Medical Bulletin of Haseki最新文献

Diagnostic Performance of a Rapid Antigen Test for the Detection of SARS-CoV-2 检测 SARS-CoV-2 的快速抗原测试的诊断性能

Medical Bulletin of Haseki Pub Date : 2024-05-08 DOI: 10.4274/haseki.galenos.2024.9748

Sema Alacam, N. Karabulut, Alper Gunduz, Busra Ozcan, Ozlem Altuntas Aydin

{"title":"Diagnostic Performance of a Rapid Antigen Test for the Detection of SARS-CoV-2","authors":"Sema Alacam, N. Karabulut, Alper Gunduz, Busra Ozcan, Ozlem Altuntas Aydin","doi":"10.4274/haseki.galenos.2024.9748","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2024.9748","url":null,"abstract":"Aim: The fight against the coronavirus disease-2019 (COVID-19) pandemic has proven crucial, necessitating the need for faster, cheaper, and more reliable detection methods. This study evaluated the performance of a rapid antigen test for the diagnosis of COVID-19 compared with reverse transcription-polymerase chain reaction (RT-PCR) results. Methods: This prospective study included 169 participants. Two simultaneous nasopharyngeal swabs were collected from the participants. Samples were tested for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) using the Panbio™ COVID-19 Ag rapid test (Abbott Rapid Diagnostics, Jena, Germany) and the Bio-Speedy® SARS-CoV-2 RT-PCR kit (Bioeksen, Istanbul, Turkey). Results: Reverse transcription-polymerase chain reaction results were positive in 90 (53.2%) of 169 patients. The antigen rapid diagnostic test (Ag-RDT) was able to find 66 (73.3%) of the 90 RT-PCR positive samples as positive (p<0.001). In all positive samples by Ag-RDT, RT-PCR was positive. The sensitivity, specificity, negative predictive value, and positive predictive value of the Ag-RDT were 73.3%, 100%, 76.7%, and 100%, respectively. The virus detection performance of the Ag-RDT was significantly more successful in the cycle threshold ≤ 20 (p<0.001). There was no correlation between PCR positivity and the time since vaccination. Conclusion: The Ag-RDT test can be a good option for early detection of cases and early prevention, as it is quick and easy to implement in every laboratory and even at the point of care.","PeriodicalId":517489,"journal":{"name":"Medical Bulletin of Haseki","volume":" 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141000665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Spinal Needles used by Anesthesia Residents on Procedural Success and the Perception of Click Sensation: A Randomized Prospective Trial 麻醉住院医师使用的脊柱针对手术成功率和点击感的影响：随机前瞻性试验

Medical Bulletin of Haseki Pub Date : 2024-05-08 DOI: 10.4274/haseki.galenos.2024.9851

Gamze Kucukosman, Bengu G. Koksal, T. Ozturk, K. Bollucuoğlu, Çağdaş Baytar, R. D. Okyay, Ozcan Piskin, H. Ayoğlu

{"title":"Effect of Spinal Needles used by Anesthesia Residents on Procedural Success and the Perception of Click Sensation: A Randomized Prospective Trial","authors":"Gamze Kucukosman, Bengu G. Koksal, T. Ozturk, K. Bollucuoğlu, Çağdaş Baytar, R. D. Okyay, Ozcan Piskin, H. Ayoğlu","doi":"10.4274/haseki.galenos.2024.9851","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2024.9851","url":null,"abstract":"Aim: The type and diameter of the needle used in spinal anesthesia (SA) affect the procedure’s success and the sensation of clicking during a dura puncture. This study aimed to compare the effects of Quincke and pencil-point needles of the same thickness, when used by anesthesia residents new to SA application, on procedural success and the number of trials required to perceive click sensation. Methods: This prospective randomized study included 213 adult patients undergoing elective surgery under SA, divided into six groups based on needle type and diameter: Group I: Quincke (Q)-25 Gauge (G), Group II: Q-26G, Group III: Q-27G, Group IV: Pencil-point (P)- 25G, Group V: P-26G, and Group VI: P-27G. The number of interventions for SA (1-3), the attempt (1, 2, or ≥ 3) during which the stylet was removed and cerebrospinal fluid (CSF) flow occurred, considering that the click sensation was felt during the procedure, and the time taken for CSF appearance (<1.9 s or ≥ 2 seconds) were recorded. Results: No difference was found between the groups in terms of demographic data, the American Society of Anesthesiologists risk, puncture site, number of click sensation trials, time for CSF appearance, and feasibility of the procedure (p>0.05). The SA success rate in the first trial (p<0.001) was higher when pencil-point needles were used. Conclusion: Although the effects of spinal needles with different tip designs and diameters on the number of trials required to perceive click sensation are similar, due to the high rate of SA success in the first trial, the use of pencil-point needles is recommended for anesthesia residents new to SA application.","PeriodicalId":517489,"journal":{"name":"Medical Bulletin of Haseki","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Blood Glucose Monitored Before Dialysis on Hypoglycemia During Dialysis in Adult Acute Hemodialysis Patients: A Multicenter Study 透析前监测血糖对成人急性血液透析患者透析期间低血糖症的影响：一项多中心研究

