based sensor platform and the integration of highly sensitive transduction materials to the NMC sensors can lead to appreciable enhancement in the performance of the sensor, thereby creating an ultra-sensitive nanomechanical sensor platform. This paper reports the development of a MEMS Thermo-Nanomechanical Membrane Flexure (T-NMF) sensor for meeting the demand for a highly sensitive, miniaturized, realtime temperature sensor, based on the principle of deflection of the bimorph membrane with change in temperature, due to the difference in thermal coefficients of expansion of different layers of materials present on the membrane. Four inverse trapezoidal flexures are used to suspend the circular membrane of the T-NMF sensor. The two layers of the membrane are selected to be silicon and aluminum. A thin film of Indium Tin Oxide (ITO), which has a high gauge factor, is deposited as a piezoresistor on each of the flexures, for electromechanical transduction. The design and simulation of the T-NMF sensor is carried out using COMSOL Multiphysics 6.0 software, after optimizing the beam geometry. This optimized design showed an improved thermal sensitivity of around 2 times higher than that of the conventional cantilever bimorph sensor of comparable dimensions.","PeriodicalId":518961,"journal":{"name":"2024 IEEE Applied Sensing Conference (APSCON)","volume":"114 2","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140531032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel SSPP Based Highly Sensitive EM Biosensor for Noninvasive Measurement of Blood Glucose 基于 SSPP 的新型高灵敏 EM 生物传感器用于无创血糖测量

2024 IEEE Applied Sensing Conference (APSCON) Pub Date : 2024-01-22 DOI: 10.1109/APSCON60364.2024.10466051

Debarati Dutta, Namrata Mendiratta, Anirban Sarkar

引用次数: 0

Temporal Behavior Analysis for the Impact of Combined Temperature and Humidity Variations on a Photoacoustic CO₂ Sensor 温度和湿度综合变化对光声二氧化碳传感器影响的时间行为分析

2024 IEEE Applied Sensing Conference (APSCON) Pub Date : 2024-01-22 DOI: 10.1109/APSCON60364.2024.10465885

Ananya Srivastava, Pranav Sharma, Axel Sikora, Achim Bittner, Alfons Dehe

引用次数: 0