有机化学Pub Date : 2021-08-23DOI: 10.6023/cjoc202100073
赵华, 赵玉芬
{"title":"联烯酮介导的无外消旋/差向异构化肽键的形成及其在多肽合成中的应用 。 Allenone-Mediated Racemization/Epimerization-Free Peptide Bond Formation and Its Application in Peptide Synthesis","authors":"赵华, 赵玉芬","doi":"10.6023/cjoc202100073","DOIUrl":"https://doi.org/10.6023/cjoc202100073","url":null,"abstract":"多肽合成在药物研发、疾病诊断、生物医学材料和高性能材料等高科技领域发挥着重要的作用,引起了化学家的广泛关注[1].酰胺键形成是多肽合成过程中的根本化学反应,同时其本身也是有机化学的一个重要研究领域[2].截止目前,已经有上百种酰胺键构建方法被开发出来[3],但是真正能够用于多肽合成的酰胺键形成方法非常有限,主要原因是这些方法在构建肽键时所需的光学纯手性原料难以获得.因此,多肽合成主要是通过缩合剂介导的天然α-氨基酸之间反复缩合来实现的.但传统多肽缩合剂经常会导致氨基酸羰基α-C位的手性中心发生外消旋化[4],不但使产物收率降低,而且导致纯化极其困难.另外,固相多肽合成(SPPS)的原子眯圆�","PeriodicalId":516855,"journal":{"name":"有机化学","volume":"174 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}