Medical Bulletin of Haseki Pub Date : 2024-05-08 DOI: 10.4274/haseki.galenos.2024.9383

Ilkay Coban, Neşe Kıskaç, E. Cebeci, V. Z. Yenen

引用次数: 0

Evaluation of Similar Genetic Pathophysiology Underlying Diabetes Mellitus and Peyronie’s Disease: WNT-2 and TGF Beta-1 Genes 评估糖尿病和佩罗尼氏病的相似遗传病理生理学：WNT-2 和 TGF Beta-1 基因

Medical Bulletin of Haseki Pub Date : 2024-05-08 DOI: 10.4274/haseki.galenos.2024.9534

E. Toprak, E. Keskin, A. Gezdirici, Alper Otunctemur, H. Canat

{"title":"Evaluation of Similar Genetic Pathophysiology Underlying Diabetes Mellitus and Peyronie’s Disease: WNT-2 and TGF Beta-1 Genes","authors":"E. Toprak, E. Keskin, A. Gezdirici, Alper Otunctemur, H. Canat","doi":"10.4274/haseki.galenos.2024.9534","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2024.9534","url":null,"abstract":"Aim: Some recent studies on PD have focused on the WNT-2 and TGF-β 1 gene loci, but its genetic basis is still not clearly known. In this context, we aimed to evaluate the presence of WNT-2 and TGF-β 1 gene expression and genetic similarity between patients with Peyronie’s disease (PD) and comorbidities, especially diabetes mellitus (DM). Methods: Between May 2020 and April 2021, 57 patients diagnosed with PD were included in this cross-sectional study. The presence of comorbidities [Dupuytren’s contracture (DC), DM, hypertension (HT), dyslipidemia, and erectile dysfunction (ED)] was recorded. For genetic analysis, the WNT-2 and TGF-β 1 genes were analyzed in the patients’ serum. Results: The mean age was found to be 50.2. 45.6% of the patients had DM, 19.1% had HT, 14% had dyslipidemia, 5.3% had DC, and 40.4% had ED. TGF-β 1 gene expression was found to be increased in all patients; WNT-2 gene expression was found to be increased in 80.7%. When subtypes of the TGF-β 1 and WNT-2 gene expression were analyzed, 52.6% of patients with WNT-2 gene expression and 95.5% of patients with TGF-β 1 gene expression were found to be homozygous, and the others were found to be heterozygous. Patients with DM and PD had significantly higher homozygous WNT-2 gene expression (p=0.03). No significant relationship was found between other comorbidities and these genes. Conclusion: Homozygous WNT-2 gene expression was found to be increased in PD with DM. These data could be used to explain the genetic pathophysiology of PD in diabetic patients.","PeriodicalId":517489,"journal":{"name":"Medical Bulletin of Haseki","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141000157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blastoid Variant Mantle Cell Lymphoma with Amplified IGH/CCND1 Fusion: A Unique Case and Current Literature Review 伴有扩增 IGH/CCND1 融合的 Blastoid 变异型套细胞淋巴瘤：一个独特的病例和当前文献综述

Medical Bulletin of Haseki Pub Date : 2024-05-08 DOI: 10.4274/haseki.galenos.2024.9567

E. Goktas, Sumeyye Sanal, Haci Hasan Esen, A. Tekinalp

引用次数: 0

Evaluation of the Association Among Cerebrospinal Fluid Protein, Inflammatory Markers, and Electromyography in Pediatric Guillain-Barre Syndrome 评估小儿格林-巴利综合征患者脑脊液蛋白、炎症标志物和肌电图之间的关系

Medical Bulletin of Haseki Pub Date : 2024-05-08 DOI: 10.4274/haseki.galenos.2024.9521

