M. Korte, D. Cerci, R. Wehry, R. Timmers, V. Williamson
{"title":"The same but different. Multidimensional assessment of depression in students of natural science and music","authors":"M. Korte, D. Cerci, R. Wehry, R. Timmers, V. Williamson","doi":"10.1101/2023.01.10.23284333","DOIUrl":"https://doi.org/10.1101/2023.01.10.23284333","url":null,"abstract":"Depression is one of the most common and debilitating health problems, however, its heterogeneity makes a diagnosis challenging. Thus far the restriction of depression variables explored within groups, the lack of comparability between groups, and the heterogeneity of depression as a concept limit a meaningful interpretation, especially in terms of predictability. Research established students in late adolescence to be particularly vulnerable, especially those with a natural science or musical study main subject. This study used a predictive design, observing the change in variables between groups as well as predicting which combinations of variables would likely determine depression prevalence. 102 under- and postgraduate students from various higher education institutions participated in an online survey. Students were allocated into three groups according to their main study subject and type of institution: natural science students, music college students and a mix of music and natural science students at university with comparable levels of musical training and professional musical identity. Natural science students showed significantly higher levels of anxiety prevalence and pain catastrophizing prevalence, while music college students showed significantly higher depression prevalence compared to the other groups. A hierarchical regression and a tree analysis found that depression for all groups was best predicted with a combination of variables: high anxiety prevalence and low burnout of students with academic staff. The use of a larger pool of depression variables and the comparison of at-risk groups provide insight into how these groups experience depression and thus allow initial steps towards personalized support structures.","PeriodicalId":51865,"journal":{"name":"Health Psychology Research","volume":"24 1","pages":"74879"},"PeriodicalIF":2.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90542228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding factors that influence whether a woman will seek care for reproductive health: A national survey.","authors":"Pooja Kanyadan, Latha Ganti, Rohan Mangal, Thor Stead, Lindsey Hahn, Marcos Sosa","doi":"10.52965/001c.67959","DOIUrl":"https://doi.org/10.52965/001c.67959","url":null,"abstract":"A number of studies have characterized the importance of regular OB/GYN visits for women who are above the age of 18. As more emphasis is placed on reproductive healthcare, there has been an overall decrease in the rates of adverse sexual and reproductive health outcomes. In this study, a population of 200 women were surveyed to find factors that influence whether they had sought care from an OB/GYN in the past year. These results can be further extrapolated to whether women will seek OB/GYN healthcare in the future. A survey research platform was used to collect demographic data in addition to the survey responses. Thirteen survey questions were designed, some of which were adapted from the NIH Healthcare Access and Utilization Survey. This study found that women of minority races (African American and Hispanic) were more likely to report that they didn't feel like they were asked for their opinions about their healthcare. Additionally, women who were younger, who didn't feel like they were asked for their opinions, and who were of minority races were more likely to have not seen an OB/GYN in the past year. These findings can be used to focus on fixing the factors that deter women from seeking regular OB/GYN care. Efforts must be made to ensure that patients feel supported and understood, for this is the only way that we can make progress towards a healthier society.","PeriodicalId":51865,"journal":{"name":"Health Psychology Research","volume":"11 ","pages":"67959"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907319/pdf/healthpsychologyresearch_2023_11_67959.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10704595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of stress amongst high school athletes (v2).","authors":"Tavish Ward, Thor Stead, Rohan Mangal, Latha Ganti","doi":"10.52965/001c.70167","DOIUrl":"https://doi.org/10.52965/001c.70167","url":null,"abstract":"<p><strong>Objective: </strong>This study sought to 1) ascertain the severity of the stress experienced by high school athletes due to playing a sport, 2) understand how these athletes deal with their stress, and if these athletes desire help from someone and 3) determine whether athletes consider their stress a debilitating factor.