MedERA - Journal of CMH LMC and IOD最新文献

{"title":"Screening for Renal Function Impairment in Patients with Chronic Type II Diabetes Mellitus in a Tertiary Care Hospital of Pakistan","authors":"Dr Rafiq Ahmad Siddiqui","doi":"10.61982/medera.v5i2.112","DOIUrl":"https://doi.org/10.61982/medera.v5i2.112","url":null,"abstract":"Objective: The objective of the present study was to detect early biochemical changes, in type II diabetics, indicating renal function impairment leading to Chronic Kidney Disease (CKD). Methodology: This study was conducted in the Department of Biochemistry at Shaikh Zayed FPGMI, Lahore during September 2016 to April 2017. It was a cross-sectional analytical study and was done through nonprobability convenient sampling The study comprised of 50 diagnosed patients of type II diabetes mellitus (for the last 10 years) and 50 healthy subjects. Both male and female participants in equal number between the age of 35-75 were included in the study. Blood glucose level (random), blood urea, serum creatinine, urinary albumin and urinary creatinine were estimated and albumin to creatinine ratio (ACR) in mg/g was calculated. eGFR was also calculated using S/creatinine. The lab values of the study parameters were recorded on the designed proforma after getting proper written consent from the participants. SPSS 20.0 was used for data entry and analysis. Results: Mean values of random plasma glucose level, blood urea, serum creatinine, urine albumin, urine creatinine, ACR and eGFR of patients when compared with those of healthy group showed significant p-values (≤0.05). Conclusion: There was a significant difference in renal laboratory parameters between diabetic patients and healthy controls indicating the presence of CKD. In a developing country like Pakistan type II diabetes mellitus is an incidental finding due to lack of regular health monitoring and it is very difficult to determine the exact duration of the disease. Patients of type II DM develop CKD (Chronic Kidney Disease) due to persistent high plasma glucose levels. Therefore good control of DM and regular monitoring of renal parameters will be helpful in preventing the development of CKD. Key Words: Diabetes Mellitus, Nephropathy, Chronic Kidney Disease, Urinary Albumin to Creatinine ratio.","PeriodicalId":518328,"journal":{"name":"MedERA - Journal of CMH LMC and IOD","volume":"127 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140531469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of Ureterorenoscopy and Extra-Corporeal Shock Wave Lithotripsy for the Treatment Of Upper Ureteric Stone Measuring Less than 1cm.","authors":"Dr Shabbir Hussain Chaudhry","doi":"10.61982/medera.v5i2.129","DOIUrl":"https://doi.org/10.61982/medera.v5i2.129","url":null,"abstract":"Objective: To compare the efficacy of Extracorporeal Shock Wave Lithotripsy (ESWL) and Ureterorenoscopy (URS) in the management of upper ureteric stone measuring <1cm. Methodology: Randomized clinical trial (RCT) was conducted by targeting the patient admitted in urology ward, Jinnah Hospital Lahorethrough a period of one year. A sample size of 132 patients fulfilling inclusion criteria were selected by employing Non-probability consecutive sampling technique was employed to select 132 (sample size) patients fulfilling inclusion criteria. Patients were randomly allocated into two groups (66 in each group A&B) using lottery method. In group-A, stones were treated using ESWL, while in group-B, URS was performed, and stones were broken with pneumatic energy. Data were analyzed using SPSS version 27, and a Chi-square test was conducted to compare the proportions of qualitative variables, while an independent sample t-test was applied to assess mean differences between two groups of quantitative variables. Asignificance level of ≤0.05 was adopted for determining statistical significance. Results: The sociodemographic profile of the two groups was comparable. It was seen that stone free rate nextto first session was higher in URS (81.8%) as compared to ESWL (63.6%) which later increased to 87.7% after completion of three session. The complaint of pain in ESWL was more as compared to URS (22.7% vs 12.1% p= 0.05)while the differences betweenthe rate of complications like fever, UTI, mucosal abrasion, hematuria or perforation were not statistically significant in both group. (p> 0.05) Conclusion: ESWL outperforms URS for the treatment of upper ureteric stones measuring <1cm in terms of efficacy and safety.Although not statistically significant, ourfindings suggest that URS achieves stone-free rates earlier than ESWL. However, according to our findings, ESWL is recommended as the treatment of choice for the majority of patients due to better compliance. Keywords: Extra-corporeal Shock Wave Lithotripsy, Nephrolithiasis, Ureterorenoscopy","PeriodicalId":518328,"journal":{"name":"MedERA - Journal of CMH LMC and IOD","volume":"196 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140531140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}