D. Ağırcan, Ozlem Ethemoglu, Mustafa Calik, Tülin Gesoğlu Demir

{"title":"Evaluation of the Association Among Cerebrospinal Fluid Protein, Inflammatory Markers, and Electromyography in Pediatric Guillain-Barre Syndrome","authors":"D. Ağırcan, Ozlem Ethemoglu, Mustafa Calik, Tülin Gesoğlu Demir","doi":"10.4274/haseki.galenos.2024.9521","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2024.9521","url":null,"abstract":"Aim: Previous studies have shown that the cerebrospinal fluid (CSF) protein level correlates with the number of demyelination criteria in electromyography in adult patients with Guillain-Barré syndrome (GBS), which is a potentially life-threatening postinfectious disease. We aimed to assess the association between CSF protein level, inflammatory markers, and electrophysiological values in the diagnosis of pediatric patients to act quickly in treating GBS. Methods: In this cross-sectional study, thirty-nine children with GBS were retrospectively analyzed from the medical records of patients who were treated as inpatients between 2013 and 2021. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, C-reactive protein, uric acid, CSF protein levels, and electrophysiological parameters of the patients on admission were recorded. Hughes disability scores (HDS) were evaluated to determine the severity of disability on admission and at the 3 rd month. Results: Cerebrospinal fluid protein was positively correlated with tibial and peroneal motor nerve distal latency (DL) and negatively correlated with tibial and peroneal sensorial nerve conduction velocities (NCV). In the acute inflammatory demyelinating polyneuropathy group, 3 rd -month HDS was significantly lower than in the acute motor axonal neuropathy group. A positive correlation was found between first-admission HDS and 3 rd -month HDS. There was no significant difference between the electrophysiological subgroups and inflammatory markers. Conclusion: In pediatric GBS patients, well-standardized ranges of the tibial and peroneal motor nerves DL, as well as medial plantar and peroneal superficial NCV, may be sensitive markers. Early rehabilitation programs could prevent disability in immobile patients.","PeriodicalId":517489,"journal":{"name":"Medical Bulletin of Haseki","volume":" 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141000008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Pain-Related Features, Maladaptive Cognitions, Depression, and Anxiety on Pain-Related Disability: A Questionnaire-Based Cross-Sectional Study 疼痛相关特征、适应不良认知、抑郁和焦虑对疼痛相关残疾的影响：基于问卷的横断面研究

Medical Bulletin of Haseki Pub Date : 2024-05-08 DOI: 10.4274/haseki.galenos.2024.9393

Erman Senturk, B. Geniş, Emine Yagmur Zorbozan, Ayşin Selcan

{"title":"Effects of Pain-Related Features, Maladaptive Cognitions, Depression, and Anxiety on Pain-Related Disability: A Questionnaire-Based Cross-Sectional Study","authors":"Erman Senturk, B. Geniş, Emine Yagmur Zorbozan, Ayşin Selcan","doi":"10.4274/haseki.galenos.2024.9393","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2024.9393","url":null,"abstract":"this study to contribute to an evolving understanding of the interplay between cognitive and affective factors in chronic pain, providing valuable insights for advancing treatment models at the intersection of psychiatry and pain medicine. This approach may enable medical professionals to customize interventions that target the most important facets of managing chronic pain while meeting the demands of specific patients. Methods: A questionnaire-based cross-sectional study was conducted among 440 patients with chronic pain in pain medicine clinics between February and June 2023. Demographic, health-related, and medical characteristics were comprehensively assessed alongside the Graded Chronic Pain Scale-Revised, Pain Anxiety Symptoms Scale, Pain Disability Questionnaire, Beck Anxiety Scale, and Beck Depression Scale. Results: Beyond the range of pain severity rates, the regression model showed that elevated levels of pain overthinking, fear and avoidance beliefs, higher depression scores, catastrophizing thoughts, and nonsmoking status were significant factors impacting pain-related disability. Conclusion: This study highlights integrative treatment modalities that address not only the physical dimensions of chronic pain but also its complex psychological aspects. A comprehensive understanding of these contributory factors provides a foundation for optimizing therapeutic approaches.","PeriodicalId":517489,"journal":{"name":"Medical Bulletin of Haseki","volume":" 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Affecting the Publication Rate of Adult Endocrinology Theses in Turkey: A Comprehensive Bibliometric Analysis 影响土耳其成人内分泌学论文发表率的因素：文献计量学综合分析

Medical Bulletin of Haseki Pub Date : 2024-05-08 DOI: 10.4274/haseki.galenos.2024.9408

