Advanced Exercise and Health Science最新文献

{"title":"Exercise-triggered cardiac remodeling: AKIP1 as a novel mediator of physiological hypertrophy","authors":"Jiahui Li, Jianghao Zhan, Yinuo Liu, Maorui Han, Jie Qi, Jun Zhang","doi":"10.1016/j.aehs.2025.05.002","DOIUrl":"https://doi.org/10.1016/j.aehs.2025.05.002","url":null,"abstract":"A kinase interacting protein 1 (AKIP1) is a signal transduction junction protein that promotes physiological hypertrophy. This study aimed to investigate whether exercise induces AKIP1 to promote physiological cardiac hypertrophy and the effects for signaling pathways. 24 6-week-old C57BL/6 N male mice were randomly divided into quiet control group (CON group), exercise group (EX group), and interference-expressing AKIP1 adeno-associated virus in vivo injection+exercise group (shAAV-AKIP1+EX group) for 10 weeks in running exercise. The cardiac were examined by ultrasound, electrocardiography, HE staining and detection of AKIP1 mRNA and protein expression. The mRNA expression of myocardial pathological markers ( ANP , BNP , α-actin , α-MHC , and β-MHC ), physiological marker ( SERCA2α ), PI3K (p110α) , and mTORC1 were also determined. The results showed that compared with CON group, the left ventricular cell volume was significantly increased, the myocardial fibers were thickened and more closely arranged in EX group. Meanwhile, there was no pathological myocardial fibrosis. The ventricular internal diameters, HW/TL ratio, LVMI, EF, FS and SERCA2α mRNA expression was significantly increased in EX group as in contrast to the CON group ( P <0.05). However, EF, FS as well as SERCA2α mRNA expression were significantly lower in shAAV-AKIP1+EX group compared with the EX group ( P <0.05), whereas cardiac indexes were not significantly affected ( P >0.05). Both AKIP1 mRNA and protein levels expression were markedly higher in EX group than CON group ( P <0.01), while notably downregulated in shAAV-AKIP1+EX group compared to the CON group and EX group ( P <0.01). The PI3K (p110α) and mTORC1 mRNA expression in EX group were significantly higher than CON group, whereas they were significantly decreased in the shAAV-AKIP1+EX group compared with the CON and EX groups ( P <0.01). Our results identify AKIP1 as a novel mediator of physiological hypertrophy, also highlight that the formation of exercise cardiac hypertrophy may be facilitated by AKIP1 through activation of the PI3K/AKT/mTOR signaling pathway.","PeriodicalId":516821,"journal":{"name":"Advanced Exercise and Health Science","volume":"2 2","pages":"151-158"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147881502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Different Breathing Conditions on Cerebral Blood Flow in Young Males During Maximal Aerobic Exercise: A Pilot Study","authors":"Jose M. Moris, Vineet K. Paidisetty, Ryan Curtis, Christian J. Chang, Kylie Allen, Yunsuk Koh","doi":"10.1016/j.aehs.2024.06.001","DOIUrl":"https://doi.org/10.1016/j.aehs.2024.06.001","url":null,"abstract":"","PeriodicalId":516821,"journal":{"name":"Advanced Exercise and Health Science","volume":"87 S1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141842429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Health-Related Fitness, Self-Efficacy, and Quality of Life in Adults with Physical Disabilities: A 9-Week Community-based Structured Exercise and Mindfulness Program","authors":"Juntack Oh, Michele Aquino","doi":"10.1016/j.aehs.2024.07.001","DOIUrl":"https://doi.org/10.1016/j.aehs.2024.07.001","url":null,"abstract":"","PeriodicalId":516821,"journal":{"name":"Advanced Exercise and Health Science","volume":"16 S1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking Barriers: Strength Training Feasibility in McArdle Syndrome- A systematic review","authors":"D. N. Ribeiro, Adelino S.R da Silva, Ana Paula Pinto","doi":"10.1016/j.aehs.2024.05.003","DOIUrl":"https://doi.org/10.1016/j.aehs.2024.05.003","url":null,"abstract":"","PeriodicalId":516821,"journal":{"name":"Advanced Exercise and Health Science","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141274874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistance exercise exacerbates muscle atrophy of skeletal muscle-specific Beclin1 conditioned knockout (cKO) mice","authors":"Zhengzhong Zeng, Hu Zhang, Jiling Liang, Jun Lv, Liangwen Wu, Ning Chen","doi":"10.1016/j.aehs.2024.03.001","DOIUrl":"https://doi.org/10.1016/j.aehs.2024.03.001","url":null,"abstract":"","PeriodicalId":516821,"journal":{"name":"Advanced Exercise and Health Science","volume":"53 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140400450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pericytes express markers of cellular proliferation without expansion of the pool in response to exercise-induced skeletal muscle damage","authors":"J. Nederveen, Katherine Manta, Donald Xhuti, Sean Y Ng, Stephen A. Fortino, T. Snijders, S. Joanisse, Dinesh Kumbhare, Hubert J M Smeets, Florence H J van Tienen, Gianni Parise","doi":"10.1016/j.aehs.2024.01.006","DOIUrl":"https://doi.org/10.1016/j.aehs.2024.01.006","url":null,"abstract":"","PeriodicalId":516821,"journal":{"name":"Advanced Exercise and Health Science","volume":"33 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140465368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of contracting muscle mass and relative exercise intensity on arterial plasma potassium concentration during and following incremental arm and leg cycling exercise.","authors":"Termboon Sangkabutra, Claudia Schneider, S. Fraser, S. Sostaric, Sandford L. Skinner, M. McKenna","doi":"10.1016/j.aehs.2024.02.001","DOIUrl":"https://doi.org/10.1016/j.aehs.2024.02.001","url":null,"abstract":"","PeriodicalId":516821,"journal":{"name":"Advanced Exercise and Health Science","volume":"810 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140469331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Physical Activity and Cardiorespiratory Fitness with Cognitive Function, Self-Control, and Resilience in Young People with Attention Deficit Hyperactivity Disorder","authors":"Elise Sibbick, R. Boat, Mustafa Sarkar, Julie P. Johnston, Maddie Groom, Ryan A Williams, Karah J Dring, Feng-Hua Sun, Simon B. Cooper","doi":"10.1016/j.aehs.2024.01.003","DOIUrl":"https://doi.org/10.1016/j.aehs.2024.01.003","url":null,"abstract":"","PeriodicalId":516821,"journal":{"name":"Advanced Exercise and Health Science","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139876414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Physical Activity and Cardiorespiratory Fitness with Cognitive Function, Self-Control, and Resilience in Young People with Attention Deficit Hyperactivity Disorder","authors":"Elise Sibbick, R. Boat, Mustafa Sarkar, Julie P. Johnston, Maddie Groom, Ryan A Williams, Karah J Dring, Feng-Hua Sun, Simon B. Cooper","doi":"10.1016/j.aehs.2024.01.003","DOIUrl":"https://doi.org/10.1016/j.aehs.2024.01.003","url":null,"abstract":"","PeriodicalId":516821,"journal":{"name":"Advanced Exercise and Health Science","volume":"48 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139816409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Challenge of Inactivity After the COVID-19 Pandemic: What Can We Learn from Australia?","authors":"Boliang Wang, Qin Sun, Xiaorui Xing, Tiemin Liu, Ru Wang","doi":"10.1016/j.aehs.2024.01.008","DOIUrl":"https://doi.org/10.1016/j.aehs.2024.01.008","url":null,"abstract":"","PeriodicalId":516821,"journal":{"name":"Advanced Exercise and Health Science","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140527119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}