Immuno最新文献 - Book学术

Immune Checkpoint Inhibitors: Fundamental Mechanisms, Current Status and Future Directions 免疫检查点抑制剂：基本机制、现状和未来方向

IF 2.1

Immuno Pub Date : 2024-07-05 DOI: 10.3390/immuno4030013

Abdullah Younis, John Gribben

引用次数: 0

Synergistic Effect of Co-Administered SARS-CoV-2 Vaccines Improves Immune Responses in BALB/c Mice: A Preliminary Study 联合接种 SARS-CoV-2 疫苗的协同效应可提高 BALB/c 小鼠的免疫反应：一项初步研究

Immuno Pub Date : 2024-06-07 DOI: 10.3390/immuno4020012

Nshimirimana Jonas, J. Kimani, James Kimotho, Matthew Mutinda Munyao, S. Nzou

{"title":"Synergistic Effect of Co-Administered SARS-CoV-2 Vaccines Improves Immune Responses in BALB/c Mice: A Preliminary Study","authors":"Nshimirimana Jonas, J. Kimani, James Kimotho, Matthew Mutinda Munyao, S. Nzou","doi":"10.3390/immuno4020012","DOIUrl":"https://doi.org/10.3390/immuno4020012","url":null,"abstract":"Various vaccine platforms have been approved for broad use to prevent the transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. However, these vaccines exhibit distinct differences in immunogenicity and efficacy, which decline after vaccination and are further exacerbated by the emergence of virus variants and mutants. This study reports the immunization outcomes against the SARS-CoV-2 virus by assessing the immune responses and safety of different SARS-CoV-2 vaccines co-administered in BALB/c mice. Vaccine combinations comprising mRNA/adenovirus26-vector, mRNA/inactivated, adenovirus26-vector/inactivated, and mRNA/adenovirus26-vector/inactivated vaccines were prepared in optimized doses, and their activities upon immunization evaluated in comparison with individual mRNA, adenovirus26-vectored, and inactivated vaccines. Fourteen- and 28-days post-immunization, we measured spike-specific IgG response using Enzyme-Linked Immunosorbent Assay (ELISA), cytokine expression profiles through Quantitative real-time polymerase chain reaction (RT-PCR), and evaluated safety through histopathological examination. The mRNA/Vector/Inactivated group exhibited slightly higher anti-spike IgG levels, albeit not statistically significant (p > 0.132). Importantly, this regimen induced elevated IL-6 and IFN-γ mRNA expression levels (p < 0.0001) compared to immunization with individual vaccines. In summary, this study demonstrated that co-administering the mRNA/adenovirus26 vector/inactivated SARS-CoV-2 vaccines improved spike-specific IgG response, triggered significantly enhanced IL-6 and IFN-γ mRNA expression levels, and proved safe in mice.","PeriodicalId":517404,"journal":{"name":"Immuno","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141372346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fulminant Recurrent Thrombosis in a Patient with Catastrophic Antiphospholipid Syndrome and Its Thirty-Day Outcome 一名重症抗磷脂综合征患者的恶性复发性血栓形成及其 30 天后的结果

Immuno Pub Date : 2024-03-04 DOI: 10.3390/immuno4010008

P. Di Micco, Maurizio Dorato, Maurizio Latte, Maria D’Antò, Vittorio Luiso, Gerolamo Sibilio

引用次数: 0

IL-12p40 Monomer: A Potential Player in Macrophage Regulation. IL-12p40 单体：巨噬细胞调控的潜在参与者

Immuno Pub Date : 2024-03-01 Epub Date: 2024-02-23 DOI: 10.3390/immuno4010005

Brian Jeong, Kalipada Pahan

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引用次数: 0