</p><p><strong>Methods: </strong>200 high school athletes between the ages of 16 and 17 were surveyed using an anonymous online survey platform to discover the relationship between stress and sports. The survey examined both male and female athletes from a variety of sports, different locations, and different ethnicities.</p><p><strong>Results: </strong>Approximately 91% of all the cohort experienced some level of stress due to sports. Interestingly, about a third claimed stress positively affected performance. Fear of failure and self-pressure were the most common causes of stress. About 27% who were experiencing moderate to extreme stress wanted, but did not receive, help from a medical professional. However, of all the participants who experienced some level of stress, only 18% believed that receiving help from a medical professional would not be beneficial for them.</p><p><strong>Conclusion: </strong>While it is easy to overlook and minimize the stress of a high school athlete, doing so may cause future problems such as anxiety and depression, both of which have been steadily increasing among that same population. It is important that, if needed, these athletes have access to medical professionals to adequately manage their stress.</p>","PeriodicalId":51865,"journal":{"name":"Health Psychology Research","volume":"11 ","pages":"70167"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946800/pdf/healthpsychologyresearch_2023_11_70167.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10792407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rocio Luana Gruppi, Cecilia Yaccarini, Agustin Freiberg Hoffmann, Andrew Futterman, Hugo Simkin
{"title":"Adaptation and Validation of the Texas Revised Inventory of Grief-Present Scale.","authors":"Rocio Luana Gruppi, Cecilia Yaccarini, Agustin Freiberg Hoffmann, Andrew Futterman, Hugo Simkin","doi":"10.52965/001c.39652","DOIUrl":"10.52965/001c.39652","url":null,"abstract":"<p><p>This study aims to evaluate the psychometric properties and internal consistency of the Spanish version of the Texas Revised Inventory of Grief- Present [TRIG-Present] in Buenos Aires, Argentina, which assesses a series of thoughts, emotions and behaviors in losses related to the present. A total of 285 adults participated in the study with ages between 18 and 80 years (M = 55.09, SD = 15.27) and both sexes (Men = 42.8%, Women = 57.2%). The three-factor model resulted in acceptable fit indices (TLI = .970; CFI = .976; SRMR = .064). The results indicated an acceptable internal consistency for Emotional Response (ω = .850), Not Acceptance (ω = .816) and Thought (ω = .837). The spanish adaptation of the TRIG-Present presents 13 items proposed by the original authors.</p>","PeriodicalId":51865,"journal":{"name":"Health Psychology Research","volume":"10 4","pages":"39652"},"PeriodicalIF":2.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760660/pdf/healthpsychologyresearch_2022_10_4_39652.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10763178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danyon J Anderson, Parsia Vazirnia, Catherine Loehr, Whitney Sternfels, Jamal Hasoon, Omar Viswanath, Alan D Kaye, Ivan Urits
{"title":"Testosterone Replacement Therapy in the Treatment of Depression.","authors":"Danyon J Anderson, Parsia Vazirnia, Catherine Loehr, Whitney Sternfels, Jamal Hasoon, Omar Viswanath, Alan D Kaye, Ivan Urits","doi":"10.52965/001c.38956","DOIUrl":"https://doi.org/10.52965/001c.38956","url":null,"abstract":"<p><strong>Background: </strong>Depression is a common disorder that affects millions globally and is linked to reduced quality of life and mortality. Its pathophysiology is complex and there are several forms of treatment proposed in the literature with differing side effect profiles. Many patients do not respond to treatment which warrants augmentation with other treatments and the investigation of novel treatments. One of these treatments includes testosterone therapy which evidence suggests might improve depressed mood in older patients with low levels of testosterone and helps restore physical impairments caused by age-related hormonal changes.</p><p><strong>Objective: </strong>The objective of this review is to synthesize information regarding clinical depression, its treatment options, and the efficacy and safety of testosterone treatment for the treatment of depression.</p><p><strong>Methods: </strong>This review utilized comprehensive secondary and tertiary data analysis across many academic databases and published work pertaining to the topic of interest.</p><p><strong>Results: </strong>Within some subpopulations such as men with dysthymic disorder, treatment resistant depression, or low testosterone levels, testosterone administration yielded positive results in the treatment of depression. Additionally, rodent models have shown that administering testosterone to gonadectomized male animals reduces symptoms of depression. Conversely, some studies have found no difference in depressive symptoms after treatment with testosterone when compared with placebo. It was also noted that over administration of testosterone is associated with multiple adverse effects and complications.