Francisco Souza Dos Santos, Gabriel Peixoto Aver, Thais Vieira Paim, Floriano Riva, Eduardo Brambilla, Jonathan Soldera
{"title":"Sodium-Polystyrene Sulfonate-Induced Colitis.","authors":"Francisco Souza Dos Santos, Gabriel Peixoto Aver, Thais Vieira Paim, Floriano Riva, Eduardo Brambilla, Jonathan Soldera","doi":"10.1159/000521195","DOIUrl":"https://doi.org/10.1159/000521195","url":null,"abstract":"a School of Medicine, Universidade de Caxias do Sul, Caxias do Sul, Brazil; b Centro de Patologia Médica (CPM), Caxias do Sul, Brazil; c Clinical Gastroenterology, School of Medicine, Universidade de Caxias do Sul, Caxias do Sul, Brazil; d Post-Graduate Program, Surgery, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; e Post-Graduate Program, Pathology, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil Received: July 20, 2021 Accepted: October 28, 2021 Published online: December 14, 2021","PeriodicalId":51838,"journal":{"name":"GE Portuguese Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fa/a0/pjg-0030-0153.PMC10050855.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9235463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabel Garrido, João Santos-Antunes, Guilherme Macedo
{"title":"An Unusual Endoscopic Finding of Gastric Crohn's Disease.","authors":"Isabel Garrido, João Santos-Antunes, Guilherme Macedo","doi":"10.1159/000520907","DOIUrl":"https://doi.org/10.1159/000520907","url":null,"abstract":"A 37-year-old woman with a past medical history of obesity (body mass index 50 kg/m2) and Crohn’s disease (Montreal classification – A2 L2+L4 B1) was referred to our institution for bariatric surgery after several unsuccessful weight loss attempts. The diagnosis of Crohn’s disease was established at age 19 (Fig. 1) and at that time she started therapy with azathioprine and a prednisolone taper. Due to poor control of the disease, the patient underwent several long courses of corticosteroid therapy. At this point, she began to gradually increase her weight. Over the past 4 years, the patient has been on infliximab at 5 mg/kg every 8 weeks, with evidence of clinical and endoscopic remission. A preoperative esophagogastroduodenoscopy was requested in order to assess the upper gastrointestinal tract for any abnormal findings as well as the presence of Helicobacter pylori (HP) infection. The endoscopy revealed retracted scar tissue in the gastric body (Fig. 2a) and antrum (Fig. 2b), with lesions with a bamboo-joint-like appearance and several pseudopolyps (Fig. 3). The esophagus and duodenum appeared normal. Histopathologic examination of biopsies from the stomach demonstrated mild foveolar hyperplasia and HP-negative chronic gastritis, with no signs of activity. No epithelioid granulomas, glandular atrophy, dysplasia, or signs of malignancy were identified. The patient underwent a sleeve gastrectomy without complications. The surgical specimen did not reveal any specific sign for inactive Crohn’s disease. Indeed, histopathological evaluation of the surgical specimen showed chronic gastritis and hyperplasia of the foveolar epithelium cells, without active inflammation, granulomas, dysplasia, or signs of malignancy. Five months after the surgery, she has already lost 36 kg and Crohn’s disease remains in remission. Crohn’s disease is defined by chronic inflammation that may involve any site of the gastrointestinal tract.","PeriodicalId":51838,"journal":{"name":"GE Portuguese Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7a/99/pjg-0030-0166.PMC10050835.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9235466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pedro Currais, Gonçalo Nunes, Marta Patita, Élia Coimbra, Jorge Fonseca
{"title":"SX-ELLA Danis-Stent for Refractory Acute Esophageal Variceal Bleeding.","authors":"Pedro Currais, Gonçalo Nunes, Marta Patita, Élia Coimbra, Jorge Fonseca","doi":"10.1159/000520273","DOIUrl":"https://doi.org/10.1159/000520273","url":null,"abstract":"a Gastroenterology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal; b Gastroenterology Department, Hospital Garcia de Orta, Almada, Portugal; c Interventional Radiology Unit, Hospital Curry Cabral, Lisbon, Portugal; d PaMNEC – Grupo de Patologia Médica, Nutrição e Exercício Clínico, CiiEM, Centro de Investigação Interdisciplinar Egas Moniz, Monte da Caparica, Portugal Received: July 7, 2021 Accepted: October 5, 2021 Published online: November 24, 2021","PeriodicalId":51838,"journal":{"name":"GE Portuguese Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/3e/pjg-0030-0162.PMC10050833.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9248531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Therapeutic Endoscopic Ultrasound: Current Indications and Future Perspectives.","authors":"Andrew Canakis, Todd H Baron","doi":"10.1159/000529089","DOIUrl":"10.1159/000529089","url":null,"abstract":"<p><p>The transcendence of endoscopic ultrasound (EUS) from diagnostic to therapeutic tool has revolutionized management options in the field of gastroenterology. Through EUS-guided methods, pancreaticobiliary obstruction can now be utilized as an alternative to surgical and percutaneous approaches. This modality also allows for gallbladder drainage in patients who are not ideal operative candidates. By utilizing its unique imaging capabilities, EUS also allows for drainage access points in cases of gastric outlet obstruction as well as windows to ablate pancreatic cystic lesions. As technical progress continues to evolve, interventional gastroenterology continues to push the envelope of minimally invasive therapeutic procedures in a multidisciplinary setting. In this comprehensive review, we set out to describe current indications and innovations through EUS.</p>","PeriodicalId":51838,"journal":{"name":"GE Portuguese Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b6/f2/pjg-0030-0004.PMC10561320.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41219863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guilherme Nogueira Fontinha, João Martins Gama, Rui Caetano Oliveira, Augusta Cipriano
{"title":"Embryonal Sarcoma of the Liver in the Adult: Challenges in the Diagnosis of a Rare Entity.","authors":"Guilherme Nogueira Fontinha, João Martins Gama, Rui Caetano Oliveira, Augusta Cipriano","doi":"10.1159/000528121","DOIUrl":"10.1159/000528121","url":null,"abstract":"<p><strong>Introduction: </strong>Embryonal sarcoma of the liver (ESL) is a rare neoplasm of the liver occurring mainly in paediatric ages. Making the correct diagnosis can be challenging as the laboratory and radiological findings that are often nonspecific, and the tumour immunophenotype is poorly defined and even somewhat variable.</p><p><strong>Case presentation: </strong>A large epigastric mass was detected in a computerized tomography scan of a 43-year-old woman presenting with abdominal pain and bloating. The mass was biopsied and submitted to histopathological study. Microscopically the tumour had sarcomatoid features and showed multinucleated cells with periodic acid-Schiff (PAS)-positive globules. Immunostaining revealed positivity for vimentin, CD10, glypican-3, and α1-antitrypsin and negativity for keratins, muscle, adipocytic, and melanocytic differentiation markers. The patient was then submitted to a left hepatectomy with similar histological findings.</p><p><strong>Discussion: </strong>ESL in adults is a rarity and its diagnosis requires the exclusion of other entities. While some microscopic features are very common, they remain nonspecific. The main feature is the presence of multinucleated cells with PAS-positive hyaline globules. While ancillary testing is key, the immunophenotype also lacks specificity and ESL may have variable staining for glypican-3 and epithelial or muscle differentiation markers. Although it has been described for more than 3 decades, the prognosis and optimal treatment are still not well defined, but surgery has yielded favourable results.</p>","PeriodicalId":51838,"journal":{"name":"GE Portuguese Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81382994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}