Çiğdem Tura Bahadır, Merve Yilmaz

{"title":"Factors Affecting the Publication Rate of Adult Endocrinology Theses in Turkey: A Comprehensive Bibliometric Analysis","authors":"Çiğdem Tura Bahadır, Merve Yilmaz","doi":"10.4274/haseki.galenos.2024.9408","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2024.9408","url":null,"abstract":"Understanding the factors that influence the probability of endocrinology thesis publication can guide aspiring researchers in their academic pursuits. This study aimed to assess the publication rate of endocrinology theses and identify the factors that affect thesis publication. Methods: Endocrinology theses between January 1980 and April 2023 were assessed. The publication rates of theses and those published in journals indexed in SCIE and Scopus were examined. The thesis topics, study design, institution, index of the journal, author’s number of first-author publications, H-index, and number of publications by thesis advisors were analyzed to determine their impact on the likelihood of publication. Results: Out of 277 theses, 142 (51.3%) of them had been published in international or national journals. One hundred seventeen (42.2%) were published in SCIE/Scopus indexed journals. A relationship was found between the thesis having a publication and that being conducted in a training and research hospital, a higher number of first-author publications, and a more recent year of the thesis. The H-index of thesis advisors for theses published in SCIE/Scopus-indexed journals was significantly higher (p=0.029). Conclusion: The rate of publication in international peer-reviewed journals for endocrinology theses was higher than the national average. However, there are still many theses waiting to be published. Enhancing the publication rate of endocrinology theses requires a systematic approach that addresses the identified factors affecting publication probability.","PeriodicalId":517489,"journal":{"name":"Medical Bulletin of Haseki","volume":" 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141001168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of a Clinical Decision- Making Scale for Medical Students 医学生临床决策量表的开发与验证

Medical Bulletin of Haseki Pub Date : 2024-05-08 DOI: 10.4274/haseki.galenos.2024.9695

Hilal Hatice Ulku, A. Saracaloglu

{"title":"Development and Validation of a Clinical Decision- Making Scale for Medical Students","authors":"Hilal Hatice Ulku, A. Saracaloglu","doi":"10.4274/haseki.galenos.2024.9695","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2024.9695","url":null,"abstract":"a valid and reliable scale to determine the clinical decision-making levels of medical students. Methods: This descriptive study was conducted between October and November 2021. Interviews were conducted with 12 clinician faculty members through semi-structured interview forms created by considering expert opinions, and an item pool was created through content analysis with support from the literature. The item pool was piloted with 20 medical students, and their feedback was used to revise the scale items. The final version of the scale was administered to 332 fourth, fifth, and sixth-grade medical students undergoing clinical training. Data were analyzed using exploratory and confirmatory factor analysis, reliability analysis, and descriptive statistics. Results: The results of the explanatory factor analysis indicated that the scale had 27 items and a three-factor structure, which explained 67,905% of the total variance. The three factors were identified as “1-defining the problem and determining its causes”, “2-evaluating alternatives”, and “3-individual and institutional factors”. Confirmatory factor analysis results confirmed the three-factor model, and fit indices indicated a good fit between the model and data. The reliability analysis showed that the scale had high internal consistency, with a Cronbach’s alpha coefficient of 0.94. Conclusion: The study suggests that the Clinical Decision-Making Scale is a valid and reliable tool for assessing medical students' clinical decision-making competence in Turkey.","PeriodicalId":517489,"journal":{"name":"Medical Bulletin of Haseki","volume":" 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MEFV Gene Mutation Analysis in Children with Immunoglobulin A Vasculitis and Its Effects on Clinical Manifestations: A Big Series from a Tertiary Center 免疫球蛋白 A 型血管炎患儿的 MEFV 基因突变分析及其对临床表现的影响：来自一家三级医疗中心的大型系列研究

Medical Bulletin of Haseki Pub Date : 2024-05-08 DOI: 10.4274/haseki.galenos.2024.9578

Sema Yildirim, Zeynep Karakaya, Ozlem Ozcay, M. Erguven

{"title":"MEFV Gene Mutation Analysis in Children with Immunoglobulin A Vasculitis and Its Effects on Clinical Manifestations: A Big Series from a Tertiary Center","authors":"Sema Yildirim, Zeynep Karakaya, Ozlem Ozcay, M. Erguven","doi":"10.4274/haseki.galenos.2024.9578","DOIUrl":"https://doi.org/10.4274/haseki.galenos.2024.9578","url":null,"abstract":"Aim: Immunoglobulin A vasculitis (IgAV) is the most common vasculitis of childhood, but its pathogenesis is largely unknown, despite evidence pointing to various environmental and genetic factors. We investigated the frequency of MEFV gene mutations that are considered in the pathogenesis and their effect on the clinical features of patients with IgAV. Methods: The study included 244 children diagnosed with IgAV, who underwent MEFV gene analyses. We recorded the demographic and clinical characteristics of the patients, along with their laboratory results. We grouped the patients based on the presence of MEFV gene mutations and MEFV variants. Results: At least one MEFV mutation was detected in 89 (36.5%) patients, with E148Q being the most common (n=31, 34.8%). Age at diagnosis and the frequency of hematuria and recurrence were significantly greater among patients with MEFV mutations (p=0.043, p=0.008, and p=0.009, respectively). Serum IgA levels were significantly higher in patients with the M694V mutation (p=0.040). Conclusion: The presence of MEFV mutations, particularly E148Q and M694V, could be associated with the development and clinical course of IgA vasculitis.","PeriodicalId":517489,"journal":{"name":"Medical Bulletin of Haseki","volume":" 45","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0