</p><p><strong>Conclusion: </strong>The current evidence provides mixed conclusions on the effectiveness of testosterone therapy for treating depression. More research is needed in adult men to see if declining testosterone levels directly influence the development of depression.</p>","PeriodicalId":51865,"journal":{"name":"Health Psychology Research","volume":" ","pages":"38956"},"PeriodicalIF":2.0,"publicationDate":"2022-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704723/pdf/healthpsychologyresearch_2022_10_4_38956.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40491704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sofia Malik, Thor S Stead, Rohan Mangal, Latha Ganti
{"title":"General Anxiety Disorder in Youth: A National Survey.","authors":"Sofia Malik, Thor S Stead, Rohan Mangal, Latha Ganti","doi":"10.52965/001c.39578","DOIUrl":"https://doi.org/10.52965/001c.39578","url":null,"abstract":"<p><p>General Anxiety Disorder has become an increasing problem in the youth population. The authors conducted a survey of youth ages 16-24, on what life is like for those who are living with anxiety. In this cohort of 200, the youngest participants were the least likely to be diagnosed, see a professional, and take medication for their anxiety. A significant number said that anxiety affects their day-to-day lives and also causes many physical side effects.</p>","PeriodicalId":51865,"journal":{"name":"Health Psychology Research","volume":" ","pages":"39578"},"PeriodicalIF":2.0,"publicationDate":"2022-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704715/pdf/healthpsychologyresearch_2022_10_4_39578.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40491703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tyler R Bendrick, Graison L Sitenga, Cameron Booth, Matthew P Sacco, Christine Erie, Danyon J Anderson, Alan D Kaye, Ivan Urits
{"title":"The Implications of Mental Health and Trauma in Interstitial Cystitis.","authors":"Tyler R Bendrick, Graison L Sitenga, Cameron Booth, Matthew P Sacco, Christine Erie, Danyon J Anderson, Alan D Kaye, Ivan Urits","doi":"10.52965/001c.40321","DOIUrl":"https://doi.org/10.52965/001c.40321","url":null,"abstract":"<p><p>This review aims to assess the relationship between interstitial cystitis (IC) and significant traumatic events or PTSD. It was shown that there is a strong correlation between past trauma and the development of interstitial cystitis, as well as a much higher incidence of PTSD in patients diagnosed with IC. It was also established that for individuals with early traumatic experiences, the more likely the development of IC later in life, and with more severe symptoms and adverse effects on quality of life. We describe three distinct hypotheses for the possible physiologic mechanism for development of IC with relation to mental health and trauma, although definitive evidence in this area is still lacking, which poses interesting avenues for further research. This review also revealed an apparent lack of, and need for, trauma informed care and screening for PTSD in patients diagnosed with IC or other chronic pain syndromes.</p>","PeriodicalId":51865,"journal":{"name":"Health Psychology Research","volume":" ","pages":"40321"},"PeriodicalIF":2.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680853/pdf/healthpsychologyresearch_2022_10_4_40321.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40485690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amnon A Berger, Joseph Keefe, Cain W Stark, Matthew Moore, Giovanni F Ramírez, Julia R Cucarola, Andrew H Han, Alan D Kaye, Latha Ganti
{"title":"Eptinezumab-jjmr, a humanized monoclonal specific to Calcitonin Gene Related Peptide, for the preventive treatment of migraine in adults.","authors":"Amnon A Berger, Joseph Keefe, Cain W Stark, Matthew Moore, Giovanni F Ramírez, Julia R Cucarola, Andrew H Han, Alan D Kaye, Latha Ganti","doi":"10.52965/001c.38439","DOIUrl":"https://doi.org/10.52965/001c.38439","url":null,"abstract":"<p><strong>Purpose of review: </strong>Migraines are prevalent and cause significant morbidity, decline in quality of life and healthcare costs universally. Treatment options are varied, but efficacy is limited. This review centers on Eptinezumab-jjmr, a humanized monoclonal specific to CGRP for the prevention of migraines in adults. Herein presented are the science and mechanism of action, indication and clinical evidence for use.