Oral Presentations最新文献

{"title":"13.03 Empowering TCR-T cells for adoptive therapy for solid tumor through engineering with PD-1-based chimeric costimulatory switch proteins","authors":"E. Noessner, C. Aman, AJ Fischbeck, K. Junker, J. Linxweiler","doi":"10.1136/jitc-2024-itoc10.10","DOIUrl":"https://doi.org/10.1136/jitc-2024-itoc10.10","url":null,"abstract":"","PeriodicalId":517941,"journal":{"name":"Oral Presentations","volume":"281 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140402497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"03.04 Targeted disruption of tumor-borne GDF-15-mediated immunoresistance restores immune checkpoint inhibitor activity in last-line cancer patients","authors":"M. Haake, N. Vashist, K. Eichler, M. Kist, S. Genssler, I. Giese, J. Weigandt, K. Klar, P. Fettes, T. Ross, J. Wischhusen, E. Leo, C. Schuberth-Wagner","doi":"10.1136/jitc-2024-itoc10.2","DOIUrl":"https://doi.org/10.1136/jitc-2024-itoc10.2","url":null,"abstract":"","PeriodicalId":517941,"journal":{"name":"Oral Presentations","volume":"288 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140402701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O18 Data-driven clustering of cerebrospinal fluid proteome reflects clinical phenotypes of systemic lupus erythematosus","authors":"Elsa Grenmyr, K. Zervides, Seyed Morteza Najibi, B. Gullstrand, Charlotte Welinder, J. Nystedt, Petra C Nilsson, Pia C Sundgren, Robin Kahn, A. Jönsen, A. Bengtsson","doi":"10.1136/lupus-2024-el.28","DOIUrl":"https://doi.org/10.1136/lupus-2024-el.28","url":null,"abstract":"","PeriodicalId":517941,"journal":{"name":"Oral Presentations","volume":"226 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140402945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O32 Impact of patient baseline characteristics on SLE Responder Index-4 (SRI[4]) responses to deucravacitinib, a first-in-class, oral, selective, allosteric tyrosine kinase 2 inhibitor in the phase 2 PAISLEY trial in systemic lupus erythematosus","authors":"Eric Morand, C. Arriens, L. Geraldino-Pardilla, Ann E Clarke, S. Pomponi, C. Hobar, Thomas L. Wegman, Ravi Koti, Subhashis Banerjee, R. V. Vollenhoven","doi":"10.1136/lupus-2024-el.41","DOIUrl":"https://doi.org/10.1136/lupus-2024-el.41","url":null,"abstract":"","PeriodicalId":517941,"journal":{"name":"Oral Presentations","volume":"9 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140286791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O40 Impact of glucocorticoid dose on complete response, serious infections, and mortality during the initial therapy of lupus nephritis: a systematic review and meta-analysis of the standard of care arms of randomized controlled trials","authors":"Gabriel Figueroa-Parra, María C Cuéllar-Gutiérrez, Mariana González-Treviño, Alain Sanchez-Rodriguez, Jaime Flores-Gouyonnet, José A Meade-Aguilar, Larry J Prokop, M. Hassan Murad, Maria Dall’Era, Brad H Rovin, Frédéric A Houssiau, F. Tamirou, F. Fervenza, C. Crowson, Michael S Putman, A. Duarte-García","doi":"10.1136/lupus-2024-el.49","DOIUrl":"https://doi.org/10.1136/lupus-2024-el.49","url":null,"abstract":"","PeriodicalId":517941,"journal":{"name":"Oral Presentations","volume":"203 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O20 Lupus low disease activity state and organ damage in relation to quality of life in SLE: a cohort study with up to 11 years of follow-up","authors":"Ioannis Parodis, Thomas Stephens, A. Dominicus, Daniel Eek, C. Sjöwall","doi":"10.1136/lupus-2024-el.30","DOIUrl":"https://doi.org/10.1136/lupus-2024-el.30","url":null,"abstract":"","PeriodicalId":517941,"journal":{"name":"Oral Presentations","volume":"34 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140286736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"104 Intended and unintended consequences of a state policy to combat opioid over-prescribing among patients receiving high dose long term opioid therapy","authors":"S. Ranapurwala, Christopher Ringwaltcring, Brian W Pence, Sharon Schirosharon, Bethany L. DiPrete, Agnieszka McCort, S. Marshall","doi":"10.1136/injuryprev-2020-savir.35","DOIUrl":"https://doi.org/10.1136/injuryprev-2020-savir.35","url":null,"abstract":"Statement of Purpose In May 2016, the North Carolina Medical Board (NCMB) launched the safe opioid prescribing initiative (SOPI) to limit overprescribing of opioids by investigating high volume prescribers and prescribers who have had two or more patient deaths due to opioid overdose. In this study we examined the immediate and sustained effects of NCMB’s SOPI on tapering and discontinuation of opioids among patients receiving high doses (>90 MME) of long-term (>90 days) opioid therapy (LTOT). Methods We conducted an interrupted time series study to examine change in temporal trends of opioid discontinuation and appropriate and inappropriate tapering among high dose LTOT patients in NC, following the NCMB’s implementation of SOPI in May 2016. We used de-identified data from January 2010 through March 2017 from the NC Controlled Substances Reporting System (CSRS). Results During the study period 205,255 people received high dose LTOT in NC. Compared to ∼0.01% monthly decline in discontinuation and tapering pre-SOPI, immediately after the implementation of SOPI, the rate of abrupt discontinuation, inappropriate tapering, and appropriate tapering of opioids among high dose LTOT patients increased by 1% (95% CI: -0.22, 2.23), 2.2% (95% CI: 0.91, 3.47) and 1.3% (95% CI: 0.96, 1.57), respectively. Those receiving opioids from one prescriber were more frequently discontinued, while multiple prescriber patients were more frequently inappropriately tapered post-SOPI. Conclusions The increase in appropriate tapering can be considered a success of SOPI, but, the simultaneous increase in discontinuations and inappropriate tapering may be cause for some concern as these results represent a chilling effect on opioid prescribing that may adversely affect those receiving high dose LTOT. Significance to Injury and Violence Prevention Science Well-intentioned policies such as the SOPI may have harmful effects when not well communicated and combined with education of prescribers to prevent potential unintended consequences.","PeriodicalId":517941,"journal":{"name":"Oral Presentations","volume":"42 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141208968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O10 Prediction of response to rituximab in SLE using a validated two-score system for interferon status","authors":"A. Alase, Z. Wigston, A. Burska, A. Psarras, Md Yuzaiful Md Yusof, J. Reynolds, Miriam Wittman, I. Bruce, Edward M Vital","doi":"10.1136/lupus-2020-eurolupus.23","DOIUrl":"https://doi.org/10.1136/lupus-2020-eurolupus.23","url":null,"abstract":"O10 Table 1 Predictor Non-responders (n=44) Responders (n=40) Univariable OR (95% CI) P Multivariable OR","PeriodicalId":517941,"journal":{"name":"Oral Presentations","volume":"139 7‐9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141228448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}