</p><p><strong>Recent findings: </strong>Migraines are severe, recurrent headaches, which are either episodic or chronic in nature. The pain is severe, often accompanied by co-morbid symptoms, such as photophobia, phonophobia, nausea and emesis, and is limiting in nature. It is a prevalent disorder that causes significant, worldwide disability, morbidity, suffering, and costs.The pathophysiology of migraines is actively studied, though recent research points to an initiating event causing migraine generation, that is then propagated by other brain regions, a significant one being the trigeminocervical complex. This is driven by biochemical transmitters, chiefly CGRP. This discovery led to the development of CGRP-targeting drugs, including gepants (small molecular antagonists) and anti-CGRP antibodies, such as Eptinezumab-jjmr.Traditional therapy includes preventative and abortive treatment; however, adherence with preventative treatment has been historically poor, and certain types of abortive therapy carry risks and side effects that preclude them from a large patient population. Moreover, traditional therapy often falls short in migraine therapy. CGRP antagonist, including Eptinezumab, aims to cover the gaps in migraine therapy. We present here evidence to support the safe and effective use of Eptinezumab for the prevention of migraines.</p><p><strong>Summary: </strong>Migraines are a prevalent primary headache disorder causing significant morbidity worldwide. Traditional abortive and preventative treatments fall short for many patients. Eptinezumab is part of new generation of CGRP-targeting medications and has shown significant evidence to support its use for the prevention of migraines. Further research is required to properly compare eptinezumab with existing pharmacotherapy and update guidelines on the appropriate combinations of therapies that are not available and the correct patient selection for each.</p>","PeriodicalId":51865,"journal":{"name":"Health Psychology Research","volume":" ","pages":"38439"},"PeriodicalIF":2.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662608/pdf/healthpsychologyresearch_2022_10_5_38439.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40489059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amber N Edinoff, Connor R Swinford, Amira S Odisho, Caroline R Burroughs, Cain W Stark, Walid A Raslan, Elyse M Cornett, Adam M Kaye, Alan D Kaye
{"title":"Clinically Relevant Drug Interactions with Monoamine Oxidase Inhibitors.","authors":"Amber N Edinoff, Connor R Swinford, Amira S Odisho, Caroline R Burroughs, Cain W Stark, Walid A Raslan, Elyse M Cornett, Adam M Kaye, Alan D Kaye","doi":"10.52965/001c.39576","DOIUrl":"https://doi.org/10.52965/001c.39576","url":null,"abstract":"<p><p>Monoamine oxidase inhibitors (MAOI) are a class of drugs that were originally developed for the treatment of depression but have since been expanded to be used in management of affective and neurological disorders, as well as stroke and aging-related neurocognitive changes. Ranging from irreversible to reversible and selective to non-selective, these drugs target the monoamine oxidase (MAO) enzyme and prevent the oxidative deamination of various monoamines and catecholamines such as serotonin and dopamine, respectively. Tyramine is a potent releaser of norepinephrine (NE) and is found in high concentrations in foods such as aged cheeses and meats. Under normal conditions, NE is unable to accumulate to toxic levels due to the presence of MAO-A, an enzyme that degrades neurotransmitters, including NE. When MAO-A is inhibited, the capacity to handle tyramine intake from the diet is significantly reduced causing the brain to be vulnerable to overstimulation of postsynaptic adrenergic receptors with as little as 8-10 mg of tyramine ingested and can result in life-threatening blood pressure elevations. In addition to adverse reactions with certain foods, both older and newer MAOIs can negatively interact with both sympathomimetic and serotonergic drugs. In general, patients on a MAOI want to avoid two types of medications: those that can elevate blood pressure via sympathomimetic actions (e.g., phenylephrine and oxymetazoline) and those that can increase serotonin levels via 5-HT reuptake inhibition (e.g., dextromethorphan, chlorpheniramine, and brompheniramine). Illicit drugs that stimulate the central nervous system such as ecstasy (MDMA, 3,4-methylenedioxymethamphetamine) act as serotonin releasers. Patient involvement is also crucial to ensure any interaction within the healthcare setting includes making other providers aware of a MAOI prescription as well as avoiding certain OTC medications that can interact adversely with MAOIs.</p>","PeriodicalId":51865,"journal":{"name":"Health Psychology Research","volume":" ","pages":"39576"},"PeriodicalIF":2.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680847/pdf/healthpsychologyresearch_2022_10_4_39576.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40485689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}